Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds
BRITE hierarchy

S-inosyl-L-homocysteine hydrolase (inosine-forming)

S-inosyl-L-homocysteine + H2O = inosine + L-homocysteine [RN:R12588]

R12588
Reaction

S-inosyl-L-homocysteine [CPD:C03431];
H2O [CPD:C00001]

The enzyme, characterized from the methanogenic archaeon Methanocaldococcus jannaschii, binds an NAD+ cofactor. It participates in an alternative pathway for the regeneration of S-adenosyl-L-methionine from S-adenosyl-L-homocysteine that involves the deamination of the latter to S-inosyl-L-homocysteine.

EC 3.13.1.9 created 2020

1  [PMID:25917907]