Entry
Name
dipeptidase E;
aspartyl dipeptidase;
peptidase E;
PepE gene product (Salmonella typhimurium)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
BRITE hierarchy
Reaction(IUBMB)
Dipeptidase E catalyses the hydrolysis of dipeptides Asp!Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides
Comment
A free carboxy group is not absolutely required in the substrate since Asp-Phe-NH2 and Asp-Phe-OMe are hydrolysed somewhat more slowly than dipeptides with free C-termini. No peptide larger than a C-blocked dipeptide is known to be a substrate. Asp-NH-Np is hydrolysed and is a convenient substrate for routine assay. The enzyme is most active near pH 7.0, and is not inhibited by di-isopropylfluorophosphate or phenylmethanesulfonyl fluoride. Belongs in peptidase family S51.
History
EC 3.4.13.21 created 2001
Orthology
Genes
PCRI : 104024030 104025184
DRE : 100149419(si:dkey-69o16.5)
SANH : 107663837 107672233
CGIB : 127964458(si:dkey-69o16.5)
PTET : 122351170(si:dkey-69o16.5)
LROH : 127170504(si:dkey-69o16.5)
OMC : 131546707(si:dkey-69o16.5)
PPRM : 120466800(si:dkey-69o16.5)
RKG : 130076691(si:dkey-69o16.5)
MAMB : 125270054(si:dkey-69o16.5)
CIDE : 127518253(si:dkey-69o16.5)
CERY : 137036056(si:dkey-69o16.5)
MASI : 127447892(si:dkey-69o16.5)
TROS : 130555898(si:dkey-69o16.5)
TDW : 130427236(si:dkey-69o16.5)
MANU : 129451594(si:dkey-69o16.5)
PDAB : 135731087 135782495
IPU : 108266448(si:dkey-69o16.5)
IFU : 128608430(si:dkey-69o16.5)
SMEO : 124382566(si:dkey-69o16.5)
TFD : 113643409(si:dkey-69o16.5)
TVC : 132850509(si:dkey-69o16.5)
CGAR : 128523763(si:dkey-69o16.5)
NGRA : 132892073(si:dkey-69o16.5)
TRN : 134324365(si:dkey-69o16.5)
AMEX : 103023225(si:dkey-69o16.5)
CMAO : 118812171(si:dkey-69o16.5)
CHAR : 105903011(si:dkey-69o16.5)
SPIL : 134077876(si:dkey-69o16.5)
TFS : 130527176(si:dkey-69o16.5)
TBEN : 117498260(si:dkey-69o16.5)
GACU : 117534360(si:dkey-69o16.5)
ELY : 117251008(si:dkey-69o16.5)
EFO : 125899808(si:dkey-69o16.5)
PLEP : 121938106(si:dkey-69o16.5)
SLUC : 116046617(si:dkey-69o16.5)
AFB : 129104733(si:dkey-69o16.5)
CLUM : 117750591(si:dkey-69o16.5)
PSWI : 130207278(si:dkey-69o16.5)
CANA : 137779368(si:dkey-69o16.5)
CVE : 137891772(si:dkey-69o16.5)
MSAM : 119903767 119918604
SCHU : 122885179(si:dkey-69o16.5)
CUD : 121522746(si:dkey-69o16.5)
LMIX : 132987566(si:dkey-69o16.5)
ALAT : 119025562(si:dkey-69o16.5)
ASTR : 137605043(si:dkey-69o16.5)
OAU : 116312453(si:dkey-69o16.5)
OML : 112154817(si:dkey-69o16.5)
CSAI : 133445831(si:dkey-69o16.5)
GAF : 122839799(si:dkey-69o16.5)
PPRL : 129361245 129379201
CTUL : 119790194(si:dkey-69o16.5)
GMU : 124870789(si:dkey-69o16.5)
KMR : 108247799(si:dkey-69o16.5)
NWH : 119419340(si:dkey-69o16.5)
AOCE : 111568073(si:dkey-69o16.5)
MCEP : 125017428(si:dkey-69o16.5)
SSEN : 122764847(si:dkey-69o16.5)
SSOE : 131444265(si:dkey-69o16.5)
HHIP : 117754493(si:dkey-69o16.5)
HSP : 118119940(si:dkey-69o16.5)
PPLT : 128455428(si:dkey-69o16.5)
SMAU : 118320440(si:dkey-69o16.5)
LCF : 108881977(si:dkey-69o16.5)
XGL : 120801598(si:dkey-69o16.5)
BSPL : 114846922(si:dkey-69o16.5)
SJO : 128367985(si:dkey-69o16.5)
SSCO : 133993442(si:dkey-69o16.5)
OTW : 112238553(si:dkey-69o16.5)
OMY : 110521215(si:dkey-69o16.5)
OGO : 124029229 124029439 124044296(si:dkey-69o16.5)
OKE : 118379136(si:dkey-69o16.5)
OMM : 135518908(si:dkey-69o16.5)
OCLA : 139404908 139406199
CCLU : 121536185(si:dkey-69o16.5)
OEP : 134016290(si:dkey-69o16.5)
AANG : 118214063(si:dkey-69o16.5)
AROT : 135240720(si:dkey-69o16.5)
CCOG : 133116614(si:dkey-69o16.5)
PSPA : 121322105(si:dkey-69o16.5)
ARUT : 117426508(si:dkey-69o16.5)
PSEX : 120519682(si:dkey-69o16.5)
RTP : 109927998(si:dkey-69o16.5)
CPLA : 122551911(si:dkey-69o16.5)
HOC : 132817578 132817580 132817584
DSI : Dsimw501_GD24804(Dsim_GD24804)
AMAP : 126559939 126562855
AALB : 109422148 109428439
BCOO : 119068734 119082815
MSEX : 115448287 119188556
MCIX : 123669215 123669568
CFEL : 113363855 113364149
CSEC : 111861745 111870556
PTEP : 107454064 122273138
RPHI : 132737895 132740644
MAEA : 128203159 128236803
TCR : 508777.100 509029.130
LMAT : 92517459(LSCM1_07581)
LOI : 92362600(LSCM4_06752)
LEIS : 94182504(GH5_07245)
LENR : 94174353(CUR178_07194)
LEIN : 94190455(JIQ42_06854)
PHET : 94292887(JKF63_06862)
EHX : EMIHUDRAFT_315428 EMIHUDRAFT_43594 EMIHUDRAFT_444465 EMIHUDRAFT_49932
ECOO : ECRM13514_5143(pepE)
ECOH : ECRM13516_4880(pepE)
ECW : EcE24377A_4565(pepE)
EDJ : ECDH1ME8569_3877(pepE)
ECOI : ECOPMV1_04394(pepE)
RTG : NCTC13098_06899(pepE_1)
KIE : NCTC12125_03480(pepE)
SMW : SMWW4_v1c02590(pepE)
SFJ : SAMEA4384070_0231(pepE)
SOF : NCTC11214_02053(pepE)
SSAR : SSARUM_000214(pepE)
SOD : Sant_3936(pepE) Sant_P0072
PRG : RB151_005840(pepE_1) RB151_029600(pepE_2)
PHEI : NCTC12003_00587(pepE_1) NCTC12003_02417(pepE_2)
PRQ : CYG50_01575(pepE) CYG50_13175(pepE)
PRJ : NCTC6933_00644(pepE)
PHAG : PZ638_02745(pepE) PZ638_06610(pepE)
LRI : NCTC12151_00202(pepE)
HIC : NTHIC486_00401(pepE)
HHZ : NCTC10839_00457(pepE)
HAEG : NCTC8502_00547(pepE)
PMV : PMCN06_0474(pepE) PMCN06_1855(pepE)
PUL : NT08PM_0861 NT08PM_1926
PMP : Pmu_05150(pepE) Pmu_18580
PMUL : DR93_1226(pepE) DR93_439
PDAG : 4362423_00681(pepE)
PCAI : K7G93_000465(pepE) K7G93_001783
ADP : NCTC12871_00644(pepE)
ALIG : NCTC10568_00426(pepE)
AAP : NT05HA_0777 NT05HA_0850
AAZ : ADJ80_08070 ADJ80_08355
ASEG : NCTC10977_01486(pepE)
AVT : NCTC3438_00009(pepE)
RPNE : NCTC8284_00176(pepE_1)
RHEY : FEE42_08295 FEE42_08395(pepE)
PAET : NCTC13378_01465(pepE)
SJA : SJ2017_1689 SJ2017_3244
SALG : BS332_16175 BS332_20840
SMAI : EXU30_00790(pepE) EXU30_16395
SKH : STH12_01076(pepE_1) STH12_03357(pepE_2)
SLIT : JQC75_07080(pepE) JQC75_17595
SCAA : TUM17387_15730(pepE) TUM17387_23210
SCHK : GII14_08765(pepE) GII14_13230
SZH : K0H63_07725(pepE) K0H63_18705
KMA : B9H00_10185 B9H00_15815
AEL : NCTC12917_03354(pepE)
REH : H16_A2300(pepE1) H16_B0135(pepE2)
CNC : CNE_1c22090(pepE) CNE_2c01200(pepE)
CUH : BJN34_11725 BJN34_20690
CTI : RALTA_A1844(pepE) RALTA_B0141(pepE2)
COX : E0W60_06710(pepE) E0W60_20990(pepE)
CUK : KB879_18380(pepE) KB879_23405(pepE)
CUPP : CTP10_R19980(pepE) CTP10_R35640(pepE)
BGP : BGL_1c17590 BGL_2c18600
AXX : ERS451415_03886(pepE)
CCV : CCV52592_2072(pepE1)
CCO : CCC13826_0798(pepE1) CCC13826_1040
CCOC : CCON33237_0026(pepE1) CCON33237_1050
CLR : UPTC16701_0807(pepE2)
CLM : UPTC16712_0812(pepE2) UPTC16712_1371(pepE1)
CLQ : UPTC4110_0814(pepE2) UPTC4110_1356(pepE1)
CLN : UPTC3659_0911(pepE2) UPTC3659_1591(pepE1)
CPEL : CPEL_0866 CPEL_1484
CAMR : CAQ16704_0746 CAQ16704_1387
CGRA : CGRAC_0115(pepE1) CGRAC_1079 CGRAC_1590(pepE2)
CHV : CHELV3228_0889(pepE)
CPIN : CPIN18020_0886(pepE)
COJ : CORN_0893(pepE1) CORN_1459(pepE2)
CRX : CRECT_0500 CRECT_0599(pepE1)
CCOR : CCORG_0872(pepE1) CCORG_1702(pepE2)
CARM : CARM_0870(pepE1) CARM_1410(pepE2)
CSHO : CSHOW_0575 CSHOW_1486(pepE1)
BHC : JFL75_05540 JFL75_11925
PCRE : NCTC12858_01311(pepE)
PCAG : NCTC12856_00433 NCTC12856_01552(pepE_1)
PSOE : CE91St14_07210(pepE)
ACOU : A5CBH24_02750(pepE)
ADA : A5CPEGH6_05900(pepE)
CPOL : WJU16_03695 WJU16_03880(pepE)
NKO : Niako_2473 Niako_3254
STHA : NCTC11429_05000(pepE)
FOK : KK2020170_02680(pepE)
COL : AM608_03995 AM608_05005
CAPN : CBG49_00835 CBG49_00840 CBG49_00845 CBG49_09435
CGH : CGC50_04505 CGC50_08510 CGC50_08515 CGC50_08520
CLK : CGC53_00520 CGC53_04480 CGC53_04485
CSPU : CGC55_01455 CGC55_07840 CGC55_07845
CCYN : CGC48_02730 CGC48_06210 CGC48_11440
CSTO : CGC58_06375 CGC58_12440
CAPF : FOC45_06060(pepE) FOC45_10395
CAPO : HW278_01520(pepE) HW278_02740
PHG : KCTC32516_01772(pepE)
MYR : MYRA21_0824(pepE) MYRA21_3569
MOD : AS202_03755 AS202_17380
MYZ : BK054_03635 BK054_16965
MOA : I6I89_00015(pepE) I6I89_07100
AALG : AREALGSMS7_00116(pepE)
AANR : KCTC52924_02222(pepE)
FEK : C1H87_06675 C1H87_11085
KOS : KORDIASMS9_02182(pepE)
KAN : IMCC3317_39550(pepE_2)
SINH : LS482_14470 LS482_20135(pepE)
HWS : RNZ46_02190 RNZ46_10135(pepE)
OHM : MSHRCOH1_03125(pepE)
CGLE : NCTC11432_01045(pepE_1)
CTAI : NCTC12078_00382(pepE)
CTAK : 4412677_02695(pepE)
CHRJ : CHRYMOREF3P_0820(pepE)
CJG : NCTC13459_03119(pepE)
CANT : NCTC13489_02934(pepE)
KFA : Q73A0000_16680(pepE)
BCAD : DBX24_08945 DBX24_09305(pepE)
CIV : IMZ16_01250(pepE) IMZ16_07370
BSON : S101395_04294(pepE)
BCER : BCK_22315 BCK_25730
BMYC : DJ92_4317 DJ92_4761
BHAI : KJK41_04785 KJK41_10330
BMUR : ABE28_010505 ABE28_018430
PSYO : PB01_02815 PB01_09295 PB01_10015
POF : GS400_05325 GS400_18775
RAZ : U9J35_04415 U9J35_04990
ROD : P8596_11360 P8596_18705
ROSS : V2W31_04335 V2W31_05025
EXM : U719_09085 U719_09125
EXU : ESP131_11145 ESP131_11180
EACE : KKI46_08965 KKI46_09005
PMS : KNP414_01160 KNP414_03824
PXL : BS614_12090 BS614_15760
PBAC : HUB98_22125 HUB98_24740
PAMY : P9222_25525 P9222_29480
TUM : CBW65_06570 CBW65_06605
SOB : CSE16_12315 CSE16_12495 CSE16_12640
PLAY : DNR44_001510 DNR44_004790
PSHX : QWY21_04065 QWY21_09930
VIJ : JNUCC6_03150 JNUCC6_22010
LPK : LACPI_0382 LACPI_0875
LHW : BSQ49_05655 BSQ49_05995
LHIL : G8J22_02674(pepE_2)
LEC : LGMK_02255 LGMK_02885
LSU : A6B45_04615 A6B45_05190
EAV : EH197_01965 EH197_09135
CLT : CM240_2708 CM240_2903
CARG : RSJ17_07445 RSJ17_10565
CMAH : C1I91_11175 C1I91_12430
FDU : GXM22_05910 GXM22_10475 GXM22_14320
FTK : PXT33_002065 PXT33_004480 PXT33_012915
AHC : JYE49_00040 JYE49_13295
CBAF : JS518_09620 JS518_11585
BLUI : Blut17040_31400 Blut17040_33880
ACHT : bsdcttw_08040 bsdcttw_26790
SCAZ : ACI3DN_01610 ACI3DN_02755
ERD : G7062_04000 G7062_09210
EIO : H9L01_04215 H9L01_04230 H9L01_07380
AARG : Aargi30884_06630 Aargi30884_13060
ABSI : A9CBEGH2_08470 A9CBEGH2_14070
RTS : CE91St31_05510 CE91St31_23470
CEI : CEPID_09390 CEPID_09500
SCO : SCO0277(SCF85.05c) SCO0575(SC5G5.07)
SVL : Strvi_1779 Strvi_5756
SLV : SLIV_35070(pepE) SLIV_36530
SNZ : DC008_16885 DC008_18195
SAQU : EJC51_43370 EJC51_44575
SFUG : CNQ36_02695 CNQ36_15800
SLUO : PS467_28555(pepE) PS467_41000
SGLY : P8A20_01500 P8A20_26185(pepE)
KIT : CFP65_1509 CFP65_7442
CRY : B7495_17435 B7495_17900 B7495_18635
LEB : G7066_05040 G7066_10400(pepE)
AGG : C1N71_01065 C1N71_14595
AAQ : AOC05_05925 AOC05_08280
AKO : N9A08_01485 N9A08_08980
BGG : CFK41_04830 CFK41_10000
LMOI : VV02_03100 VV02_03105
XYA : ET471_10995 ET471_16135
TED : U5C87_01420 U5C87_09805
ACIJ : JS278_00476(pepE_1)
MICG : GJV80_06955 GJV80_07170 GJV80_07330 GJV80_08465
NANO : G5V58_10250 G5V58_11335
NMES : H9L09_04845 H9L09_14850
NAQU : ENKNEFLB_02628(pepE_1)
KQI : F1D05_04300 F1D05_23900
KSL : OG809_15415 OG809_24125
KRI : OX958_08555 OX958_08690
ACIR : OG979_22075 OG979_26570
ABAR : AMYBAR_006247(pepE)
UME : RM788_06345 RM788_07185
MSAG : GCM10017556_00810(pepE)
ACTN : L083_3255 L083_4504
ACTL : L3i22_048440 L3i22_050520
ASIC : Q0Z83_024820 Q0Z83_036950
ATL : Athai_10290 Athai_18040(pepE)
ASER : Asera_16190 Asera_45920 Asera_56380(pepE) Asera_62950
DVC : Dvina_18315 Dvina_32115
DAUR : Daura_16505 Daura_24790
BLX : GS08_01235 GS08_04390
BBRC : B7019_0753 B7019_0860
PBF : CFX0092_A1452 CFX0092_B0172
KBS : EPA93_01045 EPA93_05430 EPA93_16610(pepE)
FGI : OP10G_3641 OP10G_4292 OP10G_4322
DSC : ABOD76_02550 ABOD76_07820
LEO : AMK43_01255 AMK43_02270
LOT : AXF11_04270 AXF11_08050
LEQ : BCB68_00430 BCB68_04265
LHF : JCM16775_0441 JCM16775_2103 JCM16775_p3002
LSZ : JCM16776_0429 JCM16776_1569
LRUG : AB8B22_03260 AB8B22_09645
LMES : AB8B23_09740 AB8B23_10020
APRD : HLG78_00395 HLG78_04905
BBGW : UT28_C0001G0765 UT28_C0001G0855
» show all
Taxonomy
Reference
Authors
Hakansson K, Wang AH, Miller CG.
Title
The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad.
Journal
Sequence
Reference
Authors
Lassy RA, Miller CG
Title
Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.13.21
LinkDB
All DBs