KEGG   ENZYME: 3.1.2.30
Entry
EC 3.1.2.30                 Enzyme                                 
Name
(3S)-malyl-CoA thioesterase;
mcl2 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
(S)-malyl-CoA hydrolase
Reaction(IUBMB)
(S)-malyl-CoA + H2O = (S)-malate + CoA [RN:R10612]
Reaction(KEGG)
R10612
Substrate
(S)-malyl-CoA [CPD:C04348];
H2O [CPD:C00001]
Product
(S)-malate [CPD:C00149];
CoA [CPD:C00010]
Comment
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
History
EC 3.1.2.30 created 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K14451  (3S)-malyl-CoA thioesterase
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
TPSY: RGQ13_18670
TFT: RI844_12640
PLEI: Q9312_08215
BOJ: CBF45_15340
KGY: EHF36_15360
BRD: JL11_15545
BRG: A4249_01015
BVC: CEP68_03750
BREV: E7T10_13660
BVY: NCTC9239_00695(mcl2)
AEX: Astex_0375
ASTI: Q1W73_06505
ASTD: ATDW_02780
SIL: SPO0352(citE)
SIT: TM1040_3520
RUA: D1823_12170
RUT: FIU92_01320(mcl1)
RCON: K3740_01470
RUY: NOR97_01010
JAN: Jann_0816
RDE: RD1_1620(citE)
RLI: RLO149_c030880
RPON: G3256_15365
RFU: ROLI_007930(mcl2)
DSH: Dshi_2874
PGA: PGA1_c03680
PGL: PGA2_c03240
PGD: Gal_03134
PHP: PhaeoP97_02988
PPIC: PhaeoP14_00285
PHQ: D1820_14695
OAT: OAN307_c41520
OAR: OA238_c04250
OTM: OSB_04760(mcl2)
OCT: FTO60_02985
LMD: METH_03315
LEJ: ETW24_04120
LAQU: R2C4_13635
LCAE: K3721_03435
RED: roselon_01727
CID: P73_3868
CMAR: IMCC12053_3020
CEH: CEW89_10100
CBAK: DA792_14115
MALG: MALG_02745
CON: TQ29_02440
YPAC: CEW88_11165
YAN: AYJ57_04550
TPRO: Ga0080559_TMP1136
PABY: Ga0080574_TMP3142
SUAM: BOO69_13680
SULZ: C1J03_18190
SULI: C1J05_18110
SULD: B5M07_04980
SPOT: G6548_04145
SMED: JNX03_18050
SINL: DSM14862_02486(mcl2)
SFAV: PL335_11845
SUAL: KDD17_02140
SDUB: R1T39_14805
SULB: IV89_002884
SPSE: SULPSESMR1_00394(mcl2)
TOM: BWR18_01025
RMM: ROSMUCSMR3_02505(mcl2)
ROK: RAK1035_0677
RID: RIdsm_04538(mcl2)
ROM: EI983_02900
ROH: FIU89_19180(mcl1)
RPEL: N7U68_08430
AHT: ANTHELSMS3_02127(mcl2)
SAGU: CDO87_04390
THAA: CFI11_04355
OCD: FHY55_05855
ROT: FIV09_01380(mcl1)
RMH: LVO79_01055
MALU: KU6B_41840(mcl2)
TGL: HFZ77_08415
HAT: RC74_09365
PALX: GQA70_04790
LSAL: KBK07_01415
LALG: LentiSH36_00609
TRY: QF118_18685
PLCG: RVY76_03675
MARU: FIU81_04115(mcl1)
RMAI: MACH21_05280(mcl2)
RSP: RSP_0970
RSH: Rsph17029_2630
RSQ: Rsph17025_0082
RSK: RSKD131_2362
CAZT: LV780_00415
RCP: RCAP_rcc00727(citE1)
RHP: LPB142_03415
RBL: B6K69_07625
FYT: QF092_08915
PDE: Pden_0563
PAMI: JCM7686_2574
PYE: A6J80_13300
PCON: B0A89_09550
PZH: CX676_05535
PARO: CUV01_17720
PAMN: JCM7685_2545
PARS: DRW48_09375
PARR: EOJ32_08540
PAAK: FIU66_10030
PKD: F8A10_02165
PPAN: ESD82_12320
PLIA: E4191_08475
PSAN: HGN31_04095
PMAU: CP157_01939(mcl2)
PMEH: JWJ88_01995
PSEW: JHW44_08040
PSAP: JHX88_13540
PFIS: JHX87_05220
PAEX: JHW48_10985
PSTL: JHW45_07345
PALP: JHW40_16600
PVER: E3U25_22180
PFEO: E3U26_10440
PTP: RCA23_c14020(citE)
RSU: NHU_00724(citE)
RHM: B5V46_04475
RHC: RGUI_0622
RMB: K529_020740
TSCO: R1T40_12735
DAA: AKL17_3637
DON: BSK21_11440
RBZ: B9057_02175
THW: BMG03_06670
TEC: AKL02_005525
LVS: LOKVESSMR4R_02803(mcl2)
GEH: HYN69_13115
GFU: KM031_13965
TAW: EI545_06975
SALO: EF888_18565
SEDI: EBB79_02250
PPSO: QPJ95_04700
HML: HmaOT1_03960
BOO: E2K80_01990
PSEB: EOK75_09400
LIT: FPZ52_01350
PPRU: FDP22_03640
PAED: G5B38_15490
MON: G8E03_14605
PAMO: BAR1_14395
POZ: I0K15_13770
PALW: PSAL_019030(mcl2)
PSHQ: F3W81_20275
PPAF: I8N54_16895
CACT: HZ995_03660
THAS: C6Y53_10240
HDH: G5B40_16110
CMAG: CBW24_13080
FAP: GR316_00365
GCE: KYE46_04235
GYJ: AADW23_01285
NSM: JO391_19965
ACRO: K3J57_02795
SINR: O5O51_12655
AALK: LGT41_0002075
AMYL: QBD29_06840
AMAQ: GO499_14350
RHOC: QTA57_01875
PBAE: P8S53_11195
RBG: BG454_13655
LVR: T8T21_09445
BOSG: GKR98_08730
FAQ: G5B39_05115
RBX: I3V23_06850
HYT: HXX25_10655
SAL: Sala_2214
SPHK: SKP52_03440
SPHP: LH20_16080
SMAG: AN936_01440
SMAZ: LH19_01485
STER: AOA14_02930
SGI: SGRAN_0950(mcl2)
SPHQ: BWQ93_11140
SPHO: C3E99_01130
SPHX: E5675_17240
SINA: KNJ79_16505
SPEG: SPYCW_0498
SPFD: SPYCA_0128
SPHU: SPPYR_0495(mcl)
SPHI: TS85_09155
SSAN: NX02_12375
SPLM: BXU08_04065
SPHC: CVN68_04030
SLAN: GV829_09535
SPAI: FPZ24_11710
SARI: H5J25_02820
SSUA: FPZ54_04690
SBIN: SBA_ch1_14890(citE)
SJP: SJA_C1-26890(citE)
SINB: SIDU_01380
SCH: Sphch_1616
SSY: SLG_14830
SYB: TZ53_00395
SBD: ATN00_05850
SPMI: K663_04105
SPHB: EP837_00844(citE)
SPHR: BSY17_744
SPHT: K426_06735
SHYD: CJD35_07870
SYA: A6768_15560
SCLO: SCLO_1015050
SPYG: YGS_C1P0058
SUFL: FIL70_12030
SBAR: H5V43_09595
SAMI: SAMIE_1022050
SPAG: sphantq_02744(mcl2)
SLAA: EUU25_05605
SPZR: G5C33_12750
PALG: HFP57_06190
SPHS: ETR14_23585
SFLV: IC614_03365
HTM: RZR91_08980
CPAF: C6V80_02765
RPY: Y013_11815
RBY: CEJ39_22715
RHQ: IM25_03505
GTA: BCM27_21690
BSOL: FSW04_20430
DDR: Deide_20020
DMR: Deima_2864
DPT: Deipr_2520
DGO: DGo_CA0363(citE)
DSW: QR90_15895
DCH: SY84_10370
DAB: AUC44_01395
DPU: SU48_13230
DWU: DVJ83_08830
DFC: DFI_10115
DEIN: DAAJ005_03145
BLQ: L21SP5_01621(mcl2)
HDL: HALDL1_15310
HHB: Hhub_3380(aceB)
HNO: LT974_13710
HLU: LT972_01030
HSU: HLASF_2007(aceB)
HSF: HLASA_1993(aceB)
HAHS: HSRCO_2658(mcl2)
SALR: FQU85_05715
HDO: MUK72_12480
HALX: M0R89_21245
SAIM: K0C01_12450
HMA: rrnAC1965(aceB)
HHI: HAH_2476(aceB)
HHN: HISP_12605
HAB: SG26_04910
HTA: BVU17_12045
HSIN: KDQ40_00995
NPH: NP_4430A(aceB)
NMO: Nmlp_2357(aceB)
NHO: HWV23_13655
NSAL: HWV07_07395
HALI: BV210_07645
SSAI: N0B31_16615
HAAD: MW046_18245
HWA: HQ_1720A(aceB)
HWC: Hqrw_1842(aceB)
HVO: HVO_1983(aceB1) HVO_B0200(aceB2)
HALE: G3A49_07690 G3A49_12900
HLN: SVXHx_2637(aceb) SVXHx_3054(aceb)
HME: HFX_2078(aceB)
HGI: ABY42_09665 ABY42_16600
HLS: KU306_02605
HBO: Hbor_30530
HLM: DV707_13970
SRUB: C2R22_21540
HALG: HUG10_03375
HALU: HUG12_13540
HMP: K6T50_01580
HRE: K6T36_01385
HRM: K6T25_15035
HACB: Hbl1158_08495
HDF: AArcSl_1031(aceB)
HTU: Htur_4695
HSAL: JMJ58_24075
NMG: Nmag_3363(aceB)
NOU: Natoc_4308
NAJ: B1756_06555
NBG: DV706_17910
NAS: GCU68_18820
 » show all
Reference
1  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase.
  Journal
J Bacteriol 192:1249-58 (2010)
DOI:10.1128/JB.01267-09
  Sequence
[rsp:RSP_0970]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.30
IUBMB Enzyme Nomenclature: 3.1.2.30
ExPASy - ENZYME nomenclature database: 3.1.2.30
BRENDA, the Enzyme Database: 3.1.2.30
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