KEGG ENZYME: 3.1.1.118

ENZYME: 3.1.1.118

Entry

EC 3.1.1.118                Enzyme

Name

phospholipid sn-1 acylhydrolase;
phospholipase DDHD1;
phosphatidic acid-preferring phospholipase A1;
PA-PLA1;
DDHD1 (gene name)

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

phospholipid sn-1 acylhydrolase

Reaction(IUBMB)

(1) a 1-phosphatidyl-1D-myo-inositol + H2O = a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol + a fatty acid [RN:R12795];
(2) a 1,2-diacyl-sn-glycerol 3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid [RN:R12796]

Reaction(KEGG)

R12795 R12796

Substrate

1-phosphatidyl-1D-myo-inositol [CPD:C01194];
H2O [CPD:C00001];
1,2-diacyl-sn-glycerol 3-phosphate [CPD:C00416]

Product

2-acyl-sn-glycero-3-phospho-1D-myo-inositol [CPD:C22400];
fatty acid [CPD:C00162];
2-acyl-sn-glycerol 3-phosphate [CPD:C03974]

Comment

The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position.

History

EC 3.1.1.118 created 2021

Orthology

K13619

phospholipase DDHD1

Genes

HSA:	80821(DDHD1)

PTR:	452911(DDHD1)

PPS:	100994366(DDHD1)

GGO:	101125781(DDHD1)

PON:	100461176(DDHD1)

PPYG:

129012073(DDHD1)

NLE:	100581601(DDHD1)

HMH:	116484537(DDHD1)

SSYN:

129487876(DDHD1)

MCC:	694361(DDHD1)

MCF:	102129871(DDHD1)

MTHB:

126960106

MNI:	105481810(DDHD1)

CSAB:

103229003(DDHD1)

CATY:

105586632(DDHD1)

PANU:

101019175(DDHD1)

TGE:	112629287(DDHD1)

MLEU:

105553595(DDHD1)

RRO:	104669158(DDHD1)

RBB:	108513691(DDHD1)

TFN:	117069632(DDHD1)

PTEH:

111555042(DDHD1)

CANG:

105525982(DDHD1)

CJC:	100397054(DDHD1)

SBQ:	101041656(DDHD1)

CIMI:

108291912(DDHD1)

ANAN:

105716412(DDHD1)

CSYR:

103264551(DDHD1)

MMUR:

105867682(DDHD1)

LCAT:

123649057(DDHD1)

PCOQ:

105825844(DDHD1)

OGA:	100962172(DDHD1)

MMU:	114874(Ddhd1)

MCAL:

110309253(Ddhd1)

MPAH:

110325222(Ddhd1)

RNO:	305816(Ddhd1)

MCOC:

116085362(Ddhd1)

ANU:	117705167(Ddhd1)

MUN:	110552221(Ddhd1)

CGE:	100761687(Ddhd1)

MAUA:

101832586(Ddhd1)

PROB:

127216405(Ddhd1)

PLEU:

114696048(Ddhd1)

MORG:

121435041(Ddhd1)

MFOT:

126513823

AAMP:

119799961(Ddhd1)

NGI:	103739232(Ddhd1)

HGL:	101712889(Ddhd1)

CPOC:

100731571(Ddhd1)

CCAN:

109691902(Ddhd1)

DORD:

105982652(Ddhd1)

DSP:	122106466(Ddhd1)

PLOP:

125363651(Ddhd1)

NCAR:

124976674

MMMA:

107137743(Ddhd1) 107155625

OCU:

100354460

OPI:	101531341(DDHD1)

TUP:	102482597(DDHD1)

GVR:	103585845(DDHD1)

CFA:	480326(DDHD1)

CLUD:

112656901(DDHD1)

VVP:	112921420(DDHD1)

VLG:	121493351(DDHD1)

NPO:	129496168(DDHD1)

AML:	100479340(DDHD1)

UMR:	103674519(DDHD1)

UAH:	113242366(DDHD1)

UAR:	123800621(DDHD1)

ELK:

111162360

LLV:

125104104

MPUF:

101683505(DDHD1)

MNP:	131999955(DDHD1)

MLK:	131836577(DDHD1)

NVS:	122893814(DDHD1)

ORO:	101383276(DDHD1)

EJU:	114207630(DDHD1)

ZCA:	113909084(DDHD1)

MLX:	118002376(DDHD1)

NSU:	110590512(DDHD1)

LWW:	102732374(DDHD1)

FCA:	101091376(DDHD1)

PYU:	121031778(DDHD1)

PCOO:

112855400(DDHD1)

PBG:	122469106(DDHD1)

PVIV:

125167762(DDHD1)

LRUF:

124512180

PTG:	102954241(DDHD1)

PPAD:

109268459(DDHD1)

PUC:

125908765

AJU:

106981957

HHV:	120237270(DDHD1)

BTA:	338047(DDHD1)

BOM:	102271817(DDHD1)

BIU:	109565171(DDHD1)

BBUB:

102399107(DDHD1)

BBIS:

104994264(DDHD1)

CHX:	102187228(DDHD1)

OAS:	101112738(DDHD1)

BTAX:

128054394(DDHD1)

ODA:	120852925(DDHD1)

CCAD:

122443658(DDHD1)

MBEZ:

129563194(DDHD1)

SSC:	100518289(DDHD1)

CFR:	102512617(DDHD1)

CBAI:

105074584(DDHD1)

CDK:	105091430(DDHD1)

VPC:	102531831(DDHD1)

BACU:

103010055(DDHD1)

BMUS:

118890714(DDHD1)

LVE:	103071873(DDHD1)

OOR:	101279589(DDHD1)

DLE:	111173146(DDHD1)

PCAD:

102979025(DDHD1)

PSIU:

116749164(DDHD1)

NASI:

112392889(DDHD1)

ECB:	100055200(DDHD1)

EPZ:	103542202 103565046

EAI:	106826766(DDHD1)

MYB:	102249329(DDHD1)

MYD:	102770195(DDHD1)

MMYO:

118655502(DDHD1)

MLF:	102437616(DDHD1)

MDT:	132234579(DDHD1)

PKL:	118718030(DDHD1)

EFUS:

103283733(DDHD1)

MNA:	107525877(DDHD1)

DRO:	112311209(DDHD1)

SHON:

118992408(DDHD1)

AJM:	119057000(DDHD1)

PDIC:

114491721(DDHD1)

PHAS:

123808201(DDHD1)

MMF:	118627137(DDHD1)

PPAM:

129066025(DDHD1)

HAI:	109384226(DDHD1)

RFQ:	117023490(DDHD1)

PALE:

102882168(DDHD1)

PGIG:

120604415(DDHD1)

PVP:	105309246(DDHD1)

RAY:	107509545(DDHD1)

MJV:	108410249(DDHD1)

TOD:	119239101(DDHD1)

SARA:

101539647(DDHD1)

SETR:

125999052(DDHD1)

LAV:	100677441(DDHD1)

TMU:

101355157

ETF:	101653198(DDHD1)

DNM:	101421583(DDHD1)

MDO:	100011027(DDHD1)

GAS:	123237678(DDHD1)

SHR:	100915122(DDHD1)

AFZ:

127549711

PCW:	110199852(DDHD1)

TVP:	118841938(DDHD1)

OAA:	100085148(DDHD1)

GGA:	423592(DDHD1)

PCOC:

116234610(DDHD1)

MGP:	100544026(DDHD1)

CJO:	107315511(DDHD1)

TPAI:

128087181(DDHD1)

LMUT:

125695073(DDHD1)

NMEL:

110401123(DDHD1)

APLA:

101791297(DDHD1)

ACYG:

106044026(DDHD1)

CATA:

118250249(DDHD1)

AFUL:

116489717(DDHD1)

TGU:	100219046(DDHD1)

LSR:	110474757(DDHD1)

SCAN:

103826841(DDHD1)

PMOA:

120500696(DDHD1)

OTC:	121338903(DDHD1)

PRUF:

121348704(DDHD1)

GFR:	102045342(DDHD1)

FAB:	101813293(DDHD1)

OMA:

130266483

PHI:	102102892(DDHD1)

PMAJ:

107206080(DDHD1)

CCAE:

111929660(DDHD1)

CCW:	104695910(DDHD1)

CBRC:

103618894(DDHD1)

ETL:	114068790(DDHD1)

ZAB:	102070745(DDHD1)

ZLE:	135449233(DDHD1)

ACHL:

103799330

SVG:	106850281(DDHD1)

HRT:	120754204(DDHD1)

SATI:

136362741(DDHD1)

FPG:	101914478(DDHD1)

FCH:	102053112(DDHD1)

CCRI:

104159791(DDHD1)

SHAB:

115607150(DDHD1)

ACUN:

113480827(DDHD1)

TALA:

104357881(DDHD1)

ACHC:

115335214(DDHD1)

HALD:

104315841(DDHD1)

HLE:	104839527(DDHD1)

AGEN:

126050577

GCL:

127016734

CSTI:

104552588(DDHD1)

LDI:

104343431

MNB:	103770635(DDHD1)

DPUB:

104299385(DDHD1)

BRHI:

104495187

EGZ:	104122999(DDHD1)

NNI:	104019476(DDHD1)

PCAO:

104048912

PADL:

103916003(DDHD1)

AFOR:

103907670(DDHD1)

FGA:	104073883(DDHD1)

CLV:	102083502(DDHD1)

MUI:	104541049(DDHD1)

PGUU:

104463393(DDHD1)

CMAC:

104485717(DDHD1)

CUCA:

104057467(DDHD1)

OHA:	104333973(DDHD1)

CPEA:

104387696(DDHD1)

CVF:	104294354(DDHD1)

RTD:	128908865(DDHD1)

AAM:

106485072

AROW:

112961230(DDHD1)

NPD:	112957773(DDHD1)

DNE:	112988542(DDHD1)

SCAM:

104141414(DDHD1)

ASN:	102385359(DDHD1)

AMJ:	102577034(DDHD1)

CPOO:

109324575(DDHD1)

GGN:	109305248(DDHD1)

PSS:	102445213(DDHD1)

CMY:	102935388(DDHD1)

CCAY:

125638071(DDHD1)

DCC:	119857721(DDHD1)

CPIC:

101953595(DDHD1)

TST:	117876177(DDHD1)

CABI:

116827382(DDHD1)

MRV:	120404415(DDHD1)

ACS:	100561471(ddhd1)

ASAO:

132760843(DDHD1)

PVT:	110088778(DDHD1)

SUND:

121927959(DDHD1)

PBI:	103055357(DDHD1)

PMUR:

107289085(DDHD1)

CTIG:

120297682(DDHD1)

TSR:	106548975(DDHD1)

PGUT:

117675059(DDHD1)

APRI:

131188094(DDHD1)

PTEX:

113435137(DDHD1)

NSS:	113414123(DDHD1)

VKO:	123026489(DDHD1)

PMUA:

114585447(DDHD1)

PRAF:

128401882(DDHD1)

ZVI:	118097760(DDHD1)

HCG:	128341127(DDHD1)

GJA:	107114080(DDHD1)

STOW:

125427085(DDHD1)

EMC:	129324968(DDHD1)

XLA:	100158329(ddhd1.L) 495273(ddhd1.S)

XTR:	100493824(ddhd1)

NPR:	108788627(DDHD1)

BBUF:

120981780(DDHD1)

BGAR:

122921608 122921731

MUO:	115477677(DDHD1)

GSH:	117364098(DDHD1)

DRE:	562868(ddhd1a) 570320(ddhd1b)

SRX:	107712414 107723264 107740295 107752719(ddhd1)

SANH:

107664821 107668131 107687830 107702228

SGH:	107549504 107565218 107577847 107582105 107589766

CCAR:

109048861 109074462 109078930 109107056 109108350

CAUA:

113060419 113062984 113116949 113121125 113121183

CGIB:

127938390 127975803 127983974 128031377

PTET:

122324672(ddhd1b) 122362225(ddhd1a)

LROH:

127179970(ddhd1a) 127182866(ddhd1b)

OMC:	131523269(ddhd1a) 131526770(ddhd1b)

PPRM:

120479070 120493910(ddhd1b)

RKG:	130076701(ddhd1a) 130096070(ddhd1b)

MAMB:

125268290(ddhd1a) 125279023(ddhd1b)

CIDE:

127498038 127501801

CERY:

137006196(ddhd1a) 137019360(ddhd1b)

MASI:

127410109 127416237 127455359

TROS:

130551058(ddhd1b) 130560278(ddhd1a)

TDW:	130434774(ddhd1b) 130436754(ddhd1a)

MANU:

129417547(ddhd1a)

IPU:	108257669(ddhd1b) 108269913(ddhd1a)

IFU:	128601177(ddhd1b) 128613153(ddhd1a)

PHYP:

113524833 113538576

SMEO:

124377096(ddhd1b) 124390038(ddhd1a)

TFD:	113647913(ddhd1b) 113659505(ddhd1a)

TVC:	132842976(ddhd1b) 132852321(ddhd1a)

TRN:	134324952(ddhd1a)

AMEX:

103023862(ddhd1a) 103030578(ddhd1b)

CMAO:

118815962(ddhd1b) 118823372(ddhd1a)

EEE:	113571722 113572646

CHAR:

105892966(ddhd1b) 105897330(ddhd1a)

TRU:	101077693(ddhd1)

TFS:	130539775(ddhd1a)

TNG:	GSTEN00031995G001

LCO:	104922405 104938520(ddhd1)

NCC:	104949736 104965147

TBEN:

117479104(ddhd1a) 117498455(ddhd1b)

CGOB:

115003711 115027276

PGEO:

117440092(ddhd1b) 117467453(ddhd1a)

GACU:

117532383(ddhd1b) 117548136(ddhd1a)

EMAC:

134877237(ddhd1b) 134881251(ddhd1a)

ELY:	117252670(ddhd1b) 117267077(ddhd1a)

EFO:	125897361(ddhd1b) 125901404(ddhd1a)

PLEP:

121953199(ddhd1a) 121955482

SLUC:

116053505(ddhd1b) 116057589(ddhd1a)

ECRA:

117935661(ddhd1a) 117961483(ddhd1b)

ESP:	116669649 116705877

PFLV:

114546810 114573014(ddhd1)

GAT:	120808396(ddhd1b) 120832866(ddhd1a)

PPUG:

119195053(ddhd1b) 119227451(ddhd1a)

AFB:	129103553(ddhd1a) 129106753(ddhd1b)

CLUM:

117727422(ddhd1b) 117751342(ddhd1a)

PSWI:

130201182(ddhd1a) 130202361(ddhd1b)

MSAM:

119909179(ddhd1b) 119910508(ddhd1a)

SCHU:

122861599(ddhd1a) 122862883(ddhd1b)

CUD:	121520894(ddhd1b) 121526264(ddhd1a)

ALAT:

119004392(ddhd1a) 119012514(ddhd1b)

MZE:	101468746(ddhd1) 101479185

ONL:	100699782(ddhd1) 100710483

OAU:	116321745(ddhd1b) 116326096(ddhd1a)

OLA:	101163939 101171796

OML:	112143675(ddhd1a) 112157645(ddhd1b)

CSAI:

133462950(ddhd1a) 133464598(ddhd1b)

XMA:	102223187(ddhd1)

XCO:	114134187(ddhd1)

XHE:	116708986(ddhd1)

PRET:

103458755(ddhd1)

PFOR:

103154895(ddhd1)

PLAI:

106953911(ddhd1)

PMEI:

106906481(ddhd1)

GAF:	122846257(ddhd1a)

PPRL:

129365301(ddhd1a)

CVG:	107096911(ddhd1)

CTUL:

119775031(ddhd1a)

GMU:	124855400(ddhd1a)

NFU:	107392165(ddhd1)

KMR:	108236473(ddhd1a)

ALIM:

106518438(ddhd1)

NWH:	119427673(ddhd1a)

AOCE:

111573281 111574124(ddhd1)

MCEP:

124999386(ddhd1b) 125023757(ddhd1a)

CSEM:

103378824 103380600(ddhd1)

POV:	109632300 109636490

SSEN:

122782832(ddhd1a) 122783827(ddhd1b)

HHIP:

117755575(ddhd1a) 117758624(ddhd1b)

HSP:	118099261(ddhd1b) 118116232(ddhd1a)

PPLT:

128450478(ddhd1a) 128460452(ddhd1b)

SMAU:

118286029(ddhd1a) 118290044(ddhd1b)

LCF:	108875010 108901771(ddhd1b)

SDU:	111225838 111239269

SLAL:

111651011 111667903

XGL:	120788681(ddhd1b) 120795654(ddhd1a)

HCQ:	109516696 109517422

SSCV:

125980851 125989764

SBIA:

133496200(ddhd1b) 133512846(ddhd1a)

PEE:	133412971(ddhd1a) 133417272(ddhd1b)

PTAO:

133468314(ddhd1b) 133488045(ddhd1a)

BPEC:

110156397(ddhd1)

MALB:

109952524 109968021 109970951

BSPL:

114848318(ddhd1a) 114849814(ddhd1b)

SJO:	128375350(ddhd1a) 128377107(ddhd1b)

SASA:

106571651 106601609 106608167 106611105

STRU:

115161217 115161793 115172444(ddhd1) 115174587

OTW:	112217915 112250487 112261631(ddhd1a)

OMY:	110497763(ddhd1a) 110504214 110521086 110529783(ddhd1b)

OGO:	123990921 123995365 124002015(ddhd1a) 124046940

ONE:	115107921 115123971 115138816 115146087

OKI:	109866354 109894392 109900896 109904564

OKE:	118362656 118368166 118387114 118398487

SALP:

111954261 111962988 111968587 111972742

SNH:	120019156 120024144 120060391(ddhd1a)

CCLU:

121539448 121544775 121548555 121552327(ddhd1b)

ELS:	105015524 105017575

SFM:	108919407(ddhd1) 108924025

PKI:	111859960(ddhd1)

AANG:

118231899(ddhd1a)

LOC:	102682572(ddhd1)

PSPA:

121324419 121329923

ARUT:

117421737 117422437 117973977

PSEX:

120518538

LCM:	102352890(DDHD1)

CMK:	103175247(ddhd1b)

RTP:

109919087

CPLA:

122553611(ddhd1b)

HOC:	132817907(ddhd1b)

LERI:

129700173

PMRN:

116947062(DDHD1)

LRJ:

133362123

BFO:

118427130

BBEL:

109470135

CIN:

100180467

SCLV:

120326450

SPU:

578370

LPIC:

129264920

APLC:

110981920

ARUN:

117306446

AJC:

117108678

SKO:

100377407

AME:

724115

ACER:

107994848

ALAB:

122712710

ADR:

102674557

AFLR:

100872592

BIM:

100742668

BBIF:

117213607

BVK:

117234301

BVAN:

117166224

BTER:

100643199

BAFF:

126915589

BPYO:

122568696

BPAS:

132907749

FVI:

122532206

CCAL:

108623811

OBB:

114874639

OLG:

117608701

MGEN:

117221152

NMEA:

116431731

CGIG:

122404698

SOC:

105201122

MPHA:

105836852

AEC:

105147258

ACEP:

105625039

PBAR:

105423097

VEM:

105557271

HST:

105183032

DQU:

106749730

CFO:

105249675

FEX:

115237467

LHU:

105674232

PGC:

109853918

OBO:

105277799

PCF:

106790640

PFUC:

122513434

VPS:

122637115

VCRB:

124431135

VVE:

124956915

NVI:

100680179

CSOL:

105367628

TPRE:

106652317

LHT:

122503295

LBD:

127276892

MDL:

103568712

CGLO:

123258812

FAS:

105271153

DAM:

107048197

AGIF:

122847338

CINS:

118069048

VCAN:

122412632

CCIN:

107263759

DSM:

124408732

NPT:

124217047

NFB:

124181018

NLO:

107216582

NVG:

124303526

AROA:

105687097

API:	100570693 103309374 107882143

DNX:

107165359

AGS:

114131494

RMD:

113549223

ACOO:

126833684 126847700

DVT:

126908513

BTAB:

109030559

DCI:

103513864

CLEC:

106662488

HHAL:

106690420

NLU:

111059161

HVI:

124366483

MQU:	129001991 129003693

PHU:	Phum_PHUM366090

FOC:

113209304

TPAL:

117641837

ZNE:

110840404

CSEC:

111863223

SGRE:

126284261

IEL:

124153339

FCD:

110843358

PVM:	113805417 113816131

PJA:

122254288

PCHN:

125024597

PMOO:

119568038

HAME:

121871172

PCLA:

123764520

CQD:

128695826

PTRU:

123503874

ESN:

127006144

MNZ:

135210770

HAZT:

108671547

EAF:

111712430

LSM:

121115374

TCF:

131884180

CEL:	CELE_M03A1.6(ipla-1)

CBR:	CBG_11786 CBG_13444(Cbr-ipla-1)

CRQ:	GCK72_004450 GCK72_004461

NAI:	NECAME_11091

BMY:	BM_BM5072(Bma-ipla-1)

LOA:	LOAG_17210

LGI:	LOTGIDRAFT_133288

PVUL:

126822349

PCAN:

112570093

BGT:

106075981

GAE:

121371612

HRF:

124118361

HRJ:

124289797

CRG:

105326251

CANU:

128177103

CVN:

111114520

OED:

125650139

MYI:

110467238

PMAX:

117323428

MCAF:

127699114

MMER:

123534323

RPHI:

132730024

DPOL:

127870829

MAEA:

128209114

OBI:

106876756

OSN:

115218077

LJP:

135466326

LAK:

106175188

SMM:	Smp_141150 Smp_210300

OVI:	T265_03979 T265_09016

EGL:	EGR_00152 EGR_09695

LLON:

135484057

NVE:

5512722

EPA:

110249081

ATEN:

116295478

ADF:

107350406

AMIL:

114977148

PDAM:

113671503

SPIS:

111334534

DGT:

114531681

XEN:

124452750

HMG:

101234320

HSY:

130642121

RES:

135681661

AQU:

100640606

DPP:	DICPUDRAFT_50997

TAN:

TA16640

TPV:

TP01_1157

TOT:	TOT_010001100

BBO:	BBOV_IV011470

BMIC:

BMR1_02g02600

CPV:

cgd2_1280

CHO:	Chro.20140

PIF:	PITG_18070

PSOJ:

PHYSODRAFT_554083

» show all

Reference

1 [PMID:20359546]

Authors

Yamashita A, Kumazawa T, Koga H, Suzuki N, Oka S, Sugiura T.

Title

Generation of lysophosphatidylinositol by DDHD domain containing 1 (DDHD1): Possible involvement of phospholipase D/phosphatidic acid in the activation of DDHD1.

Journal

Biochim Biophys Acta 1801:711-20 (2010)
DOI:10.1016/j.bbalip.2010.03.012

Reference

2 [PMID:24599962]

Authors

Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K.

Title

Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.

Journal

J Biol Chem 289:11497-11511 (2014)
DOI:10.1074/jbc.M113.531921

Other DBs

ExplorEnz - The Enzyme Database: