KEGG   ENZYME: 3.1.3.26
Entry
EC 3.1.3.26                 Enzyme                                 
Name
4-phytase;
6-phytase (name based on 1L-numbering system and not 1D-numbering);
phytase;
phytate 6-phosphatase;
myo-inositol-hexakisphosphate 6-phosphohydrolase (name based on 1L-numbering system and not 1D-numbering)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
myo-inositol-hexakisphosphate 4-phosphohydrolase
Reaction(IUBMB)
myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,3,5,6-pentakisphosphate + phosphate [RN:R03372]
Reaction(KEGG)
R03372
Substrate
myo-inositol hexakisphosphate [CPD:C01204];
H2O [CPD:C00001]
Product
1D-myo-inositol 1,2,3,5,6-pentakisphosphate [CPD:C04579];
phosphate [CPD:C00009]
History
EC 3.1.3.26 created 1972, modified 1976, modified 2002
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
Orthology
K01093  4-phytase / acid phosphatase
Genes
ECO: b0980(appA)
ECJ: JW0963(appA)
ECD: ECDH10B_1050(appA)
EBW: BWG_0832(appA)
ECOK: ECMDS42_0832(appA)
ECOC: C3026_05980
ECE: Z1397(appA)
ECS: ECs_1136(appA)
ECF: ECH74115_1216(appA)
ETW: ECSP_1149(appA)
ELX: CDCO157_1101
EOI: ECO111_1091(appA)
EOJ: ECO26_1535(appA)
EOH: ECO103_1025(appA)
ECOO: ECRM13514_1157(appA)
ECOH: ECRM13516_1086(appA)
ESL: O3K_16440
ESO: O3O_08855
ESM: O3M_16415
ECK: EC55989_1088(appA)
ECG: E2348C_0965(appA)
EOK: G2583_1215(appA)
ELR: ECO55CA74_05935
ELH: ETEC_1049
ECW: EcE24377A_1096(appA)
EUN: UMNK88_1135
ECP: ECP_0985
ENA: ECNA114_1060(appA)
ECOS: EC958_1185(appA)
ECV: APECO1_84(appA)
ECOA: APECO78_08890
ECX: EcHS_A1089(appA)
ECM: EcSMS35_2136(appA)
ECY: ECSE_1042
ECR: ECIAI1_1021(appA)
ECQ: ECED1_1064(appA)
EUM: ECUMN_1170(appA)
ECT: ECIAI39_2166(appA)
EOC: CE10_1008(appA)
EBR: ECB_00983(appA)
ECOB: C3029_09330
EBL: ECD_00983(appA)
EBE: B21_00990(appA)
EBD: ECBD_2614
ECI: UTI89_C1049(appA)
EIH: ECOK1_1042(appA)
ECZ: ECS88_1002(appA)
ECC: c1121(appA)
ELO: EC042_1065(appA)
ELN: NRG857_04465
ESE: ECSF_0894
ECL: EcolC_2616
EKF: KO11_17825(appA)
EAB: ECABU_c10140(appA)
EDH: EcDH1_2663
EDJ: ECDH1ME8569_0932(appA)
ELU: UM146_12675
ELW: ECW_m1091(appA)
ELL: WFL_05315(appA)
ELC: i14_1025(appA)
ELD: i02_1025(appA)
ELP: P12B_c0967(appA)
ELF: LF82_0100(appA)
ECOL: LY180_05140
ECOI: ECOPMV1_01011(appA_1)
ECOJ: P423_05380
EFE: EFER_3043
EAL: EAKF1_ch0429c(appA)
EMA: C1192_07320
ESZ: FEM44_19790
ERUY: OSH18_04765
SFL: SF0982(appA)
SFX: S1048(appA)
SFV: SFV_0989(appA)
SFE: SFxv_1064(appA)
SFN: SFy_1341
SFS: SFyv_1383
SFT: NCTC1_01020(appA_1)
SSN: SSON_0987(appA)
SBO: SBO_2250(appA)
SBC: SbBS512_E2335(appA)
SDY: SDY_0956(appA)
SDZ: Asd1617_01201
SHQ: A0259_09025
SHIG: LXH19_13705(appA)
ENR: H650_02130
ESA: ESA_02095
CSK: ES15_2251(appA)
CSZ: CSSP291_09965
CSJ: CSK29544_03387
CSI: P262_03255
CUI: AFK65_08545
CTU: CTU_18700(appA)
KPN: KPN_00628
KPU: KP1_1578
KPM: KPHS_14650
KPP: A79E_3612
KPH: KPNIH24_21485
KPZ: KPNIH27_06790
KPV: KPNIH29_07485
KPW: KPNIH30_07515
KPY: KPNIH31_07390
KPG: KPNIH32_07620
KPC: KPNIH10_07305
KPQ: KPR0928_07215
KPT: VK055_1906(phyK)
KPO: KPN2242_01675 KPN2242_06005
KPR: KPR_3951
KPJ: N559_3698
KPI: D364_03295
KPA: KPNJ1_03953
KPS: KPNJ2_03943
KPX: PMK1_02960(agp_1)
KPB: FH42_24175
KPNE: KU54_019140
KPNU: LI86_18965
KPNK: BN49_1685 BN49_4737(appA)
KVA: Kvar_3740
KPE: KPK_3948
KPK: A593_17605
KVD: KR75_15065
KQU: AVR78_11805
KQV: B8P98_20555
KOX: KOX_14030
KOE: A225_1624
KOY: J415_23510
KOM: HR38_12765
KOK: KONIH1_07970
EAE: EAE_02525
EAR: CCG33480
KLL: BJF97_08350
KLW: DA718_20335
KAR: LGL98_18165
KGR: JJJ10_20205
KPAS: LUW96_14725
KLC: K7H21_20230
KLM: BWI76_07830
KLP: GUC22_19460
ROR: RORB6_11940
RON: TE10_08950
RPLN: B1209_19645
RAO: DSD31_18475
RTG: NCTC13098_04907(agp_2)
CWE: CO701_07465
CFQ: C2U38_04960
CAF: AL524_16675
CIR: C2U53_20695
CIB: HF677_011420
CIY: HAP28_10535
HDE: HDEF_2244(appA)
KSA: C813_02725
KRD: A3780_12010
KPSE: IP581_11955
KOU: C0557_12900
BUF: D8682_18890
BFT: MNO13_03200
BSEL: RHD99_03160
IZH: FEM41_23385
PSHI: SAMEA2665130_1541(appA_4)
MPHG: MPHASIOC01_000055
EBU: CUC76_08260
EBB: F652_938
YPE: YPO1648
YPK: y1810(appA)
YPH: YPC_1753
YPA: YPA_1875
YPN: YPN_1982
YPM: YP_1778(appA)
YPP: YPDSF_1799
YPG: YpAngola_A2841(appA)
YPZ: YPZ3_2046
YPT: A1122_17635
YPD: YPD4_2087
YPX: YPD8_2084
YPW: CH59_189(appA)
YPJ: CH55_223(appA)
YPV: BZ15_1903(appA)
YPL: CH46_3477(appA)
YPS: YPTB2421
YPO: BZ17_30(appA)
YPI: YpsIP31758_1622(appA)
YPY: YPK_1730
YPB: YPTS_2503
YPQ: DJ40_4145(appA)
YPU: BZ21_1712(appA)
YPR: BZ20_3780(appA)
YPC: BZ23_1998(appA)
YPF: BZ19_1789(appA)
YEN: YE2600
YEP: YE105_C1662
YEY: Y11_14891
YEW: CH47_1942(appA)
YET: CH48_3266(appA)
YEF: FORC2_2576
YEE: YE5303_23821
YSI: BF17_21295
YAL: AT01_51(appA)
YFR: AW19_831(appA)
YIN: CH53_3517(appA)
YKR: CH54_831
YRO: CH64_183(appA)
YAK: ACZ76_01245
YMA: DA391_08650
YHI: D5F51_10995
YEL: LC20_02112
YCA: F0T03_13360
YMO: HRD69_13485
YAS: N0H69_16565
YKI: HRD70_18130
YEG: PL78_17440
SMAF: D781_3671
SRZ: AXX16_1414
SERM: CLM71_23710
SOF: NCTC11214_01745(appA_1)
SRHZ: FO014_10010
GQU: AWC35_02855
RBAD: H2866_12100
SERA: Ser39006_002070
SERQ: CWC46_02070
PROD: PCO85_00245
ECA: ECA4198
PATR: EV46_20920
PATO: GZ59_42580
PCT: PC1_3998
PCC: PCC21_039770
PWA: Pecwa_4189
PPAR: A8F97_20560
PEC: W5S_4347
PWS: A7983_06065
PPOA: BJK05_14960
PBRA: B5S52_01235
PPUJ: E2566_20310
PARI: I2D83_01305
PAQU: DMB82_0019175
PVZ: OA04_42630
PPAV: LOZ86_02330
PQU: IG609_018905
PPOO: LW347_20415
PARL: PEC302110_01660
PPEU: DUT67_01435
DDD: Dda3937_01138
DZE: Dd1591_4136
DDC: Dd586_4105
DZC: W909_19900
DSO: A4U42_08550
CED: LH89_12890
DFN: CVE23_22000
DDQ: DDI_4181
DAQ: DAQ1742_00052
DIC: Dpoa569_0000070
DLC: O1Q98_11355
DDA: Dd703_3938
LBQ: CKQ53_08705
LPOP: I6N93_12585
EBI: EbC_09720(appa)
EPE: CI789_13695
ERWI: GN242_16350 GN242_16370
ERP: LJN55_04955 LJN55_04965
EPI: Q3V30_16445
ERWE: GKQ23_18760
EGE: EM595_0941
PAM: PANA_0959(agp)
PLF: PANA5342_3343(phyK)
PAJ: PAJ_0285(agp)
PAQ: PAGR_g3246
PVA: Pvag_0342(phyK)
PAGG: AL522_08675
PAO: Pat9b_0907
PANT: PSNIH1_09405
PAGC: BEE12_11405
PSTW: DSJ_05650
PEY: EE896_14885
PDIS: D8B20_04380 D8B20_04945
PER: LAC65_03650
PJI: KTJ90_14745
PANO: OJ965_16610
KPIE: N5580_12010
PALF: K6R05_14485
PPHO: CTZ24_04700 CTZ24_26115
PDIP: KFZ74_15390
PAMT: IAI47_14825
TPTY: NCTC11468_02898(appA)
TATU: EFZ10_07050
EIC: NT01EI_1443
ETD: ETAF_1224
ETE: ETEE_3291(appA)
ETR: ETAE_1316
ETC: ETAC_06220
EDW: QY76_13330
EDL: AAZ33_06825
EHO: A9798_10215
HAV: AT03_09325
HPAR: AL518_16440
OPO: DSM2777_09415
XCC: XCC0760(appA)
XCB: XC_3473
XCA: xcc-b100_3594
XCP: XCR_0938
XCV: XCV0590(appA) XCV0864(appA) XCV4225
XAX: XACM_0548(appA) XACM_0808 XACM_4001
XAC: XAC0557(appA) XAC0812(appA) XAC4132(appA)
XCI: XCAW_00167(appA) XCAW_03768(appA)
XCT: J151_00678 J151_00938 J151_04311
XCJ: J158_00675 J158_00935 J158_04264
XCU: J159_00675 J159_00935 J159_04260
XCN: J169_00674 J169_00934 J169_04308
XCW: J162_00674 J162_00934 J162_04266
XCR: J163_00674 J163_00934 J163_04260
XCM: J164_00674 J164_00934 J164_04261
XCF: J172_00669 J172_00929 J172_04301
XFU: XFF4834R_chr05530 XFF4834R_chr08180(appA) XFF4834R_chr40020
XAO: XAC29_02840 XAC29_04140 XAC29_20810
XOM: XOO3574(XOO3574)
XOO: XOO3792(appA)
XOP: PXO_04687
XOY: AZ54_04960
XOR: XOC_0877
XOZ: BE73_19995
XAL: XALC_2788
XSA: SB85_06825 SB85_08885 SB85_15620
XTN: FD63_15880 FD63_18170
XGM: KFS84_14530 KFS84_16715
XCS: KHA79_16010 KHA79_18210
XVE: BJD12_17075
XPE: BJD13_12650 BJD13_14080 BJD13_18375
XHR: XJ27_11295
XGA: BI317_04905
XPH: XppCFBP6546_07375(XppCFBP6546P_07375) XppCFBP6546_08950(XppCFBP6546P_08950) XppCFBP6546_13775(XppCFBP6546P_13775)
XVA: C7V42_02915 C7V42_04510
XAN: AC801_02705 AC801_04200 AC801_20520
XAR: XB05_00730 XB05_20985
XHY: FZ025_13610
XCZ: EBN15_03110
XTH: G4Q83_01245 G4Q83_02555
XEU: XSP_000818
XHD: LMG31886_31450(appA_1) LMG31886_35170(appA_2)
XPR: MUG10_05930 MUG10_07485 MUG10_11530
XAG: HEP73_03047 HEP73_03517 HEP73_04026
XDY: NYR95_04835 NYR95_06630
XAS: HEP74_00735 HEP74_02873 HEP74_03883
XHA: PG878_03080 PG878_05690 PG878_17160
XRY: QN244_02915 QN244_15225 QN244_17475
XSO: RAB70_06275 RAB70_18675 RAB70_20780
XIN: Q7W82_00155 Q7W82_06685 Q7W82_08790
XAI: HEP75_00752 HEP75_02946 HEP75_03945
XAZ: XSP_000818
XTS: AB3X08_15330 AB3X08_17885 AB3X08_20320
XMD: AB3X07_16175 AB3X07_18565 AB3X07_21090
XBN: AB3X10_15990 AB3X10_18405 AB3X10_21070
DCS: ISN74_19960
DTL: H8F01_03305
DTA: DYST_00700
DYG: DYGSA30_40520
LRZ: BJI69_17270
LPY: FIV34_11065
LANH: KR767_00010 KR767_15775
LAEO: L2Y97_12045
LAES: L2Y96_11800
PSB: Psyr_4500
PRX: HRH33_09805 HRH33_09810
PSK: U771_10000 U771_10005
PFZ: AV641_16965 AV641_16970
PLQ: AA042_16710 AA042_16715
PPSY: AOC04_14235 AOC04_14240
PPSH: G5J76_20705
PEZ: HWQ56_10970
PTAE: NCTC10697_03275(agp)
PSKU: KUIN1_45030
PBUB: V6B39_21030
PSML: V6P94_21255
PSMZ: V6L79_21145
PSIV: LZ023_28555
MMOB: F6R98_16485
ZPL: ZBT109_1255
ATY: A9R16_007405
CDIZ: CEDIAZO_01004(agp)
DEE: HQN60_06560
LHK: LHK_03226
PPNO: DA70_12870
PPNM: LV28_17830
PRB: X636_14000
PPUL: RO07_12025
PSPU: NA29_08045
PAPI: SG18_25920
PVE: UC34_03875
POX: MB84_08330
PFG: AB870_14950
PNR: AT302_02035 AT302_12140
PFIB: PI93_003430
PCOM: NTU39_04140
OTK: C6570_10225
OFO: BRW83_1278(appA_1) BRW83_1307(appA_2)
BBAY: A4V04_07650
ARUI: G6M88_09665
AVV: RvVAT039_21250
AVF: RvVAR031_08550
AVI: Avi_0609
RRHO: PR018_00770
RTU: PR017_00875
BAPI: BBC0122_017370
BAPA: BBC0178_017330
AZC: AZC_4319
AQI: J5J86_04400
CCR: CC_0542
CCS: CCNA_00576(oppA)
CSE: Cseg_2456 Cseg_3136
CFH: C1707_14850
CAUF: CSW63_14990
ASTM: MMA231_03609(agp) MMA231_04086(appA)
ZMO: ZMO0061
ZMN: Za10_1128
ZMM: Zmob_0756
ZMB: ZZ6_1138
ZMI: ZCP4_1165
ZMC: A265_01156(appA)
ZMR: A254_01155(appA)
NRE: BES08_21135 BES08_24235
NOV: TQ38_024435 TQ38_025560
NOR: FA702_18675
NCP: U0041_19555
SMAG: AN936_11405
SMAZ: LH19_12560
SPHO: C3E99_18720
SINA: KNJ79_15450
SPBS: L7H23_11130
SPJJ: V6U71_07045
STAX: MC45_02080 MC45_11915
SNJ: A7E77_13750
SMY: BJP26_19115
SPAN: AWL63_14190
SPLK: AV944_00945 AV944_08690
SPHF: DM480_08675 DM480_15510
SPAU: DRN02_015065
SAER: NEF64_09695
SHAN: PPZ50_15935
SSAG: KV697_01050 KV697_10165
SABI: PBT88_01385 PBT88_10755
SAAP: E2E30_12160
GOX: GOX1076 GOX1190
GOH: B932_1054
GOY: GLS_c11450(appA)
GAL: A0U94_13015
GTI: FXF46_05795
GSP: IGS75_07320
GFA: MKW11_05760
GBC: GbCGDNIH3_1410
GBS: GbCGDNIH4_1410
KEU: S101446_02698(appA)
KSC: CD178_00707(appA)
KOI: LV478_07490
APT: APA01_03230
APW: APA42C_03230
APF: APA03_03230
APU: APA07_03230
APG: APA12_03230
APQ: APA22_03230
APX: APA26_03230
APZ: APA32_03230
APK: APA386B_1808(appA)
ASZ: ASN_1924(appA)
ASV: WG31_01590
APOM: CPF11_05710
ATO: CIW82_02435
AASC: A4S02_10975
ACET: DS739_01710
AOY: EOV40_001640
ACEK: FLP30_10775
ABG: Asbog_01039
NTN: D5366_04285
AZL: AZL_b01070
AZM: DM194_22125
AZZ: DEW08_01260
NAO: Y958_04115 Y958_13160 Y958_24860
NCB: C0V82_17515
DFI: AXF13_09085
DPG: DESPIGER_0144
LIP: LI0436 LI0438
LIR: LAW_00452
ACA: ACP_1579
GMA: AciX8_0270
GRW: FTO74_19065
TALB: FTW19_21545
ABAS: ACPOL_3731
EDA: GWR55_14565
PFER: IRI77_10650 IRI77_15290 IRI77_16660 IRI77_16665
MHAD: B586_02085
MLL: B1R94_26470
MAIC: MAIC_03690(appA)
MANY: MANY_34820(appA)
CPOR: BED41_01000
 » show all
Reference
1  [PMID:4310376]
  Authors
Johnson LF, Tate ME.
  Title
The structure of myo-inositol pentaphosphates.
  Journal
Ann N Y Acad Sci 165:526-32 (1969)
DOI:10.1111/j.1749-6632.1970.tb56420.x
Reference
2  [PMID:13921788]
  Authors
TOMLINSON RV, BALLOU CE.
  Title
Myoinositol polyphosphate intermediates in the dephosphorylation of phytic acid by phytase.
  Journal
Biochemistry 1:166-71 (1962)
DOI:10.1021/bi00907a025
Reference
3  [PMID:4349266]
  Authors
Lim PE, Tate ME.
  Title
The phytases. II. Properties of phytase fractions F 1  and F 2  from wheat bran and the myoinositol phosphates produced by fraction F 2 .
  Journal
Biochim Biophys Acta 302:316-28 (1973)
DOI:10.1016/0005-2744(73)90160-5
Reference
4
  Authors
Cosgrove DJ.
  Title
In: Inositol Phosphates: Their Chemistry, Biochemistry, and Physiology. Amsterdam: Elsevier; 1980.
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.26
IUBMB Enzyme Nomenclature: 3.1.3.26
ExPASy - ENZYME nomenclature database: 3.1.3.26
BRENDA, the Enzyme Database: 3.1.3.26
CAS: 9001-89-2
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