KEGG ENZYME: 3.4.11.3

ENZYME: 3.4.11.3

Entry

EC 3.4.11.3                 Enzyme

Name

cystinyl aminopeptidase;
cystyl-aminopeptidase;
oxytocinase;
cystine aminopeptidase;
L-cystine aminopeptidase;
oxytocin peptidase;
vasopresssinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases

Reaction(IUBMB)

Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4]

Comment

A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family)

History

EC 3.4.11.3 created 1972

Orthology

K01257

cystinyl aminopeptidase

Genes

HSA:	4012(LNPEP)

PTR:	461960(LNPEP)

PPS:	100975663(LNPEP)

GGO:	101139054(LNPEP)

PON:	100439455(LNPEP)

PPYG:

129036515(LNPEP)

NLE:	100603383(LNPEP)

HMH:	116470981(LNPEP)

SSYN:

129457837(LNPEP)

MCC:	703949(LNPEP)

MCF:	102115644(LNPEP)

MTHB:

126957459

MNI:	105484008(LNPEP)

CSAB:

103225023(LNPEP)

CATY:

105580982(LNPEP)

PANU:

101013078(LNPEP)

TGE:	112625855(LNPEP)

MLEU:

105546279(LNPEP)

RRO:	104657441(LNPEP)

RBB:	108519674(LNPEP)

TFN:	117064881(LNPEP)

PTEH:

111542652(LNPEP)

CANG:

105513429(LNPEP)

CJC:	100391174(LNPEP)

SBQ:	101040288(LNPEP)

CIMI:

108288407

ANAN:

105711053 105712381 135274889

CSYR:

103257321(LNPEP)

MMUR:

105876112(LNPEP)

LCAT:

123648582

PCOQ:

105805875(LNPEP)

OGA:	100958484(LNPEP)

MMU:	240028(Lnpep)

MCAL:

110312590(Lnpep)

MPAH:

110338032(Lnpep)

RNO:	171105(Lnpep)

MCOC:

116078963(Lnpep)

ANU:	117700191(Lnpep)

ASYL:

127673652(Lnpep)

MUN:	110559507(Lnpep)

CGE:	100759698(Lnpep)

MAUA:

101826656

PROB:

127237720(Lnpep)

PLEU:

114691312

MORG:

121466643

MFOT:

126497573

AAMP:

119820551

NGI:	103732022(Lnpep)

HGL:	101709446(Lnpep)

CPOC:

100718730(Lnpep)

CCAN:

109695473(Lnpep)

DORD:

105989819(Lnpep)

DSP:

122117366

PLOP:

125339769

NCAR:

124986562

MMMA:

107148611

ITI:

101968824

OCU:

100353022

OPI:

101528559

TUP:	102474416(LNPEP)

GVR:	103605383(LNPEP)

CFA:	488896(LNPEP)

CLUD:

112654107

VVP:	112915468(LNPEP)

VLG:

121489040

NPO:	129501615(LNPEP)

AML:	100473699(LNPEP)

UMR:

103672209

UAH:	113255059(LNPEP)

UAR:

123799294

ELK:

111148261

LLV:

125100824

MPUF:

101682451(LNPEP)

MNP:	132028816(LNPEP)

MLK:	131832487(LNPEP)

NVS:

122917317

ORO:	101372794(LNPEP)

EJU:	114200055(LNPEP)

ZCA:

113929649

MLX:	118017034(LNPEP)

NSU:

110590814

LWW:

102738475

FCA:	101083321(LNPEP)

PYU:

121012608

PCOO:

112860935(LNPEP)

PBG:

122491501

PVIV:

125162216(LNPEP)

LRUF:

124519350

LGF:

123608818

AJU:

106969070

PTG:	102969445(LNPEP)

PPAD:

109254719(LNPEP)

PUC:

125934320

PLEZ:

122223115

HHV:

120236530

BTA:	521633(LNPEP)

BOM:	102267303(LNPEP)

BIU:	109562347(LNPEP)

BBUB:

102393847

BBIS:

104982539(LNPEP)

CHX:	102186394(LNPEP)

OAS:	101102729(LNPEP)

BTAX:

128051242(LNPEP)

CSUM:

138085959(LNPEP)

ODA:

120863263

CCAD:

122439506

MREE:

136156802(LNPEP)

OVR:	110126011(LNPEP)

MBEZ:

129558371(LNPEP)

SSC:	100125826(LNPEP)

CFR:	102509485(LNPEP)

CBAI:

105064569(LNPEP)

CDK:	105100897(LNPEP)

VPC:	102541002(LNPEP)

BACU:

103014830(LNPEP)

LVE:	103071064(LNPEP)

OOR:	101286074(LNPEP)

LALB:

132518157(LNPEP)

DLE:	111184087(LNPEP)

PCAD:

102992893(LNPEP)

PSIU:

116750716(LNPEP)

NASI:

112394747(LNPEP)

ECB:	100073222(LNPEP)

EPZ:	103560188(LNPEP)

EAI:

106847763

MYB:	102260924(LNPEP)

MYD:	102768292(LNPEP)

MMYO:

118656789

MLF:	102425594(LNPEP)

MDT:	132233400(LNPEP)

MYUM:

139008775(LNPEP)

PKL:

118702709

EFUS:

103288756(LNPEP)

MNA:	107539602(LNPEP)

DRO:	112307209(LNPEP)

SHON:

118977438

AJM:	119055587(LNPEP)

PDIC:

114496094

PHAS:

123824824

MMF:

118641862

PPAM:

129074695(LNPEP)

HAI:	109390161(LNPEP)

RFQ:	117025328(LNPEP)

PALE:

102892183(LNPEP)

PGIG:

120612567

PVP:	105304796(LNPEP)

RAY:	107518277(LNPEP)

MJV:

108392001

TOD:	119260432(LNPEP)

SARA:

101548854(LNPEP)

SFUM:

130021699(LNPEP)

SETR:

126001925(LNPEP)

LAV:	100664517(LNPEP)

TMU:

101354580

ETF:

101651260

DNM:	101433270(LNPEP)

MDO:	100015080(LNPEP)

GAS:

123236302

SHR:	100925233(LNPEP)

AFZ:

127559968

PCW:	110223535(LNPEP)

TVP:

118857610

PBRV:

138158861(LNPEP)

OAA:

100081694

TACU:

119944618

GGA:	427279(LNPEP)

PCOC:

116239038(LNPEP)

MGP:

104915194

CJO:	107306379(LNPEP)

TPAI:

128089579(LNPEP)

LMUT:

125687087

NMEL:

110389598(LNPEP)

APLA:

101792280

ACYG:

106046475(LNPEP)

CATA:

118256857(LNPEP)

AFUL:

116500756(LNPEP)

TGU:	100218959(LNPEP)

LSR:	110473200(LNPEP)

SCAN:

103821215(LNPEP)

PMOA:

120509472

OTC:

121338542

PRUF:

121355019

ATRC:

139588863(LNPEP)

GFR:	102036062(LNPEP)

FAB:	101815820(LNPEP)

OMA:	130265072(LNPEP)

PHI:	102109326(LNPEP)

PMAJ:

107198251(LNPEP)

CCW:

104689772

CBRC:

103616381(LNPEP)

ACOE:

138103198(LNPEP)

ETL:	114056953(LNPEP)

ZAB:	102066074(LNPEP)

ZLE:	135459799(LNPEP)

ACHL:

103807397(LNPEP)

SVG:	106859668(LNPEP)

MMEA:

130577591(LNPEP)

HRT:	120765380(LNPEP)

SATI:

136374390(LNPEP)

CCIC:

134056518(LNPEP)

FPG:	101921722(LNPEP)

FCH:	102053784(LNPEP)

CCRI:

104165166(LNPEP)

NNT:	104411089(LNPEP)

SHAB:

115600573(LNPEP)

ACUN:

113489982(LNPEP)

TALA:

104362884

ACHC:

115336548

HLE:	104830502(LNPEP)

AGEN:

126036475

HHAR:

128136408(LNPEP)

GCL:

127027269

CSTI:

104560770(LNPEP)

LDI:	104347568(LNPEP)

MNB:

103782452

EGZ:

104135054

NNI:	104014064(LNPEP)

PCAO:

104053487

PADL:

103915039(LNPEP)

AFOR:

103896078(LNPEP)

CLV:	102089254(LNPEP)

MUI:	104545691(LNPEP)

PGUU:

104469357(LNPEP)

PLET:

104622895

CMAC:

104478481(LNPEP)

CUCA:

104059922(LNPEP)

TEO:

104382899

OHA:	104336223(LNPEP)

ACAR:

104523898(LNPEP)

CVF:	104289558(LNPEP)

RTD:	128902356(LNPEP)

CRID:

134508226(LNPEP)

AROW:

112976935(LNPEP)

NPD:	112951436(LNPEP)

TGT:	104580399(LNPEP)

DNE:	112980261(LNPEP)

SCAM:

104150448(LNPEP)

ASN:	102376681(LNPEP)

AMJ:	106736966(LNPEP)

CPOO:

109308132(LNPEP)

GGN:	109297449(LNPEP)

PSS:

102451133

CMY:

102930761

CCAY:

125636834

DCC:

119855860

CPIC:

101948346

TST:	117878811(LNPEP)

CABI:

116835677(LNPEP)

MRV:

120407783

ACS:	100565555(lnpep)

ASAO:

132767167(LNPEP)

PVT:	110078770(LNPEP)

SUND:

121920968

PBI:	103049159(LNPEP)

PMUR:

107302784(LNPEP)

CTIG:

120306715

TSR:	106540963(LNPEP)

PGUT:

117679086(LNPEP)

APRI:

131190659(LNPEP)

PTEX:

113448454(LNPEP)

NSS:	113415177(LNPEP)

VKO:

123031173

PMUA:

114606174(LNPEP)

PRAF:

128423339(LNPEP)

ZVI:	118076743(LNPEP)

HCG:	128344961(LNPEP)

GJA:	107107285(LNPEP)

STOW:

125436421

EMC:	129335075(LNPEP)

XLA:	379719(lnpep.S) 495293(lnpep.L)

XTR:	100216271(lnpep)

NPR:	108790051(LNPEP)

RTEM:

120931284

BBUF:

120992535

BGAR:

122924659

PWL:

138285660

MUO:	115463162(LNPEP)

GSH:	117345568(LNPEP)

DRE:	322814(lnpep)

SRX:	107720271 107756310

SANH:

107699734 107703263

SGH:	107555501 107587503

CCAR:

109064775 109082479

CAUA:

113049633 113080511

CGIB:

127957097 127998323

PTET:

122345207

LROH:

127165334(lnpep)

OMC:	131540300(lnpep)

PPRM:

120472049

RKG:	130072449(lnpep)

MAMB:

125267531

CIDE:

127512717

CERY:

137033803(lnpep)

MASI:

127430871 127439800

TROS:

130545099(lnpep)

TDW:	130419596(lnpep)

MANU:

129441124(lnpep)

PDAB:

135774418(lnpep)

IPU:	108255525(lnpep)

IFU:	128625725(lnpep)

PHYP:

113537004(lnpep)

SMEO:

124380905

TFD:

113637661

TVC:	132855267(lnpep)

CGAR:

128509227(lnpep)

NGRA:

132872274(lnpep)

TRN:	134335157(lnpep)

AMEX:

103042675

CMAO:

118827134

EEE:	113574970(lnpep)

CHAR:

122130533

SPIL:

134088791(lnpep)

TRU:	101075332(lnpep)

TFS:	130525544(lnpep)

TNG:	GSTEN00028656G001

LCO:	104921214(lnpep)

NCC:

104943771

TBEN:

117475964(lnpep)

CGOB:

115013600(lnpep)

PGEO:

117442383(lnpep)

GACU:

117546833(lnpep)

EMAC:

134873962(lnpep)

ELY:	117252398(lnpep)

EFO:

125889827

PLEP:

121944168

SLUC:

116056647

ECRA:

117945190(lnpep)

ESP:

116689361

PFLV:

114555125(lnpep)

GAT:

120830366

PPUG:

119225218(lnpep)

AFB:	129101250(lnpep)

CLUM:

117736810(lnpep)

PSWI:

130196418(lnpep)

CANA:

137805025(lnpep)

CVE:	137866958(lnpep)

MSAM:

119892233

SCHU:

122876429

CUD:

121509809

SPUL:

138610336(lnpep)

LMIX:

132974179(lnpep)

ALAT:

119019277

ASTR:

137592531(lnpep)

MZE:

101464558

ONL:	100692735(lnpep)

OAU:

116332525

OLA:

101154957

OML:

112148247

CSAI:

133450434(lnpep)

XMA:

102233247

XCO:

114154379

XHE:

116729613

PRET:

103470390

PFOR:

103142937

PLAI:

106944598(lnpep)

PMEI:

106920931

GAF:

122828809

PPRL:

129372067(lnpep)

CVG:	107083671(lnpep)

CTUL:

119786572

GMU:

124877870

NFU:	107393919(lnpep)

KMR:

108234607

ALIM:

106521748(lnpep)

NWH:

119413091

AOCE:

111587793(lnpep)

EJA:	138215980(lnpep)

BFRE:

138627219(lnpep)

MCEP:

125012234

CSEM:

103398275

POV:	109638180(lnpep)

SSEN:

122769635

SSOE:

131464188(lnpep)

HHIP:

117767225(lnpep)

HSP:

118114816

PPLT:

128437825(lnpep)

SMAU:

118313331

LCF:

108878318

SDU:	111227707(lnpep)

SLAL:

111660327(lnpep)

XGL:

120804849

HCQ:

109514097

SSCV:

125994498(lnpep)

SBIA:

133499700(lnpep)

PEE:	133399820(lnpep)

PTAO:

133475357(lnpep)

BPEC:

110156743(lnpep)

ENY:	140346474(lnpep)

MALB:

109956957(lnpep)

BSPL:

114862642(lnpep)

SJO:	128365338(lnpep)

SSCO:

133978462(lnpep)

GMH:

115553745

SASA:

106580282(lnpep) 106585016

STRU:

115164396 115200251(lnpep)

OTW:	112248569 112262802

OMY:	110525774(lnpep) 110535084

OGO:	124034239 124036411

ONE:	115117285 115117953

OKI:	109880995 109895999(lnpep)

OKE:	118374175 118393305(lnpep)

OMM:	135513996 135542561(lnpep)

OCLA:

139390098 139411004

SALP:

111958167 111974780

SNH:	120029584 120062898

CCLU:

121573642 121584938

ELS:

105007007

OEP:	134011908(lnpep)

SFM:	108938375(lnpep)

PKI:	111839226(lnpep)

AANG:

118206239(lnpep)

AROT:

135233328(lnpep)

CCOG:

133141256(lnpep)

LOC:	102683571(lnpep)

PSPA:

121299611 121313833

ARUT:

117403961(lnpep)

PSEX:

120532402

LCM:	102360095(LNPEP)

CMK:

103178390

RTP:

109933513

CPLA:

122559783

HOC:

132823281

LERI:

129695873(lnpep)

PMRN:

116950706

LRJ:

133354243

BBEL:

109468396

AARA:

120898825

ASTE:

118502692

AFUN:

125765870

AMOU:

128304963

SOY:

115886622

MSEX:

115449147

TNL:

113500536

DSV:

119463958

» show all

Reference

1 [PMID:6041057]

Authors

Sjoholm I.

Title

Biochemical studies on oxytocin and oxytocinase.

Journal

Acta Pharm Suec 4:81-96 (1967)

Reference

2 [PMID:4292447]

Authors

Sjoholm I, Yman L.

Title

Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase).

Journal

Acta Pharm Suec 4:65-76 (1967)

Reference

3 [PMID:5421622]

Authors

Yman L.

Title

Studies on human serum aminopeptidases. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.

Journal

Acta Pharm Suec 7:75-86 (1970)

Reference

Authors

Sakura H, Lin TY, Doi M, Mizutani S, Kawashima Y.

Title

Purification and properties of oxytocinase, a metalloenzyme.

Journal

Biochem Int 2:173-179 (1981)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.11.3