KEGG   ENZYME: 3.2.1.114
Entry
EC 3.2.1.114                Enzyme                                 
Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
MAN2A1 (gene name);
MAN2A2 (gene name);
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase;
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)
Reaction(IUBMB)
Man5GlcNAc3-[protein] + 2 H2O = Man3GlcNAc3-[protein] + 2 alpha-D-mannopyranose [RN:R05984]
Reaction(KEGG)
R05984(G)
Substrate
Man5GlcNAc3-[protein];
H2O [CPD:C00001]
Product
Man3GlcNAc3-[protein];
alpha-D-mannopyranose [CPD:C00936]
Comment
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
History
EC 3.2.1.114 created 1986, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01231  alpha-mannosidase II
Genes
HSA4122(MAN2A2) 4124(MAN2A1)
PTR461982(MAN2A1) 745986(MAN2A2)
PPS100973826(MAN2A1) 100975142(MAN2A2)
GGO101130735(MAN2A2) 101130746(MAN2A1)
PON100449341(MAN2A2) 100455258(MAN2A1)
PPYG129014215(MAN2A2) 129036493(MAN2A1)
NLE100581120(MAN2A1) 100598002(MAN2A2)
HMH116463308 116463662 116470951(MAN2A1)
SSYN129482053(MAN2A2) 129492829(MAN2A1)
MCC705480(MAN2A1) 715720(MAN2A2)
MCF101865831(MAN2A1) 102118107(MAN2A2)
MTHB126956217 126958892
MNI105471104(MAN2A1) 105488288(MAN2A2)
CSAB103231182(MAN2A2) 103244316(MAN2A1)
CATY105576648(MAN2A1) 105601196(MAN2A2)
PANU101004326(MAN2A1) 101020239(MAN2A2)
TGE112626169(MAN2A1) 112628732(MAN2A2)
MLEU105538487(MAN2A2) 105552522(MAN2A1)
RRO104675604(MAN2A1) 104679282(MAN2A2)
RBB108517212(MAN2A2)
TFN117064837(MAN2A1) 117070195(MAN2A2)
PTEH111528634(MAN2A2) 111542679(MAN2A1)
CANG105516184(MAN2A2) 105516982(MAN2A1)
CJC100394604(MAN2A2) 100415670(MAN2A1)
SBQ101028436(MAN2A1) 101032034(MAN2A2)
CIMI108287585(MAN2A2) 108303398(MAN2A1)
ANAN105724938(MAN2A2) 105731962(MAN2A1)
CSYR103251650(MAN2A2) 103258927(MAN2A1)
MMUR105870622(MAN2A2) 105885357(MAN2A1)
LCAT123645112(MAN2A2) 123648579(MAN2A1)
PCOQ105809856(MAN2A2) 105812819(MAN2A1)
OGA100953447(MAN2A1) 100957305(MAN2A2)
MMU140481(Man2a2) 17158(Man2a1)
MCAL110298418(Man2a2) 110302683 110312160(Man2a1)
MPAH110327713(Man2a2) 110335524(Man2a1)
RNO25478(Man2a1) 308757(Man2a2)
MCOC116088842(Man2a1) 116102462(Man2a2)
ANU117707782(Man2a2) 117722464(Man2a1)
MUN110552374(Man2a1) 110553370(Man2a2)
CGE100757006(Man2a1) 100764014(Man2a2)
MAUA101827164(Man2a1) 101828565(Man2a2)
PROB127226754(Man2a1) 127238075(Man2a2)
PLEU114696192(Man2a2) 114696324(Man2a1)
MORG121433416(Man2a1) 121453316(Man2a2)
MFOT126508290 126508667
AAMP119802698(Man2a2) 119820806(Man2a1)
NGI103749886(Man2a2) 103752287(Man2a1)
HGL101697315(Man2a1) 101717094(Man2a2)
CPOC100722220(Man2a1) 100734282(Man2a2)
CCAN109695085(Man2a2) 109699084(Man2a1)
DORD105982460(Man2a2) 105988705(Man2a1)
DSP122099994(Man2a2) 122118070(Man2a1)
PLOP125338967(Man2a2) 125340211(Man2a1)
NCAR124975905 124986848
MMMA107148410(Man2a2) 107150060(Man2a1)
OCU100345634 100350334
OPI101522683(MAN2A2) 101535285(MAN2A1)
TUP102469872(MAN2A2) 102485972(MAN2A1)
GVR103583574(MAN2A2) 103596889(MAN2A1)
CFA488745(MAN2A2) 488878(MAN2A1)
CLUD112653238(MAN2A2) 112653892(MAN2A1)
VVP112915442(MAN2A1) 112921479(MAN2A2)
VLG121488991(MAN2A2) 121489296(MAN2A1)
NPO129503299(MAN2A1) 129510463(MAN2A2)
AML100474640(MAN2A1) 100475150(MAN2A2)
UMR103660265(MAN2A2) 103675784(MAN2A1)
UAH113255007(MAN2A1) 113263716(MAN2A2)
UAR123799253(MAN2A1) 123802468(MAN2A2)
ELK111148294 111152536
LLV125099905 125104118
MPUF101673986(MAN2A2) 101676924(MAN2A1)
MNP131999027(MAN2A2) 132028838(MAN2A1)
MLK131832518(MAN2A1) 131835580(MAN2A2)
NVS122894235(MAN2A2) 122916980(MAN2A1)
ORO101368244(MAN2A1) 101371875(MAN2A2)
EJU114208623(MAN2A1) 114223292(MAN2A2)
ZCA113909908(MAN2A2) 113928715(MAN2A1)
MLX118023074(MAN2A2)
NSU110572308(MAN2A2) 110590651(MAN2A1)
LWW102728690(MAN2A1) 102745949(MAN2A2)
FCA101086451(MAN2A1) 101101317(MAN2A2)
PYU121012159(MAN2A1) 121042360(MAN2A2)
PCOO112855181(MAN2A2) 112860896(MAN2A1)
PBG122467536(MAN2A2) 122491884(MAN2A1)
PVIV125167882(MAN2A2) 125167980(MAN2A1)
LRUF124517254 124519720
PTG102953845(MAN2A1) 102959757(MAN2A2)
PPAD109267616(MAN2A1) 109273465(MAN2A2)
PUC125910734 125934356
AJU106965940 106975671
HHV120222486(MAN2A1) 120249001(MAN2A2)
BTA521539(MAN2A1) 527449(MAN2A2)
BOM102269911(MAN2A2) 102286530(MAN2A1)
BIU109562380(MAN2A1) 109575464(MAN2A2)
BBUB102393495(MAN2A2) 102396245(MAN2A1)
BBIS104989398(MAN2A2) 104991361(MAN2A1)
CHX102171012(MAN2A2) 102182591(MAN2A1)
OAS101106798(MAN2A2) 101116572(MAN2A1)
BTAX128051192(MAN2A1) 128066788(MAN2A2)
ODA120863464(MAN2A1) 120875582(MAN2A2)
CCAD122419747(MAN2A2) 122439466(MAN2A1)
MBEZ129550300(MAN2A2) 129558808(MAN2A1)
SSC100154397(MAN2A2) 100514631(MAN2A1)
CFR102512093(MAN2A2) 102513706(MAN2A1)
CBAI105069081(MAN2A2) 105082023(MAN2A1)
CDK105094696(MAN2A2) 105095392(MAN2A1)
VPC102539333(MAN2A1) 102542027(MAN2A2)
BACU103020657(MAN2A1) 103021128(MAN2A2)
BMUS118890210(MAN2A2) 118892852(MAN2A1)
LVE103074675(MAN2A2) 103076739(MAN2A1)
OOR101272169(MAN2A1) 101272204(MAN2A2)
DLE111169626(MAN2A2) 111183761(MAN2A1)
PCAD102974194(MAN2A2) 102974411(MAN2A1)
PSIU116747493(MAN2A2) 116751733(MAN2A1)
NASI112398681(MAN2A1) 112414199(MAN2A2)
ECB100053432(MAN2A2) 100064575(MAN2A1)
EPZ103546211(MAN2A2) 103551677(MAN2A1)
EAI106832048(MAN2A2) 106832412(MAN2A1)
MYB102239755(MAN2A2) 102241544(MAN2A1)
MYD102760778(MAN2A1) 102764752(MAN2A2)
MMYO118656377(MAN2A1) 118679225(MAN2A2)
MLF102429994 102435674(MAN2A1) 102439002
PKL118703963(MAN2A1) 118706308(MAN2A2)
EFUS103288792(MAN2A1) 103303009(MAN2A2)
MNA107540397(MAN2A2) 107546496(MAN2A1)
DRO112305889(MAN2A2) 112307206(MAN2A1)
SHON118977338(MAN2A1) 118991941(MAN2A2)
AJM119052124(MAN2A2) 119065110(MAN2A1)
PDIC114488515(MAN2A2) 114494997(MAN2A1)
PHAS123809609(MAN2A2) 123818093(MAN2A1)
MMF118640879(MAN2A2) 118642854(MAN2A1)
PPAM129073923(MAN2A2) 129083917(MAN2A1)
HAI109371540(MAN2A1) 109381472(MAN2A2)
RFQ117018934(MAN2A2) 117024814(MAN2A1)
PALE102878318(MAN2A1) 102884371(MAN2A2)
PGIG120590802(MAN2A1) 120599240(MAN2A2)
PVP105295470(MAN2A1) 105302879(MAN2A2)
RAY107506530(MAN2A1) 107514130(MAN2A2)
MJV108407113(MAN2A1)
TOD119244240(MAN2A2) 119260546(MAN2A1)
SARA101541026(MAN2A2) 101541110(MAN2A1)
SETR126001981(MAN2A1) 126008639 126022401(MAN2A2)
LAV100669338(MAN2A1) 100671385(MAN2A2)
TMU101344297 101354641
ETF101652531(MAN2A2) 101658351(MAN2A1)
DNM101436317(MAN2A2) 101439931(MAN2A1)
MDO100010442(MAN2A1) 100014504(MAN2A2)
GAS123234215(MAN2A2) 123236188(MAN2A1)
SHR100913308(MAN2A1) 100922248(MAN2A2)
AFZ127551411 127560295
PCW110193635(MAN2A2) 110195899(MAN2A1)
TVP118828447(MAN2A2) 118828977(MAN2A1)
OAA100082559(MAN2A1) 100090754(MAN2A2)
GGA415585(MAN2A2) 415611(MAN2A1)
PCOC116225521(MAN2A2) 116234843(MAN2A1)
MGP100539000(MAN2A2) 104915174(MAN2A1)
CJO107306350(MAN2A1) 107318993(MAN2A2)
TPAI128075423(MAN2A2) 128089486(MAN2A1)
LMUT125686853(MAN2A1) 125698331(MAN2A2)
NMEL110389397(MAN2A1) 110403851(MAN2A2)
APLA101790343(MAN2A2) 101792614(MAN2A1)
ACYG106042345(MAN2A1) 106048641(MAN2A2)
CATA118255954(MAN2A1) 118259410
AFUL116493695(MAN2A2) 116501098(MAN2A1)
TGU100226019(MAN2A2) 100227845(MAN2A1)
LSR110467593(MAN2A1) 110476670(MAN2A2)
SCAN103816135(MAN2A2) 103824196(MAN2A1)
PMOA120509098(MAN2A2) 120513740(MAN2A1)
OTC121331463(MAN2A1) 121343669(MAN2A2)
PRUF121352247(MAN2A2) 121354031(MAN2A1)
GFR102041186(MAN2A1) 102041635(MAN2A2)
FAB101806895(MAN2A2) 101819402(MAN2A1)
OMA130257455(MAN2A2) 130265066(MAN2A1)
PHI102101154(MAN2A2) 102113458(MAN2A1)
PMAJ107209587(MAN2A2) 107216400(MAN2A1)
CCAE111940865(MAN2A1) 111943021(MAN2A2)
CCW104683853(MAN2A2) 104693206(MAN2A1)
CBRC103611667(MAN2A1) 103618817(MAN2A2)
ETL114056033(MAN2A1) 114064253(MAN2A2)
ZAB102061220(MAN2A1) 102071919(MAN2A2)
ZLE135452215(MAN2A2) 135459817(MAN2A1)
ACHL103797001 103812036
SVG106853824(MAN2A1) 106860150(MAN2A2)
MMEA130574340(MAN2A1) 130575801(MAN2A2)
HRT120758869(MAN2A2) 120765291(MAN2A1)
FPG101913159(MAN2A2) 101921020
FCH102048168(MAN2A2) 102050767(MAN2A1)
CLV102090971(MAN2A2) 102097702(MAN2A1)
EGZ104133484(MAN2A2) 104135037(MAN2A1)
NNI104017021(MAN2A2) 104022201(MAN2A1)
PLET104624182(MAN2A2)
EHS104506599
ACUN113484037(MAN2A2) 113489918(MAN2A1)
TALA104358494(MAN2A1) 116961121(MAN2A2)
PADL103914784(MAN2A2) 103920875(MAN2A1)
AFOR103899825(MAN2A2) 103903072(MAN2A1)
ACHC115336851(MAN2A1) 115342030(MAN2A2)
HLE104829309(MAN2A1) 104834654(MAN2A2)
AGEN126036159 126044133
GCL127027130
CSTI104553919(MAN2A1)
GSTE104259095
LDI104345790(MAN2A1)
MNB103781774
OHA104337837(MAN2A1)
SHAB115612934(MAN2A2) 115619670(MAN2A1)
DPUB104297367(MAN2A2) 104306042
CPEA104385796(MAN2A2) 104397284(MAN2A1)
AVIT104279066
CVF104282395(MAN2A1) 104284686(MAN2A2)
RTD128902300(MAN2A1) 128915165(MAN2A2)
CUCA104056420(MAN2A2) 104061125(MAN2A1)
TEO104374022(MAN2A1)
BRHI104496142(MAN2A1)
AAM106491449(MAN2A2)
AROW112964263(MAN2A1) 112976300(MAN2A2)
NPD112948334(MAN2A2) 112951728(MAN2A1)
TGT104580109(MAN2A1)
DNE112994987(MAN2A2) 112995230(MAN2A1)
SCAM104150970(MAN2A1) 104151025(MAN2A2)
ASN102369470(MAN2A1) 102383379(MAN2A2)
AMJ102561641(MAN2A1) 102566705(MAN2A2)
CPOO109308162(MAN2A1)
GGN109297471(MAN2A1)
PSS102459905(MAN2A1)
CMY102941559(MAN2A2) 102944199(MAN2A1)
CCAY125636418(MAN2A1) 125643432(MAN2A2)
DCC119855693(MAN2A1) 119863076(MAN2A2)
CPIC101937670 101953630(MAN2A2)
TST117878692(MAN2A1) 117884331(MAN2A2)
CABI116814770(MAN2A1) 116833017(MAN2A2)
MRV120373280(MAN2A2) 120407767(MAN2A1)
ACS100555933(man2a1) 100568077(man2a2)
ASAO132762458(MAN2A2) 132767194(MAN2A1)
PVT110072017(MAN2A1) 110084439(MAN2A2)
SUND121924154(MAN2A1) 121933219(MAN2A2)
PBI103053695(MAN2A1) 103058391(MAN2A2)
PMUR107289784(MAN2A2) 107293675(MAN2A1)
CTIG120305939(MAN2A1) 120316415(MAN2A2)
TSR106543694(MAN2A1) 106553803(MAN2A2)
PGUT117674626(MAN2A1) 117676225(MAN2A2)
APRI131184847(MAN2A2) 131190475(MAN2A1)
PTEX113441970(MAN2A2) 113448933(MAN2A1)
NSS113415592(MAN2A1) 113423348(MAN2A2)
VKO123030714(MAN2A2) 123031172(MAN2A1)
PMUA114584355(MAN2A2) 114606107(MAN2A1)
PRAF128401365(MAN2A2) 128423003(MAN2A1)
ZVI118076729(MAN2A1) 118092868(MAN2A2)
HCG128334883(MAN2A2) 128343434(MAN2A1)
GJA107120457(MAN2A1) 107125467(MAN2A2)
STOW125424513(MAN2A2) 125436400(MAN2A1)
EMC129334247(MAN2A1) 129345420(MAN2A2)
XLA108707218(man2a1.S) 108712863(man2a2.S) 108717353(man2a1.L) 443991(man2a2.L)
XTR100036612(man2a1) 448465(man2a2)
NPR108789334(MAN2A1) 108798147(MAN2A2)
RTEM120931239(MAN2A2) 120931614(MAN2A1)
BBUF120985902(MAN2A2) 120992563(MAN2A1)
BGAR122924645(MAN2A1) 122927556(MAN2A2)
MUO115459854(MAN2A2) 115463184(MAN2A1)
GSH117348402(MAN2A2) 117352594(MAN2A1)
DRE100333987(man2a2) 560219(man2a1)
SRX107720774 107721641(man2a1) 107750719 107751258
SANH107663767 107670215 107673231(man2a2) 107691725(man2a1)
SGH107564047(man2a1) 107564609 107581805 107603169
CCAR109078545
CAUA113043692 113049817 113066713 113082394
CGIB127946829 127958588 127994174 128014540
PTET122330519(man2a2) 122345307(man2a1)
LROH127156867(man2a2) 127164981(man2a1)
OMC131534202(man2a2) 131540636(man2a1)
PPRM120468300(man2a2) 120472040(man2a1)
RKG130073650(man2a2) 130086772(man2a1)
MAMB125246718(man2a2) 125267915(man2a1)
CIDE127506522 127512194
MASI127426773 127435890 127437632 127439837
TROS130551908(man2a2) 130564495(man2a1)
TDW130414186(man2a2) 130418969(man2a1)
MANU129434111(man2a2) 129440807(man2a1)
IPU108274717
IFU128618098(man2a2)
PHYP113529699(man2a2)
SMEO124392803(man2a2)
TFD113660003(man2a2)
TVC132856545(man2a2)
TRN134309856(man2a2)
AMEX103023301(man2a1) 103041860(man2a2)
CMAO118811581(man2a2) 118814604(man2a1)
EEE113572463 113588518(man2a2)
CHAR105891042(man2a1) 105900766(man2a2)
TRU101061792(man2a2) 101077627(man2a1)
TFS130517573(man2a1) 130536873(man2a2)
TNGGSTEN00003927G001 GSTEN00022835G001
LCO104925267(man2a2) 104932414
NCC104944004(man2a2)
TBEN117475808 117491582(man2a2) 117491941
PGEO117447933(man2a2)
GACU117545751(man2a2) 117562801
EMAC134868627(man2a1) 134877465(man2a2)
ELY117262193(man2a2) 117270133(man2a1)
EFO125887197(man2a2) 125906294(man2a1)
PLEP121949968(man2a2) 121959715(man2a1)
SLUC116038801(man2a2) 116065613
ECRA117949100(man2a2) 117959781(man2a1)
ESP116694124(man2a2)
PFLV114552021 114560151(man2a2) 114570585(man2a1)
GAT120809442(man2a2) 120812180 120831692(man2a1)
PPUG119196376(man2a2) 119226927(man2a1)
AFB129102709(man2a1) 129108212(man2a2)
CLUM117732108(man2a2) 117740498(man2a1)
PSWI130205721(man2a1)
MSAM119893108(man2a2) 119914086 119914087
SCHU122865858(man2a1) 122875582(man2a2)
CUD121514902(man2a2) 121524694(man2a1)
ALAT119024918(man2a2) 119030211(man2a1)
MZE101474154 101483319(man2a2)
ONL100708597(man2a2) 102081444
OAU116321290 116335402(man2a2)
OLA101158104(man2a2) 101174073
OML112152466(man2a2) 112162978(man2a1)
CSAI133444057(man2a2) 133455504(man2a1)
XMA102218498(man2a1) 102232197(man2a2)
XCO114136954 114155110(man2a2)
XHE116724829(man2a1) 116733889(man2a2)
PRET103460455(man2a1) 103466353(man2a2)
PFOR103131079(man2a1) 103133657(man2a2)
PLAI106943897 106945048(man2a2)
PMEI106909111 106927549(man2a2)
GAF122819277(man2a1) 122835727(man2a2)
PPRL129356208 129356960 129361968(man2a2)
CVG107098036(man2a1) 107104235(man2a2)
CTUL119774472(man2a1) 119793068(man2a2)
GMU124872651(man2a1) 124884982(man2a2)
NFU107374983(man2a1) 107388979(man2a2)
KMR108228395 108239965(man2a2)
ALIM106515631(man2a2) 106536243
NWH119415567(man2a2) 119424942
AOCE111563148(man2a2) 111564348
MCEP124996980(man2a1) 125014490(man2a2)
CSEM103380513(man2a2) 103390365(man2a1)
POV109624583(man2a2) 109642276
SSEN122775906(man2a2) 122776385
HHIP117762833(man2a2) 117771297(man2a1)
HSP118109956(man2a2) 118125907(man2a1)
PPLT128424578(man2a1) 128443965(man2a2)
SMAU118284525(man2a1) 118315804(man2a2)
LCF108874626 108875305
SDU111228707(man2a2) 111238819(man2a1)
SLAL111651803 111655358(man2a2)
XGL120792691(man2a2) 120806732(man2a1)
HCQ109530362(man2a2)
SSCV125971370
SBIA133501778(man2a2)
PEE133403077(man2a2)
PTAO133477757(man2a2)
BPEC110153167 110165893(man2a2)
MALB109968742(man2a2) 109973112(man2a1)
BSPL114856995(man2a2) 114867106(man2a1)
SJO128358721(man2a2) 128379782(man2a1)
SASA106561301 106562091(man2a1) 106568341 106573342(man2a2)
STRU115149336 115152135(man2a2) 115159214(man2a1) 115197323
OTW112214463(man2a1) 112218991 112252518 112257442
OMY110522404(man2a2) 110523878 110536799
OGO124000099 124002196 124048631(man2a1)
ONE115105938 115109522(man2a2) 115126674
OKI109868056(man2a1) 109889493(man2a2) 109892411
OKE118387850 118391493 118396027(man2a2) 118401132
SALP111952337(man2a2) 111961325(man2a1) 111962448 111981710
SNH120025911 120044213 120054035 120065912(man2a2)
CCLU121532213 121574167 121577036 121582802
ELS105018384(man2a2) 105027936(man2a1)
SFM108932015(man2a1) 108941123(man2a2)
PKI111835779(man2a1) 111845078(man2a2)
AANG118212479(man2a1) 118227271(man2a2)
LOC102691193(man2a2) 102696037(man2a1)
PSPA121294610 121299015 121301854 121315950
ARUT117409290 117428313 117429435 117973182
PSEX120532080(man2a1) 120541429(man2a2)
LCM102355620 102360088(MAN2A2)
CMK103178412(man2a1) 103188552(man2a2)
RTP109930439(man2a2) 109938999(man2a1)
CPLA122542573(man2a2) 122560138(man2a1)
HOC132823439(man2a1) 132834639(man2a2)
LERI129695847(man2a1) 129713516(man2a2)
PMRN116941070(MAN2A2) 116942119
LRJ133343643 133346779
BFO118411916
BBEL109468568
CIN100180083
SCLV120343811
SPU594620
LPIC129257693
APLC110979321
AJC117125135
SKO102802038
DMEDmel_CG18802(alpha-Man-IIa)
DER6552301
DSE6607114
DSIDsimw501_GD18615(Dsim_GD18615)
DYADyak_GE25950
DAN6500000
DSR110191164
DPO4800594
DPE6595142
DMN108155782
DWI6647583
DGR6563084
DMODmoj_GI24010
DAZ108614123
DNV108653307
DHE111593673
DVI6629947
CCAT101462695
BOD106615218
BDR105225843
RZE108378692
AOQ129235669
TDA119663712 119663713 119679537 119679563 119679940 119684395
MDE101898268 131805876
SCAC106086721
LCQ111685869
LSQ119601914
GFS119635041
ECOE129939611
CLON129614464
HIS119651272 119652370
AGA1278838
ACOZ120949537
AARA120895003
AMER121587851
ASTE118503462
AFUN125764931
AMOU128299381
AALI118457399
AAG5575653
AALB109402419 109405454
ASUA134225723
CQUCpipJ_CPIJ009720
CPII120423830
CNS116349279
BCOO119070080
AME552382
ACER107994422
ALAB122714930
ADR102679465
AFLR100863782
BIM100749601
BBIF117205087
BVK117231097
BVAN117157558
BTER100646824
BAFF126921954
BPYO122567772
BPAS132912694
FVI122538581
CCAL108623658
OBB114880562
OLG117603026
MGEN117224144
NMEA116423930
CGIG122398868
SOC105198479
MPHA105836778
AEC105154407
ACEP105623777
PBAR105423365
VEM105565777
HST105190974
DQU106750368
CFO105253605
FEX115237693
LHU105674564
PGC109851679
OBO105274664
PCF106789840
PFUC122513263
VPS122636855
VCRB124430970
VVE124956883
NVI100116564
CSOL105364669
TPRE106650757
LHT122504425
LBD127281187
MDL103577084 103579008
CGLO123259501 123274900
FAS105270282
DAM107035984
AGIF122857485 122857617
CINS118073819
VCAN122410275
CCIN107264491
DSM124407997
NPT124216049
NFB124180581
NLO107224161
NVG124302073
AROA105693438
TCA660728
DPA109544976
SOY115888958
AGRG126742788
ATD109605290
CSET123307622
AGB108912629
LDC111514244
DVV126880396
NVL108562674
APLN108743170 108743178
PPYR116159269
OTU111420892
BMOR101742043
BMAN114250890
MSEX115449114 119189147
DPLKGM_214574
BANY112058378
MJU123875010
NIQ126775935
VCD124538591
MCIX123662181
PMAC106721685
PPOT106103852
PXU106120187
PRAP110993078
PBX123716701
PNAP125063158
ZCE119828502
CCRC123699655
LSIN126970230
AAGE121726058
HAW110380432
HZE124640060
TNL113499077
SLIU111350250
OFU114356108
ATRA106136241
GMW113519805
PXY105380392
PGW126374824
LGLY125232524
CFEL113385536
CCRN123292918
API100169064
DNX107161638
AGS114131656
RMD113555742
ACOO126834595
DVT126906382
BTAB109044339
CLEC106666206
HHAL106677705 106677835
NLU111054344
HVI124353043
MQU128986337
PHUPhum_PHUM459490
FOC113214831
TPAL117650266
ZNE110835247
CSEC111868354
SGRE126340516
BROR134535806
IEL124163701
FCD110848037
DMK116923686
DPZ124315071
PVM113815567
PJA122246341
PCHN125044374
PMOO119578776
HAME121876770
PCLA123775118
CQD128694208
PTRU123514813
ESN126982525
MNZ135195825
HAZT108678706
EAF111710355
LSM121120461
TCF131889120
PPOI119095240 119095241
DSV119456041
RSAN119393875
RMP119172694
VDE111246456
VJA111261034
TUT107360206
DPTE113797886
DFR124494692
CSCU111620191 111620547
PTEP107455528
ABRU129958148
UDV129231375 129232560 129233569
SDM118186080 118200216 118204655
LPOL106464502 106465597 106467018 106468759
PMEO129590602 129598492 129599344 129599393
CELCELE_F58H1.1(aman-2)
CBRCBG_23330(Cbr-aman-2)
CRQGCK72_018141
NAINECAME_08623 NECAME_08624
BMYBM_BM4567(Bma-aman-2)
LOALOAG_06074 LOAG_08114 LOAG_18290
TSPTsp_10745
HROHELRODRAFT_110840
LGILOTGIDRAFT_164424 LOTGIDRAFT_188902
PVUL126814437 126821931
PCAN112556419 112570581 112570746
BGT106053755 106061128 106069804
GAE121371265 121373761 121384824
HRF124122870 124143923 124148741
HRJ124255342 124260264 124285348
CRG105331810 105332200 105341572 105343542 117687453
CANU128164504 128171314 128176071 128176081
CVN111113429 111118581 111119558 111128282 111128909
OED125652552 125652850 125667404 125670941
MYI110442311 110449962 110450072 110450325 110454737 110465474
PMAX117314924 117323212 117324211 117324627 117326963
MCAF127722088
MMER123530261 123530275 123531139 123537102 123537266 123541858 123541918 123543018 123546697 123550153 123553765 123560815
RPHI132715898 132727022 132728908 132735624 132742306 132742637 132742860 132748309 132749472 132750378 132759591
DPOL127834601 127860058 127865646 127871286 127872109 127872786 127873344
MAEA128207835 128207836 128208889 128208946 128211246 128213111 128213583 128217244 128219229 128220757 128222038 128228614
OBI106875435 106875688
OSN115231032 115231539
LJP135467195 135467754 135478124
LAK106153188 106156030 106166353 106176305
SMMSmp_143430
SHXMS3_00009069(MAN2A1_1)
OVIT265_07096
EGLEGR_08871
LLON135484178 135484882 135485130 135498633
NVE5512609
EPA110234138
ATEN116299384
ADF107347367
AMIL114961754
PDAM113670726
SPIS111324658
DGT114525319
XEN124451115
HMG100198326 100202382
HSY130644326
RES135690200
TADTRIADDRAFT_60265
ATHAT5G14950(GMII)
ALY9309767
CRB17881567
CSAT104709139 104735512 104769734
EUSEUTSA_v10012487mg
BRP103850958 103856103
BNA106429929 106431756 111204299
BOE106327011 106334765
RSZ108842391 108847660
THJ104821170
CIT102615196
CICCICLE_v10014083mg
PVY116142958
MINC123195543
TCC18601342
GRA105768375 105798286
GHI107888651 107892313 107955563 107958597
GAB108454878 108457471
HSYR120147408 120171969
DZI111291640 111316658
EGR104422581
GMX100806647 100811858
GSJ114381996 114398155
PVUPHAVU_004G022500g
VRA106770832
VAR108345656
VUN114180334
VUM124833975
CCAJ109817438
APRC113867315
MTR11439146
TPRA123906481
CAM101499632(MAN2A2)
PSAT127122848
VVO131627041 131652785
LJALj2g3v1022240.1(Lj2g3v1022240.1)
ADU107471073
AIP107622688
AHF112716315 112784225
LANG109335920 109347307 109347309
PCIN129302384 129305873
QSAO6P43_004554 O6P43_009021
FVE101296768
RCN112184196
PPER18782416
PMUM103329931
PAVI110756683
PDUL117620960
MDM103404378 103442297
MSYL126583615 126610645
PXB103928463
ZJU107415425
MNT21393801
CSV101208332
CMO103487047
BHJ120090184
MCHA111018346
CMAX111469337 111482230
CMOS111433153 111441463
CPEP111790312 111792352
RCU8280600
JCU105642251
HBR110641257 110654833
MESC110601253
POP18095306 7495932
PEU105114251 105141682
PALZ118036907 118058267
JRE108992841
CILL122302525
CAVE132180583
QSU111999605
QLO115976745
TWL120008882
VVI100243903
VRI117929602
SLY101266287
SPEN107011510
SOT102605224
SSTN125846408
SDUL129872278
CANN107860595
LBB132623099
NTA107777832 107829947
NSY104211404
NTO104108022
NAU109205422
INI109158199 109180593
ITR116000145 116012756
SIND105177181
OEU111409226
EGT105968893
SSPL121767131 121771656
SMIL130989517
SHIS125205490
APAN127242012 127257835
HAN110903921
ECAD122603697
LSV111891915
CCAV112523600
DCR108214457
CSIN114263477 114296797
RVL131302330
AEW130769312 130776973
BVG104905356
SOE110786831
CQI110715303 110724888
ATRI130802356
MOF131160561
NNU104607979
MING122075952 122079250
TSS122654368 122670711
PSOM113276377 113343777
OSA4340636
DOSAOs06t0245700-00(Os06g0245700)
OBR102707404
OGL127776136
BDI100822520
ATS109783252
TDC119329460 119336349
TAES123149332 123156793 123165270
TUA125522393
LPER127317442
LRD124685381 124685461
SBI8061493
ZMA100502340 103629954
SITA101761357
SVS117852889
PVIR120669859 120703002
PHAI112889969
PDA103710003
EGU105039124 105050069
MUS103990861
ZOF122008780 122017400
DCT110092430
PEQ110026121
AOF109820905
MSIN131258333
NCOL116250575 116258674
ATR18446724
SMOSELMODRAFT_104910 SELMODRAFT_116442 SELMODRAFT_154366 SELMODRAFT_228
PPP112275693
SREPTSG_03147 PTSG_07075 PTSG_11582
DPPDICPUDRAFT_45100 DICPUDRAFT_74852
DFADFA_02000 DFA_07693(manD)
ACANACA1_068820
TETTTHERM_00230960
FCYFRACYDRAFT_250184
NGRNAEGRDRAFT_57722
 » show all
Reference
1  [PMID:863880]
  Authors
Tulsiani DR, Opheim DJ, Touster O.
  Title
Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.
  Journal
J Biol Chem 252:3227-33 (1977)
Reference
2  [PMID:212436]
  Authors
Tabas I, Kornfeld S
  Title
The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides.
  Journal
J Biol Chem 253:7779-86 (1978)
Reference
3  [PMID:6445359]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
  Journal
J Biol Chem 255:4894-902 (1980)
Reference
4  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J Biol Chem 257:3660-8 (1982)
Reference
5  [PMID:1757461]
  Authors
Moremen KW, Robbins PW
  Title
Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to  complex N-glycans.
  Journal
J Cell Biol 115:1521-34 (1991)
DOI:10.1083/jcb.115.6.1521
  Sequence
[hsa:4124] [mmu:17158]
Reference
6  [PMID:8524845]
  Authors
Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN
  Title
Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.
  Journal
Proc Natl Acad Sci U S A 92:11766-70 (1995)
DOI:10.1073/pnas.92.25.11766
  Sequence
[hsa:4124 4122]
Reference
7  [PMID:11406577]
  Authors
van den Elsen JM, Kuntz DA, Rose DR
  Title
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
  Journal
EMBO J 20:3008-17 (2001)
DOI:10.1093/emboj/20.12.3008
  Sequence
Reference
8  [PMID:15721331]
  Authors
Athanasopoulos VI, Niranjan K, Rastall RA.
  Title
The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis.
  Journal
Carbohydr Res 340:609-17 (2005)
DOI:10.1016/j.carres.2005.01.005
Reference
9  [PMID:18599462]
  Authors
Shah N, Kuntz DA, Rose DR
  Title
Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic  site.
  Journal
Proc Natl Acad Sci U S A 105:9570-5 (2008)
DOI:10.1073/pnas.0802206105
  Sequence
Reference
10 [PMID:22819743]
  Authors
Rose DR
  Title
Structure, mechanism and inhibition of Golgi alpha-mannosidase II.
  Journal
Curr Opin Struct Biol 22:558-62 (2012)
DOI:10.1016/j.sbi.2012.06.005
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.114
IUBMB Enzyme Nomenclature: 3.2.1.114
ExPASy - ENZYME nomenclature database: 3.2.1.114
BRENDA, the Enzyme Database: 3.2.1.114
CAS: 82047-77-6
LinkDB

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