| Entry |
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| Name |
micrococcal nuclease;
spleen endonuclease;
thermonuclease;
nuclease T;
micrococcal endonuclease;
nuclease T';
staphylococcal nuclease;
spleen phosphodiesterase;
Staphylococcus aureus nuclease;
Staphylococcus aureus nuclease B;
ribonucleate (deoxynucleate) 3'-nucleotidohydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters
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| Reaction(IUBMB) |
Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products
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| Comment |
Hydrolyses double- or single-stranded substrate.
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| History |
EC 3.1.31.1 created 1961 as EC 3.1.4.7, transferred 1978 to EC 3.1.31.1, modified 1981
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| Orthology |
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| Genes |
| ELX: | CDCO157_A0070 CDCO157_B0026(yeaA) |
| EOI: | ECO111_p1-095 ECO111_p3-11 |
| EUM: | ECUMN_p10073 ECUMN_p20017 |
| ECOI: | ECOPMV1_p00064(nuc) |
| ECOJ: | P423_25460 P423_25795 |
| SHIG: | LXH19_23230 LXH19_23855 |
| ECLX: | LI66_23130 LI66_24235 |
| ECLZ: | LI64_22535 LI64_23755 |
| KOC: | AB185_00280 AB185_04885 |
| REE: | electrica_05643(exoI) |
| CIE: | AN232_26505 AN232_26610 AN232_30320 AN232_30775 AN232_31265 |
| LEH: | C3F35_23135 C3F35_26005 |
| PSTW: | DSJ_00750 DSJ_22740 |
| AET: | LDL57_16420 LDL57_17190 |
| ACIP: | CBP36_19090 CBP36_20640 |
| ACIS: | CBP35_19040 CBP35_20720 |
| PACE: | A6070_03145 A6070_10730 |
| DFI: | AXF13_05105 AXF13_07505 |
| DEF: | CNY67_05020 CNY67_06565 |
| DAW: | HS1_000861 HS1_001046 HS1_001135 |
| LCRE: | Pla8534_08200(nucH) |
| AAGG: | ETAA8_51460(nucH_3) |
| TPOL: | Mal48_24860(nucH_1) |
| SPHN: | BV902_08015 BV902_23295 |
| STHA: | NCTC11429_00551(nucH) |
| SSIY: | JVX97_07975 JVX97_25325 |
| SFAE: | MUK51_03725 MUK51_08935 |
| SBAM: | SCB77_04910 SCB77_18160 |
| SOP: | PQ465_07120 PQ465_15355 |
| SPRZ: | VXM68_00205 VXM68_10770 |
| ALAM: | RT761_00303(yokF_1) RT761_02295(yokF_2) |
| BTHR: | YBT1520_29964 YBT1520_32181 |
| BTHI: | BTK_29759 BTK_32231 |
| BACA: | FAY30_09480 FAY30_27005 |
| BON: | A361_11980 A361_28985 |
| LGY: | T479_03660 T479_15505 |
| LYB: | C3943_04595 C3943_13230 C3943_18145 |
| LPAK: | GDS87_03890 GDS87_11170 |
| VIG: | BKP57_01900 BKP57_15395 BKP57_15455 |
| VPT: | KBP50_06900 KBP50_14470 |
| MENL: | MVE64_22020 MVE64_26540 |
| MEBZ: | LPC09_08095 LPC09_25675 |
| BLEN: | NCTC4824_02894(yokF) |
| BBAD: | K7T73_07290 K7T73_09740 |
| AGN: | AFK25_07805 AFK25_10595 |
| AAYD: | B379_11405 B379_14545 |
| SAV: | SAV0815(nuc) SAV1324(nuc) |
| SAW: | SAHV_0811(nuc) SAHV_1313(nuc) |
| SAH: | SaurJH1_0832 SaurJH1_1412 |
| SAJ: | SaurJH9_0816 SaurJH9_1385 |
| SAR: | SAR0847(nuc) SAR1334(nucI) |
| SAC: | SACOL0860(nuc) SACOL1357 |
| SAX: | USA300HOU_0823(nuc) USA300HOU_1268(nucA) |
| SAA: | SAUSA300_0776(nuc) SAUSA300_1222(nuc) |
| SAO: | SAOUHSC_00818 SAOUHSC_01316 |
| SAE: | NWMN_0760 NWMN_1236(nuc) |
| SAD: | SAAV_0761(nuc) SAAV_1303 |
| SUU: | M013TW_0782 M013TW_1272 |
| SUV: | SAVC_03605 SAVC_05860 |
| SUE: | SAOV_0832(nuc) SAOV_1337(nucI) |
| SUJ: | SAA6159_00747 SAA6159_01191 |
| SUK: | SAA6008_00807 SAA6008_01288(nuc) |
| SUC: | ECTR2_1183 ECTR2_743 |
| SUT: | SAT0131_00892 SAT0131_01393 |
| SUQ: | HMPREF0772_11884 HMPREF0772_12387(nuc) |
| SUZ: | MS7_0843(nuc) MS7_1283(nucH) |
| SUD: | ST398NM01_0871 ST398NM01_1326 |
| SUX: | SAEMRSA15_07180(nuc) SAEMRSA15_11710(nucI) |
| SUW: | SATW20_08660(nuc) SATW20_13260(nucI) |
| SUF: | SARLGA251_07230(nuc) SARLGA251_12330(nucI) |
| SAUA: | SAAG_01215 SAAG_01934 |
| SAUE: | RSAU_000769 RSAU_001206(nuc) |
| SAUN: | SAKOR_00795 SAKOR_01259 |
| SAUS: | SA40_0730(nuc) SA40_1203(nucI) |
| SAUU: | SA957_0745(nuc) SA957_1218(nucI) |
| SAUG: | SA268_0744(nuc) SA268_1223(nucI) |
| SAUZ: | SAZ172_0804(nuc) SAZ172_1337(nucI) |
| SAUT: | SAI1T1_2006220(nuc) SAI1T1_2009500(nuc) |
| SAUJ: | SAI2T2_1006240(nuc) SAI2T2_1009520(nuc) |
| SAUK: | SAI3T3_1006230(nuc) SAI3T3_1009510(nuc) |
| SAUQ: | SAI4T8_1006220(nuc) SAI4T8_1009500(nuc) |
| SAUV: | SAI7S6_1006230(nuc) SAI7S6_1009510(nuc) |
| SAUW: | SAI5S5_1006190(nuc) SAI5S5_1009470(nuc) |
| SAUX: | SAI6T6_1006200(nuc) SAI6T6_1009480(nuc) |
| SAUY: | SAI8T7_1006230(nuc) SAI8T7_1009510(nuc) |
| SAUF: | X998_0840 X998_1334 |
| SAB: | SAB0748(nuc) SAB1182(nucI) |
| SUY: | SA2981_0770 SA2981_1279(nuc) |
| SAUB: | C248_0884(nuc) C248_1358(nucI) |
| SAUM: | BN843_12400 BN843_7920 |
| SAUC: | CA347_1263(nucH) CA347_810(nuc) |
| SAUR: | SABB_00184 SABB_04455(nuc) |
| SAUD: | CH52_01800 CH52_12445 |
| SAMS: | NI36_04025 NI36_06515 |
| SUH: | SAMSHR1132_07400 SAMSHR1132_11690 |
| SHH: | ShL2_01460 ShL2_01620 |
| SDP: | NCTC12225_01656(nucA) |
| SCAP: | AYP1020_0535(nuc) AYP1020_0632(nucH) |
| SCAR: | DWB96_07750 DWB96_08255 |
| SPIC: | SAMEA4384060_1613(nuc_1) |
| SSH: | NCTC13712_00829(nuc) NCTC13712_01317(nucH) |
| SSIM: | SAMEA4384339_1221(nucH) |
| STAS: | HYI43_07365 HYI43_07840 |
| SROT: | ML435_03870 ML435_06125 |
| GMO: | NCTC11323_00754(yncB) |
| GHA: | NCTC10459_00776(yncB) |
| TCO: | Theco_2202 Theco_4087 |
| ANX: | ACH33_02600 ACH33_09610 |
| ATHE: | K3F53_09455 K3F53_16345 |
| PMAR: | B0X71_12815 B0X71_19635 |
| PLX: | CW734_00440 CW734_12110 |
| TVU: | AB849_010020 AB849_011360 |
| CBAR: | PATL70BA_2967(nucH) |
| PEB: | O0R46_08070 O0R46_08200 |
| EAC: | EAL2_808p06360(nucH) |
| FAA: | HMPREF0389_00861(nucH) |
| CHY: | CHY_1644(nucH1) CHY_1698 CHY_1699(nucH2) |
| PIV: | NCTC13079_01583(nucH) |
| MMIR: | HLA87_00230 HLA87_01545 |
| MNU: | NCTC10166_00702(nucH) |
| MCR: | MCFN_01585 MCFN_03150 |
| MCM: | MCAL160_0102(snc) MCAL160_0569 |
| MGLY: | NCTC10194_00563(yhcR) |
| MCOU: | NCTC10179_00681(yokF) |
| MPU: | MYPU_1390(MYPU_1390) |
| MBOV: | MBVG596_0209 MBVG596_0788 |
| MEDW: | NCTC10132_00215(nucH) |
| MGAL: | NCTC10186_00274(nucH) |
| MCIT: | NCTC10181_00341(nucH) |
| MMAU: | NCTC10168_00429(nucH) |
| MMEL: | NCTC10153_00434(nucH) |
| MCOB: | NCTC10184_00102(yncB) |
| MSAI: | NCTC10113_01278(yncB) |
| MCB: | Mycch_5371 Mycch_5406 |
| MMAG: | MMAD_33420 MMAD_54880 MMAD_56820 |
| MGAD: | MGAD_02160 MGAD_02350 |
| MFLV: | NCTC10271_02377(nucH) |
| MPLN: | VC184_14795 VC184_15210 |
| JTE: | ASJ30_00415 ASJ30_06125 |
| DCO: | SAMEA4475696_0605(nucH) |
| RUB: | GBA63_19680 GBA63_22600 |
| CYB: | CYB_0109(nucH) CYB_2295 |
| PRUN: | PCC7821_03051(nucH) |
| NSPH: | BDGGKGIB_03994(nucH) |
| RRS: | RoseRS_0371 RoseRS_0374 |
| FPE: | Ferpe_1689 Ferpe_2001 |
| FIA: | NA23_08370 NA23_10020 |
| FRR: | IB67_00390 IB67_03110 |
| MINF: | MESINF_0928 MESINF_1209 |
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| Reference |
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| Authors |
ALEXANDER M, HEPPEL LA, HURWITZ J. |
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| Title |
The purification and properties of micrococcal nuclease. |
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| Journal |
J Biol Chem 236:3014-9 (1961) |
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| Reference |
2 |
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| Authors |
Anfinsen CB, Cuatrecasas P, Taniuchi H. |
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| Title |
Staphylococcal nuclease, chemical properties and catalysis. |
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| Journal |
In: Boyer PD (ed). The Enzymes. 3rd ed. Vol. 4. New York: Academic Press; 1971. p. 177-204. |
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| Reference |
3 |
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| Authors |
Reddi KK. |
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| Title |
Micrococcal nuclease. |
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| Journal |
Methods Enzymol 12A:257-262 (1967) |
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| Reference |
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| Authors |
Sulkowski E, Laskowski M Sr. |
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| Title |
Phosphatase-free crystalline micrococcal nuclease. |
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| Journal |
J Biol Chem 241:4386-8 (1966) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.31.1 |
| ExPASy - ENZYME nomenclature database: | 3.1.31.1 |
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| LinkDB |
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