KEGG   ENZYME: 3.1.2.32
Entry
EC 3.1.2.32                 Enzyme                                 
Name
2-aminobenzoylacetyl-CoA thioesterase;
pqsE (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
(2-aminobenzoyl)acetyl-CoA hydrolase
Reaction(IUBMB)
(2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA [RN:R11542]
Reaction(KEGG)
R11542
Substrate
(2-aminobenzoyl)acetyl-CoA [CPD:C21452];
H2O [CPD:C00001]
Product
(2-aminobenzoyl)acetate [CPD:C21453];
CoA [CPD:C00010]
Comment
The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ).
History
EC 3.1.2.32 created 2016
Pathway
ec00405  Phenazine biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20257  2-aminobenzoylacetyl-CoA thioesterase
Genes
PAEPA1000(pqsE)
PAEVN297_1033
PAEIN296_1033
PAUPA14_51380(pqsE)
PAPPSPA7_4398
PAGPLES_43251(pqsE)
PAFPAM18_4048(pqsE)
PNCNCGM2_1854(pqsE)
PAEBNCGM1900_1668(pqsE)
PDKPADK2_20740
PSGG655_20300
PRPM062_05450
PAEPPA1S_20970
PAERPA1R_gp4597
PAEMU769_20815
PAELT223_22095
PAESSCV20265_4442
PAEUBN889_01052(pqsE)
PAEGAI22_12970
PAECM802_1030
PAEOM801_1033
BPSBPSS0485
BPMBURPS1710b_A2038
BPLBURPS1106A_A0657
BPDBURPS668_A0749
BPSEBDL_3711
BPSMBBQ_5711
BPSUBBN_3885
BPSDBBX_5548
BPZBP1026B_II0539
BPQBPC006_II0703
BPKBBK_5690
BPSHDR55_4867
BPSABBU_5562
BPSOX996_4617
BUTX994_4135
BTEBTH_II1931
BTQBTQ_5214
BTJBTJ_3845
BTZBTL_4699
BTDBTI_4293
BTVBTHA_5528
BTHEBTN_4338
BTHMBTRA_4604
BTHADR62_4387
BTHLBG87_4671
BOKDM82_4588
BOCBG90_6004
BUUWS70_19845
BSAVWS86_21100
BAMBamb_5767
BACBamMC406_5527
BCEPAPZ15_37365
BPYRABD05_31295
BCONNL30_31565
BUBBW23_4061
BSTGWT74_17005
BULBW21_3834
BUDAQ610_21735
GMEGmet_2200
DOLDole_1494
DMLDmul_20230
DALDalk_0799 Dalk_3752
DOVDSCO28_47760
DWDDSCW_14780
DALKDSCA_14130 DSCA_25720
DMMdnm_046970
DTIDesti_1708
DBRDeba_1389
SECHB18_16630
CKLCKL_0030
CKRCKR_0021
CAPREQM14_09425
SWOSwol_1292 Swol_1480
SLPSlip_0679 Slip_1105
DDLDesdi_0644
DMTDESME_05105
DGIDesgi_1436 Desgi_3231
ALKAJ0B03_08435
CMIUB1H56_12515
BPRSCK3_16350
PUFUFO1_3636
PFTJBW_00392
STEDSPTER_30530(gloB_2)
ARHAHiyo8_45130
CCUCcur_01300
OLSOlsu_1018
CAPCLDAP_39220
COYHF329_06220
CHZCHSO_1946
TTKTST_1179
GACGACE_1202
GAHGAH_01404
 » show all
Reference
1  [PMID:19788310]
  Authors
Yu S, Jensen V, Seeliger J, Feldmann I, Weber S, Schleicher E, Haussler S, Blankenfeldt W
  Title
Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
  Journal
Biochemistry 48:10298-307 (2009)
DOI:10.1021/bi900123j
  Sequence
[pae:PA1000]
Reference
2  [PMID:25960261]
  Authors
Drees SL, Fetzner S
  Title
PqsE of Pseudomonas aeruginosa Acts as Pathway-Specific Thioesterase in the Biosynthesis of Alkylquinolone Signaling Molecules.
  Journal
Chem Biol 22:611-8 (2015)
DOI:10.1016/j.chembiol.2015.04.012
  Sequence
[pae:PA1000]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.32
IUBMB Enzyme Nomenclature: 3.1.2.32
ExPASy - ENZYME nomenclature database: 3.1.2.32
BRENDA, the Enzyme Database: 3.1.2.32
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