Entry
Name
adenosylcobalamin/alpha-ribazole phosphatase;
CobC;
adenosylcobalamin phosphatase;
alpha-ribazole phosphatase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
adenosylcobalamin/alpha-ribazole-5'-phosphate phosphohydrolase
Reaction(IUBMB)
(1) adenosylcobalamin 5'-phosphate + H2O = adenosylcobalamin + phosphate [RN:
R11173 ];
(2) alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate [RN:
R04594 ]
Reaction(KEGG)
Substrate
adenosylcobalamin 5'-phosphate [CPD:
C21153 ];
H2O [CPD:
C00001 ];
alpha-ribazole 5'-phosphate [CPD:
C04778 ]
Product
Comment
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3].It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].
History
EC 3.1.3.73 created 2004, modified 2011
Pathway
Orthology
K02226 alpha-ribazole phosphatase
K22316 ribonuclease H / adenosylcobalamin/alpha-ribazole phosphatase
Genes
ECD : ECDH10B_0599(cobC) ECDH10B_0707(cobC)
ECOO : ECRM13514_0662(phpB)
ECOH : ECRM13516_0607(phpB)
ECW : EcE24377A_0664(cobC)
EDJ : ECDH1ME8569_0607(cobC)
ECOI : ECOPMV1_00655(cobC_1)
REE : electrica_03660(cobC_2)
RTG : NCTC13098_05358(cobC_2)
KIE : NCTC12125_02336(cobC_1)
AHN : NCTC12129_03557(phpB)
METY : MRY16398_40880(cobC)
ROX : BV494_03780 BV494_19865
LRI : NCTC12151_01596(cobC_1)
XFU : XFF4834R_chr14450(cobC)
XPH : XppCFBP6546_18120(XppCFBP6546P_18120)
PJP : LAG73_00290 LAG73_07140
VAU : VANGNB10_cI1525c(cobC?)
VSR : Vspart_04288(pspB_2)
PAEB : NCGM1900_5294(cobC)
PPUD : DW66_1253 DW66_1615
PMUD : NCTC8068_03841(cobC)
PFW : PF1751_v1c39770(cobC)
PPUU : PputUW4_03767(cobC1)
PTAE : NCTC10697_01159(cobC_1)
AJN : BVL33_05185 BVL33_09430
SLJ : EGC82_06020 EGC82_11290
SCAA : TUM17387_32410(cobC)
SYOU : RGE70_03150 RGE70_08450
PSEN : PNC201_13530(pspA3)
METU : GNH96_03785 GNH96_09870
MMEO : OOT43_03740 OOT43_09665
MMT : Metme_0061 Metme_1353
MSZE : MSZNOR_1438 MSZNOR_3414
TSE : THMIRHAS_14880(cobC)
THIS : HZT40_05070 HZT40_05830 HZT40_19005
TUN : J9260_06855 J9260_14490
TLO : J9253_10210 J9253_14495
TSB : HMY34_10280 HMY34_16090
TWN : L2Y54_03395 L2Y54_18805
TLC : RCF98_08305 RCF98_14245(cobC)
TSJ : L3K52_03280 L3K52_16190
TPUT : QJT81_01160 QJT81_06365(cobC)
ALV : Alvin_0850 Alvin_2702
ATEP : Atep_01410 Atep_24060
TVI : Thivi_1671 Thivi_2773
TMB : Thimo_3123 Thimo_3560
MPUR : MARPU_00720 MARPU_04820
TSY : THSYN_08625 THSYN_17270
THIP : N838_05335 N838_09875
CJAP : GWK36_08760 GWK36_11610
TBOG : LT988_06955 LT988_09940
TLR : Thiosp_02569(cobC_1) Thiosp_02671(cobC_2)
TFRI : Thiofri_02324(cobC_1) Thiofri_02432(cobC_2)
TWG : Thiowin_01996(cobC_1) Thiowin_02198(cobC_2)
HHC : M911_07600 M911_11105
EBS : ECTOBSL9_0032 ECTOBSL9_1482
TNI : TVNIR_0467 TVNIR_3486
TTI : THITH_14960 THITH_15350
EPS : L0Y14_02125 L0Y14_06345(cobC)
HCS : FF32_07730 FF32_13040
HAK : KO116_01850 KO116_04065
HHH : CLM76_03860 CLM76_13580
HAG : BB497_02475 BB497_14190
HPRO : LMS44_01525 LMS44_13555
HQD : K1Y77_06690 K1Y77_16040
HBP : HPTD01_3541 HPTD01_846
HALF : QEN58_01340 QEN58_11420
HASO : B2G49_09480 B2G49_20665
HAMS : NF683_08580 NF683_14640
HAAH : HALA3H3_320016 HALA3H3_800118
HAXH : J4377_01570 J4377_06890
HABD : OM794_01680 OM794_13035
HQN : M0220_00815 M0220_08465
HAFN : KF947_02385 KF947_13065
HANY : LG409_01530 LG409_10580
HAMZ : P8S55_00490 P8S55_12845
HALK : CUU95_04440 CUU95_17105
HVN : EI420_01400 EI420_07455
HOL : HORIV_04030 HORIV_40980
HSR : HSBAA_04670 HSBAA_39250
HPIZ : GYM47_01520 GYM47_07020
HNP : SR894_01095 SR894_11865
HTT : HZS52_02880 HZS52_14705
HMD : CTT34_01345 CTT34_07340
HAXI : HAALTHF_12170n HAALTHF_42460n
BMN : BMA10247_1634(cobC-2)
BPL : BURPS1106A_1039(cobC)
BTD : BTI_2846(cobC) BTI_4931
BOK : DM82_414(cobC) DM82_6372
BOC : BG90_4302 BG90_614(cobC)
BHG : I6G56_05975(cobC) I6G56_28385
BUD : AQ610_14230 AQ610_30825
BUL : BW21_2983(cobC) BW21_4459
PACP : FAZ97_03320 FAZ97_03670(cobC)
PLG : NCTC10937_04020(cobC)
BUO : BRPE64_ACDS06520(cobC)
ASAH : AVXHC19_09240(cobC)
CSER : CCO03_14255 CCO03_14660
MPT : Mpe_A2301(gmpB) Mpe_B0521(gpmB)
NII : Nit79A3_0193 Nit79A3_2880
NCO : AAW31_02955 AAW31_04065
SULF : CAP31_05505 CAP31_14195
SPLB : SFPGR_10170 SFPGR_26660
SLAC : SKTS_26440 SKTS_29450
THAG : CKCBHOJB_03387(pspB)
RBS : RHODOSMS8_01710(pspA) RHODOSMS8_03452(pspB)
BJA : bll3277(bluF) bll5443(bll5443)
BJU : BJ6T_43660 BJ6T_64730
BJP : RN69_21185 RN69_31375
AOL : S58_27740(cobC) S58_45630
BRC : BCCGELA001_14760 BCCGELA001_22910
BRAD : BF49_1421 BF49_6189
BIC : LMTR13_04015 LMTR13_16605 LMTR13_27065
BRO : BRAD285_2319 BRAD285_2793
BRK : CWS35_11480 CWS35_20470
BOT : CIT37_27090 CIT37_37175
BRQ : CIT40_10870 CIT40_19235
BGQ : X265_22950 X265_24740
BGZ : XH91_14315 XH91_22780
BSYM : CIT39_09850 CIT39_18585
BBET : F8237_03765 F8237_29245
BARH : WN72_17895 WN72_30160
BVZ : BRAD3257_3651 BRAD3257_5422(bluF)
BEL : BE61_46660 BE61_86070(bluF)
BDG : LPJ38_19200 LPJ38_28815
BSEP : HAP48_0020885 HAP48_0044085
BQB : J4P68_0003290 J4P68_0013205
BBAN : J4G43_018910 J4G43_032495
BCAN : BcanWSM471_15610 BcanWSM471_24105
BAUT : QA635_18530 QA635_37210
BBRA : QA636_19130 QA636_38295
BGK : IC762_05390 IC762_22135
BCOU : IC761_14425 IC761_23180
BPAH : QA639_26350 QA639_36705
BXN : I3J27_12800 I3J27_23310
BROS : QUH67_05445 QUH67_13815
BRAZ : LRP30_14530 LRP30_24465
BOY : LQG66_09355 LQG66_36930
BRAY : ML401_11740 ML401_20370
RPX : Rpdx1_1145 Rpdx1_2151
VGO : GJW-30_1_02902(pspB)
MAQU : Maq22A_c23855(gpmB)
ROH : FIU89_17300 FIU89_18445(cobC)
NOR : FA702_01475 FA702_20550
SPHM : G432_03935 G432_21430
SJP : SJA_C1-11140 SJA_C2-03330
SINB : SIDU_08670 SIDU_11715
SYB : TZ53_06830 TZ53_21585
SPMI : K663_04885 K663_18336
SPHT : K426_22584 K426_29205
SUFL : FIL70_10765 FIL70_22680
SBAR : H5V43_08500 H5V43_18140
SPPH : KFK14_08315 KFK14_09765
SPAG : sphantq_04017(pspB)
GTI : FXF46_05645 FXF46_12935
GFA : MKW11_05600 MKW11_13460
GDI : GDI0663 GDI1629(cobC)
KNA : B0W47_06185 B0W47_09505
KEU : S101446_01597(cobC) S101446_02371
KSC : CD178_01059(cobC_2) CD178_01755(pspB)
KRE : GWK63_00375 GWK63_11580
KOI : LV478_05890 LV478_18320
APT : APA01_22500 APA01_25880
APW : APA42C_22500 APA42C_25880
APF : APA03_22500 APA03_25880
APU : APA07_22500 APA07_25880
APG : APA12_22500 APA12_25880
APQ : APA22_22500 APA22_25880
APX : APA26_22500 APA26_25880
APZ : APA32_22500 APA32_25880
APK : APA386B_1109(gpmA) APA386B_1392
ASZ : ASN_1739(cobC) ASN_2740
ASV : WG31_11390 WG31_12775
AACE : A0U92_10760 A0U92_14285
APOM : CPF11_07855 CPF11_09370
ATO : CIW82_03520 CIW82_17650
AASC : A4S02_00505 A4S02_11750
ACET : DS739_11040 DS739_12555
AOT : AcetOri_orf02824 AcetOri_orf03953
AOY : EOV40_010685 EOV40_012525
ACEK : FLP30_04630 FLP30_06805
ABG : Asbog_00443 Asbog_00565
COQ : D9V35_07740 D9V35_08595
COMM : GN303_07530 GN303_08395
NTN : D5366_08415 D5366_09670
SSAM : E3D00_04480 E3D00_09315
EBLA : JGUZn3_04910(gpmB) JGUZn3_06330
LCK : HN018_05860 HN018_21145
KHA : IFJ82_00640 IFJ82_04730
NGU : QN315_11530 QN315_14995
AMV : ACMV_05280 ACMV_P1_00720
RGI : RGI145_04945 RGI145_06780
ROS : CTJ15_10645 CTJ15_12435
RMUC : FOB66_06765 FOB66_08825
RCV : PFY06_02200 PFY06_04985
DVN : HQ394_01535 HQ394_01540
MAES : Ga0123461_0273 Ga0123461_1662
MFN : Ga0123462_0359 Ga0123462_1995
SMUL : SMUL_1550(cobC) SMUL_2092
SHAL : SHALO_1514 SHALO_1846
SULS : Sdiek1_1607 Sdiek1_1929
SULJ : SJPD1_1527 SJPD1_1846
SULT : FA592_00175 FA592_01760
GEC : GEO60473_24300(cobC)
GBN : GEOBRER4_37020(cobC)
PEF : A7E78_06120 A7E78_10970
LRS : PX52LOC_03909 PX52LOC_04142 PX52LOC_06889 PX52LOC_07275(pspB) PX52LOC_08239
PBAP : Pla133_21000(gpgP) Pla133_26340(pspB)
LAJ : A0128_18665 A0128_21250
LKM : EFP84_10220(cobC) EFP84_20195
LCIN : AB3N61_06930 AB3N61_16440(cobC)
BCEL : BcellWH2_00329(pspB)
PGT : PGTDC60_0303 PGTDC60_1827
PAH : Poras_0194 Poras_1508
PCAG : NCTC12856_00458 NCTC12856_00652
PEND : LA319_04935 LA319_07450
PSOE : CE91St14_13460 CE91St14_16920
POC : NCTC13071_01277(cobC_2)
SRHO : HH216_15350(cobC) HH216_21900
FLM : MY04_3468 MY04_5402(cobC)
FLL : EI427_18450 EI427_19975
FYA : KMW28_19420 KMW28_21460(cobC)
FKA : KM029_11275 KM029_12790(cobC)
POLQ : JOP69_01210(cobC) JOP69_04105(cobC)
TSX : RHP49_02740(cobC) RHP49_16470(cobC)
CGLE : NCTC11432_05058(cobC)
PARG : PspKH34_12470(cobC)
LMOC : LMOSLCC5850_1138(cobC)
LMW : LMOSLCC2755_1141(cobC)
LMX : LMOSLCC2372_1144(cobC)
LMZ : LMOSLCC2482_1187(cobC)
LMON : LMOSLCC2376_1100(cobC)
LMOS : LMOSLCC7179_1116(cobC)
LMOO : LMOSLCC2378_1152(cobC)
LMOY : LMOSLCC2479_1145(cobC)
LMOT : LMOSLCC2540_1127(cobC)
LMOA : LMOATCC19117_1148(cobC)
PDH : B9T62_01480 B9T62_37350
KZO : NCTC404_00495(cobC_1)
STHO : QNH10_00420 QNH10_10330
SOW : QWT69_02240 QWT69_14490
SMEN : SAMEA4412692_0380(cobC_1)
CLJ : CLJU_c23980 CLJU_c35540(cobC)
CSR : Cspa_c06970 Cspa_c14670
CAH : CAETHG_0464(cobC) CAETHG_1462(cobC)
CCK : Ccar_18195 Ccar_24825
CTYK : CTK_C17110 CTK_C25590(cobC)
CEU : A7L45_05870 A7L45_18880
CFM : BJL90_10785 BJL90_11405
CDRK : B9W14_03755 B9W14_21635
CCOH : SAMEA4530647_0600(cobC)
CLOS : DMR38_12315(cobC) DMR38_17845(cobC)
CRW : CROST_019520(pspA_1)
CAUN : CLAUR_010380(pspA_1)
CGEL : psyc5s11_37620(cobC)
FPLA : A4U99_04110 A4U99_06370
FPRA : CG447_06690 CG447_11860 CG447_14330
FDU : GXM22_09630 GXM22_12105
PETR : QKW49_07680(cobC) QKW49_23145
FWA : DCMF_14130 DCMF_28220
AWO : Awo_c19250(cobC) Awo_c27100(pgm4)
BPRO : PMF13cell1_04257(pspB)
CSCI : HDCHBGLK_00113(pspB)
ACEL : acsn021_39590(cobC_2)
ACHT : bsdcttw_22250(cobC)
CBAR : PATL70BA_0696 PATL70BA_1267
GFE : Gferi_19210 Gferi_24195
PDF : CD630DERM_34360(cobC)
PHX : KGNDJEFE_02263(pspA_2)
TPET : TPHSE_02710(pspA_1)
VRM : 44547418_00928(cobC)
SRI : SELR_12290(cobC) SELR_20680
PFAC : PFJ30894_01708(pspA)
MAVM : MAA44156_02204(pspA_3)
MCHI : AN480_11370 AN480_24395
MBAI : MB901379_02991(pspA_3)
MSEO : MSEO_19280 MSEO_45070
MLM : MLPF_0904(rhnA-cobC)
MPHL : MPHLCCUG_03371(pspA_6)
MSAL : DSM43276_01700(pspA_1)
CMIN : NCTC10288_00740(rnhA)
CAUS : CAURIC_03755(pspA1)
NTP : CRH09_12105 CRH09_15315
NHU : H0264_15455 H0264_23255
NYA : LTV02_17610 LTV02_35305
NYU : D7D52_02820 D7D52_36285
SLE : sle_48850(sle_48850)
SLX : SLAV_19965(pspA3) SLAV_25795(pspA5)
SCYA : EJ357_13535 EJ357_22080
SKA : CP970_08745 CP970_30790
SGZ : C0216_16175 C0216_24480
SNK : CP967_12635 CP967_24400
SGF : HEP81_00918 HEP81_05454
SHUN : DWB77_05410(pspA_1)
STRZ : OYE22_13325 OYE22_25290
SLUO : PS467_10915 PS467_13150
SRPZ : HEP85_12775 HEP85_40275
SCAT : P8A18_08685 P8A18_12290
TED : U5C87_17440 U5C87_21020
KSL : OG809_10015 OG809_25725
ACTQ : OG417_38805 OG417_39260
NGN : LCN96_39565 LCN96_41760
SACC : EYD13_03945(pspA2) EYD13_07590
AMYZ : HUW46_02510 HUW46_07734
PBRO : HOP40_14140 HOP40_29700
SSYI : EKG83_04650 EKG83_14290
ACTU : Actkin_00935(pspA_2)
MICF : QQG74_01130 QQG74_24365
PSUU : Psuf_014000 Psuf_014010
JTL : M6D93_04160 M6D93_13430
ATQ : GH723_03570 GH723_11175
SYY : SYNGTS_0920(slr1748)
SYT : SYNGTI_0920(slr1748)
SYS : SYNPCCN_0919(slr1748)
SYQ : SYNPCCP_0919(slr1748)
MIQ : B5D77_14020 B5D77_20905
MVZ : myaer102_25750 myaer102_47400
DFO : Dform_00896 Dform_00923
KBS : EPA93_23835 EPA93_37885
DAQU : M8445_02825 M8445_04385
DSC : ABOD76_07095 ABOD76_21225
PPIO : CE91St28_02640 CE91St28_18650
FPOL : ERS445057_01316(cobC_1)
LOT : AXF11_05670 AXF11_06835
LEQ : BCB68_02070 BCB68_03430
LHF : JCM16775_0452 JCM16775_2176
LSZ : JCM16776_1539 JCM16776_1810
LHG : JMUB5056_1820 JMUB5056_1987
LTE : JMUB4039_0376 JMUB4039_2145
LWD : JCM16777_0214 JCM16777_1732
LOB : NEF87_003418 NEF87_004206 NEF87_004869
» show all
Taxonomy
Reference
Authors
O'Toole GA, Trzebiatowski JR, Escalante-Semerena JC
Title
The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.
Journal
J Biol Chem 269:26503-11 (1994)
Sequence
Reference
Authors
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
Title
The biosynthesis of adenosylcobalamin (vitamin B12).
Journal
Reference
Authors
Zayas CL, Escalante-Semerena JC
Title
Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.73
ExPASy - ENZYME nomenclature database: 3.1.3.73
LinkDB
All DBs