Entry
Name
[acyl-carrier-protein] phosphodiesterase;
ACP hydrolyase;
ACP phosphodiesterase;
AcpH;
[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase;
holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
holo-[acyl-carrier protein] 4'-pantetheine-phosphohydrolase
Reaction(IUBMB)
holo-[acyl-carrier protein] + H2O = 4'-phosphopantetheine + apo-[acyl-carrier protein] [RN:
R01623 ]
Reaction(KEGG)
Substrate
Product
4'-phosphopantetheine [CPD:
C01134 ];
apo-[acyl-carrier protein] [CPD:
C03688 ]
Comment
The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP cofactor turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC
2.7.8.7 , holo-[acyl-carrier-protein] synthase.
History
EC 3.1.4.14 created 1972, modified 2006
Pathway
ec00770 Pantothenate and CoA biosynthesis
Orthology
K08682 acyl carrier protein phosphodiesterase
Genes
ECOO : ECRM13514_0441(yajB)
ECOH : ECRM13516_0386(yajB)
ECW : EcE24377A_0434(acpH)
EDJ : ECDH1ME8569_0389(yajB)
SEM : STMDT12_C04670(acpH)
REE : electrica_03966(acpH)
AHN : NCTC12129_01189(yajB)
METY : MRY16398_44420(acpH)
MPHG : MPHASIOC01_002718(acpH)
YPG : YpAngola_A3386(acpH)
YPI : YpsIP31758_3125(acpH)
PVD : CFBP1590__1230 CFBP1590__5085
PPRC : PFLCHA0_c13740(acpH)
PMUD : NCTC8068_01284(acpH)
PQI : KH389_16285 KH389_17390 KH389_21775
PCAS : LOY40_17825 LOY40_21965
PTAE : NCTC10697_03422(acpH)
PSMZ : V6L79_16090 V6L79_22235
SALH : HMF8227_00663(acpH)
RHEI : ATY27_05065 ATY27_11880
GAI : IMCC3135_10650(acpH)
ALCA : ASALC70_03147(acpH)
CDIZ : CEDIAZO_01527(acpH)
PLG : NCTC10937_01225(acpH)
THAG : CKCBHOJB_01606(acpH)
GBN : GEOBRER4_18570(acpH)
PHG : KCTC32516_01677(acpH)
AALG : AREALGSMS7_04549(acpH)
AANR : KCTC52924_03734(acpH)
KOS : KORDIASMS9_03419(acpH)
KAN : IMCC3317_02910(acpH)
SPON : HME9304_03248(acpH)
PTAN : CRYO30217_01541(acpH)
LET : O77CONTIG1_01431(acpH)
» show all
Taxonomy
Reference
Authors
Sobhy C.
Title
Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver.
Journal
J Biol Chem 254:8561-6 (1979)
Reference
Authors
Vagelos PR, Larrabes AR.
Title
Acyl carrier protein. IX. Acyl carrier protein hydrolase.
Journal
J Biol Chem 242:1776-81 (1967)
Reference
Authors
Thomas J, Cronan JE
Title
The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.14
ExPASy - ENZYME nomenclature database: 3.1.4.14
LinkDB
All DBs