KEGG   ENZYME: 3.1.2.21
Entry
EC 3.1.2.21                 Enzyme                                 
Name
dodecanoyl-[acyl-carrier-protein] hydrolase;
lauryl-acyl-carrier-protein hydrolase;
dodecanoyl-acyl-carrier-protein hydrolase;
dodecyl-acyl-carrier protein hydrolase;
dodecanoyl-[acyl-carrier protein] hydrolase;
dodecanoyl-[acyl-carrier-protein] hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
dodecanoyl-[acyl-carrier protein] hydrolase
Reaction(IUBMB)
a dodecanoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + dodecanoate [RN:R04014]
Reaction(KEGG)
R04014;
(other) R08157 R08158 R12329
Substrate
dodecanoyl-[acyl-carrier protein] [CPD:C05223];
H2O [CPD:C00001]
Product
[acyl-carrier protein] [CPD:C00229];
dodecanoate [CPD:C02679]
Comment
Acts on the acyl-carrier-protein thioester of C12 and, with a much lower activity, C14 fatty acids. The derivative of oleic acid is hydrolysed very slowly (cf. EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase).
History
EC 3.1.2.21 created 1999
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K01071  medium-chain acyl-[acyl-carrier-protein] hydrolase
K10781  fatty acyl-ACP thioesterase B
Genes
HSA55301(OLAH)
PTR450320(OLAH)
PPS100969629(OLAH)
PON100441345(OLAH)
NLE100601676(OLAH)
HMH116473822(OLAH)
MCC697753
MCF102142933(OLAH)
MTHB126962398 126962958
MNI105468343 105490647(OLAH)
CSAB103237931(OLAH)
CATY105583885(OLAH) 105584580
PANU101003297(OLAH)
TGE112631348(OLAH)
MLEU105530558(OLAH)
RRO104664475(OLAH)
RBB108530852(OLAH)
TFN117082669(OLAH)
PTEH111550042(OLAH)
CANG105506223(OLAH)
CJC100402846(OLAH)
SBQ101043966(OLAH)
CIMI108305185(OLAH)
CSYR103267724(OLAH)
MMUR105856354(OLAH)
LCAT123625433(OLAH)
PCOQ105823702(OLAH)
OGA100963077(OLAH)
MMU99035(Olah)
MCAL110290252(Olah)
MPAH110334162(Olah)
RNO64669(Olah)
MCOC116082275(Olah)
ANU117714040(Olah)
MUN110564304(Olah)
CGE100755723(Olah)
MAUA101830993(Olah)
PROB127237520(Olah)
PLEU114710817(Olah)
MORG121432539(Olah)
MFOT126506768
AAMP119817836(Olah)
NGI103735189(Olah)
HGL101699165(Olah)
CPOC100730585(Olah)
DORD105984432(Olah)
DSP122113237(Olah)
PLOP125367175(Olah)
NCAR124962152
MMMA107140257(Olah)
OCU100349940
OPI101536726(OLAH)
TUP102488474(OLAH)
GVR103608020(OLAH)
BTA617347(OLAH)
BOM102273387(OLAH)
BIU109567605(OLAH)
BBUB102413725(OLAH)
BBIS105003035(OLAH)
CHX102180055(OLAH)
OAS101116669(OLAH)
ODA120868612(OLAH)
CCAD122448461
MBEZ129558232(OLAH)
SSC100627446(OLAH)
CFR102522778(OLAH)
CBAI105072476(OLAH)
VPC102529434(OLAH)
BACU103001653(OLAH)
PCAD102991368(OLAH)
ECB100068833(OLAH)
EPZ103556832(OLAH)
EAI106840468(OLAH)
MYB102239550(OLAH)
MYD102759672(OLAH)
MMYO118655462(OLAH)
MLF102436487(OLAH)
MNA107534813(OLAH)
PKL118719611(OLAH)
EFUS103292622(OLAH)
HAI109393805(OLAH)
DRO112320938(OLAH)
PDIC114491925(OLAH)
PHAS123831089(OLAH)
MMF118643242(OLAH)
RFQ117019110(OLAH)
PPAM129084763(OLAH)
PGIG120614701(OLAH)
PVP105291715(OLAH)
RAY107504822(OLAH)
TOD119245273(OLAH)
SARA101551105(OLAH)
LAV100675942(OLAH)
TMU101361105
ETF101651008(OLAH)
DNM101415627(OLAH)
MDO100027206(OLAH)
GAS123249804(OLAH)
SHR100914322(OLAH)
AFZ127564857
PCW110209026(OLAH)
OAA100077700(OLAH)
GGA420532(OLAH)
PCOC116243282(OLAH)
MGP100547884(OLAH)
CJO107309023(OLAH)
TPAI128086388(OLAH)
LMUT125695997(OLAH)
NMEL110393652(OLAH)
APLA101793583(OLAH)
ACYG106039692(OLAH)
CATA118247444(OLAH)
AFUL116485827(OLAH)
TGU100224799(OLAH)
LSR110482463(OLAH)
SCAN103813106(OLAH)
PMOA120503875(OLAH)
OTC121338143(OLAH)
PRUF121353101(OLAH)
GFR102031766(OLAH)
FAB101815966(OLAH)
OMA130248929(OLAH)
PHI102106226(OLAH)
PMAJ107198685(OLAH)
CCAE111924181(OLAH)
CCW104689201(OLAH)
CBRC103612339(OLAH)
ETL114065102(OLAH)
ZAB102074087(OLAH)
ACHL103804692(OLAH)
SVG106852799(OLAH)
MMEA130583645(OLAH)
HRT120749960(OLAH)
FPG101922325(OLAH)
FCH102058635(OLAH)
CLV102084717(OLAH)
EGZ104128444(OLAH)
NNI104022905(OLAH)
PCRI104026616(OLAH)
PLET104625413(OLAH)
EHS104502497(OLAH)
PCAO104047264(OLAH)
ACUN113477405(OLAH)
TALA104358957(OLAH)
PADL103922402(OLAH)
AFOR103895942(OLAH)
ACHC115339272(OLAH)
AGEN126037952
GCL127013650
CCRI104158046(OLAH)
CSTI104561432(OLAH)
CMAC104487451(OLAH)
MUI104533426(OLAH)
BREG104629022(OLAH)
FGA104069112(OLAH)
GSTE104258972(OLAH)
LDI104339726(OLAH)
MNB103776212(OLAH)
OHA104332535(OLAH)
NNT104412137(OLAH)
SHAB115612550(OLAH)
DPUB104307001(OLAH)
PGUU104467261(OLAH)
ACAR104528435(OLAH)
CPEA104394074(OLAH)
AVIT104267019(OLAH)
CVF104289933(OLAH)
RTD128905594(OLAH)
TEO104383546(OLAH)
AAM106483605(OLAH)
AROW112967012(OLAH)
NPD112947374(OLAH)
TGT104580897(OLAH)
DNE112982319(OLAH)
SCAM104144105(OLAH)
ASN102386110(OLAH)
AMJ102557880(OLAH)
CPOO109308412(OLAH)
GGN109291372(OLAH)
PSS102454966(OLAH)
CMY102930778(OLAH)
CCAY125630824(OLAH)
DCC119852288(OLAH)
CPIC101937274(OLAH)
CABI116840020(OLAH)
MRV120397059(OLAH)
XLA108718823(olah.L)
XTR407865(olah)
NPR108795592(OLAH)
RTEM120939957(OLAH)
BBUF121002900(OLAH)
BGAR122939021(OLAH)
MUO115460090 115468269
GSH117354191(OLAH)
DRE568096(olah)
SRX107739590 107748745
SANH107656617 107693288
SGH107589366 107599545
CCAR109111875
CAUA113120148(olah)
CGIB127979255
PTET122323400(olah)
LROH127181777(olah)
OMC131525541(olah)
PPRM120483503(olah)
RKG130097357(olah)
MAMB125275314(olah)
CIDE127500761
MASI127421544 127424983
TROS130566826(olah)
TDW130416077(olah)
MANU129455720(olah)
IPU100528864(olah)
IFU128616237(olah)
PHYP113534943(olah)
SMEO124382229(olah)
TFD113641319(olah)
TVC132842898(olah)
AMEX103035172(olah)
CMAO118806058(olah)
EEE113578374(olah)
CHAR105902009(olah)
TRU101061874(olah)
TFS130518146(olah)
TNGGSTEN00003671G001
LCO104928057(olah)
TBEN117477937(olah)
CGOB115015784(olah)
PGEO117455010(olah)
GACU117559292(olah)
ELY117263941(olah)
EFO125904844(olah)
PLEP121958300(olah)
SLUC116047173(olah)
ECRA117957244(olah)
ESP116702048(olah)
PFLV114567813(olah)
GAT120826636(olah)
PPUG119218896(olah)
AFB129097144(olah)
CLUM117739549(olah)
MSAM119908035(olah)
SCHU122864998(olah)
CUD121524056(olah)
ALAT119016758(olah)
MZE101474377(olah)
ONL100691905(olah)
OAU116318887(olah)
OLA101160493(olah)
OML112161056(olah)
XMA102216960(olah)
XCO114155297(olah)
XHE116730514(olah)
PRET103473026(olah)
PFOR103143486(olah)
PLAI106946895(olah)
PMEI106927639(olah)
GAF122844276(olah)
PPRL129375918(olah)
CVG107098937(olah)
CTUL119771383(olah)
GMU124879812(olah)
NFU107394887(olah)
KMR108228836(olah)
ALIM106530105(olah)
NWH119425964(olah)
AOCE111586624(olah)
MCEP125020273(olaH)
CSEM103393954(olah)
POV109643703(olah)
SSEN122786240(olah)
HHIP117770252(olah)
HSP118124551(olah)
LCF108899375
SDU111230514(olah)
SLAL111661082(olah)
XGL120786826(olah)
HCQ109513606(olah)
SSCV125987375
SBIA133492458(olah)
PEE133395360(olah)
PTAO133470835(olah)
BPEC110168928(olah)
MALB109958738(olah)
BSPL114865427(olah)
SJO128373769(olah)
SASA100196232(olah)
STRU115173388(olah)
OTW112264938(olah)
OMY100301766(olah)
OGO124013211(olah)
ONE115128270(olah)
OKI109907629(olah)
OKE118399180(olah)
SALP111956208(olah)
SNH120022734(olah)
CCLU121586277(olah)
ELS105009858(olah)
SFM108933393(olah)
PKI111834098(olah)
AANG118234258(olah)
LOC102684274(olah)
PSPA121313185(olah)
ARUT117400293(olah)
PSEX120515463(olah)
LCM102354603(OLAH)
CMK103181559(olah)
RTP109926026(olah)
CPLA122549991
HOC132816103(olah)
LERI129709353(olah)
BFO118407981
BBEL109478146
SPU582714
LPIC129275205
APLC110974650 110977368
AJC117109975
LGILOTGIDRAFT_184680
PVUL126815866
PCAN112565315
BGT106061994
GAE121384619
HRF124138500
HRJ124267554
CRG105339010
CVN111124570
CANU128191508
OED125678620
MYI110445787
PMAX117329480
MCAF127714981
MMER123557628
RPHI132734153
DPOL127877749
LAK106152278 106181168
NVE5513765
EPA110234691
ATEN116297757
PDAM113679240
SPIS111321809
ATHAT1G08510(FATB)
ALY9325763
CRB17897852
CSAT104739442 104755032 104766704
EUSEUTSA_v10007761mg
BRP103836386 103843393 103871592
BNA106346329 106362292 106377030 106383116 106415535 106420175
BOE106295830 106312522 106312734
RSZ108805233 108823083 108861314 130509222
THJ104809019 104826529
CPAP110823017
CIT102577983(FATB) 102623135
CICCICLE_v10008435mg CICLE_v100336872m
PVY116105440 116118105 116118107 116121683 116121693 116121983 116124154 116143815
MINC123195058 123217660 123218962 123227893
TCC18588657 18595859 18605136
GRA105765848 105771957 105773608 105781329 105792884
GHI107901209 107902762 107930856 107932089 107932873 107933005 107938815 107939491 107962656
GAB108451200 108461691 108470202 108473564 108486625
HSYR120117613 120144613 120144624 120144661 120149811 120149877 120159265 120164707 120166267 120176735 120197279 120211819
DZI111284999 111290330 111299072 111303232 111303822
EGR104416677 104436629 104438474
GMX100170693(FAT1) 100781381 100787680(FATB1B) 100791281 100791811 100795014 100797796 100814191
GSJ114393555 114408211 114409600 114409960 114411725 114414050 114416123 114416682
PVUPHAVU_003G176200g PHAVU_009G164200g PHAVU_009G164800g PHAVU_009G200200g
VRA106756605 106760302 106761669 106768841
VAR108320727 108330264 108330613 108331107
VUN114162762 114163002 114178102 114196246
VUM124820729 124834898 124840550 124840552
CCAJ109792425 109796024 109808042 109813179 109818220
APRC113845895 113845962 113868476 113868495 113868516
MTR112419006 11419965 11445423
TPRA123884572 123918013 123921695
CAM101502796 101506785 101507613
PSAT127073633 127085613 127086354 127093886
VVO131599190 131631392 131634168 131655406
LJALj0g3v0119999.1(Lj0g3v0119999.1) Lj1g3v1498440.1(Lj1g3v1498440.1)
ADU107463448 107469463 107470945 107471251 107471935
AIP107611783 107623121 107626543 107626553 107630423 107633058 107634421
AHF112708367 112708432 112708494 112716234 112717838 112729053 112729098 112729101 112735907 112738250 112738255 112761935 112772103 112782702
LANG109327356 109327494 109328449 109336962 109343614 109345129 109354183 109362625
PCIN129299538 129309387 129320796 129320873
FVE101292829 101297137
RCN112180142 112187492
PPER18770729 18776586 18781921 18782856
PMUM103338095 103340987
PAVI110760089 110760376 110771268
PDUL117612679 117622644 117628034 117633951
MDM103400481 103437519 103448739 103455000
MSYL126583057 126593952 126599568 126601588 126626891
PXB103936166 103949986 103960678 103962990 103964031
ZJU107406654 107406660 107406718 107418024 107435376 125420663
MNT112094260 21393434 21408286
CSAV115705304 115706172 115708944
CSV101206509 101210955 101218502
CMO103484573 103497577 103501532
BHJ120071362 120080246 120083717
MCHA111012889 111014514 111025297
CMAX111465562 111485199 111493525 111495310 111497736
CMOS111431501 111440932 111444205 111450443 111461080 111461803
CPEP111778784 111780651 111783499 111793517 111798693 111806062
RCU8269197 8271338 8278580
JCU105634942(FAT-L2) 105634943(FAT-L3) 105639285
HBR110631965 110645490 110655148 110659295
MESC110600334 110603870 110607705 110625829 110625830 110626527 110631177
POP112327864 7458749 7463140 7484691 7484856 7490983 7490985
PEU105109650 105115906 105119571 105125284 105139390
PALZ118031742 118044656 118047982 118050679 118054123 118057544
JRE108992677 108997545 109004120 109011019
CILL122280875 122305060 122308327
CAVE132165515 132176275 132188490
QSU111992796 112027571 112028149
QLO115962879 115976982
TWL119986193 119992857 119995911 120005081
VVI100254336 100257579
VRI117904960 117925270
SLY101245130 101261397
SPEN107007182 107013824
SOT102584501 102595208
SSTN125858467 125861909
SDUL129870130 129895229
CANN107841760 107862897
LBB132634111 132636768 132640966
NTA107758962(NtTE) 107770446 107785685 107789402 107793720 107816769 107824843
NSY104213511 104235585
NTO104090382 104106300 104120713
NAU109209927 109237319
INI109148196 109168713 109186555
ITR115999631 116012017 116030155
SIND105158149 105162096
OEU111380614 111411282 111412963 111412964
EGT105951633 105974064
SSPL121747436 121748446 121751285 121753332 121764974 121805566 121808565
SMIL130987839 130988320 131020157
APAN127239166 127239789 127254816
HAN110865595 110877217 110883188 110883191 110886372 110886373 110886378 110886379 110940305
ECAD122592278 122597131 122597133 122597659 122597666 122599234 122608756 122610689
LSV111877545 111877561 111882802 111883800 111885680 111891607 111897937 111897947 111897954 111897955 111897957
CCAV112500834 112506644 112514238 112516804 112516805
DCR108199923 108215198 108221107 108222429
CSIN114264135 114292046 114322109
RVL131301689 131320198 131335183
AEW130757322 130767422 130779627 130788993 130796192
BVG104900372 104902140 104908278
SOE110785861 110786001 110800859
CQI110684304 110707842 110719839 110723382 110729089 110739680
ATRI130798165 130812636 130815246 130824560
MOF131158108 131161006
NNU104592290
MING122057040 122057929 122062163 122075561 122080762 122080975 122082115
TSS122645079 122645080 122646643 122652359 122671710 122671761
PSOM113271692 113277242 113277794 113279584 113279586 113281006 113282666 113299722 113303627 113347984 113351354 113351356 113351359 113352148 113354080 113355955 113359337 113361171
OSA4340093 4341431 4351056
DOSAOs02t0644700-01(Os02g0644700) Os06t0143400-01(Os06g0143400) Os06t0596300-01(Os06g0596300) Os11t0659500-01(Os11g0659500)
OBR102700717 102709182 102714591
OGL127754549 127762308 127777096 127777753
BDI100821684 100827301
ATS109747972 109761208
TDC119287811 119329540 119330094 119337588
TAES123087981 123147228 123148128 123156838 123164387 123168027
TUA125521347 125525935
LPER127311338 127313445 127332012
LRD124672830 124684860 124685045 124694876 124695069
SBI8065057 8070721 8082941 8084639
ZMA100281497 100283590 100284647 100284999 103638097
SITA101757281 101770614 101775948
SVS117842871 117852738 117852979
PVIR120655062 120658086 120668927 120669896 120671047 120686506 120702572 120703818
PHAI112878804 112882401 112889102 112889420
PDA103697375 103704422 103720846 103720983 120111519
EGU105040257 105047747 105047881(PTE) 105049016
MUS103975330 103986019 103986595 103992592 103999297
ZOF121967815 121973049 121974354 121991719 121995611 122027139 122029552 122031787 122034220 122036776 122038760 122053036
DCT110093301 110102359 110106288 110106936 110108241 110111960
PEQ110025999 110027988 110039424
AOF109822131 109825405 109826182 109835670 109844902
MSIN131239447 131255145
NCOL116256015 116264416
ATR18434274 18434284
SMOSELMODRAFT_103466 SELMODRAFT_13356 SELMODRAFT_15558 SELMODRAFT_15559 SELMODRAFT_233217 SELMODRAFT_425816
PPP112274563 112274729 112292328 112294324 112295522
 » show all
Reference
1  [PMID:1989513]
  Authors
Pollard MR, Anderson L, Fan C, Hawkins DJ, Davies HM.
  Title
A specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica.
  Journal
Arch Biochem Biophys 284:306-12 (1991)
DOI:10.1016/0003-9861(91)90300-8
Reference
2  [PMID:1898097]
  Authors
Davies HM, Anderson L, Fan C, Hawkins DJ.
  Title
Developmental induction, purification, and further characterization of 12:0-ACP thioesterase from immature cotyledons of Umbellularia californica.
  Journal
Arch Biochem Biophys 290:37-45 (1991)
DOI:10.1016/0003-9861(91)90588-A
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.21
IUBMB Enzyme Nomenclature: 3.1.2.21
ExPASy - ENZYME nomenclature database: 3.1.2.21
BRENDA, the Enzyme Database: 3.1.2.21
CAS: 137903-37-8
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