| Entry |
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| Name |
ribosylpyrimidine nucleosidase;
N-ribosylpyrimidine nucleosidase;
pyrimidine nucleosidase;
N-ribosylpyrimidine ribohydrolase;
pyrimidine nucleoside hydrolase;
RihB;
YeiK;
nucleoside ribohydrolase
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| Class |
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
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| Sysname |
pyrimidine-nucleoside ribohydrolase
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| Reaction(IUBMB) |
a pyrimidine nucleoside + H2O = D-ribose + a pyrimidine base [RN: R02172]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also hydrolyses purine D-ribonucleosides, but much more slowly. 2'-, 3'- and 5'-deoxynucleosides are not substrates [3].
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| History |
EC 3.2.2.8 created 1972
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| Pathway |
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| Orthology |
| K10213 | ribosylpyrimidine nucleosidase |
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| Genes |
| ECOO: | ECRM13514_2924(rihB) |
| ECOH: | ECRM13516_2864(rihB) |
| ELR: | ECO55CA74_13375(rihB) |
| ECOA: | APECO78_14530(rihB) |
| EDJ: | ECDH1ME8569_2098(rihB) |
| ECOI: | ECOPMV1_02322(rihB) |
| RTG: | NCTC13098_05754(rihB) |
| LRI: | NCTC12151_01991(rihB) |
| BFD: | NCTC4823_01338(rihB_1) |
| STR: | Sterm_3626 Sterm_3734 |
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| Reference |
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| Authors |
Terada M, Tatibana M, Hayaishi O. |
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| Title |
Purification and properties of nucleoside hydrolase from Pseudomonas fluorescens. |
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| Journal |
J Biol Chem 242:5578-85 (1967) |
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| Reference |
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| Authors |
Petersen C, Moller LB |
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| Title |
The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Giabbai B, Degano M. |
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| Title |
Cloning, purification, crystallization and X-ray analysis of the Escherichia coli pyrimidine nucleoside hydrolase YeiK. |
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| Journal |
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| Reference |
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| Authors |
Giabbai B, Degano M. |
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| Title |
Crystal structure to 1.7 a of the Escherichia coli pyrimidine nucleoside hydrolase YeiK, a novel candidate for cancer gene therapy. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.2.2.8 |
| ExPASy - ENZYME nomenclature database: | 3.2.2.8 |
| BRENDA, the Enzyme Database: | 3.2.2.8 |
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| LinkDB |
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