KEGG ENZYME: 3.1.4.37

ENZYME: 3.1.4.37

Entry

EC 3.1.4.37                 Enzyme

Name

2',3'-cyclic-nucleotide 3'-phosphodiesterase;
cyclic-CMP phosphodiesterase;
2',3'-cyclic AMP phosphodiesterase;
cyclic 2',3'-nucleotide 3'-phosphodiesterase;
cyclic 2',3'-nucleotide phosphodiesterase;
2',3'-cyclic nucleoside monophosphate phosphodiesterase;
2',3'-cyclic nucleotide 3'-phosphohydrolase;
CNPase;
2',3'-cyclic nucleotide phosphohydrolase;
2':3'-cyclic nucleotide 3'-phosphodiesterase;
2':3'-CNMP-3'-ase

Class

Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases

Sysname

nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase

Reaction(IUBMB)

nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate [RN:R03422]

Reaction(KEGG)

R03422

Substrate

nucleoside 2',3'-cyclic phosphate [CPD:C01240];
H2O [CPD:C00001]

Product

nucleoside 2'-phosphate [CPD:C03418]

Comment

The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.

History

EC 3.1.4.37 created 1976

Orthology

K01121

2',3'-cyclic-nucleotide 3'-phosphodiesterase

K15435

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Genes

HSA:

1267(CNP)

PTR:	454673(CNP)

PPS:	100983181(CNP)

GGO:	101154558(CNP)

PON:	100171506(CNP)

PPYG:

129017261(CNP)

NLE:	100595130(CNP)

HMH:	116474849(CNP)

SSYN:

129469981(CNP)

MCC:	641337(CNP)

MCF:	101866793(CNP)

MTHB:

126938500

MNI:	105472136(CNP)

CSAB:

103243434(CNP)

CATY:

105579659(CNP)

PANU:

101024891(CNP)

TGE:	112609141(CNP)

MLEU:

105552968(CNP)

RRO:	104680442(CNP)

RBB:	108518345(CNP)

TFN:	117066981(CNP)

PTEH:

111537385(CNP)

CANG:

105503023(CNP)

CJC:	100409009(CNP)

SBQ:	101050949(CNP)

CIMI:

108289841

ANAN:

105713391(CNP)

CSYR:

103274482(CNP)

MMUR:

105872016(CNP)

LCAT:

123620943

PCOQ:

105820240(CNP)

OGA:	100964028(CNP)

MMU:	12799(Cnp)

MCAL:

110305046(Cnp)

MPAH:

110332178(Cnp)

RNO:	25275(Cnp)

MCOC:

116079258(Cnp)

ANU:	117711466(Cnp)

ASYL:

127695293(Cnp)

MUN:	110540732(Cnp)

CGE:	100753220(Cnp)

MAUA:

101830936

PROB:

127216178(Cnp)

PLEU:

114682839

MORG:

121442498

MFOT:

126510310

AAMP:

119812538

NGI:	103735880(Cnp)

HGL:	101703085(Cnp)

CPOC:

100715967(Cnp)

CCAN:

109695787(Cnp)

DORD:

106003154(Cnp)

DSP:

122103490

PLOP:

125365773

NCAR:

124980972

MMMA:

107150579

ITI:

101962838

OCU:

103351568

OPI:

101525323

TUP:	102488860(CNP)

GVR:	103583990 103589187(CNP)

CFA:	607694(CNP)

CLUD:

112655268

VVP:	112910800(CNP)

VLG:

121473301

NPO:	129504783(CNP)

AML:	100467749(CNP)

UMR:

103672615

UAH:	113265436(CNP)

UAR:

123781824

ELK:

111151693

LLV:

125087130

MPUF:

101686926(CNP)

MNP:	132004051(CNP)

MLK:	131815842(CNP)

NVS:

122906209

ORO:	101368654(CNP)

EJU:	114201337(CNP)

ZCA:

113939250

MLX:	118024898(CNP)

NSU:

110573238

LWW:	102743527(CNP)

FCA:	101093220(CNP)

PYU:

121045009

PCOO:

112854149(CNP)

PBG:

122485589

PVIV:

125158478(CNP)

LRUF:

124522212

LGF:

123603718

AJU:

106972562

PTG:	102971900(CNP)

PPAD:

109258574(CNP)

PUC:

125926554

PLEZ:

122206796

HHV:

120248439

BTA:	280752(CNP)

BOM:	102286486(CNP)

BIU:	109573868(CNP)

BBUB:

102392413

BBIS:

104990792(CNP)

CHX:	102182826(CNP)

OAS:	101120423(CNP)

BTAX:

128065057(CNP)

CSUM:

138084017(CNP)

ODA:

120867110

CCAD:

122441757

MREE:

136149928(CNP)

OVR:	110133800(CNP)

MBEZ:

129544411(CNP)

SSC:	100511587(CNP)

CFR:	102508768(CNP)

CBAI:

105080128(CNP)

CDK:	105090447(CNP)

VPC:	102545095(CNP)

BMUS:

118887132

LVE:	103078417(CNP)

OOR:	101277548(CNP)

LALB:

132511264(CNP)

DLE:	111166446(CNP)

PCAD:

102986171(CNP)

NASI:

112400001(CNP)

ECB:	100066401(CNP)

EPZ:	103550374(CNP)

EAI:

106826330

MYB:	102246257(CNP)

MYD:	102757958(CNP)

MMYO:

118671523

MLF:	102431066(CNP)

MDT:	132218640(CNP)

MYUM:

138994500(CNP)

PKL:

118726612

EFUS:

103293239(CNP)

MNA:	107544199(CNP)

DRO:	112298555(CNP)

SHON:

118978179

AJM:	119037549(CNP)

PDIC:

114503573

PHAS:

123817605

MMF:

118634649

PPAM:

129086911(CNP)

HAI:	109395745(CNP)

RFQ:	117013700(CNP)

PALE:

102887386(CNP)

PGIG:

120611119

PVP:	105306307(CNP)

RAY:	107513810(CNP)

MJV:

108388336

TOD:	119232110(CNP)

SARA:

101557614(CNP)

SFUM:

130036209(CNP)

SETR:

126018000(CNP)

LAV:	100670728(CNP)

TMU:

101346552

ETF:

101653360

DNM:	101434978(CNP)

MDO:	100012666(CNP)

GAS:

123243922

SHR:	105748993(CNP)

AFZ:

127560137

PCW:	110198448(CNP)

TVP:	118847730 118848100

PBRV:

138145981(CNP)

OAA:

114815024

TACU:

119934382

GGA:	395921(CNP)

PCOC:

116233623(CNP)

MGP:	104914621(CNP)

CJO:	107325125(CNP)

TPAI:

128089171(CNP)

LMUT:

125684581

NMEL:

110388457(CNP)

APLA:

101794702

ACYG:

106048016(CNP)

CATA:

118259124(CNP)

AFUL:

116498388(CNP)

TGU:	100223675(CNP)

LSR:	110471853(CNP)

SCAN:

103821597(CNP)

PMOA:

120496579

OTC:

121347531

PRUF:

121351093

ATRC:

139601508(CNP)

GFR:	102036395(CNP)

FAB:	101806325(CNP)

OMA:	130263991(CNP)

PHI:	102099592(CNP)

PMAJ:

107215150(CNP)

CCAE:

111939964(CNP)

CCW:

104697757

CBRC:

103619705(CNP)

ACOE:

138099511(CNP)

ETL:	114063640(CNP)

ZAB:	102067391(CNP)

ZLE:	135458682(CNP)

ACHL:

103799853(CNP)

SVG:	106858678(CNP)

MMEA:

130585424(CNP)

HRT:	120763913(CNP)

SATI:

136372215(CNP)

CCIC:

134053238(CNP)

FPG:	101923806(CNP)

FCH:	102051933(CNP)

CCRI:

104155843(CNP)

NNT:	104411884(CNP)

SHAB:

115617598(CNP)

ACUN:

113489131(CNP)

TALA:

104365619

ACHC:

115344432

HALD:

104312407(CNP)

HLE:	104842932(CNP)

AGEN:

126038164

HHAR:

128141007(CNP)

GCL:

127026615

CSTI:

104549593(CNP)

LDI:	104353466(CNP)

MNB:	103770339(CNP)

DPUB:

104309565(CNP)

PPUS:

135191768(CNP)

AVIT:

104272585(CNP)

BRHI:

104492654(CNP)

EGZ:

104131388

NNI:	104009869(CNP)

PCRI:

104029526(CNP)

PCAO:

104042936(CNP)

PADL:

103919492(CNP)

AFOR:

103901747(CNP)

FGA:	104077628(CNP)

GSTE:

104263521(CNP)

CLV:	102094445(CNP)

MUI:	104548203(CNP)

PGUU:

104461535(CNP)

PLET:

104614897(CNP)

EHS:

104513822

CMAC:

104482477(CNP)

CUCA:

104054412(CNP)

TEO:	104377962(CNP)

BREG:

104637264(CNP)

OHA:	104330595(CNP)

ACAR:

104517964

CPEA:

104385663(CNP)

CVF:	104294777(CNP)

RTD:	128919170(CNP)

CRID:

134524645(CNP)

AAM:	106487631(CNP)

AROW:

112968736(CNP)

NPD:	112951793(CNP)

TGT:	104572239(CNP)

DNE:	112992597(CNP)

SCAM:

104152417(CNP)

ASN:	102370911(CNP)

AMJ:	102573017(CNP)

CPOO:

109320351(CNP)

GGN:	109289946(CNP)

PSS:	102444316(CNP)

CMY:

102931370

CCAY:

125626696

DCC:

119848909

CPIC:

101941109

TST:	117869293(CNP)

CABI:

116829914(CNP)

MRV:

120392092

ACS:	100562366(cnp)

ASAO:

132778312(CNP)

PVT:	110088998(CNP)

SUND:

121917743 121932990 121935086

PBI:	103058614(CNP)

PMUR:

107303041(CNP)

CTIG:

120315178

TSR:	106538255(CNP)

PGUT:

117664717(CNP)

APRI:

131198364(CNP)

PTEX:

113447853(CNP)

NSS:	113422066(CNP)

VKO:

123031726

PMUA:

114581999(CNP)

PRAF:

128400209(CNP)

ZVI:	118094457(CNP)

HCG:	128331503(CNP)

GJA:	107116247(CNP)

STOW:

125444688

XLA:	108702467(cnp.S) 444056(cnp.L)

XTR:	100492391(cnp)

NPR:	108792991(CNP)

RTEM:

120918723

BBUF:

121003504

BGAR:

122940201 122941235

PWL:	138299428(CNP)

MUO:	115481890(CNP)

GSH:	117347352(CNP)

DRE:	325896(cnp)

SRX:	107729184 107755574

SANH:

107687004 107690289

SGH:	107567700 107590558

CCAR:

109057191 109108741

CAUA:

113046939 113047371

CGIB:

127948393 127952881

PTET:

122341692

LROH:

127162913(cnp)

OMC:	131537828(cnp)

PPRM:

120489630

RKG:	130090646(cnp)

MAMB:

125279643

CIDE:

127508040

CERY:

137017491(cnp)

MASI:

127450501 127451135

MANU:

129436233(cnp)

PDAB:

135759047 135770046

IPU:	108256586(cnp)

IFU:	128601969(cnp)

PHYP:

113528287(cnp)

SMEO:

124397326

TFD:

113652151

TVC:	132860814(cnp)

CGAR:

128544541(cnp)

NGRA:

132868802(cnp)

TRN:	134300069(cnp)

AMEX:

103043047

CMAO:

118821365

EEE:	113592330(cnp)

TRU:	101073131(cnp)

TFS:	130514604(cnp)

TNG:	GSTEN00021423G001

LCO:	104926069(cnp)

NCC:	104949163(cnp)

TBEN:

117492458(cnp)

CGOB:

115012153(cnp)

PGEO:

117450918(cnp)

GACU:

117548710(cnp)

EMAC:

134878325(cnp)

ELY:	117268847(cnp)

EFO:

125879459

PLEP:

121956989

SLUC:

116059487

ECRA:

117958418(cnp)

ESP:	116702483(cnp)

PFLV:

114570104(cnp)

GAT:

120828430

PPUG:

119220185(cnp)

AFB:	129098489(cnp)

CLUM:

117735032(cnp)

PSWI:

130188493(cnp)

CANA:

137787204(cnp)

CVE:	137878415(cnp)

MSAM:

119892447

SCHU:

122869482

CUD:

121529595

SPUL:

138604142(cnp)

LMIX:

132995401(cnp)

ALAT:

119013391

ASTR:

137609361(cnp)

MZE:	101484788(cnp)

ONL:	100702081(cnp)

OAU:

116312463

OLA:	101161559(cnp)

CSAI:

133422441(cnp)

XMA:	102221544(cnp)

XCO:	114159621(cnp)

XHE:	116735629(cnp)

PRET:

103469413(cnp)

PFOR:

103142185(cnp)

PLAI:

106950772(cnp)

PMEI:

106921564(cnp)

GAF:

122822638

PPRL:

129374018(cnp)

CVG:	107099620(cnp)

CTUL:

119778893

GMU:	124862418 124863688

NFU:	107395299(cnp)

KMR:

108243754

ALIM:

106527949(cnp)

NWH:

119421382

AOCE:

111584365(cnp)

EJA:	138197759(cnp)

BFRE:

138627004(cnp)

MCEP:

124998452

CSEM:

103393138(cnp)

POV:	109634035(cnp)

SSEN:

122785682

SSOE:

131476003(cnp)

HHIP:

117765772(cnp)

HSP:

124854970

PPLT:

128458277(cnp)

SMAU:

118289287

LCF:

108901289

SDU:	111217693(cnp)

SLAL:

111652815(cnp)

XGL:

120788285

HCQ:	109532536(cnp)

SSCV:

125983301(cnp)

SBIA:

133514250(cnp)

PEE:	133415372(cnp)

PTAO:

133466359(cnp)

BPEC:

110161626(cnp)

ENY:	140358109(cnp)

MALB:

109964255(cnp)

BSPL:

114860754(cnp)

SJO:	128379139(cnp)

SSCO:

134000184(cnp)

GMH:	115539163(cnp)

SASA:

100306871(cn37) 106601016

STRU:

115171102 115197748

OTW:	112225979 112258647

OMY:	110486251 110538182

OGO:	123999955 124015688

ONE:	115110871 115123342(cnp)

OKI:	109893308 109898418

OKE:	118365261 118370456

OMM:

135555728

OCLA:

139364666 139421162

SALP:

111976172 112068733

SNH:	120033958 120035753

CCLU:

121569590 123482614

ELS:	105013339(cnp)

OEP:

134006980

SFM:	108918982(cnp)

PKI:	111842498 111855988(cnp)

AANG:

118216801 118221444(cnp)

AROT:

135243764 135247885(cnp)

CCOG:

133122992(cnp)

LOC:	102685682(cnp)

PSPA:

121301796 121324917

ARUT:

117433278 117434464

PSEX:

120517483

LCM:	102366632(CNP)

CMK:

103183808

RTP:

109913243

CPLA:

122539841

HOC:	132830790(cnp)

LERI:

129710194(cnp)

PMRN:

116940939(CNP)

LRJ:	133344832(CNP)

BFO:

118405679

BBEL:

109465322

SPU:	115917953 582388

LPIC:

129254813

AJJ:

139980800

APLC:

110985385

ARUN:

117291109

AAMU:

139939326

AFIL:

140155726

SKO:

100373038

PFLL:

139143921

FOC:

113207652

TPAL:

117651277

CSEC:

111872167

BROR:

134538720

DPX:	DAPPUDRAFT_109194

DMK:

116931132

PJA:

122251457

PCHN:

125045145

PMOO:

119583070

HAME:

121855476

PCLA:

123745548 123766250

CQD:	128684162 128697567

PTRU:

123513153 123514060

ESN:	127007269 127010329

MNZ:

135212459

MRJ:

136832701

PORN:

139751479 139767445

HAZT:

108681948

LSM:

121127590

TCF:	131880903 131885664

PPOI:

119103100

DSV:	119445058 119446166 119446167

RSAN:

119389990

RMP:

119174425

CSCU:

111615988

PTEP:

107441103 107441104 107446139 107446140 107446143

UDV:

129230727

SDM:

118198139

LPOL:

106475258 106477729

PMEO:

129601042 129601050

HRO:	HELRODRAFT_170216

LGI:	LOTGIDRAFT_167168

PCAN:

112569653

LSAX:

138958412

BGT:

106066505

GAE:

121386688

HRF:

124113743

HRJ:	124253315 124264566

HASI:

137298183

HCRA:

139465838

CRG:

105320298

CANU:

128192188

CVN:

111125538

OED:

125680717

MYI:

110442976

PMAX:

117317612

AIRR:

138310778

MMER:

123538711

RPHI:

132745465

OBI:

106867694

OSN:

115223283

LJP:

135464545

LAK:

106159031

SMM:	Smp_147600

OVI:	T265_04033

EGL:

EGR_08413

LLON:

135483435

ADF:

107343453

AMIL:

114959905

MCAZ:

138042694

MFOO:

138007867

PDAM:

113670801

SPIS:

111324359

DGT:

114517431

HSY:

130641066

SCE:	YGR247W(CPD1)

SEUB:

DI49_2210

SPAO:

SPAR_G04560

AGO:	AGOS_AEL214C

ERC:

Ecym_5571

KLA:	KLLA0_A05412g

KMX:	KLMA_10332(CPD1)

LTH:	KLTH0H00946g

VPO:	Kpol_1050p76

ZRO:	ZYRO0C11462g

CGR:	2887610(GVI51_F07733)

NCS:	NCAS_0E03850(NCAS0E03850)

NDI:	NDAI_0B00960(NDAI0B00960)

TPF:	TPHA_0A05230(TPHA0A05230)

TBL:	TBLA_0B08020(TBLA0B08020)

TGB:	HG536_0A01010

TDL:	TDEL_0G01030(TDEL0G01030)

KAF:	KAFR_0B04390(KAFR0B04390)

KNG:	KNAG_0K00500(KNAG0K00500)

ZMK:	HG535_0E00980

DHA:	DEHA2G23430g

PIC:	PICST_54649

PGU:	PGUG_04071

SPAA:

SPAPADRAFT_134037

LBG:	92206943(LODBEIA_P17470)

CAL:	CAALFM_CR06690CA(CaO19.703)

CTP:	CTRG_00666

COT:	CORT_0D04920

CDU:	CD36_32230

CTEN:

18248026(CPD1)

CLU:	CLUG_02481

CLUS:

A9F13_28g00209

CAUR:

CJI96_0003924

ASAU:

88173313(PUMCH_002248)

YLI:	2906534(YALI2_A00316g)

SLB:	AWJ20_4080(CPD1)

NCR:

NCU05539

NTE:	NEUTE1DRAFT124587(NEUTE1DRAFT_124587)

SMP:	10810597(SMAC4_03260)

PAN:	PODANSg2780

PBEL:

QC761_403970

PPSD:

QC762_403970

PPSP:

QC763_403970

PPSA:

QC764_403970

TTT:	THITE_2126759

MTM:	MYCTH_2307154

CTHR:

CTHT_0044820

RTHE:

98126588(VTJ83DRAFT_5353)

ELA:	UCREL1_742

PFY:	PFICI_08582

PNO:	SNOG_07066

PTE:

PTT_19261

PTRR:

6338220(PtrM4_011320)

BZE:	COCCADRAFT_39693

BSC:	COCSADRAFT_173787

BOR:	COCMIDRAFT_1102

AALT:

CC77DRAFT_1093588

ADAC:

96090110(ACET3X_009788)

ARAB:

EKO05_0001678

ZTR:	MYCGRDRAFT_107673

PFJ:	MYCFIDRAFT_26614

FFU:	CLAFUR5_02370

CBET:

CB0940_04581

BCOM:

BAUCODRAFT_43864

NPA:	UCRNP2_1162

CNE:

CND00730

CNG:	CNAG_00933

CDEU:

CNBG_6031

KMG:	30162502(I203_101053)

KNE:	92179325(IAR55_002066)

CCAC:

CcaHIS019_0111810(CcaverHIS019_0111810)

TVS:	TRAVEDRAFT_136556

PCO:	PHACADRAFT_255378

SHS:	STEHIDRAFT_39301

ADL:	AURDEDRAFT_180777

FME:	FOMMEDRAFT_103881

GTR:	GLOTRDRAFT_109971

RSX:	RhiXN_02041

CCI:	CC1G_01080

ABP:	AGABI1DRAFT68346(AGABI1DRAFT_68346)

MRR:	Moror_8394

» show all

Reference

Authors

Drummond GI, Iyer NT, Keith J.

Title

Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.

Journal

J Biol Chem 237:3535-3539 (1962)

Reference

2 [PMID:6274851]

Authors

Helfman DM, Kuo JF.

Title

A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.

Journal

J Biol Chem 257:1044-7 (1982)

Reference

3 [PMID:6263914]

Authors

Helfman DM, Shoji M, Kuo JF.

Title

Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.

Journal

J Biol Chem 256:6327-34 (1981)

Reference

4 [PMID:6272743]

Authors

Kurihara T, Nishizawa Y, Takahashi Y, Odani S.

Title

Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.

Journal

Biochem J 195:153-7 (1981)
DOI:10.1042/bj1950153

Reference

5 [PMID:6258586]

Authors

Nishizawa Y, Kurihara T, Takahashi Y.

Title

Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.

Journal

Biochem J 191:71-82 (1980)
DOI:10.1042/bj1910071

Other DBs

ExplorEnz - The Enzyme Database:

3.1.4.37

IUBMB Enzyme Nomenclature:

3.1.4.37

ExPASy - ENZYME nomenclature database:

3.1.4.37

BRENDA, the Enzyme Database:

3.1.4.37

CAS:	60098-35-3

LinkDB

DBGET integrated database retrieval system