KEGG   ENZYME: 3.2.1.106
Entry
EC 3.2.1.106                Enzyme                                 
Name
mannosyl-oligosaccharide glucosidase;
Glc3Man9NAc2 oligosaccharide glucosidase;
trimming glucosidase I;
CWH41 (gene name);
MOGS (gene name);
mannosyl-oligosaccharide glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting)
Reaction(IUBMB)
Glc3Man9GlcNAc2-[protein] + H2O = Glc2Man9GlcNAc2-[protein] + beta-D-glucopyranose [RN:R05979]
Reaction(KEGG)
R05979(G)
Substrate
Glc3Man9GlcNAc2-[protein];
H2O [CPD:C00001]
Product
Glc2Man9GlcNAc2-[protein];
beta-D-glucopyranose [CPD:C00221]
Comment
This enzyme catalyses the first step in the processing of the N-glycan tetradecasaccharide precursor Glc3Man9GlcNAc2, which takes place in the endoplasmic reticulum, by removing the distal alpha-1,2-linked glucose residue. This and subsequent processing steps are required before complex N-glycans can be synthesized.
History
EC 3.2.1.106 created 1984, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01228  mannosyl-oligosaccharide glucosidase
Genes
HSA7841(MOGS)
PTR740472(MOGS)
PPS100989540(MOGS)
GGO101148967(MOGS)
PON100456318(MOGS)
NLE100587064(MOGS)
MCC708913(MOGS)
MCF102131903(MOGS)
CSAB103220027(MOGS)
CATY105596862(MOGS)
PANU101020139(MOGS)
TGE112604892(MOGS)
RRO104674816(MOGS)
RBB108531677(MOGS)
TFN117062056(MOGS)
PTEH111523414(MOGS)
CJC100399857(MOGS)
SBQ101050054(MOGS)
CSYR103266729(MOGS)
MMUR105884584(MOGS)
OGA100941152(MOGS)
MMU57377(Mogs)
MCAL110296892(Mogs)
MPAH110316001(Mogs)
RNO78947(Mogs)
MCOC116099128(Mogs)
MUN110559323(Mogs) 110559328
CGE100689098(Mogs)
PLEU114694418(Mogs)
NGI103726994(Mogs)
HGL101699668(Mogs)
CPOC100736016(Mogs)
CCAN109692434(Mogs)
DORD105999585(Mogs)
DSP122125223(Mogs)
OCU100349132(MOGS)
OPI101536109(MOGS)
TUP102469724(MOGS)
CFA483104(MOGS)
VVP112916713(MOGS)
VLG121490648(MOGS)
AML100473274(MOGS)
UMR103671412(MOGS)
UAH113243493(MOGS)
UAR123786071(MOGS)
ELK111148165
LLV125109013
MPUF101677707(MOGS)
ORO101380088(MOGS)
EJU114218993(MOGS)
ZCA113937508(MOGS)
MLX118007948(MOGS)
FCA101086221(MOGS)
PYU121019225(MOGS)
PBG122497043(MOGS)
PTG102965884(MOGS)
PPAD109263071(MOGS)
AJU106988593(MOGS)
HHV120237029(MOGS)
BTA516155(MOGS)
BOM102271661(MOGS)
BIU109565909
BBUB102393218(MOGS)
CHX102171985(MOGS)
OAS101118003(MOGS)
ODA120851236(MOGS)
CCAD122441482(MOGS)
SSC100513204(MOGS)
CFR102503430(MOGS)
CBAI105078082(MOGS)
CDK105105961(MOGS)
VPC102537373(MOGS)
BACU102999832(MOGS)
LVE103084054(MOGS)
OOR101274685(MOGS)
DLE111169093(MOGS)
PCAD102973351(MOGS)
PSIU116764325(MOGS)
ECB100069105(MOGS)
EPZ103557690(MOGS)
EAI106823842(MOGS)
MYB102262392(MOGS)
MYD102775421(MOGS)
MLF102429020(MOGS)
MNA107529255(MOGS)
PKL118717563(MOGS)
HAI109371217(MOGS)
DRO112303069(MOGS)
SHON119000091(MOGS)
AJM119038382(MOGS)
PDIC114499650(MOGS)
PHAS123811418(MOGS)
MMF118630703(MOGS)
RFQ117032934(MOGS)
PALE102887551(MOGS)
PGIG120594554(MOGS)
PVP105290731(MOGS)
RAY107502936(MOGS)
MJV108402288(MOGS)
TOD119259092(MOGS)
SARA101545162(MOGS)
LAV100657938(MOGS)
TMU101345839
DNM101428482(MOGS)
MDO100017334(MOGS)
GAS123253026(MOGS)
SHR100925812(MOGS)
PCW110221002(MOGS)
OAA114811204(MOGS)
GGA107049491(MOGS)
PCOC116225620(MOGS)
MGP104916406(MOGS)
CJO107306839(MOGS)
AFUL116489278(MOGS)
TGU115494857(MOGS)
LSR110468700(MOGS)
PMOA120509127(MOGS)
OTC121334937(MOGS)
PRUF121364692(MOGS)
PHI102101442(MOGS)
PMAJ107203112(MOGS)
CCW120409966(MOGS)
ETL114068886(MOGS)
FPG101910764(MOGS)
TALA116965399 122154900
AROW112961117(MOGS)
NPD112954025(MOGS)
DNE112993223(MOGS)
ASN112548011(MOGS)
AMJ102576397(MOGS)
CMY102941231(MOGS)
CPIC101939841(MOGS)
TST117878271(MOGS)
CABI116829266(MOGS)
MRV120405983(MOGS)
ACS100558509(mogs)
PVT110079822(MOGS)
SUND121930509(MOGS)
PBI103067986(MOGS)
PMUR107292508(MOGS)
TSR106538914(MOGS)
PGUT117670708(MOGS)
VKO123022537(MOGS)
PMUA114604469(MOGS)
ZVI118094292(MOGS)
GJA107114281(MOGS)
XLA100158418(mogs.L)
XTR619362(mogs)
NPR108796278 108803080(MOGS)
RTEM120917150(MOGS)
BBUF120990575(MOGS)
DRE567913(mogs)
SRX107711520 107719770
SANH107689467 107692169
SGH107551727 107567052
CCAR109067866 109068405 109076645
CAUA113109480
PPRM120491354(mogs)
IPU108260492 108260493
PHYP113525839 113545786
SMEO124381661(mogs)
TFD113650045(mogs)
AMEX103032841(mogs)
EEE113578999(mogs)
TRU101061971(mogs)
TNGGSTEN00033486G001
LCO104926976(mogs)
NCC104951177(mogs)
CGOB115014974(mogs)
ELY117254577(mogs)
PLEP121942341(mogs)
SLUC116034210(mogs)
ECRA117955271(mogs)
PFLV114568158(mogs)
GAT120825858(mogs)
PPUG119218365(mogs)
MSAM119898950(mogs)
CUD121508989(mogs)
MZE101475138(mogs)
ONL100708454(mogs)
OAU116330030(mogs)
OLA101164458(mogs)
OML112157387(mogs)
XMA102226259(mogs)
XCO114144736(mogs)
XHE116720326(mogs)
PRET103466387(mogs)
PFOR103148467(mogs)
PLAI106949614(mogs)
PMEI106919327(mogs)
GAF122829917(mogs)
CVG107091135(mogs)
CTUL119796264(mogs)
GMU124868901(mogs)
NFU107375288(mogs)
KMR108231066(mogs)
ALIM106517046(mogs)
NWH119408050(mogs)
AOCE111575465(mogs)
CSEM103383539(mogs)
POV109638361(mogs)
SSEN122770911(mogs)
HHIP117766362(mogs)
LCF108896565(mogs)
SDU111236637(mogs)
SLAL111670425(mogs)
XGL120800908(mogs)
HCQ109511469(mogs)
BPEC110165316(mogs)
MALB109961400(mogs)
SASA106602766 106609973
OTW112231722
OMY110534337
OGO124012877
ONE115137269(mogs)
SALP111958376 111964400
SNH120035170 120052786(mogs)
ELS105029335(mogs)
SFM108924334(mogs)
PKI111837272(mogs)
AANG118227281(mogs)
LOC102696758(mogs)
PSPA121325791 121331101
ARUT117408679 117420866
LCM102359377(MOGS)
RTP109934039(mogs)
BFO118413255
BBEL109470925
CIN100183132
SCLV120339076
SPU115924219 591837(mogs)
APLC110981262
SKO100372636
DMEDmel_CG1597(GCS1)
DER6551432
DSE6617655
DSIDsimw501_GD15993(Dsim_GD15993)
DYADyak_GE17302
DAN6504477
DSR110181677
DPODpse_GA27923
DPE6602679
DMN108152970
DWI6648708
DGR6565583
DMODmoj_GI15075
DAZ108619758
DNV115565244
DHE111603188
DVI6632177
CCAT101450781
BOD106620448
MDE101894492
SCAC106087614
LCQ111674816
AAG5576381
AALB109408217 115254177
CQUCpipJ_CPIJ010621
CPII120413722
CNS116346122
AME411730
ACER107997995
ALAB122713696
BIM100745926
BBIF117209675
BVK117238616
BVAN117164363
BTER100642977
BPYO122575624
CCAL108631859
OBB114876763
MGEN117219508
NMEA116431471
CGIG122405190
SOC105201295
MPHA105838053
AEC105151670
ACEP105621167
PBAR105428250
VEM105561383
HST105189509
DQU106745826
CFO105249065
FEX115246272
LHU105674772
PGC109853555
OBO105275198
PCF106788557
PFUC122518116
VPS122628233
NVI100119845
CSOL105365662
TPRE106659062
MDL103570799
CGLO123265664
FAS105266550
DAM107048825
AGIF122849290
CCIN107265939
TCA661492
DPA109543454
SOY115889614
ATD109597104
CSET123316069
AGB108914645
LDC111508595
NVL108567459
APLN108733382
PPYR116164345
OTU111428326
BMOR101742535
BMAN114243551
MSEX115447157
DPLKGM_201579
BANY112052836
PMAC106710507
PPOT106110665
PXU106122821
PRAP110996650
ZCE119839272
HAW110380113
TNL113492303
SLIU111351216
OFU114354243
PXY105395184 105395186
API100159015
DNX107161371
AGS114118986
RMD113559408
BTAB109030234
DCI103515416
CLEC106670041
HHAL106690855
NLU111047775
PHUPhum_PHUM515250
FOC113215351
ZNE110837085
CSEC111875707
FCD110857076 110857078 110861721 110861723
DPXDAPPUDRAFT_314562
DMK116930296
PVM113810984
PJA122247223
PCHN125024930
HAME121873302
PCLA123756861
PTRU123507862
HAZT108677023
EAF111710007
ISCIscW_ISCW022122
DSV119458461
RSAN119379255
RMP119175791
VDE111251352
VJA111267014
TUT107359578
DPTE113789944
DFR124495038
CSCU111619659
PTEP107441175
SDM118199717
CELCELE_F13H10.4(mogs-1)
CBRCBG_05981
BMYBM_BM3361(Bma-mogs-1)
LOALOAG_03690
NAINECAME_07435
HROHELRODRAFT_70793
LGILOTGIDRAFT_214385
PCAN112564864
BGT106074605
GAE121384133 121392738
HRF124142031
HRJ124267359
CRG105331294
MYI110460508
PMAX117339100
MMER123546800
OBI106869785
OSN115232304 115232534
LAK106158814
SMMSmp_024580.1
OVIT265_00111
EGLEGR_08968
NVE5511507
EPA110250425
ATEN116301958
ADF107327751
AMIL114960255
PDAM113667488
SPIS111320660
DGT114538040
XEN124444895
HMG100204917
TADTRIADDRAFT_19077
AQU100634542 100637722
ATHAT1G24320 AT1G67490(GCS1)
ALY9324664 9329518
CRB17896512 17897224
CSAT104701354 104741330 104750548 104757041 104787756
EUSEUTSA_v10006835mg EUTSA_v10018104mg
BRP103829083 103831024
BNA106356351 106411018 106413559 106425420
BOE106300894 106304711
RSZ108818375 108858324
THJ104807884
CPAP110815960
CIT102626422
CICCICLE_v10030695mg
PVY116126429
MINC123214948
TCC18609047
GRA105785861
GHI107918230 107922345
GAB108467160
DZI111281979 111317988
EGR104433660
GMX100795161 100795691
GSJ114412819 114412821 114421609
PVUPHAVU_002G174800g PHAVU_002G174900g
VRA106780217 106780218
VAR108326975 108342881
VUN114176371 114178344
CCAJ109810676 109810719
APRC113855839 113856448
MTRMTR_8g080290 MTR_8g080360
CAM101496671 101497432
LJALj4g3v2539160.1(Lj4g3v2539160.1) Lj4g3v2949800.1(Lj4g3v2949800.1)
ADU107482112
AIP107632002
AHF112734839 112792583
LANG109359940 109359950
FVE101304833
RCN112200307
PPER18789500 18791687
PMUM103322046 103322055
PAVI110769517 110769798
PDUL117633557 117633563
MDM103403150 103414334 103431926
PXB103961481 103961483
ZJU107428386 107434007
MNT21388932
CSV101210818
CMO103488898
BHJ120081361
MCHA111019700
CMAX111492274
CMOS111458598
CPEP111801444
RCU8286815
JCU105636116
HBR110634955 110634979 110640454
MESC110629359
POP7477030
PEU105137467
PALZ118048788
JRE109003148
QSU112010124 112011637
QLO115982239
TWL120000167 120006906
VVI100264375
VRI117911660
SLY101267114
SPEN107020771
SOT102580572
CANN107856548 107866840
NTA107788762 107796835 107810418
NSY104228399
NTO104084717 104118252
NAU109244799
INI109172062
ITR116025923
SIND105168395
OEU111378359 111393410
EGT105970889
SSPL121794579 121798415 121807521
HAN110926203
ECAD122578897
LSV111881539
CCAV112527654
DCR108198605 108201839
CSIN114310315
BVG104897586
SOE110794228
CQI110710782 110712428
NNU104591694
MING122074570
TSS122654596
PSOM113276595 113281500 113319001
NCOL116248809
OSA4327748
DOSAOs01t0921200-01(Os01g0921200)
BDI100822845
ATS109778661
TDC119270373 119278174
TAES123063379 123080307
SBI8059369
ZMA103652327
SVS117856578
PVIR120672892 120709082
PHAI112892061
PDA103706515
EGU105051156
MUS103987628
DCT110097965
PEQ110032801
AOF109823842
ATR18438178
SMOSELMODRAFT_101915 SELMODRAFT_165919
PPP112289032
CRECHLRE_13g579734v5
VCNVOLCADRAFT_58521
MNGMNEG_6941
CSLCOCSUDRAFT_65044
CVRCHLNCDRAFT_20925
APROF751_4830
CMECYME_CMF070C
GSLGasu_23130
CCPCHC_T00009379001
SCEYGL027C(CWH41)
SEUBDI49_1941
SPAOSPAR_G02080
AGOAGOS_AFR483C
ERCEcym_1427
KLAKLLA0_E10693g
KMXKLMA_20048(CWH41)
LTHKLTH0E07304g
VPOKpol_1026p1
ZROZYRO0G09702g
CGRCAGL0A01452g
NCSNCAS_0A01760(NCAS0A01760)
NDINDAI_0D03690(NDAI0D03690)
TPFTPHA_0K01720(TPHA0K01720)
TBLTBLA_0A08950(TBLA0A08950)
TDLTDEL_0F02570(TDEL0F02570)
TGBHG536_0D04640
KAFKAFR_0F03510(KAFR0F03510)
KNGKNAG_0D03680(KNAG0D03680)
ZMKHG535_0E04140
PPAPAS_chr1-1_0215
DHADEHA2D12254g
PICPICST_39865(CWH41)
PGUPGUG_04830
SPAASPAPADRAFT_146978(CWH41)
LELLELG_04520
CALCAALFM_C406100WA(CWH41)
CTPCTRG_04033
COTCORT_0B01540
CDUCD36_45640(CWH41)
CTENCANTEDRAFT_130333
YLIYALI0F14927g
CLUCLUG_04367
CLUSA9F13_04g01419
CAURCJI97_003422
SLBAWJ20_2073(CWH41)
PKZC5L36_0B03510
BNNFOA43_003524
BBRXBRETT_004384
OPAHPODL_02285
NCRNCU03657(gh63-1)
NTENEUTE1DRAFT35029(NEUTE1DRAFT_35029)
SMPSMAC_02532
PANPODANSg8409
TTTTHITE_157561 THITE_2108507
MTMMYCTH_2302289
CTHRCTHT_0061620
MGRMGG_04045 MGG_09721
PPEIPpBr36_04524 PpBr36_10133
TMNUCRPA7_7539 UCRPA7_7817
SSCKSPSK_05967
FGRFGSG_05218
FPUFPSE_07274
FVRFVEG_04883
FOXFOXG_07965
NHENECHADRAFT_96381
TRETRIREDRAFT_22072
TRRM419DRAFT_98040
MAWMAC_03939
MAJMAA_01473
CMTCCM_07809
PLJVFPFJ_08193
VALVDBG_00104
VDAVDAG_08395
CFJCFIO01_02475
CHIGCH63R_06675
SAPOSAPIO_CDS3042 SAPIO_CDS6484
ELAUCREL1_392 UCREL1_4725
PFYPFICI_04949 PFICI_08338
SSLSS1G_08744
BFUBCIN_16g01950
MBEMBM_05686
PSCOLY89DRAFT_625006
GLZGLAREA_00990
ANIAN6606.2
AFMAFUA_6G04210
ACTACLA_096520
NFINFIA_050730
AORAO090701000141
ANGANI_1_240134(An15g01420)
AFVAFLA_004635
ALUCAKAW2_60552A(CWH41)
ACHEACHE_50140A(CWH41)
APUUAPUU_10668A(CWH41)
PCSPc20g12700
PDPPDIP_17330
TMFPMAA_017980
TRGTRUGW13939_04202
CIMCIMG_13554(CIMG10187)
CPWCPC735_012890
UREUREG_03540
PBLPAAG_04602
PBNPADG_04761
ABEARB_07582
TVETRV_07006
AJEHCAG_05129
BGHBDBG_05285
PNOSNOG_01504 SNOG_05140
PTEPTT_00918 PTT_07345
BZECOCCADRAFT_106371 COCCADRAFT_5608
BSCCOCSADRAFT_152571 COCSADRAFT_167604
BORCOCMIDRAFT_94773 COCMIDRAFT_99881
AALTCC77DRAFT_940352 CC77DRAFT_950947
ZTRMYCGRDRAFT_48810
PFJMYCFIDRAFT_59272
FFUCLAFUR5_03604
BCOMBAUCODRAFT_156617
NPAUCRNP2_10005
TMLGSTUM_00006099001
SPOSPAC6G10.09
PPLPOSPLDRAFT_107259
TVSTRAVEDRAFT_57800
DSQDICSQDRAFT_160864
PCOPHACADRAFT_256571
SHSSTEHIDRAFT_51990
HIRHETIRDRAFT_150185
PSQPUNSTDRAFT_70269
ADLAURDEDRAFT_142326
FMEFOMMEDRAFT_87056
GTRGLOTRDRAFT_35943
MRRMoror_2306
MOREE1B28_008596
CCICC1G_03818
SCMSCHCODRAFT_65761
ABPAGABI1DRAFT53637(AGABI1DRAFT_53637)
ABVAGABI2DRAFT217075(AGABI2DRAFT_217075)
CPUTCONPUDRAFT_47986
SLASERLADRAFT_351106
UMAUMAG_11723
PFPPFL1_03809
MGLMGL_1071
MRTMRET_3083
MSYMMSY001_0793
PGRPGTG_01626
MLRMELLADRAFT_109969
SREPTSG_01395
DDIDDB_G0280145
DPPDICPUDRAFT_53711
DFADFA_05938
ACANACA1_098260
TGOTGME49_242020
TETTTHERM_000636933 TTHERM_00305410 TTHERM_00329690
PTMGSPATT00008864001 GSPATT00018064001
SMINv1.2.029725.t1(symbB.v1.2.029725.t1)
PIFPITG_17592
PSOJPHYSODRAFT_337930
SPARSPRG_06895
EHXEMIHUDRAFT_114881 EMIHUDRAFT_198328
TCR509201.10 510895.9 511015.10 511805.10
LMALMJF_28_2200
LIFLINJ_28_2350
LDOLDBPK_282350
LMILMXM_28_2200
LBZLBRM_28_2400
LPANLPMP_282330
NGRNAEGRDRAFT_57460 NAEGRDRAFT_79164
 » show all
Reference
1  [PMID:7358674]
  Authors
Elting JJ, Chen WW, Lennarz WJ.
  Title
Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
  Journal
J Biol Chem 255:2325-31 (1980)
Reference
2  [PMID:479161]
  Authors
Grinna LS, Robbins PW.
  Title
Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
  Journal
J Biol Chem 254:8814-8 (1979)
Reference
3  [PMID:7014569]
  Authors
Kilker RD Jr, Saunier B, Tkacz JS, Herscovics A.
  Title
Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
  Journal
J Biol Chem 256:5299-603 (1981)
Reference
4  [PMID:7358666]
  Authors
Grinna LS, Robbins PW.
  Title
Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
  Journal
J Biol Chem 255:2255-8 (1980)
Reference
5  [PMID:7356331]
  Authors
Michael JM, Kornfeld S.
  Title
Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
  Journal
Arch Biochem Biophys 199:249-58 (1980)
DOI:10.1016/0003-9861(80)90278-7
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.106
IUBMB Enzyme Nomenclature: 3.2.1.106
ExPASy - ENZYME nomenclature database: 3.2.1.106
BRENDA, the Enzyme Database: 3.2.1.106
CAS: 78413-07-7
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