KEGG   ENZYME: 3.1.4.43
Entry
EC 3.1.4.43                 Enzyme                                 
Name
glycerophosphoinositol inositolphosphodiesterase;
1,2-cyclic-inositol-phosphate phosphodiesterase;
D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase;
D-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase;
1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase;
inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
Sysname
1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase
Reaction(IUBMB)
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate [RN:R03331]
Reaction(KEGG)
R03331;
(other) R03333
Substrate
1-(sn-glycero-3-phospho)-1D-myo-inositol [CPD:C01225];
H2O [CPD:C00001]
Product
glycerol [CPD:C00116];
1D-myo-inositol 1-phosphate [CPD:C01177]
Comment
This enzyme also hydrolyses Ins(cyclic1,2)P to Ins-1-P
History
EC 3.1.4.43 created 1984, (EC 3.1.4.36 created 1976, incorporated 2002), modified 2002
Orthology
K01124  glycerophosphoinositol inositolphosphodiesterase
Genes
HSA54857(GDPD2)
PTR465687(GDPD2)
PPS100969535(GDPD2)
GGO101125597(GDPD2)
PON100446576(GDPD2)
NLE100582979(GDPD2)
HMH116811767(GDPD2)
MCC695687(GDPD2)
MCF102136065(GDPD2)
MTHB126946178
MNI105476664(GDPD2)
CSAB103232133(GDPD2)
CATY105586132(GDPD2)
PANU101002823(GDPD2)
TGE112615625(GDPD2)
MLEU105548145(GDPD2)
RRO104678788(GDPD2)
RBB108539315(GDPD2)
TFN117077616(GDPD2)
PTEH111536117(GDPD2)
CANG105512622(GDPD2)
CJC100412949(GDPD2)
SBQ101038113(GDPD2)
CIMI108297593(GDPD2)
CSYR103261388(GDPD2)
MMUR105855328(GDPD2)
LCAT123628754(GDPD2)
PCOQ105809305(GDPD2)
OGA100954786(GDPD2)
MMU71584(Gdpd2)
MCAL110286954(Gdpd2)
MPAH110313610(Gdpd2)
RNO302421(Gdpd2)
MCOC116093783(Gdpd2)
ANU117694409(Gdpd2)
MUN110542516(Gdpd2)
CGE100771225(Gdpd2)
MAUA101837360(Gdpd2)
PROB127218011(Gdpd2)
PLEU114703179(Gdpd2)
MORG121443316 121444963
MFOT126487083
AAMP119805398(Gdpd2)
NGI103743163(Gdpd2)
HGL101706272(Gdpd2)
CPOC100732849(Gdpd2)
CCAN109680749(Gdpd2)
DORD105997262(Gdpd2)
DSP122120678(Gdpd2)
PLOP125343416(Gdpd2)
NCAR124972329
MMMA107155682(Gdpd2)
OCU100346403
OPI101525704(GDPD2)
TUP102484003(GDPD2)
GVR103596960(GDPD2)
CFA480951(GDPD2)
CLUD112671805(GDPD2)
VVP112907588(GDPD2)
VLG121483508(GDPD2)
NPO129518902(GDPD2)
AML100477309(GDPD2)
UMR103682623(GDPD2)
UAH113245592(GDPD2)
UAR123786188(GDPD2)
ELK111161024
LLV125091348
MPUF101674035(GDPD2)
MNP132007365(GDPD2)
MLK131821186(GDPD2)
NVS122897186(GDPD2)
ORO101376595(GDPD2)
EJU114200108(GDPD2)
ZCA113930860(GDPD2)
MLX118026009(GDPD2)
NSU110572099(GDPD2)
LWW102739994(GDPD2)
FCA101088650(GDPD2)
PYU121025245(GDPD2)
PCOO112870991(GDPD2)
PBG122476906(GDPD2)
LRUF124521616
PTG102967871(GDPD2)
PPAD109254601(GDPD2)
PUC125931730
AJU106982398
HHV120246034(GDPD2)
BTA514673(GDPD2)
BOM102272674(GDPD2)
BIU109555339(GDPD2)
BBUB102395386(GDPD2)
CHX102173824(GDPD2)
OAS101101866(GDPD2)
BTAX128070282(GDPD2)
ODA120882018(GDPD2)
CCAD122434860(GDPD2)
MBEZ129564435(GDPD2)
SSC100516309(GDPD2)
CFR102513549(GDPD2)
CBAI105083696(GDPD2)
CDK105087975(GDPD2)
VPC102529108(GDPD2)
BACU103013177(GDPD2)
LVE103091359(GDPD2)
OOR101289657(GDPD2)
DLE111167777(GDPD2)
PCAD102978987(GDPD2)
PSIU116747377(GDPD2)
NASI112407180(GDPD2)
ECB100055691(GDPD2)
EPZ103544986(GDPD2)
EAI106827113(GDPD2)
MYB102238745(GDPD2)
MYD102760571(GDPD2)
MMYO118654483(GDPD2)
MLF102417970(GDPD2)
MNA107532876(GDPD2)
PKL118704114(GDPD2)
EFUS103299108(GDPD2)
HAI109385582(GDPD2)
DRO112300077(GDPD2)
SHON118996725(GDPD2)
AJM119040217(GDPD2)
PDIC114505016(GDPD2)
PHAS123824306(GDPD2)
MMF118636249(GDPD2)
RFQ117020552(GDPD2)
PPAM129071076(GDPD2)
PALE102886565(GDPD2)
PGIG120585409(GDPD2)
PVP105299611(GDPD2)
RAY107503837(GDPD2)
MJV108403636(GDPD2)
TOD119246100(GDPD2)
SARA101550095(GDPD2)
LAV100665406(GDPD2)
TMU101356229
ETF101640650(GDPD2)
DNM101447384(GDPD2)
MDO100014029(GDPD2)
GAS123253998(GDPD2)
SHR100932224(GDPD2)
AFZ127542491
PCW110201085(GDPD2)
OAA114812948(GDPD2)
GGA422217(GDPD2)
PCOC116229608(GDPD2)
MGP100544970(GDPD2)
CJO107312626(GDPD2)
TPAI128076026(GDPD2)
LMUT125699539(GDPD2)
NMEL110403328(GDPD2)
APLA101792816(GDPD2)
ACYG106037473(GDPD2)
CATA118245497(GDPD2)
AFUL116494445(GDPD2)
TGU100231010(GDPD2)
LSR110472672(GDPD2)
PMOA120506202(GDPD2)
OTC121331832(GDPD2)
PRUF121363145(GDPD2)
GFR102031707(GDPD2)
FAB101814282(GDPD2)
OMA130252977(GDPD2)
PHI102100679(GDPD2)
PMAJ107204083(GDPD2)
CCAE111942692(GDPD2)
CCW104691662(GDPD2)
CBRC103617822(GDPD2)
ETL114067446(GDPD2)
ZAB102068205(GDPD2)
ACHL103806847(GDPD2)
SVG106853717(GDPD2)
MMEA130577347(GDPD2)
HRT120762054(GDPD2)
FPG101922487(GDPD2)
FCH102051523(GDPD2)
CLV102095560(GDPD2)
EGZ104124264(GDPD2)
NNI104012895(GDPD2)
PCRI104024139
PLET104613576(GDPD2)
EHS104502488(GDPD2)
PCAO104041667(GDPD2)
ACUN113480044(GDPD2)
TALA104362601(GDPD2)
PADL103923351(GDPD2)
AFOR103905833(GDPD2)
ACHC115333854(GDPD2)
HALD104315215(GDPD2)
HLE104830416(GDPD2)
AGEN126050179
GCL127019644
CCRI104169575(GDPD2)
CSTI104549389(GDPD2)
CMAC104477455(GDPD2)
MUI104547021(GDPD2)
BREG104638762(GDPD2)
FGA104081462(GDPD2)
GSTE104250352(GDPD2)
LDI104339716(GDPD2)
MNB103769023(GDPD2)
OHA104335744(GDPD2)
NNT104401554(GDPD2)
SHAB115603088(GDPD2)
DPUB104296359(GDPD2)
PGUU104461906(GDPD2)
ACAR104517413(GDPD2)
CPEA104388224(GDPD2)
AVIT104272356(GDPD2)
CVF104283540(GDPD2)
RTD128914870(GDPD2)
CUCA104063662(GDPD2)
TEO104374290(GDPD2)
BRHI104498580(GDPD2)
AAM106496634(GDPD2)
AROW112966326(GDPD2)
NPD112948676(GDPD2)
TGT104567519(GDPD2)
DNE112989767(GDPD2)
SCAM104150589(GDPD2)
ASN102381477(GDPD2)
AMJ102574797(GDPD2)
CPOO109310975(GDPD2)
GGN109300569(GDPD2)
CMY102941248(GDPD2)
CCAY125643077(GDPD2)
DCC119861630(GDPD2)
CPIC101950361(GDPD2)
TST117883116(GDPD2)
CABI116834986(GDPD2)
MRV120371999(GDPD2)
ACS100566715(gdpd2)
ASAO132762880(GDPD2)
PVT110080167(GDPD2)
SUND121937044(GDPD2)
PBI103063018(GDPD2)
PMUR107303215(GDPD2)
CTIG120313198(GDPD2)
PGUT117679612(GDPD2)
APRI131183873(GDPD2)
PTEX113446822(GDPD2)
NSS113423075(GDPD2)
VKO123034975(GDPD2)
PMUA114589141(GDPD2)
PRAF128406372(GDPD2)
ZVI118083745(GDPD2)
HCG128335478(GDPD2)
GJA107108520(GDPD2)
STOW125442955(GDPD2)
EMC129341658(GDPD2)
XLA108698333(gdpd2.L)
XTR100038173(gdpd2)
NPR108800179(GDPD2)
RTEM120921948(GDPD2)
BBUF120977396(GDPD2)
BGAR122919646(GDPD2)
MUO115474258(GDPD2)
GSH117360960(GDPD2)
DRE563198(gdpd2)
SRX107744531(gdpd2) 107752000
SANH107658123(gdpd2) 107664355
SGH107550770(gdpd2) 107560350
CCAR109060314 109102259 109111173
CAUA113057760 113058034 113113941
CGIB127971918 128026969
PTET122357207(gdpd2)
LROH127176119(gdpd2)
OMC131552877(gdpd2)
PPRM120474408(gdpd2)
RKG130072990(gdpd2)
MAMB125259132(gdpd2)
CIDE127494763
MASI127413270 127417695
TROS130564285(gdpd2)
TDW130437988(gdpd2)
MANU129422716(gdpd2)
IPU108268889
IFU128611469(gdpd2)
PHYP113529405(gdpd2)
SMEO124386502(gdpd2)
TFD113636095(gdpd2)
TVC132856164(gdpd2)
AMEX103040773(gdpd2)
CMAO118807169(gdpd2)
EEE113582678(gdpd2)
CHAR105913079
TRU101070529(gdpd2)
TFS130530959(gdpd2)
TNGGSTEN00031233G001
LCO104923477(gdpd2)
NCC104958393(gdpd2)
TBEN117488466(gdpd2)
CGOB115015175(gdpd2)
PGEO117454043(gdpd2)
GACU117537651(gdpd2)
ELY117261247(gdpd2)
EFO125894578(gdpd2)
PLEP121947661 121947770 121948467
SLUC116052340(gdpd2)
ECRA117951769(gdpd2)
ESP116697286(gdpd2)
PFLV114562368(gdpd2)
GAT120818121(gdpd2)
PPUG119210503(gdpd2)
AFB129090125(gdpd2)
CLUM117738033(gdpd2)
MSAM119889173(gdpd2)
SCHU122880425(gdpd2)
CUD121516641(gdpd2)
MZE101481713
ONL100706815(gdpd2)
OAU116323526(gdpd2)
OLA101168550(gdpd2)
OML112142577(gdpd2)
XMA102230452
XCO114139550
XHE116714470
PRET103471626(gdpd2)
PFOR103140130(gdpd2)
PLAI106940877(gdpd2)
PMEI106926642(gdpd2)
GAF122836824(gdpd2)
PPRL129360681 129360805
CVG107092566(gdpd2)
CTUL119795758(gdpd2)
GMU124860986(gdpd2)
NFU107378587(gdpd2)
KMR108231120(gdpd2)
ALIM106515379
NWH119408678(gdpd2)
AOCE111579648(gdpd2)
MCEP125007852(gdpd2)
CSEM103390757(gdpd2)
POV109632286(gdpd2)
SSEN122778928(gdpd2)
HHIP117769511(gdpd2)
HSP118112630(gdpd2)
LCF108872608
SDU111232775(gdpd2)
SLAL111666338(gdpd2)
XGL120785761(gdpd2)
HCQ109516566(gdpd2)
SSCV125989274
SBIA133508850(gdpd2)
PEE133407948(gdpd2)
PTAO133484462(gdpd2)
BPEC110158919(gdpd2)
MALB109953061(gdpd2)
BSPL114863922(gdpd2)
SJO128362791(gdpd2)
SASA106604731 106611742
STRU115172685(gdpd2) 115205266
OTW112220887(gdpd2) 112256194
OMY110488768 110504963
OGO123994070(gdpd2) 124011473
ONE115129420 115130644(gdpd2)
OKI109906009 109910151
OKE118363437 118377296(gdpd2)
SALP111965676 111967449
SNH120047464(gdpd2) 120061963
CCLU121532058 121546572
ELS105029530(gdpd2)
SFM108922931(gdpd2)
PKI111835039(gdpd2)
AANG118222833(gdpd2)
LOC107077912(gdpd2)
PSPA121295874(gdpd2) 121318847
ARUT117411955 117430758
PSEX120537293(gdpd2)
LCM102357097(GDPD2)
 » show all
Reference
1  [PMID:192216]
  Authors
Dawson RM, Hemington N.
  Title
A phosphodiesterase in rat kidney cortex that hydrolyses glycerylphosphorylinositol.
  Journal
Biochem J 162:241-5 (1977)
DOI:10.1042/bj1620241
Reference
2  [PMID:4342209]
  Authors
Dawson RM, Clarke N.
  Title
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.
  Journal
Biochem J 127:113-8 (1972)
DOI:10.1042/bj1270113
Reference
3  [PMID:4353088]
  Authors
Dawson RM, Clarke NG.
  Title
A comparison of D-inositol 1:2-cyclic phosphate 2-phosphohydrolase with other phosphodiesterases of kidney.
  Journal
Biochem J 134:59-67 (1973)
DOI:10.1042/bj1340059
Reference
4  [PMID:1845995]
  Authors
Ross TS, Majerus PW.
  Title
Inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase. Substrate specificity and regulation of activity by phospholipids, metal ion chelators, and inositol 2-phosphate.
  Journal
J Biol Chem 266:851-6 (1991)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.43
IUBMB Enzyme Nomenclature: 3.1.4.43
ExPASy - ENZYME nomenclature database: 3.1.4.43
BRENDA, the Enzyme Database: 3.1.4.43
CAS: 9076-91-9 72414-13-2
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