KEGG   ENZYME: 3.1.1.121
Entry
EC 3.1.1.121                Enzyme                                 
Name
ergosteryl-3beta-O-L-aspartate hydrolase;
ErdH
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
ergosteryl-3beta-O-L-aspartate aminoacylesterase
Reaction(IUBMB)
1-(ergostan-3beta-yl) L-aspartate + H2O = ergosterol + L-aspartate [RN:R13190]
Reaction(KEGG)
R13190
Substrate
1-(ergostan-3beta-yl) L-aspartate;
H2O [CPD:C00001]
Product
ergosterol [CPD:C01694];
L-aspartate [CPD:C00049]
Comment
The enzyme has been detected in fungal species that belong to the Ascomycota and Basidiomycota phyla, and has been characterized from the fungus Aspergillus fumigatus.
History
EC 3.1.1.121 created 2023
Orthology
K24279  ergosteryl-3beta-O-L-aspartate hydrolase
Genes
BCOO: 119074887
NCR: NCU07081
NTE: NEUTE1DRAFT124341(NEUTE1DRAFT_124341)
SMP: 10805234(SMAC4_03898)
PAN: PODANSg3376
PBEL: QC761_405100
PPSD: QC762_405100
PPSP: QC763_405100
PPSA: QC764_405100
TTT: THITE_2109403
MTM: MYCTH_2299837
RTHE: 98128439(VTJ83DRAFT_7019)
MGR: MGG_04680
PPEI: PpBr36_05420
PGRI: PgNI_02915
TMN: UCRPA7_8014
SSCK: SPSK_09366
FGR: FGSG_01975
FPU: FPSE_09209
FPOA: FPOAC1_002102
FVN: FVRRES_02345
FVR: FVEG_07263
FOX: FOXG_04149
NHE: NECHADRAFT_49962
FFC: NCS54_01271800
FKR: NCS57_01237600
FMU: J7337_010724
TRE: TRIREDRAFT_62985
TRR: M419DRAFT_137130
TATV: 25781972(TrAtP1_001212)
TASP: 36617786(TrAFT101_001260)
MAW: 19251088(J3458_020463)
MAJ: MAA_01126
MBRN: 26239228(ABHS)
PCHM: VFPPC_03565
CMT: CCM_02982
AMUS: LMH87_006951
PLJ: 28882821(PLICBS_001152)
PTKZ: JDV02_007962
VDA: VDAG_02040
CFJ: CFIO01_08750
CLUP: CLUP02_06616
CHIG: CH63R_01435
CDET: 87940189(CDEST_03686)
ELA: UCREL1_7941
PFY: PFICI_05046
SSL: SS1G_11473
BFU: BCIN_08g05780
MBE: MBM_03825
PSCO: LY89DRAFT_596963
GLZ: GLAREA_06462
ANI: ANIA_00313
AFM: AFUA_1G02580
ACT: ACLA_031830
NFI: NFIA_022040
AOR: AO090005000837
ANG: An01g05620
AFV: AFLA_003656
ALUC: AKAW2_20667A
ACHE: ACHE_11808A
APUU: APUU_11797S
PCS: N7525_004214
PDP: PDIP_63510
POU: POX_b03342
TMF: EYB26_008490
TRG: TRUGW13939_00065
CIM: CIMG_04733
CPW: 9697055(D8B26_008102)
URE: UREG_06778
ABE: ARB_01268
TVE: TRV_01139
PBL: PAAG_05665
PBN: PADG_07731
PNO: SNOG_02132
PTE: PTT_15281
PTRR: 6345659(PtrM4_039780) 6346569(PtrM4_149540)
BZE: COCCADRAFT_93282
BSC: COCSADRAFT_41976
BOR: COCMIDRAFT_94292
AALT: CC77DRAFT_625032
ADAC: 96081269(ACET3X_000947)
ARAB: EKO05_0004157 EKO05_0005007
ZTR: MYCGRDRAFT_68502
PFJ: MYCFIDRAFT_80112
FFU: CLAFUR5_10727
CBET: CB0940_06674
BCOM: BAUCODRAFT_76924
NPA: UCRNP2_7146
TML: GSTUM_00003345001
CNE: CNG00390
CNB: CNBG4390
CNG: CNAG_03564
CGI: CGB_G6330W
CDEU: CNBG_2058
CDEP: 91085494(L203_101281)
KNE: 92180500(IAR55_003242)
ADL: AURDEDRAFT_50139
MPR: MPER_04335
MRR: Moror_17304
MORE: E1B28_013124
SGRA: EX895_005175
 » show all
Reference
1  [PMID:32541034]
  Authors
Yakobov N, Fischer F, Mahmoudi N, Saga Y, Grube CD, Roy H, Senger B, Grob G, Tatematsu S, Yokokawa D, Mouyna I, Latge JP, Nakajima H, Kushiro T, Becker HD
  Title
RNA-dependent sterol aspartylation in fungi.
  Journal
Proc Natl Acad Sci U S A 117:14948-14957 (2020)
DOI:10.1073/pnas.2003266117
  Sequence
[afm:AFUA_1G02580]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.121
IUBMB Enzyme Nomenclature: 3.1.1.121
ExPASy - ENZYME nomenclature database: 3.1.1.121
BRENDA, the Enzyme Database: 3.1.1.121
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