KEGG   ENZYME: 3.2.1.114
Entry
EC 3.2.1.114                Enzyme                                 
Name
mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase;
MAN2A1 (gene name);
MAN2A2 (gene name);
mannosidase II;
exo-1,3-1,6-alpha-mannosidase;
alpha-D-mannosidase II;
alpha-mannosidase II;
alpha1-3,6-mannosidase;
GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase;
Golgi alpha-mannosidase II;
ManII;
1,3(1,6)-alpha-D-mannosidase;
1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase;
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
(1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining)
Reaction(IUBMB)
Man5GlcNAc3-[protein] + 2 H2O = Man3GlcNAc3-[protein] + 2 alpha-D-mannopyranose [RN:R05984]
Reaction(KEGG)
R05984(G)
Substrate
Man5GlcNAc3-[protein];
H2O [CPD:C00001]
Product
Man3GlcNAc3-[protein];
alpha-D-mannopyranose [CPD:C00936]
Comment
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. It removes two mannosyl residues, one linked by alpha1,3 linkage, and the other linked by alpha1,6 linkage, both of which are removed by the same catalytic site. The enzyme is sensitive to swainsonine.
History
EC 3.2.1.114 created 1986, modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K01231  alpha-mannosidase II
Genes
HSA: 4122(MAN2A2) 4124(MAN2A1)
PTR: 461982(MAN2A1) 745986(MAN2A2)
PPS: 100973826(MAN2A1) 100975142(MAN2A2)
GGO: 101130735(MAN2A2) 101130746(MAN2A1)
PON: 100449341(MAN2A2) 100455258(MAN2A1)
PPYG: 129014215(MAN2A2) 129036493(MAN2A1)
NLE: 100581120(MAN2A1) 100598002(MAN2A2)
HMH: 116463308 116463662 116470951(MAN2A1)
SSYN: 129482053(MAN2A2) 129492829(MAN2A1)
MCC: 705480(MAN2A1) 715720(MAN2A2)
MCF: 101865831(MAN2A1) 102118107(MAN2A2)
MTHB: 126956217 126958892
MNI: 105471104(MAN2A1) 105488288(MAN2A2)
CSAB: 103231182(MAN2A2) 103244316(MAN2A1)
CATY: 105576648(MAN2A1) 105601196(MAN2A2)
PANU: 101004326(MAN2A1) 101020239(MAN2A2)
TGE: 112626169(MAN2A1) 112628732(MAN2A2)
MLEU: 105538487(MAN2A2) 105552522(MAN2A1)
RRO: 104675604(MAN2A1) 104679282(MAN2A2)
RBB: 108517212(MAN2A2)
TFN: 117064837(MAN2A1) 117070195(MAN2A2)
PTEH: 111528634(MAN2A2) 111542679(MAN2A1)
CANG: 105516184(MAN2A2) 105516982(MAN2A1)
CJC: 100394604(MAN2A2) 100415670(MAN2A1)
SBQ: 101028436(MAN2A1) 101032034(MAN2A2)
CIMI: 108287585(MAN2A2) 108303398(MAN2A1)
ANAN: 105724938(MAN2A2) 105731962(MAN2A1)
CSYR: 103251650(MAN2A2) 103258927(MAN2A1)
MMUR: 105870622(MAN2A2) 105885357(MAN2A1)
LCAT: 123645112(MAN2A2) 123648579(MAN2A1)
PCOQ: 105809856(MAN2A2) 105812819(MAN2A1)
OGA: 100953447(MAN2A1) 100957305(MAN2A2)
MMU: 140481(Man2a2) 17158(Man2a1)
MCAL: 110298418(Man2a2) 110302683 110312160(Man2a1)
MPAH: 110327713(Man2a2) 110335524(Man2a1)
RNO: 25478(Man2a1) 308757(Man2a2)
MCOC: 116088842(Man2a1) 116102462(Man2a2)
ANU: 117707782(Man2a2) 117722464(Man2a1)
ASYL: 127666928(Man2a2) 127692028(Man2a1)
MUN: 110552374(Man2a1) 110553370(Man2a2)
CGE: 100757006(Man2a1) 100764014(Man2a2)
MAUA: 101827164(Man2a1) 101828565(Man2a2)
PROB: 127226754(Man2a1) 127238075(Man2a2)
PLEU: 114696192(Man2a2) 114696324(Man2a1)
MORG: 121433416(Man2a1) 121453316(Man2a2)
MFOT: 126508290 126508667
AAMP: 119802698(Man2a2) 119820806(Man2a1)
NGI: 103749886(Man2a2) 103752287(Man2a1)
HGL: 101697315(Man2a1) 101717094(Man2a2)
CPOC: 100722220(Man2a1) 100734282(Man2a2)
CCAN: 109695085(Man2a2) 109699084(Man2a1)
DORD: 105982460(Man2a2) 105988705(Man2a1)
DSP: 122099994(Man2a2) 122118070(Man2a1)
PLOP: 125338967(Man2a2) 125340211(Man2a1)
NCAR: 124975905 124986848
MMMA: 107148410(Man2a2) 107150060(Man2a1)
ITI: 101955390(Man2a1) 101977982(Man2a2)
OCU: 100345634 100350334
OPI: 101522683(MAN2A2) 101535285(MAN2A1)
TUP: 102469872(MAN2A2) 102485972(MAN2A1)
GVR: 103583574(MAN2A2) 103596889(MAN2A1)
CFA: 488745(MAN2A2) 488878(MAN2A1)
CLUD: 112653238(MAN2A2) 112653892(MAN2A1)
VVP: 112915442(MAN2A1) 112921479(MAN2A2)
VLG: 121488991(MAN2A2) 121489296(MAN2A1)
NPO: 129503299(MAN2A1) 129510463(MAN2A2)
AML: 100474640(MAN2A1) 100475150(MAN2A2)
UMR: 103660265(MAN2A2) 103675784(MAN2A1)
UAH: 113255007(MAN2A1) 113263716(MAN2A2)
UAR: 123799253(MAN2A1) 123802468(MAN2A2)
ELK: 111148294 111152536
LLV: 125099905 125104118
MPUF: 101673986(MAN2A2) 101676924(MAN2A1)
MNP: 131999027(MAN2A2) 132028838(MAN2A1)
MLK: 131832518(MAN2A1) 131835580(MAN2A2)
NVS: 122894235(MAN2A2) 122916980(MAN2A1)
ORO: 101368244(MAN2A1) 101371875(MAN2A2)
EJU: 114208623(MAN2A1) 114223292(MAN2A2)
ZCA: 113909908(MAN2A2) 113928715(MAN2A1)
MLX: 118023074(MAN2A2)
NSU: 110572308(MAN2A2) 110590651(MAN2A1)
LWW: 102728690(MAN2A1) 102745949(MAN2A2)
FCA: 101086451(MAN2A1) 101101317(MAN2A2)
PYU: 121012159(MAN2A1) 121042360(MAN2A2)
PCOO: 112855181(MAN2A2) 112860896(MAN2A1)
PBG: 122467536(MAN2A2) 122491884(MAN2A1)
PVIV: 125167882(MAN2A2) 125167980(MAN2A1)
LRUF: 124517254 124519720
LGF: 123584449(MAN2A2) 123609485(MAN2A1)
AJU: 106965940 106975671
PTG: 102953845(MAN2A1) 102959757(MAN2A2)
PPAD: 109267616(MAN2A1) 109273465(MAN2A2)
PUC: 125910734 125934356
PLEZ: 122221592(MAN2A2) 122223858(MAN2A1)
HHV: 120222486(MAN2A1) 120249001(MAN2A2)
BTA: 521539(MAN2A1) 527449(MAN2A2)
BOM: 102269911(MAN2A2) 102286530(MAN2A1)
BIU: 109562380(MAN2A1) 109575464(MAN2A2)
BBUB: 102393495(MAN2A2) 102396245(MAN2A1)
BBIS: 104989398(MAN2A2) 104991361(MAN2A1)
CHX: 102171012(MAN2A2) 102182591(MAN2A1)
OAS: 101106798(MAN2A2) 101116572(MAN2A1)
BTAX: 128051192(MAN2A1) 128066788(MAN2A2)
CSUM: 138085407(MAN2A1) 138094881(MAN2A2)
ODA: 120863464(MAN2A1) 120875582(MAN2A2)
CCAD: 122419747(MAN2A2) 122439466(MAN2A1)
MREE: 136146875(MAN2A2) 136160246(MAN2A1)
OVR: 110145464(MAN2A2) 110149341(MAN2A1)
MBEZ: 129550300(MAN2A2) 129558808(MAN2A1)
SSC: 100154397(MAN2A2) 100514631(MAN2A1)
CFR: 102512093(MAN2A2) 102513706(MAN2A1)
CBAI: 105069081(MAN2A2) 105082023(MAN2A1)
CDK: 105094696(MAN2A2) 105095392(MAN2A1)
VPC: 102539333(MAN2A1) 102542027(MAN2A2)
BACU: 103020657(MAN2A1) 103021128(MAN2A2)
BMUS: 118890210(MAN2A2) 118892852(MAN2A1)
LVE: 103074675(MAN2A2) 103076739(MAN2A1)
OOR: 101272169(MAN2A1) 101272204(MAN2A2)
LALB: 132516982(MAN2A1) 132525546(MAN2A2)
DLE: 111169626(MAN2A2) 111183761(MAN2A1)
PCAD: 102974194(MAN2A2) 102974411(MAN2A1)
PSIU: 116747493(MAN2A2) 116751733(MAN2A1)
NASI: 112398681(MAN2A1) 112414199(MAN2A2)
ECB: 100053432(MAN2A2) 100064575(MAN2A1)
EPZ: 103546211(MAN2A2) 103551677(MAN2A1)
EAI: 106832048(MAN2A2) 106832412(MAN2A1)
MYB: 102239755(MAN2A2) 102241544(MAN2A1)
MYD: 102760778(MAN2A1) 102764752(MAN2A2)
MMYO: 118656377(MAN2A1) 118679225(MAN2A2)
MLF: 102429994 102435674(MAN2A1) 102439002
MDT: 132222920(MAN2A2) 132233372(MAN2A1)
MYUM: 138998504(MAN2A2) 139008797(MAN2A1)
PKL: 118703963(MAN2A1) 118706308(MAN2A2)
EFUS: 103288792(MAN2A1) 103303009(MAN2A2)
MNA: 107540397(MAN2A2) 107546496(MAN2A1)
DRO: 112305889(MAN2A2) 112307206(MAN2A1)
SHON: 118977338(MAN2A1) 118991941(MAN2A2)
AJM: 119052124(MAN2A2) 119065110(MAN2A1)
PDIC: 114488515(MAN2A2) 114494997(MAN2A1)
PHAS: 123809609(MAN2A2) 123818093(MAN2A1)
MMF: 118640879(MAN2A2) 118642854(MAN2A1)
PPAM: 129073923(MAN2A2) 129083917(MAN2A1)
HAI: 109371540(MAN2A1) 109381472(MAN2A2)
RFQ: 117018934(MAN2A2) 117024814(MAN2A1)
PALE: 102878318(MAN2A1) 102884371(MAN2A2)
PGIG: 120590802(MAN2A1) 120599240(MAN2A2)
PVP: 105295470(MAN2A1) 105302879(MAN2A2)
RAY: 107506530(MAN2A1) 107514130(MAN2A2)
MJV: 108407113(MAN2A1)
TOD: 119244240(MAN2A2) 119260546(MAN2A1)
SARA: 101541026(MAN2A2) 101541110(MAN2A1)
SFUM: 130032727(MAN2A2) 130046160(MAN2A1)
SETR: 126001981(MAN2A1) 126008639 126022401(MAN2A2)
LAV: 100669338(MAN2A1) 100671385(MAN2A2)
TMU: 101344297 101354641
ETF: 101652531(MAN2A2) 101658351(MAN2A1)
DNM: 101436317(MAN2A2) 101439931(MAN2A1)
MDO: 100010442(MAN2A1) 100014504(MAN2A2)
GAS: 123234215(MAN2A2) 123236188(MAN2A1)
SHR: 100913308(MAN2A1) 100922248(MAN2A2)
AFZ: 127551411 127560295
PCW: 110193635(MAN2A2) 110195899(MAN2A1)
TVP: 118828447(MAN2A2) 118828977(MAN2A1)
PBRV: 138161335(MAN2A1) 138169302(MAN2A2)
OAA: 100082559(MAN2A1) 100090754(MAN2A2)
TACU: 119945857(MAN2A2) 119948938(MAN2A1)
GGA: 415585(MAN2A2) 415611(MAN2A1)
PCOC: 116225521(MAN2A2) 116234843(MAN2A1)
MGP: 100539000(MAN2A2) 104915174(MAN2A1)
CJO: 107306350(MAN2A1) 107318993(MAN2A2)
TPAI: 128075423(MAN2A2) 128089486(MAN2A1)
LMUT: 125686853(MAN2A1) 125698331(MAN2A2)
NMEL: 110389397(MAN2A1) 110403851(MAN2A2)
APLA: 101790343(MAN2A2) 101792614(MAN2A1)
ACYG: 106042345(MAN2A1) 106048641(MAN2A2)
CATA: 118255954(MAN2A1) 118259410
AFUL: 116493695(MAN2A2) 116501098(MAN2A1)
TGU: 100226019(MAN2A2) 100227845(MAN2A1)
LSR: 110467593(MAN2A1) 110476670(MAN2A2)
SCAN: 103816135(MAN2A2) 103824196(MAN2A1)
PMOA: 120509098(MAN2A2) 120513740(MAN2A1)
OTC: 121331463(MAN2A1) 121343669(MAN2A2)
PRUF: 121352247(MAN2A2) 121354031(MAN2A1)
ATRC: 139596640(MAN2A2) 139600408(MAN2A1)
GFR: 102041186(MAN2A1) 102041635(MAN2A2)
FAB: 101806895(MAN2A2) 101819402(MAN2A1)
OMA: 130257455(MAN2A2) 130265066(MAN2A1)
PHI: 102101154(MAN2A2) 102113458(MAN2A1)
PMAJ: 107209587(MAN2A2) 107216400(MAN2A1)
CCAE: 111940865(MAN2A1) 111943021(MAN2A2)
CCW: 104683853(MAN2A2) 104693206(MAN2A1)
CBRC: 103611667(MAN2A1) 103618817(MAN2A2)
ACOE: 138103931(MAN2A1) 138116476(MAN2A2)
ETL: 114056033(MAN2A1) 114064253(MAN2A2)
ZAB: 102061220(MAN2A1) 102071919(MAN2A2)
ZLE: 135452215(MAN2A2) 135459817(MAN2A1)
ACHL: 103797001 103812036
SVG: 106853824(MAN2A1) 106860150(MAN2A2)
MMEA: 130574340(MAN2A1) 130575801(MAN2A2)
HRT: 120758869(MAN2A2) 120765291(MAN2A1)
SATI: 136366853(MAN2A2) 136374483(MAN2A1)
CCIC: 134048988(MAN2A2) 134056206(MAN2A1)
FPG: 101913159(MAN2A2) 101921020
FCH: 102048168(MAN2A2) 102050767(MAN2A1)
SHAB: 115612934(MAN2A2) 115619670(MAN2A1)
ACUN: 113484037(MAN2A2) 113489918(MAN2A1)
TALA: 104358494(MAN2A1) 116961121(MAN2A2)
ACHC: 115336851(MAN2A1) 115342030(MAN2A2)
HLE: 104829309(MAN2A1) 104834654(MAN2A2)
AGEN: 126036159 126044133
HHAR: 128136593(MAN2A1) 128151173(MAN2A2)
GCL: 127027130
CSTI: 104553919(MAN2A1)
LDI: 104345790(MAN2A1)
MNB: 103781774
DPUB: 104297367(MAN2A2) 104306042
PPUS: 135173199(MAN2A1) 135183035(MAN2A2)
AVIT: 104279066
BRHI: 104496142(MAN2A1)
EGZ: 104133484(MAN2A2) 104135037(MAN2A1)
NNI: 104017021(MAN2A2) 104022201(MAN2A1)
PADL: 103914784(MAN2A2) 103920875(MAN2A1)
AFOR: 103899825(MAN2A2) 103903072(MAN2A1)
GSTE: 104259095
CLV: 102090971(MAN2A2) 102097702(MAN2A1)
PLET: 104624182(MAN2A2)
EHS: 104506599
CUCA: 104056420(MAN2A2)
TEO: 104374022(MAN2A1)
OHA: 104337837(MAN2A1)
CPEA: 104385796(MAN2A2) 104397284(MAN2A1)
CVF: 104282395(MAN2A1) 104284686(MAN2A2)
RTD: 128902300(MAN2A1) 128915165(MAN2A2)
CRID: 134508444(MAN2A1) 134520910(MAN2A2)
AAM: 106491449(MAN2A2)
AROW: 112964263(MAN2A1) 112976300(MAN2A2)
NPD: 112948334(MAN2A2) 112951728(MAN2A1)
TGT: 104580109(MAN2A1)
DNE: 112994987(MAN2A2) 112995230(MAN2A1)
SCAM: 104150970(MAN2A1) 104151025(MAN2A2)
ASN: 102369470(MAN2A1) 102383379(MAN2A2)
AMJ: 102561641(MAN2A1) 102566705(MAN2A2)
CPOO: 109308162(MAN2A1)
GGN: 109297471(MAN2A1)
PSS: 102459905(MAN2A1)
CMY: 102941559(MAN2A2) 102944199(MAN2A1)
CCAY: 125636418(MAN2A1) 125643432(MAN2A2)
DCC: 119855693(MAN2A1) 119863076(MAN2A2)
CPIC: 101937670 101953630(MAN2A2)
TST: 117878692(MAN2A1) 117884331(MAN2A2)
CABI: 116814770(MAN2A1) 116833017(MAN2A2)
MRV: 120373280(MAN2A2) 120407767(MAN2A1)
ACS: 100555933(man2a1) 100568077(man2a2)
ASAO: 132762458(MAN2A2) 132767194(MAN2A1)
PVT: 110072017(MAN2A1) 110084439(MAN2A2)
SUND: 121924154(MAN2A1) 121933219(MAN2A2)
PBI: 103053695(MAN2A1) 103058391(MAN2A2)
PMUR: 107289784(MAN2A2) 107293675(MAN2A1)
CTIG: 120305939(MAN2A1) 120316415(MAN2A2)
TSR: 106543694(MAN2A1) 106553803(MAN2A2)
PGUT: 117674626(MAN2A1) 117676225(MAN2A2)
APRI: 131184847(MAN2A2) 131190475(MAN2A1)
PTEX: 113441970(MAN2A2) 113448933(MAN2A1)
NSS: 113415592(MAN2A1) 113423348(MAN2A2)
VKO: 123030714(MAN2A2) 123031172(MAN2A1)
PMUA: 114584355(MAN2A2) 114606107(MAN2A1)
PRAF: 128401365(MAN2A2) 128423003(MAN2A1)
ZVI: 118076729(MAN2A1) 118092868(MAN2A2)
HCG: 128334883(MAN2A2) 128343434(MAN2A1)
GJA: 107120457(MAN2A1) 107125467(MAN2A2)
STOW: 125424513(MAN2A2) 125436400(MAN2A1)
EMC: 129334247(MAN2A1) 129345420(MAN2A2)
XLA: 108707218(man2a1.S) 108712863(man2a2.S) 108717353(man2a1.L) 443991(man2a2.L)
XTR: 100036612(man2a1) 448465(man2a2)
NPR: 108789334(MAN2A1) 108798147(MAN2A2)
RTEM: 120931239(MAN2A2) 120931614(MAN2A1)
BBUF: 120985902(MAN2A2) 120992563(MAN2A1)
BGAR: 122924645(MAN2A1) 122927556(MAN2A2)
PWL: 138284159(MAN2A2) 138285897(MAN2A1)
MUO: 115459854(MAN2A2) 115463184(MAN2A1)
GSH: 117348402(MAN2A2) 117352594(MAN2A1)
DRE: 100333987(man2a2) 560219(man2a1)
SRX: 107720774 107721641(man2a1) 107750719 107751258
SANH: 107663767 107670215 107673231(man2a2) 107691725(man2a1)
SGH: 107564047(man2a1) 107564609 107581805 107603169
CCAR: 109051095 109061037 109078545(man2a1) 122134346(man2a2)
CAUA: 113043692 113049817 113066713 113082394
CGIB: 127946829 127958588 127994174 128014540
PTET: 122330519(man2a2) 122345307(man2a1)
LROH: 127156867(man2a2) 127164981(man2a1)
OMC: 131534202(man2a2) 131540636(man2a1)
PPRM: 120468300(man2a2) 120472040(man2a1)
RKG: 130073650(man2a2) 130086772(man2a1)
MAMB: 125246718(man2a2) 125267915(man2a1)
CIDE: 127506522 127512194
CERY: 137014678(man2a2) 137033700(man2a1)
MASI: 127426773 127435890 127437632 127439837
TROS: 130551908(man2a2) 130564495(man2a1)
TDW: 130414186(man2a2) 130418969(man2a1)
MANU: 129434111(man2a2) 129440807(man2a1)
PDAB: 135774180(man2a1) 135781193 135787757
IPU: 108274717
IFU: 128618098(man2a2)
PHYP: 113529699(man2a2)
SMEO: 124392803(man2a2)
TFD: 113660003(man2a2)
TVC: 132856545(man2a2)
CGAR: 128514796(man2a2)
NGRA: 132881932(man2a2)
TRN: 134309856(man2a2)
AMEX: 103023301(man2a1) 103041860(man2a2)
CMAO: 118811581(man2a2) 118814604(man2a1)
EEE: 113572463 113588518(man2a2)
CHAR: 105891042(man2a1) 105900766(man2a2)
SPIL: 134094048(man2a2) 134100933(man2a1)
TRU: 101061792(man2a2) 101077627(man2a1)
TFS: 130517573(man2a1) 130536873(man2a2)
TNG: GSTEN00003927G001 GSTEN00022835G001
LCO: 104925267(man2a2) 104932414
NCC: 104944004(man2a2)
TBEN: 117475808 117491582(man2a2) 117491941
PGEO: 117447933(man2a2)
GACU: 117545751(man2a2) 117562801
EMAC: 134868627(man2a1) 134877465(man2a2)
ELY: 117262193(man2a2) 117270133(man2a1)
EFO: 125887197(man2a2) 125906294(man2a1)
PLEP: 121949968(man2a2) 121959715(man2a1)
SLUC: 116038801(man2a2) 116065613
ECRA: 117949100(man2a2) 117959781(man2a1)
ESP: 116694124(man2a2)
PFLV: 114552021 114560151(man2a2) 114570585(man2a1)
GAT: 120809442(man2a2) 120812180 120831692(man2a1)
PPUG: 119196376(man2a2) 119226927(man2a1)
AFB: 129102709(man2a1) 129108212(man2a2)
CLUM: 117732108(man2a2) 117740498(man2a1)
PSWI: 130205721(man2a1)
CANA: 137779318(man2a1) 137804003(man2a2)
CVE: 137869407(man2a1) 137880843(man2a2)
MSAM: 119893108(man2a2) 119914086 119914087
SCHU: 122865858(man2a1) 122875582(man2a2)
CUD: 121514902(man2a2) 121524694(man2a1)
SPUL: 138601975(man2a1) 138613074(man2a2)
LMIX: 132973239(man2a2) 132992639(man2a1)
ALAT: 119024918(man2a2) 119030211(man2a1)
ASTR: 137593836(man2a2) 137608774(man2a1)
MZE: 101474154 101483319(man2a2)
ONL: 100708597(man2a2) 102081444
OAU: 116321290 116335402(man2a2)
OLA: 101158104(man2a2) 101174073
OML: 112152466(man2a2) 112162978(man2a1)
CSAI: 133444057(man2a2) 133455504(man2a1)
XMA: 102218498(man2a1) 102232197(man2a2)
XCO: 114136954 114155110(man2a2)
XHE: 116724829(man2a1) 116733889(man2a2)
PRET: 103460455(man2a1) 103466353(man2a2)
PFOR: 103131079(man2a1) 103133657(man2a2)
PLAI: 106943897 106945048(man2a2)
PMEI: 106909111 106927549(man2a2)
GAF: 122819277(man2a1) 122835727(man2a2)
PPRL: 129356208 129356960 129361968(man2a2)
CVG: 107098036(man2a1) 107104235(man2a2)
CTUL: 119774472(man2a1) 119793068(man2a2)
GMU: 124872651(man2a1) 124884982(man2a2)
NFU: 107374983(man2a1) 107388979(man2a2)
KMR: 108228395 108239965(man2a2)
ALIM: 106515631(man2a2) 106536243
NWH: 119415567(man2a2) 119424942
AOCE: 111563148(man2a2) 111564348(man2a1)
EJA: 138206355(man2a2) 138209199(man2a1)
BFRE: 138622277(man2a1) 138622823(man2a2)
MCEP: 124996980(man2a1) 125014490(man2a2)
CSEM: 103380513(man2a2) 103390365(man2a1)
POV: 109624583(man2a2) 109642276
SSEN: 122775906(man2a2) 122776385
SSOE: 131446270(man2a1) 131469770(man2a2)
HHIP: 117762833(man2a2) 117771297(man2a1)
HSP: 118109956(man2a2) 118125907(man2a1)
PPLT: 128424578(man2a1) 128443965(man2a2)
SMAU: 118284525(man2a1) 118315804(man2a2)
LCF: 108874626 108875305
SDU: 111228707(man2a2) 111238819(man2a1)
SLAL: 111651803 111655358(man2a2)
XGL: 120792691(man2a2) 120806732(man2a1)
HCQ: 109530362(man2a2)
SSCV: 125971370(man2a2)
SBIA: 133501778(man2a2)
PEE: 133403077(man2a2)
PTAO: 133477757(man2a2)
BPEC: 110153167 110165893(man2a2)
ENY: 140349552(man2a2) 140367073(man2a1)
MALB: 109968742(man2a2) 109973112(man2a1)
BSPL: 114856995(man2a2) 114867106(man2a1)
SJO: 128358721(man2a2) 128379782(man2a1)
SSCO: 133981461(man2a2) 133995035(man2a1)
GMH: 115550557(man2a2)
SASA: 106561301 106562091(man2a1) 106568341 106573342(man2a2)
STRU: 115149336 115152135(man2a2) 115159214(man2a1) 115197323
OTW: 112214463(man2a1) 112218991 112252518 112257442
OMY: 110522404(man2a2) 110523878 110536799
OGO: 124000099 124002196 124048631(man2a1)
ONE: 115105938 115109522(man2a2) 115126674
OKI: 109868056(man2a1) 109889493(man2a2) 109892411
OKE: 118387850 118391493 118396027(man2a2) 118401132
OMM: 135517676(man2a1) 135524268(man2a2) 135548195
OCLA: 139406672 139408866 139422779
SALP: 111952337(man2a2) 111961325(man2a1) 111962448 111981710
SNH: 120025911 120044213 120054035 120065912(man2a2)
CCLU: 121532213 121574167 121577036 121582802
ELS: 105018384(man2a2) 105027936(man2a1)
OEP: 134021281(man2a2) 134034415(man2a1)
SFM: 108932015(man2a1) 108941123(man2a2)
PKI: 111835779(man2a1) 111845078(man2a2)
AANG: 118212479(man2a1) 118227271(man2a2)
AROT: 135239135(man2a1) 135255487(man2a2)
CCOG: 133130906(man2a2) 133142312(man2a1)
LOC: 102691193(man2a2) 102696037(man2a1)
PSPA: 121294610 121299015 121301854 121315950
ARUT: 117409290 117428313 117429435 117973182
PSEX: 120532080(man2a1) 120541429(man2a2)
LCM: 102355620 102360088(MAN2A2)
CMK: 103178412(man2a1) 103188552(man2a2)
RTP: 109930439(man2a2) 109938999(man2a1)
CPLA: 122542573(man2a2) 122560138(man2a1)
HOC: 132823439(man2a1) 132834639(man2a2)
LERI: 129695847(man2a1) 129713516(man2a2)
PMRN: 116941070(MAN2A2) 116942119
LRJ: 133343643 133346779
BFO: 118411916
BBEL: 109468568
CIN: 100180083
SCLV: 120343811
SPU: 594620
LPIC: 129257693
AJJ: 139966819
APLC: 110979321
ARUN: 117288503
AAMU: 139936959
AFIL: 140142635
AJC: 117125135
SKO: 102802038
PFLL: 139123588 139123815
DME: Dmel_CG18802(alpha-Man-IIa)
DER: 6552301
DSE: 6607114
DSI: Dsimw501_GD18615(Dsim_GD18615)
DYA: Dyak_GE25950
DAN: 6500000
DSR: 110191164
DPO: 4800594
DPE: 6595142
DMN: 108155782
DWI: 6647583
DGR: 6563084
DMO: Dmoj_GI24010
DAZ: 108614123
DNV: 108653307
DHE: 111593673
DVI: 6629947(alpha-Man-IIa)
CCAT: 101462695
BOD: 106615218
BDR: 105225843
RZE: 108378692
AOQ: 129235669
ALUD: 128855020
TDA: 119663712 119663713 119679537 119679563 119679940 119684395
MDE: 101898268 131805876
SCAC: 106086721
LCQ: 111685869
LSQ: 119601914
CVJ: 135964169(alpha-Man-IIa)
GFS: 119635041
ECOE: 129939611
CLON: 129614464
HIS: 119651272 119652370
AGA: 1278838
ACOZ: 120949537
AARA: 120895003
AMER: 121587851
ASTE: 118503462
AMAP: 126556836
AFUN: 125764931
AMOU: 128299381
AMRS: 128719831
AALI: 118457399
ACOS: 131260710
AAG: 5575653
AALB: 109402419 109405454
ASUA: 134225723
CQU: CpipJ_CPIJ009720
CPII: 120423830
CNS: 116349279
BCOO: 119070080
LLL: 129791679
PPAP: 129805990
AME: 552382
ACER: 107994422
ALAB: 122714930
ADR: 102679465
AFLR: 100863782
BIM: 100749601
BBIF: 117205087
BVK: 117231097
BVAN: 117157558
BHUN: 126871620
BTER: 100646824
BAFF: 126921954
BPYO: 122567772
BPAS: 132912694
FVI: 122538581
CCAL: 108623658
OBB: 114880562
OLG: 117603026
MGEN: 117224144
NMEA: 116423930
CGIG: 122398868
SOC: 105198479
MPHA: 105836778
AEC: 105154407
ACEP: 105623777
PBAR: 105423365
VEM: 105565777
COBS: 139108234(Alpha-man-iia)
TLN: 139822588(Alpha-man-iia)
HST: 105190974
DQU: 106750368
CFO: 105253605
FEX: 115237693
PMEC: 138944080(Alpha-man-iia)
LHU: 105674564(alpha-Man-IIa)
PGC: 109851679
OBO: 105274664
PCF: 106789840
PFUC: 122513263
VPS: 122636855
VCRB: 124430970
VVE: 124956883
NVI: 100116564
CSOL: 105364669
TPRE: 106650757
LHT: 122504425
LBD: 127281187
MDL: 103577084 103579008
CGLO: 123259501 123274900
FAS: 105270282
DAM: 107035984
AGIF: 122857485 122857617
CINS: 118073819
VCAN: 122410275
CCIN: 107264491
DSM: 124407997
NPT: 124216049(alpha-Man-IIa)
NFB: 124180581
NLO: 107224161
NVG: 124302073
AROA: 105693438
TCA: 660728
TMOL: 138123014(alpha-Man-IIa)
DPA: 109544976
ESIM: 136419647(alpha-Man-IIa)
EFOR: 136341718(alpha-Man-IIa)
SOY: 115888958
AGRG: 126742788
ATD: 109605290
CSET: 123307622
HAXR: 123679073
AGB: 108912629
LDC: 111514244
DVV: 126880396
NVL: 108562674
APLN: 108743170 108743178
PPYR: 116159269
OTU: 111420892
BMOR: 101742043
BMAN: 114250890
MSEX: 115449114 119189147
DPL: KGM_214574
BANY: 112058378
MJU: 123875010
NIQ: 126775935
VCD: 124538591
MCIX: 123662181
PMAC: 106721685
PPOT: 106103852
PXU: 106120187
BPHI: 137919679(alpha-Man-IIa)
PRAP: 110993078
PBX: 123716701
PNAP: 125063158
ZCE: 119828502
CCRC: 123699655
LSIN: 126970230
AAGE: 121726058
HAW: 110380432
HZE: 124640060
TNL: 113499077
SLIU: 111350250
OFU: 114356108
ONU: 135080887
ATRA: 106136241
GMW: 113519805
PXY: 105380392
PGW: 126374824
LGLY: 125232524
CSTB: 134748635
CFEL: 113385536
CCRN: 123292918
API: 100169064
DNX: 107161638
AGS: 114131656
RMD: 113555742
ACOO: 126834595
DVT: 126906382
BTAB: 109044339
CLEC: 106666206
HHAL: 106677705 106677835
NLU: 111054344
HVI: 124353043
MQU: 128986337
PHU: Phum_PHUM459490
FOC: 113214831
TPAL: 117650266
ZNE: 110835247
CSEC: 111868354
SGRE: 126340516
BROR: 134535806
IEL: 124163701
HAMR: 139696814(alpha-Man-IIa)
FCD: 110848037
DMK: 116923686
DPZ: 124315071
AFRA: 136033445 136038119
PVM: 113815567
PJA: 122246341
PCHN: 125044374
PMOO: 119578776
HAME: 121876770
PCLA: 123775118
CQD: 128694208
PTRU: 123514813
ESN: 126982525
MNZ: 135195825
MRJ: 136838536
PORN: 139746483(alpha-Man-IIa)
HAZT: 108678706
EAF: 111710355
LSM: 121120461(alpha-Man-IIa)
TCF: 131889120
PPOI: 119095240 119095241
DSV: 119456041
RSAN: 119393875
RMP: 119172694
VDE: 111246456
VJA: 111261034
TUT: 107360206
DPTE: 113797886
DFR: 124494692
CSCU: 111620191 111620547
CVS: 136973723(alpha-Man-IIa) 136987077
PTEP: 107455528
ABRU: 129958148
UDV: 129231375 129232560 129233569
SDM: 118186080 118200216 118204655
LPOL: 106464502 106465597 106467018 106468759
PMEO: 129590602 129598492 129599344 129599393
CEL: CELE_F58H1.1(aman-2)
CBR: CBG_23330(Cbr-aman-2)
CRQ: GCK72_018141
NAI: NECAME_08623 NECAME_08624
BMY: BM_BM4567(Bma-aman-2)
LOA: LOAG_06074 LOAG_08114 LOAG_18290
TSP: Tsp_10745
HRO: HELRODRAFT_110840
LGI: LOTGIDRAFT_164424 LOTGIDRAFT_188902
PVUL: 126814437 126821931
PCAN: 112556419 112570581 112570746
LSAX: 138950477 138953633 138953807
BGT: 106053755 106061128 106069804
GAE: 121371265 121373761 121384824
HRF: 124122870 124143923 124148741
HRJ: 124255342 124260264 124285348
HASI: 137260464 137293619 137293738
HCRA: 139443932 139444032 139461023
CRG: 105331810 105332200 105341572 117687453
CANU: 128164504 128171314 128176071 128176081
CVN: 111113429 111118581 111119558 111128282 111128909
OED: 125652552 125652850 125667404 125670941
MYI: 110442311 110449962 110450072 110450325 110454737 110465474
PMAX: 117314924 117323212 117324211 117324627 117326963
AIRR: 138306694 138318617 138318651 138319084 138324008
MCAF: 127722088
MMER: 123530261 123530275 123531139 123537102 123537266 123541858 123541918 123543018 123546697 123550153 123553765 123560815
RPHI: 132715898 132727022 132728908 132735624 132742306 132742637 132742860 132748309 132749472 132750378 132759591
DPOL: 127834601 127860058 127865646 127871286 127872109 127872786 127873344
MAEA: 128207835 128207836 128208889 128208946 128211246 128213111 128213583 128217244 128219229 128220757 128222038 128228614
OBI: 106875435 106875688
OSN: 115231032 115231539
LJP: 135467195 135467754 135478124
LAK: 106153188 106156030 106166353 106176305
SMM: Smp_143430
SHX: MS3_00009069(MAN2A1_1)
OVI: T265_07096
EGL: EGR_08871
LLON: 135484178 135484882 135485130 135498633
NVE: 5512609
EPA: 110234138
ATEN: 116299384
ADF: 107347367
AMIL: 114961754
MCAZ: 138042570
MFOO: 138007675
PDAM: 113670726
SPIS: 111324658
DGT: 114525319
XEN: 124451115
HMG: 100198326 100202382
HSY: 130644326
RES: 135690200
TAD: TRIADDRAFT_60265
ATH: AT5G14950(GMII)
ALY: 9309767
CRB: 17881567
CSAT: 104709139 104735512 104769734
EUS: EUTSA_v10012487mg
BRP: 103850958 103856103
BNA: 106429929 106431756 111204299
BOE: 106327011 106334765
RSZ: 108842391 108847660
THJ: 104821170
CIT: 102615196
CIC: CICLE_v10014083mg
PVY: 116142958
MINC: 123195543
TCC: 18601342
GRA: 105768375 105798286
GHI: 107888651 107892313 107955563 107958597
GAB: 108454878 108457471
HSYR: 120147408 120171969
DZI: 111291640 111316658
EGR: 104422581
RARG: 115741322
GMX: 100806647 100811858
GSJ: 114381996 114398155
PVU: 137836837
VRA: 106770832
VAR: 108345656
VUN: 114180334
VUM: 124833975
CCAJ: 109817438
APRC: 113867315
MTR: 11439146
TPRA: 123906481
CAM: 101499632(MAN2A2)
PSAT: 127122848
VVO: 131627041 131652785
LJA: 130739293
ADU: 107471073
AIP: 107622688
AHF: 112716315 112784225
LANG: 109335920 109347307 109347309
PCIN: 129302384 129305873
QSA: O6P43_004554 O6P43_009021
FVE: 101296768
AANS: 126801174
RCN: 112184196
PPER: 18782416
PMUM: 103329931
PAVI: 110756683
PDUL: 117620960
MDM: 103404378 103442297
MSYL: 126583615 126610645
PXB: 103928463
PCOX: 137740124 137749536
ZJU: 107415425
MNT: 21393801
CSAV: 133030347
CSV: 101208332
CMO: 103487047
BHJ: 120090184
MCHA: 111018346
CMAX: 111469337 111482230
CMOS: 111433153 111441463
CPEP: 111790312 111792352
RCU: 8280600
MEAN: 126672961
JCU: 105642251
HBR: 110641257 110654833
MESC: 110601253
POP: 18095306 7495932
PEU: 105114251 105141682
PALZ: 118036907 118058267
PNZ: 133671129 133699733
JRE: 108992841
CILL: 122302525
CAVE: 132180583
AGLU: 133859778
QSU: 111999605
QLO: 115976745
TWL: 120008882
VVI: 100243903
VRI: 117929602
SLY: 101266287
SPEN: 107011510
SOT: 102605224
SSTN: 125846408
SDUL: 129872278
CANN: 107860595
LBB: 132623099
NTA: 107777832 107829947
NSY: 104211404
NTO: 104108022
NAU: 109205422
INI: 109158199 109180593
ITR: 116000145 116012756
SIND: 105177181
OEU: 111409226
EGT: 105968893
SSPL: 121767131 121771656
SMIL: 130989517
SHIS: 125205490
APAN: 127242012 127257835
HAN: 110903921
ECAD: 122603697
LSV: 111891915
CCAV: 112523600
DCR: 108214457
CSIN: 114263477 114296797
RVL: 131302330
AEW: 130769312 130776973
DLT: 127803433
BVG: 104905356
SOE: 110786831
CQI: 110715303 110724888
ATRI: 130802356
MOF: 131160561
NNU: 104607979
MING: 122075952 122079250
TSS: 122654368 122670711
PSOM: 113276377 113343777
OSA: 4340636
DOSA: Os06g0245700
OBR: 102707404
OGL: 127776136
BDI: 100822520
ATS: 109783252
TDC: 119329460 119336349
TAES: 123149332 123156793 123165270
TUA: 125522393
LPER: 127317442
LRD: 124685381 124685461
SBI: 8061493
ZMA: 100502340 103629954
MFLO: 136522945
SITA: 101761357
SVS: 117852889
PVIR: 120669859 120703002
PHAI: 112889969
PAUA: 133926596 133930537
PDA: 103710003
EGU: 105039124 105050069
MUS: 135616559
ZOF: 122008780 122017400
DCT: 110092430
PEQ: 110026121
AOF: 109820905
MSIN: 131258333
ACAK: 137941054
NCOL: 116250575 116258674
ATR: 18446724
CJF: 131065615
SMO: SELMODRAFT_104910 SELMODRAFT_116442 SELMODRAFT_154366 SELMODRAFT_228
PPP: 112275693
SRE: PTSG_03147 PTSG_07075 PTSG_11582
DPP: DICPUDRAFT_45100 DICPUDRAFT_74852
DFA: DFA_02000 DFA_07693(manD)
ACAN: ACA1_068820
TET: TTHERM_00230960
FCY: FRACYDRAFT_250184
NGR: NAEGRDRAFT_57722
 » show all
Reference
1  [PMID:863880]
  Authors
Tulsiani DR, Opheim DJ, Touster O.
  Title
Purification and characterization of alpha-D-mannosidase from rat liver golgi membranes.
  Journal
J Biol Chem 252:3227-33 (1977)
Reference
2  [PMID:212436]
  Authors
Tabas I, Kornfeld S
  Title
The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides.
  Journal
J Biol Chem 253:7779-86 (1978)
Reference
3  [PMID:6445359]
  Authors
Harpaz N, Schachter H.
  Title
Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi alpha-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I.
  Journal
J Biol Chem 255:4894-902 (1980)
Reference
4  [PMID:7061502]
  Authors
Tulsiani DR, Hubbard SC, Robbins PW, Touster O.
  Title
alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
  Journal
J Biol Chem 257:3660-8 (1982)
Reference
5  [PMID:1757461]
  Authors
Moremen KW, Robbins PW
  Title
Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to  complex N-glycans.
  Journal
J Cell Biol 115:1521-34 (1991)
DOI:10.1083/jcb.115.6.1521
  Sequence
[hsa:4124] [mmu:17158]
Reference
6  [PMID:8524845]
  Authors
Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN
  Title
Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.
  Journal
Proc Natl Acad Sci U S A 92:11766-70 (1995)
DOI:10.1073/pnas.92.25.11766
  Sequence
[hsa:4124 4122]
Reference
7  [PMID:11406577]
  Authors
van den Elsen JM, Kuntz DA, Rose DR
  Title
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.
  Journal
EMBO J 20:3008-17 (2001)
DOI:10.1093/emboj/20.12.3008
  Sequence
[dme:Dmel_CG18802]
Reference
8  [PMID:15721331]
  Authors
Athanasopoulos VI, Niranjan K, Rastall RA.
  Title
The production, purification and characterisation of two novel alpha-D-mannosidases from Aspergillus phoenicis.
  Journal
Carbohydr Res 340:609-17 (2005)
DOI:10.1016/j.carres.2005.01.005
Reference
9  [PMID:18599462]
  Authors
Shah N, Kuntz DA, Rose DR
  Title
Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic  site.
  Journal
Proc Natl Acad Sci U S A 105:9570-5 (2008)
DOI:10.1073/pnas.0802206105
  Sequence
[dme:Dmel_CG18802]
Reference
10 [PMID:22819743]
  Authors
Rose DR
  Title
Structure, mechanism and inhibition of Golgi alpha-mannosidase II.
  Journal
Curr Opin Struct Biol 22:558-62 (2012)
DOI:10.1016/j.sbi.2012.06.005
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.114
IUBMB Enzyme Nomenclature: 3.2.1.114
ExPASy - ENZYME nomenclature database: 3.2.1.114
BRENDA, the Enzyme Database: 3.2.1.114
CAS: 82047-77-6
LinkDB

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