KEGG   ENZYME: 3.13.1.6
Entry
EC 3.13.1.6                 Enzyme                                 
Name
[CysO sulfur-carrier protein]-S-L-cysteine hydrolase;
mec (gene name)
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds
Sysname
[CysO sulfur-carrier protein]-S-L-cysteine sulfohydrolase
Reaction(IUBMB)
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine + H2O = [CysO sulfur-carrier protein]-Gly-NH-CH2-COOH + L-cysteine [RN:R11523 R11524]
Reaction(KEGG)
R11523 R11524
Substrate
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine;
H2O [CPD:C00001]
Product
[CysO sulfur-carrier protein]-Gly-NH-CH2-COOH;
L-cysteine [CPD:C00097]
Comment
Requires Zn2+. The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in an L-cysteine biosynthesis pathway. It acts on the product of EC 2.5.1.113, [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase.
History
EC 3.13.1.6 created 2017
Orthology
K21140  [CysO sulfur-carrier protein]-S-L-cysteine hydrolase
Genes
ESZFEM44_13280
CYOCD187_06155
MMKMU9_1634
GANUMN179_01047
PAEVN297_2167
PAEIN296_2167
PAFPAM18_2941
PAEUBN889_02300
PAEOM801_2166
PFEPSF113_2612(pdtG)
PBCCD58_15620
PPVNJ69_03200
POJPtoMrB4_26880 PtoMrB4_37670
PVKEPZ47_16045
PWYHU734_013870
ASOLBEN76_14330
ALJG8D99_03280
MCSDR90_1352
TTUTERTU_3904
MCELLPW13_02375
MVBMJO52_04630
METUGNH96_02795
MKOMKLM6_3646
METLU737_04160
MBUREQU24_03735
MPSYCEK71_18520
MMAIsS8_3314
MMOBF6R98_18435
MEINmethR_P3515
CYYCPC19_04130
NWRE3U44_05740
NTTTAO_1665
NTGNSCAC_1614
GAIIMCC3135_20115
TTCFOKN1_2845
HCHHCH_02850
HAHEENC22_17545
HHUAR456_08815
GSNYC6258_01605
SOKD0B54_07900
SLIMSCL_0707
SALNSALB1_0312
REVHUE57_06600
RSLRPSI07_mp0912
RSNRSPO_m01251
RSYRSUY_41510(mec)
RSGJK151_18815
BCENDM39_4551(mec)
BGDbgla_4p2540
CKSH9L41_15680
BOJCBF45_04110
AFAUZ73_17435
AFQAFA_08170
AAQUD3M96_09365
NEUNE2352
NIINit79A3_1639
NCOAAW31_03640
NMUNmul_A0971
NIZNNRS527_02154
FPHOSHINM1_002680
HCLNCTC13205_01324
WSUWS1005
SBASulba_2393
SMULSMUL_3091
SHALSHALO_2856
SULSSdiek1_2865
SULJSJPD1_2762
SULTFA592_06610
GMEGmet_1569
GPIGPICK_04850
GEMGM21_2241
GEBGM18_2230
GEFFO488_13605
GURGura_3942
GEOGeob_0799
GBMGbem_1979
GBNGEOBRER4_17970
GERKP004_08795
GSUBKP001_06365
GNTKP003_08320
GPLM1B72_11980
DAKDaAHT2_0588 DaAHT2_0869
ADEAdeh_3492
ACPA2cp1_3645
AFWAnae109_3610
ANKAnaeK_3576
MXAMXAN_4065
CCXCOCOR_03885
SURSTAUR_4521
AVMJQX13_43995
MBDMEBOL_006425
CFUSCYFUS_003918
SCLsce5752
SCUSCE1572_34175
CCROCMC5_032970
SAMYDB32_003960
LLUAKJ09_09065
MRMA7982_06711 A7982_12831
HOHHoch_4180
BSEDDN745_06225
PCAYFRD00_25660
AGTEYD00_23435
RPCRPC_2021
SECHB18_22415
SPHLLPB140_08295
TFVIDJ81_15045
GDIGDI0123
NCHA0U93_02420
FERFNB15_04420
BONA361_11885
ASEDIRT44_11155
HHDHBHAL_1459
HLIHLI_02650
VIGBKP57_14050
VPTKBP50_15885
PFRIL8956_13810
GRCGI584_14780
SEDDERJ70_00850
BVQFHE72_10235
RMFD5E69_10550
BBEBBR47_17340 BBR47_48390
BLRBRLA_c041190
BFMBP422_03850 BP422_20015
BAGRBA6348_07300
BRWGOP56_13235
BCHSJNE38_09430 JNE38_26020
PPSCEHS13_22360
ANXACH33_10605
ATHEK3F53_08370
AACAaci_1812
AADTC41_1907
EFFskT53_09890
PANCE2636_02400
LFBC1X05_02620
TVUAB849_002540
KPULGXN76_03700
KEBGXN75_03850
PABSJIR001_05900
CBEILF65_03276
CKLCKL_1806
CKRCKR_1679
CLSCXIVA_15230
CPASClopa_4351
CPATCLPA_c35300
CPAECPAST_c35300
CACECACET_c13310
CTYKCTK_C28190
CFMBJL90_11980
CDYF3K33_11390
AMTAmet_3500
GFEGferi_06130
CTHCthe_2540
CTXClo1313_0123
HSCHVS_02745(mec)
EHAEthha_2039
RUSRBI_I01804
RUJE5Z56_09510
BFICIY_11900
RIXRO1_41750
RIMROI_01660
COOCCU_23380
CEVLK421_04905
BLABEYS05_06485
EHLEHLA_0517
ANRAna3638_03715
EELEUBELI_00645
DFMNQ560_04630
WCPH9Q76_03860
EREEUBREC_0900
ERTEUR_19570
ERAERE_21950
STHSTH1150 STH1151
CMICcaldi_16680
DSYDSY2949
DHDDhaf_4108
SGYSgly_0510 Sgly_2526
FWADCMF_27945
TJRTherJR_2271
VPYHZI73_21155
TMRTmar_1104
THEFE1B22_09185
THEPDYI95_005495
ABUTAmi103574_01250
CSCCsac_1636
ATEAthe_1187
CHDCalhy_1546
CKICalkr_1170
CKNCalkro_1511
CCHAELD05_08175
CDIACaldiYA01_13200
TTMTthe_1591
TTOThethe_01564
TSHTsac_1658
NTHNther_1093
HHLHalha_2342
MHWACT01_04040
EBMSG0102_26780
LPILLIP_0057
MTURv1334(mec)
MTVRVBD_1334
MTCMT1376
MRAMRA_1342
MTBTBMG_02644
MTKTBSG_02658
MTZTBXG_002624
MTGMRGA327_08365
MTIMRGA423_08360
MTECCDC5079_1236
MTURCFBS_1419
MTLCCDC5180_1227
MTOMTCTRI2_1371
MTDUDA_1334
MTNERDMAN_1494
MTJJ112_07195
MTUBMT7199_1366(mec)
MTUCJ113_09295
MTUEJ114_07175
MTXM943_06995
MTUHI917_09480
MTULTBHG_01321
MTUTHKBT1_1418
MTUUHKBT2_1424
MTQHKBS1_1422
MBOBQ2027_MB1369(mec)
MBBBCG_1396
MBTJTY_1370
MBMBCGMEX_1368
MBKK60_014330
MBXBCGT_1169
MAFMAF_13580
MMICRN08_1493
MCEMCAN_13521
MCQBN44_11500
MCVBN43_30433
MCXBN42_21243
MCZBN45_30416
MSAMycsm_04619
MULMUL_3928
MMIMMAR_4064
MMAEMMARE11_38740
MLIMULP_04230
MPSEMPSD_18120(mec)
MSHOMSHO_00460(mec)
MMCMmcs_3850
MKMMkms_3924
MJLMjls_3836
MKNMKAN_06215
MYVG155_21145
MYEAB431_22055
MGOAFA91_15965
MHADB586_08330
MDXBTO20_10015
MFJMFLOJ_50310(mec)
MSIMMSIM_39990(mec)
MKUI2456_19225
MGROFZ046_24920
MXEMYXE_16630(mec)
MNVMNVI_03300
MPAGC0J29_22310
MBAIMB901379_03528(mec)
MHEKJMUB5695_01730(mec)
MGAUMGALJ_26860
MLJMLAC_10020(mec)
MBRDMBRA_31170(mec)
MSHJMSHI_05590(mec)
MKRMKOR_08410
MDFK0O62_20970
MMAMK3U93_17370
MHOLK3U96_07700
MSENK3U95_08750
MSPGF6B93_16235
MOTLTS72_05025
MRFMJO55_19480
MSMMSMEG_4907
MSGMSMEI_4780
MSBLJ00_24265
MSNLI99_24270
MSHLI98_24275
MVAMvan_4293
MGIMflv_2352
MSPMspyr1_17850
MCBMycch_3738
MNED174_20025
MYNMyAD_19650
MFTXA26_43160
MPHLMPHLCCUG_03884(mec)
MVQMYVA_4108
MLLB1R94_08130
MRHMycrhN_3864
MTHN4412656_03141(mec)
MHASMHAS_02667(mec)
MDUMDUV_03780
MDRMDOR_27090
MAUUNCTC10437_04037(mec)
MMORMMOR_22540
MALVMALV_51370
MTYMTOK_00970
MPSCMPSYJ_25280
MARZMARA_57170
MGADMGAD_55740
MHEVMHEL_06140(mec)
MANYMANY_22450
MPOFMPOR_43900
MMATMMAGJ_01760
MBOKMBOE_30680
MFGK6L26_10595
MSEIMSEDJ_51690
MFLVNCTC10271_01411(mec)
MCEEMCEL_47000
MABMAB_1478
MMVMYCMA_0802
MABBMASS_1470
MABLMMASJCM_1497
MCHEBB28_07360
MIZBAB75_07985
MSTEMSTE_01455
MSAOMYCSP_06570
MSALDSM43276_01341(mec)
MPAKMIU77_08570
NFANFA_10890
NFRERS450000_03022(mec)
NCYNOCYR_1174
NBRO3I_006470
NNONONO_c12890(mec)
NSLBOX37_25305
NSRNS506_07157
NTPCRH09_07255
NOZDMB37_27405
NODFOH10_24805
NAHF5544_07725
NADNCTC11293_01985(mec)
NWLNWFMUON74_59210
NIEKV110_07060
NTCKHQ06_37860
NHUH0264_37015
NYALTV02_36205
NGPLTT66_05900
RHARHA1_ro01438
ROPROP_11470
ROAPd630_LPD05562
RHWBFN03_11010
RTMG4H71_02335
RKOJWS14_07400
ROZCBI38_10785
RPSKJWS13_38780
GBRGbro_1965
GPOGPOL_c18600
GORKTR9_1897
GOQACH46_07400
GTABCM27_10195
GRUGCWB2_09575(mec)
GOMD7316_00474(mec)
GAVC5O27_18180
GODGKZ92_09180
GAMGII34_08830
GPDGII33_08220
GJIH1R19_09465
GOILK459_00865
GHNMVF96_09590
GAMIIHQ52_12470
GMGNWF22_19875
SPINKV203_05200
TPRTpau_1289
TSMASU32_07335
TPULTPB0596_32940
SCOSCO2913(SCE19A.13c)
SALBXNR_1787
SMASAVERM_5162
SGRSGR_4626
SGBWQO_12395
SCBSCAB_56511
SSXSACTE_2389
SVLStrvi_8265
SHYSHJG_4389
SHOSHJGH_4152
SRCM271_30285
SMALSMALA_2977
SSOII1A49_18805
SFASfla_3983
SBHSBI_06681
SVESVEN_2669
SDVBN159_5376
SALSSLNWT_2456
STRPF750_2739(mec)
SFISFUL_2509
SCIB446_15225
SLVSLIV_23130
SGUSGLAU_13180
SVTSVTN_14265
STREGZL_05557
SCWTU94_12675
SLDT261_5205
SLCSL103_04765
SXISXIM_39000
STRMM444_13805
STRCAA958_10725
SAMBSAM23877_2950(mec)
SPRISPRI_4637
SCZABE83_23440
SCXAS200_27875
SRWTUE45_03505(mec)
STRFASR50_14090
SLEsle_43590(sle_43590)
SRNA4G23_01931(mec)
SPAVSpa2297_12460
STRTA8713_11710
SCLFBB341_18190
SGSAVL59_42300
STSIA4E84_15320
SKYD0C37_10690
SGMGCM10017557_51660
SCADDN051_24105
SPHWNFX46_35400
SLSSLINC_3315
SNRSNOUR_25960
SALUDC74_3346
SALLSAZ_17825
SPLULK06_011195
STRDNI25_24195
SAUOBV401_18545
SSIAA7J05_22365
SVUB1H20_11650
SPUNBFF78_25935
SGVB1H19_16145
SLAUSLA_2645
SALFSMD44_03221
SALJSMD11_4297
SLXSLAV_23430(mec)
STROSTRMOE7_15115
SFKKY5_3053c
SNZDC008_12835
SGEDWG14_05206(mec)
SRJSRO_4570
SLKSLUN_14900
SDXC4B68_25115
SGDELQ87_24025
SQZFQU76_10830
SCYAEJ357_17440
SASTCD934_20805
SNQCP978_13435
STIRDDW44_09575
SKACP970_27250
SGZC0216_26590
SVNCP980_21055
SNKCP967_21730
SHAWCEB94_15855
SRKFGW37_12010
SFICEIZ62_20870
SGALCP966_13875
SSPODDQ41_07970
SVRCP971_21205
SPADDVK44_10520
SFYGFH48_25065
SAQUEJC51_19865
SGFHEP81_04909
SCAVCVT27_11115
SSEOD0Z67_10715
SBYH7H31_22950
SRIMCP984_25595
SSUBCP968_20855
SPHVF9278_17475
SCINCP977_12970
SFUGCNQ36_13205
SPACB1H29_22925
STSUB7R87_10485
SCHACP983_26730
SGXH4W23_15445
SCOECP976_17000
SBATG4Z16_22125
SSPBCP982_17245
SNFJYK04_03505(mec)
SPLACP981_14775
SBROGQF42_18215
STUIGCM10017668_26030
SATAC5746_15795
SCHFIPT68_14120
SHUNDWB77_04788(mec)
SHARHUT13_19490
SCYGS1361_15740(mec)
SFEUIM697_06530
SLIAHA039_22120
SDWK7C20_13825
SVDCP969_15630
SCALI6J39_11850
SAUHSU9_012350
SFBCP974_10740
SMOBJ7W19_11815
SPRACP972_13920
SPEUCGZ69_13100
SROIIAG44_25545
SXNIAG42_21835
SGJIAG43_11640
SHKJ2N69_13310
SANUK7396_22790
SDDD9753_21935
SACTDMT42_15235
SMAOCAG99_17785
SGOBtest1122_07900
SINEKI385_17840
SLFJEQ17_29045
SDECL3078_17680
SAOVG3H79_23240
SDURM4V62_26275
SYANNRK68_12885
SRUGF0345_19220
SAKBK1J60_27345
STAALDH80_24985
SCTSCAT_1944
SCYSCATT_19350
KSKKSE_28280
KABB7C62_11300
KAUB6264_15875
KITCFP65_2634
KISHUT16_12140
STRIC7M71_010105
YIALO772_22050
STRHGXP74_06445
ABRYNYE86_05630
MPHMLP_38910
MIKFOE78_07650
MICGGJV80_00360
NCANoca_1310
NDKI601_2310(mec)
NOYEXE57_17270
NOIFCL41_04350
NOOFE634_04905
NSNEXE58_02100
NBEBack2_09660
NANOG5V58_03440
NMESH9L09_03410
NAROCFH99_07555
NPIG7071_00060
NAQUENKNEFLB_03481(mec)
NROK8W59_14830
NOQLN652_07310
NCQK6T13_12985
NPCKUV85_00950
NPSKRR39_13940
PSIMKR76_08140
AERAERYTH_05530
AEZC3E78_04865
AEBC6I20_10860
AEFGEV26_04675
MUZH4N58_15000
KFLKfla_1839
KQIF1D05_29000
TFUTfu_2370
THAONI17_014750
TALXFOF52_12050
NDANdas_0381
NALB005_3249(mec)
NGVCDO52_22920
NEXNE857_08150
STRREKD16_05480(mec)
SNAHOUQ99_25375
SAIUJ4H86_11120
TCUTcur_3873
ACTWF7P10_27490
AGRAAGRA3207_002608
SROSros_1725
NOABKM31_36140
NOWGBF35_08925
NCXNocox_08285(mec)
NGNLCN96_09285
TBITbis_0936
FRAFrancci3_0866
FREFranean1_5654
FRIFraEuI1c_5853
FALFRAAL1498
FSYFsymDg_1242
ACEAcel_1689
NMLNamu_1696
GOBGobs_1356
BSDBLASA_1166
BLAPMVA48_09500
MMARMODMU_1390
SENSACE_1204
SACGFDZ84_17705
SVISvir_29180
SACCEYD13_16135(mec)
AMDAMED_7713
AMNRAM_39630
AMMAMES_7596
AMZB737_7596
AOIAORI_6494
AJAAJAP_06495(mec)
AMQAMETH_1414
AMYCCU254_31030
AMYBBKN51_25925
AABA4R43_36325
AMYYYIM_41680(mec)
AORISD37_07940
AACDLWP59_06900
APRTMUY14_45650
AROONQK81_33345
ATHML1857_09680
PDXPsed_1509
PSEAWY02_22430
PSEEFRP1_20230
PSEHXF36_03560
PSEQAD006_27645
PECQAD017_07240
PHHAFB00_18195
PAUTPdca_14330(mec)
PBROHOP40_01795
PPELH6H00_02445
APRECNX65_05070
AMIAmir_1009
SESPBN6_11640(mec)
SSYIEKG83_05900
KALKALB_1249
KPHYAOZ06_09760
LEDBBK82_03315 BBK82_06125
AHMTL08_06490
ACTIUA75_06215
ACADUA74_06215
AHGAHOG_05955(mec)
ACTAC1701_06780
ALOCRK62181
PMADBAY61_25255
SACEGIY23_05335
ACTUActkin_01151(mec)
STPStrop_1100
SAQSare_0989
MAUMicau_1156
MILML5_1419
MICBMicB006_1188
MTUACSH63_18750
MICHFJK98_05895
MTEMGCE86_00065
MCABHXZ27_07115
MSAGGCM10017556_37020
VMAVAB18032_10370
MCRAID554_06150
VERHUT12_06875
ASEACPL_1165
AMSAMIS_9410
ACTNL083_1274
AFSAFR_06340
ACTSACWT_1046
AIHAiant_53290
ACTRAsp14428_34530
PLKCIK06_06050
PLABC6361_13090
PLATC6W10_12315
PFLAPflav_060720
PSUUPsuf_022510
ATLAthai_51080
ASERAsera_23760
PRYPrubr_12270
CATICS0771_03810
DVCDvina_48125
DFUDfulv_42655
DROSDrose_32630
DAURDaura_46230
DMATDmats_42675
NHYJQS43_04165
CCAZCOUCH_33180
CAICaci_0313
SNASnas_1539
NAVJQS30_02995
GLYK3N28_07465
AEYCDG81_16675
PLANA1s21148_01295
PLAKA1s21155_01090
PLIMPHILAsVB114_05925
PSUFA1sIA56_01100
PVSA1sIA79_01035
JTLM6D93_06190
ABAIIMCC26256_111572
BSOLFSW04_21905
CWOCwoe_1850
PARNNBH00_12255
AFOAfer_1753
AYMYM304_27760
ATQGH723_12055
AQZKSP35_08290
IAMHC251_15350
ATBJ4859_04355
ERZER308_03715
EUZDVS28_a1369
SYGsync_0451
SYNKKR100_03455
SYNRKR49_11015
SYNCCB0101_10590
CGCCyagr_1675
CYICBM981_1839
PMTPMT_1720
PMNPMN2A_1140
PMFP9303_22901
PMJP9211_16881
PMENATL1_20141
PRMEW15_2087
CMPCha6605_1386
CYTcce_1056
PBFCFX0092_A1412
KBSEPA93_42450 EPA93_44665
TBHTbon_03255
THUGKNN16_12135
TTRTter_1309
GOGC1280_03660
GMSSOIL9_53420
TIMGMBLW1_36290
LRSPX52LOC_06035
FTJFTUN_3779
ULIETAA1_40350(mec)
TSPHKIH39_24365
SACISinac_2590
PBORBSF38_00432(mec)
AGVOJF2_65380(mec)
TPITREPR_0258
STASTHERM_c16220
STQSpith_1682
TAZTREAZ_1739
FSUFisuc_0166
FSCFSU_0569
PPNPalpr_1594
FSEDI487_11060
CTAINCTC12078_03091
CPBCphamn1_0646
MROMROS_0875
FSIFlexsi_0582
TYETHEYE_A1988
DTPJZK55_03980
NIONITINOP_3047
NJANSJP_3097
LFCLFE_1735
LFILFML04_0893
LFPY981_03895
LEGABH19_09205
NLIG3M70_02190
MOXDAMO_1029
FPLFerp_0703
GACGACE_1958
PFIPFC_04575
PHOPH1488(PH1488)
PYNPNA2_0076
PYAPYCH_03250
PYSPy04_1032
PYCTQ32_04415
TONTON_1119
TSITSIB_0762
TBATERMP_01270
THMCL1_1564
TLTOCC_04767
THSTES1_1302
THVADU37_CDS10970
TCHCHITON_0884
TPIEA7C91_01090
TCEA3L02_08700
TBSA3L01_06350
THHCDI07_06295
TSLA3L11_10585
TTDA3L14_08745
TRLA3L10_00240
TPAFA3L08_09545
TICFH039_09765
TCQTIRI35C_1588
PPACPAP_08315
MMHMmah_0694
MPLMpal_1140
RCIRRC67
HJEHacjB3_16356
HSINKDQ40_20870
SRUBC2R22_18850
HAEhalTADL_1128
PISPisl_1835
PCLPcal_1011
PASPars_2085
PYRP186_0258
POGPogu_0039
TNETneu_1283
PYWPYWP30_01362
TTNTTX_0675
TUZTUZN_0314
THBN186_08935
TCBTCARB_0866
THFMA03_00595
ACIASE86_05615
NMRNmar_1227
NIRNSED_06880
NKRNKOR_06910
NIDNPIRD3C_0889
NINNADRNF5_0716
NIWNisw_07610
NCLC5F47_06710
NOXC5F49_06675
NUEC5F50_09235
NIPNsoK4_01870
NZTNZOSNM25_000613
NCTNMSP_0447
NICDSQ20_07660
CSYCENSYa_0531
NGANgar_c18870
NVNNVIE_003440
NEVNTE_01664
TAANMY3_03111
NFNNFRAN_0527
NCVNCAV_0848
NBVT478_0503
TAHSU86_000095
NIUDSQ19_06875
NDVNDEV_1212
BARCAOA65_1746
 » show all
Reference
1  [PMID:16104727]
  Authors
Burns KE, Baumgart S, Dorrestein PC, Zhai H, McLafferty FW, Begley TP
  Title
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis.
  Journal
J Am Chem Soc 127:11602-3 (2005)
DOI:10.1021/ja053476x
  Sequence
[mtu:Rv1334]
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.6
IUBMB Enzyme Nomenclature: 3.13.1.6
ExPASy - ENZYME nomenclature database: 3.13.1.6
BRENDA, the Enzyme Database: 3.13.1.6
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