Entry
Name
5''-phosphoribostamycin phosphatase;
btrP (gene name);
neoI (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
BRITE hierarchy
Sysname
5''-phosphoribostamycin phosphohydrolase
Reaction(IUBMB)
5''-phosphoribostamycin + H2O = ribostamycin + phosphate [RN:
R08899 ]
Reaction(KEGG)
Substrate
Product
Comment
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.
History
EC 3.1.3.88 created 2012
Pathway
ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13555 5''-phosphoribostamycin phosphatase
Genes
Taxonomy
Reference
Authors
Kudo F, Fujii T, Kinoshita S, Eguchi T
Title
Unique O-ribosylation in the biosynthesis of butirosin.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.88
ExPASy - ENZYME nomenclature database: 3.1.3.88
LinkDB
All DBs