KEGG   ENZYME: 3.2.1.33
Entry
EC 3.2.1.33                 Enzyme                                 
Name
amylo-alpha-1,6-glucosidase;
amylo-1,6-glucosidase;
dextrin 6-alpha-D-glucosidase;
amylopectin 1,6-glucosidase;
dextrin-1,6-glucosidase;
glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
glycogen phosphorylase-limit dextrin 6-alpha-glucohydrolase
Reaction(IUBMB)
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin
Reaction(KEGG)
(other) R02109 R06158(G)
Comment
This enzyme hydrolyses an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain. The enzyme activity found in mammals and yeast is in a polypeptide chain containing two active centres. The other activity is similar to that of EC 2.4.1.25 (4-alpha-glucanotransferase), which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyse. Together, these two activities constitute the glycogen debranching system.
History
EC 3.2.1.33 created 1965, modified 2000
Orthology
K01196  glycogen debranching enzyme
Genes
HSA178(AGL)
PTR469392(AGL)
PPS100970156(AGL)
GGO101124513(AGL)
PON100462408(AGL)
NLE100607309(AGL)
MCC710910(AGL)
MCF102141897(AGL)
MTHB126947693
CSAB103224377(AGL)
CATY105590153(AGL)
PANU101009695(AGL)
TGE112635037(AGL)
RRO104673244(AGL)
RBB108524169(AGL)
TFN117075120(AGL)
PTEH111525759(AGL)
CJC100393172(AGL)
SBQ101049181(AGL)
CSYR103267113(AGL)
MMUR105862376(AGL)
LCAT123635361(AGL)
OGA100964110(AGL)
MMU77559(Agl)
MCAL110290945(Agl)
MPAH110319888(Agl)
RNO362029(Agl)
MCOC116093690(Agl)
MUN110551860(Agl)
CGE100772306(Agl)
MAUA101834646(Agl)
PLEU114707438(Agl)
MORG121448373(Agl)
MFOT126498378
AAMP119800747(Agl)
NGI103734650(Agl)
HGL101717426(Agl)
CPOC100721296(Agl)
CCAN109691863
DORD105997118(Agl)
DSP122110393(Agl)
NCAR124982601
OCU100009066(AGL)
OPI101536321(AGL)
TUP102486200(AGL)
CFA479931(AGL)
CLUD112640786(AGL)
VVP112918465(AGL)
VLG121486801(AGL)
AML100478160(AGL)
UMR103669338(AGL)
UAH113254363(AGL)
UAR123795170(AGL)
ELK111143215
LLV125096917
MPUF101687415(AGL)
ORO101374591(AGL)
EJU114208047(AGL)
ZCA113917026(AGL)
MLX118019096(AGL)
NSU110580561(AGL)
FCA101086077(AGL)
PYU121027547(AGL)
PBG122480826(AGL)
LRUF124515294
PTG102963048(AGL)
PPAD109271910(AGL)
AJU106976407(AGL)
HHV120229450(AGL)
BTA517397(AGL)
BOM102270729(AGL)
BIU109556025(AGL)
BBUB102396028(AGL)
CHX102178874(AGL)
OAS101111501(AGL)
ODA120856809(AGL)
CCAD122436647(AGL)
CFR102515206(AGL)
CBAI105065350(AGL)
CDK105085047(AGL)
VPC102534130(AGL)
BACU103004932(AGL)
LVE103085945(AGL)
OOR101281941(AGL)
DLE111180126(AGL)
PCAD102980196(AGL)
PSIU116753134(AGL)
ECB100050695(AGL)
EPZ103540873(AGL)
EAI106837787(AGL)
MYB102252935(AGL)
MYD102755651(AGL)
MMYO118672977(AGL)
MLF102425936(AGL)
MNA107530672(AGL)
PKL118727490(AGL)
HAI109374607(AGL)
DRO112314089(AGL)
SHON118990640(AGL)
AJM119054905(AGL)
PDIC114488807(AGL)
PHAS123833470(AGL)
MMF118637295(AGL)
RFQ117014584(AGL)
PALE102880281(AGL)
PGIG120607830(AGL)
PVP105298178(AGL)
RAY107504281(AGL)
MJV108388161(AGL)
TOD119235334(AGL)
SARA101543591(AGL)
LAV100659336(AGL)
TMU101343034
DNM101421048(AGL)
MDO100032952(AGL)
GAS123243944(AGL)
SHR100934625(AGL)
PCW110217353(AGL)
OAA100081547(AGL)
GGA424474(AGL)
PCOC116243483(AGL)
MGP100551267(AGL)
CJO107317427(AGL)
NMEL110402482(AGL)
APLA101794374(AGL)
ACYG106039458(AGL)
AFUL116491743(AGL)
TGU100217722(AGL)
LSR110467898(AGL)
SCAN103814871(AGL)
PMOA120506577(AGL)
OTC121344967(AGL)
PRUF121362239(AGL)
GFR102034726(AGL)
FAB101815607(AGL)
PHI102100235(AGL)
PMAJ107208094(AGL)
CCAE111932714(AGL)
CCW104695373(AGL)
CBRC103612579(AGL)
ETL114061659(AGL)
ZAB102069680(AGL)
ACHL103804557(AGL)
FPG101911809(AGL)
FCH102054834(AGL)
CLV102084204(AGL)
EGZ104134027(AGL)
NNI104015510(AGL)
PLET104621062(AGL)
PCRI104034119(AGL)
ACUN113482581(AGL)
TALA104368753(AGL)
PADL103925100(AGL)
AFOR103908124(AGL)
ACHC115349229(AGL)
HALD104315418(AGL)
CCRI104167684(AGL)
CSTI104550061(AGL)
EHS104513779(AGL)
CMAC104482712(AGL)
MUI104541882(AGL)
FGA104080910(AGL)
GSTE104251000(AGL)
LDI104340356(AGL)
MNB103769146(AGL)
OHA104332575(AGL)
NNT104406891(AGL)
DPUB104307035(AGL)
PGUU104470131(AGL)
ACAR104518251(AGL)
AVIT104274882(AGL)
CVF104286192(AGL)
AAM106499569(AGL)
AROW112961937(AGL)
NPD112946107(AGL)
TGT104566926(AGL)
DNE112979779(AGL)
SCAM104151251
ASN102369862(AGL)
AMJ102570293(AGL)
CPOO109306970(AGL)
GGN109286872(AGL)
PSS102446584(AGL)
CMY102947904(AGL)
CPIC101952161(AGL)
TST117882211(AGL)
CABI116839209(AGL)
MRV120369978(AGL)
ACS100565632(agl)
PVT110086303(AGL)
SUND121927948(AGL)
PBI103050283(AGL)
PMUR107290193(AGL)
CTIG120312059(AGL)
TSR106539927(AGL)
PGUT117677202(AGL)
VKO123024506(AGL)
PMUA114598754(AGL)
ZVI118088334(AGL)
GJA107119045(AGL)
STOW125432681(AGL)
XLA108715682(agl.S) 779381(agl.L)
XTR780065(agl)
NPR108799770(AGL)
RTEM120945778(AGL)
BBUF120978905(AGL)
BGAR122944260(AGL)
DRE567798(agla)
SRX107712821 107718145 107722579 107739006
SANH107693749(agl) 107697901
SGH107548909 107589898 107590314 107590315 107594650(agl)
CCAR109053523 109110256
CAUA113045793 113093821 113115849
PPRM120478505 120481972(agla)
MAMB125251584(agla) 125257930
IPU108272764 108277686 108277899(agla)
PHYP113533703 113539206(agl)
SMEO124384950 124394637(agla)
TFD113643453(agla) 113663728
AMEX103029371 103032775
EEE113586563 113588063(agl)
TRU101071621(agl)
TNGGSTEN00033680G001
LCO104934804
NCC104947281 104957520(agl)
CGOB115022457 115025484
ELY117272125(agla)
EFO125902778(agla)
PLEP121951216
SLUC116043967(agla) 116055780
ECRA117937719 117953970
ESP116671907 116699345
PFLV114549238 114565141(agl)
GAT120816025(agla)
PPUG119209110(agla)
MSAM119902607(agla)
CUD121520008(agla)
ALAT119010827(agla)
MZE101474686(agl)
ONL100703226(agl)
OAU116311490(agla)
OLA101163765(agl)
OML112144421(agla)
XMA102230673(agl)
XCO114146159(agl)
XHE116721402(agl)
PRET103479203(agl)
PFOR103129993(agl)
GAF122840792(agla)
CVG107099264 107103298(agl)
CTUL119794130(agla)
GMU124869704(agla)
NFU107384360(agl)
KMR108248238(agla)
ALIM106510843 106523907
NWH119414865(agla)
AOCE111578483(agl)
MCEP125010480(agla)
CSEM103396633(agl)
POV109643969(agl)
SSEN122759958 122772849 122781471
HHIP117777807(agla)
HSP118118396(agla)
LCF108885336 108898788
SDU111233892(agl) 111237619
SLAL111648380(agl) 111665497
XGL120798587(agla)
HCQ109521259(agl)
BPEC110155709(agl)
MALB109953042(agl)
BSPL114844675 114844762
SASA106568905 106578509 106599117
STRU115153237 115156796 115169902
OTW112215549 112227058(agla) 112260354
OMY110508855(agla) 110530174 110535501
OGO123991177 124009671
ONE115103201 115105065 115114284
SALP111956742 111973033 111978993
SNH120020446 120028117 120055831
CCLU121535098 121549916 121580813(agla)
ELS105007682(agl)
SFM108935200
PKI111858465(agl)
AANG118226618 118230160(agla)
LOC102684736(agl)
PSPA121326705 121330871
ARUT117412199 117417034
LCM102354072(AGL)
CMK103174627(agla)
RTP109918362(agl)
BFO118431363
BBEL109475173
CIN100181714
SCLV120346827
SPU592988
APLC110977745
SKO102803842
DMEDmel_CG9485(CG9485)
DER6547862
DSE6615352
DSIDsimw501_GD11587(Dsim_GD11587)
DYADyak_GE12190
DAN6495657
DSR110180042
DPO4803778
DPE6590563
DMN108159067
DWI6640393
DGR6560790
DMODmoj_GI19003
DAZ108616386
DNV108654556
DHE111593735
DVI6625866
CCAT101461022
BOD106620920
RZE108367530
MDE101894191
SCAC106087675
LCQ111685094
LSQ119607106
HIS119652547
AGAAgaP_AGAP001200
ACOZ120953075
AARA120897818
ASTE118502507
AAG5572509
AALB109427995 115268733
CQUCpipJ_CPIJ013040 CpipJ_CPIJ020026
CPII120423932
CNS116345005
BCOO119077293
AME411488
ACER107995527
ALAB122710861
BIM100741946
BBIF117210735
BVK117232264
BVAN117157848
BTER100651379
BPYO122573967
CCAL108623291
OBB114874841
MGEN117225668
NMEA116435132
CGIG122395952
SOC105196942
MPHA105836240
AEC105146017
ACEP105623566
PBAR105431025
VEM105560800
HST105185268
DQU106741907
CFO105249351
FEX115244323
LHU105678778
PGC109855360
OBO105282711
PCF106786622
PFUC122519642
VPS122630783
NVI100117168
CSOL105359595
TPRE106659319
MDL103573379
CGLO123262000
FAS105269145
DAM107039603
AGIF122848710
LHT122499250
CCIN107270664
TCA662526
DPA109539064
SOY115878093
ATD109599085 109604535
CSET123312805
AGB108914662
LDC111517270
NVL108558748
APLN108734200 112905727
PPYR116175729
OTU111417335
BMOR101746747
BMAN114240094
MSEX115452988
DPLKGM_205833
BANY112049425
NIQ126768467
PMAC106709834
PPOT106100088
PXU106125059
PRAP110998633
ZCE119831194 119831431
HAW110377945
HZE124630268
TNL113495376
SLIU111362742
OFU114353523
CFEL113372206
API100159564
DNX107168952
AGS114125446
RMD113558409
BTAB109041111
DCI103522335
CLEC106663696
HHAL106677050
NLU111056404
PHUPhum_PHUM336820
FOC113205959
TPAL117645562
ZNE110832695
CSEC111865022
FCD110853518
DMK116917426
PVM113809771 113809777
PJA122251878
PCHN125027076
HAZT108669760
EAF111717975
LSM121121670
PPOI119107223 119107310
ISCIscW_ISCW022516
DSV119432850
RSAN119404628
RMP119181297
VDE111244580
VJA111264332
TUT107371305
DPTE113790974
DFR124500168
CSCU111620046
PTEP107444927
SDM118201712
CELCELE_R06A4.8(agl-1)
CBRCBG_11104(Cbr-agl-1)
BMYBM_BM5241(Bma-agl-1)
LOALOAG_07652 LOAG_11769
NAINECAME_08416
TSPTsp_07883
HROHELRODRAFT_109597
LGILOTGIDRAFT_215487
PCAN112573491
BGT106059117
GAE121374897
HRF124112001
HRJ124254862
CRG105323132
MYI110465491
PMAX117325070
MMER123525931
OBI106878848
OSN115216320
LAK106156752
SMMSmp_007640
SHXMS3_00002958
OVIT265_15000
EGLEGR_01998
NVE116619305
EPA110253248
ATEN116302781
ADF107330168 107358137
AMIL114974401
PDAM113670759
SPIS111335292
DGT114527262
XEN124444428
HMG100212805
AQU100641813
QSU112011486 112029856
SCEYPR184W(GDB1)
SEUBDI49_5628
SPAOSPAR_P04260
AGOAGOS_AEL276C
ERCEcym_2815
KMXKLMA_40472(GDB1)
LTHKLTH0A00726g
VPOKpol_1013p31
ZROZYRO0D00946g
CGRCAGL0G09977g
NCSNCAS_0A15250(NCAS0A15250)
NDINDAI_0J00180(NDAI0J00180)
TPFTPHA_0I03290(TPHA0I03290)
TBLTBLA_0J00110(TBLA0J00110)
TDLTDEL_0H00300(TDEL0H00300)
TGBHG536_0F00340
KAFKAFR_0B00300(KAFR0B00300)
KNGKNAG_0F03960(KNAG0F03960)
ZMKHG535_0C06200
PPAPAS_chr2-2_0437
DHADEHA2C06864g
PICPICST_74319(GDB1)
PGUPGUG_05358
SPAASPAPADRAFT_132625
LELLELG_04604
CALCAALFM_C405140CA(GDB1)
CTPCTRG_03951
COTCORT_0B00110
CDUCD36_44790
CTENCANTEDRAFT_109322
YLIYALI0A19074g
CLUCLUG_04515
CLUSA9F13_25g00561
CAURCJI97_003275
SLBAWJ20_1844(GDB1)
PKZC5L36_0C11440
BNNFOA43_002560
BBRXBRETT_000120
OPAHPODL_05177
SLUDSCDLUD_000007
NCRNCU00743
NTENEUTE1DRAFT149613(NEUTE1DRAFT_149613)
SMPSMAC_01428
PANPODANSg09886
TTTTHITE_2114181
MTMMYCTH_2295601
CTHRCTHT_0056040
MGRMGG_00063
PPEIPpBr36_09099
TMNUCRPA7_6677
SSCKSPSK_00070
FGRFGSG_09704
FPUFPSE_04308
FVRFVEG_06308
FOXFOXG_08364
NHENECHADRAFT_99118
TRETRIREDRAFT_57128
TRRM419DRAFT_73564
MAWMAC_03960
MAJMAA_06996
CMTCCM_03522
PLJVFPFJ_01625
VALVDBG_05054 VDBG_05055
VDAVDAG_10382
CFJCFIO01_00951
CLUPCLUP02_11741
CHIGCH63R_11243
SAPOSAPIO_CDS0680
ELAUCREL1_7294
PFYPFICI_00843
SSLSS1G_12795
BFUBCIN_01g10310(Bcgdb1)
MBEMBM_04879
PSCOLY89DRAFT_607404
GLZGLAREA_04863
ANIAN0352.2
AFMAFUA_1G02140
ACTACLA_032290
NFINFIA_022510
AORAO090005000884
ANGANI_1_788014(An01g06120)
AFVAFLA_003700
ALUCAKAW2_20712S
APUUAPUU_11748A
PCSPc22g22120
PDPPDIP_63110
TMFPMAA_089110
TRGTRUGW13939_01668
CIMCIMG_09981
CPWCPC735_011570
UREUREG_06030
PBLPAAG_12154(PAAG_06098)
PBNPADG_08019
ABEARB_07179
TVETRV_07707
AJEHCAG_03268
BGHBDBG_03414
PNOSNOG_03601
PTEPTT_07191
BZECOCCADRAFT_2155
BSCCOCSADRAFT_227145
BORCOCMIDRAFT_7427
AALTCC77DRAFT_867889
ZTRMYCGRDRAFT_74222
PFJMYCFIDRAFT_56808
FFUCLAFUR5_04910
BCOMBAUCODRAFT_318661
NPAUCRNP2_3942
TMLGSTUM_00004119001
CNECNJ03090
CNBCNBJ0440
CNGCNAG_04879
CGICGB_J0390W
TMSTREMEDRAFT_37541
TASAA1Q1_04893
TVSTRAVEDRAFT_72126
DSQDICSQDRAFT_53427
PCOPHACADRAFT_213770
SHSSTEHIDRAFT_97477
HIRHETIRDRAFT_156063
PSQPUNSTDRAFT_90662
ADLAURDEDRAFT_86126
FMEFOMMEDRAFT_143821
GTRGLOTRDRAFT_138185
LBCLACBIDRAFT_302750
CCICC1G_12049
ABPAGABI1DRAFT118950(AGABI1DRAFT_118950)
ABVAGABI2DRAFT206172(AGABI2DRAFT_206172)
PCUBJR316_0008177
MPRMPER_03030 MPER_11198
MRRMoror_6922
MOREE1B28_007515
SCMSCHCO_02598145(SCHCODRAFT_02598145)
CPUTCONPUDRAFT_83536
SLASERLADRAFT_362517
UMAUMAG_03949
PFPPFL1_00750
PGRPGTG_14216
MLRMELLADRAFT_117001
MBRMONBRDRAFT_27381
SREPTSG_10237
DDIDDB_G0287569(agl)
DPPDICPUDRAFT_45888
DFADFA_01273(agl)
EHIEHI_098360(77.t00009)
EIVEIN_064680 EIN_175730
TGOTGME49_226910
TETTTHERM_000128319 TTHERM_00128330
PTMGSPATT00025969001 GSPATT00028373001 GSPATT00032669001
SMINv1.2.030503.t1(symbB.v1.2.030503.t1)
TVATVAG_2v0353620 TVAG_2v0583500 TVAG_2v0978730
 » show all
Reference
1
  Authors
Brown, D.H. and Brown, B.I.
  Title
Enzymes of glycogen debranching: Amylo-1,6-glucosidase (I) and oligo-1,4->1,4-glucanotransferase (II).
  Journal
Methods Enzymol 8:515-524 (1966)
Reference
2  [PMID:5424210]
  Authors
Lee EY, Carter JH, Nielsen LD, Fischer EH.
  Title
Purification and properties of yeast amylo-1,6-glucosidase--oligo-1,4 leads to 1,4-glucantransferase.
  Journal
Biochemistry 9:2347-55 (1970)
DOI:10.1021/bi00813a019
Reference
3  [PMID:5805288]
  Authors
Nelson TE, Kolb E, Larner J.
  Title
Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.
  Journal
Biochemistry 8:1419-28 (1969)
DOI:10.1021/bi00832a017
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.33
IUBMB Enzyme Nomenclature: 3.2.1.33
ExPASy - ENZYME nomenclature database: 3.2.1.33
BRENDA, the Enzyme Database: 3.2.1.33
CAS: 9012-47-9
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