KEGG   ENZYME: 3.1.3.88
Entry
EC 3.1.3.88                 Enzyme                                 
Name
5''-phosphoribostamycin phosphatase;
btrP (gene name);
neoI (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
5''-phosphoribostamycin phosphohydrolase
Reaction(IUBMB)
5''-phosphoribostamycin + H2O = ribostamycin + phosphate [RN:R08899]
Reaction(KEGG)
R08899
Substrate
5''-phosphoribostamycin [CPD:C18004];
H2O [CPD:C00001]
Product
ribostamycin [CPD:C01759];
phosphate [CPD:C00009]
Comment
Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. No metal is required for activity.
History
EC 3.1.3.88 created 2012
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13555  5''-phosphoribostamycin phosphatase
Genes
SRNA4G23_05122(btrP)
SFBCP974_27335
Reference
1  [PMID:17482823]
  Authors
Kudo F, Fujii T, Kinoshita S, Eguchi T
  Title
Unique O-ribosylation in the biosynthesis of butirosin.
  Journal
Bioorg Med Chem 15:4360-8 (2007)
DOI:10.1016/j.bmc.2007.04.040
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.88
IUBMB Enzyme Nomenclature: 3.1.3.88
ExPASy - ENZYME nomenclature database: 3.1.3.88
BRENDA, the Enzyme Database: 3.1.3.88
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