KEGG   ENZYME: 3.4.13.23
Entry
EC 3.4.13.23                Enzyme                                 
Name
cysteinylglycine-S-conjugate dipeptidase;
tpdA (gene name);
LAP3 (gene name)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases
Sysname
cysteinylglycine-S-conjugate dipeptide hydrolase
Reaction(IUBMB)
an [L-cysteinylglycine]-S-conjugate + H2O = an L-cysteine-S-conjugate + glycine [RN:R12514]
Reaction(KEGG)
R12514
Substrate
[L-cysteinylglycine]-S-conjugate [CPD:C05729];
H2O [CPD:C00001]
Product
L-cysteine-S-conjugate [CPD:C02882];
glycine [CPD:C00037]
Comment
The enzyme participates in a widespread glutathione-mediated detoxification pathway. In animals the activity is usually catalysed by enzymes that have numerous additional activities, such as EC 3.4.11.1, leucyl aminopeptidase, EC 3.4.11.2, membrane alanyl aminopeptidase, and EC 3.4.13.19, membrane dipeptidase. However, in the bacterium Corynebacterium sp. Ax20, which degrades axillary secretions, the enzyme appears to be specific for this task.
History
EC 3.4.13.23 created 2019
Orthology
K23980  cysteinylglycine-S-conjugate dipeptidase
Genes
CCRO: CMC5_047020
CGL: Cgl2726(Cgl2726)
CGB: cg3021
CGU: WA5_2631
CGT: cgR_2629
CGS: C624_13395
CGG: C629_13400
CGM: cgp_3021(tpdA)
CGJ: AR0_13230
CGQ: CGLAR1_13095
CGX: SB89_12850
CEF: CE2564
CDI: DIP2037
CDP: CD241_1936(tpdA)
CDH: CDB402_1895(tpdA)
CDT: CDHC01_1936(tpdA)
CDE: CDHC02_1943(tpdA)
CDR: CDHC03_1920(tpdA)
CDA: CDHC04_1962(tpdA)
CDZ: CD31A_2030(tpdA)
CDB: CDBH8_2002(tpdA)
CDS: CDC7B_1990(tpdA)
CDD: CDCE8392_1915(tpdA)
CDW: CDPW8_2009(tpdA)
CDV: CDVA01_1867(tpdA)
CDIP: ERS451417_02043(tpdA)
CJK: jk0266
CUR: cu1717
CUA: CU7111_1654
CAR: cauri_2265(tpdA)
CKP: ckrop_1668
CPU: CPFRC_09155
CPL: Cp3995_1857(tpdA)
CPG: CP316_09360
CPP: CpP54B96_1838(tpdA)
CPK: CP1002_03995
CPQ: CPC231_09150
CPX: CPI19_09160
CPZ: CpPAT10_1810(tpdA)
COR: Cp267_1878(tpdA)
COP: CP31_09575
COD: Cp106_1767(tpdA)
COS: Cp4202_1799(tpdA)
COI: CPCIP5297_09370
COE: CP258_09370
COU: CP162_09360
CPSE: CPTA_00189
CPSU: CPTB_01340
CPSF: CPTC_01010
CRD: CRES_0164(tpdA)
CUL: CULC22_02041
CUC: CULC809_01885
CUE: CULC0102_2031
CUN: Cul210932_2012(tpdA)
CUQ: Cul210931_1959(tpdA)
CUZ: Cul05146_1997(tpdA)
CUJ: CUL131002_1921(tpdA)
CUS: CulFRC11_1902(tpdA)
CVA: CVAR_0473
CHN: A605_12380
CCN: H924_11505
CTER: A606_01890
CMD: B841_11335
CAZ: CARG_08800
CFN: CFAL_01640
CCG: CCASEI_12660 CCASEI_12665
CVT: B843_11310
CGY: CGLY_13715
CAX: CATYP_09170
CII: CIMIT_10355
CUV: CUREI_09875
COA: DR71_821
CDO: CDOO_11845
CHM: B842_11365
CSX: CSING_11745(tpdA)
CMQ: B840_11030
CKU: UL82_02505(tpdA)
CCJ: UL81_10180
CMV: CMUST_08185 CMUST_13480
CEI: CEPID_10890
CTED: CTEST_11780
CUT: CUTER_09630
CLW: CLAC_10945
CDX: CDES_12275
CSP: WM42_1733
CSTA: CSTAT_11565 CSTAT_11570
CCJZ: ccrud_12305
CFK: CFRA_10400
CPHO: CPHO_10790
CFC: CFLV_11210
CGV: CGLAU_10890(dapE3)
CSTR: CBE89_02630
CAQU: CAQU_11190
CSPH: CSPHI_10860
CAMG: CAMM_11320 CAMM_11325
CMIN: NCTC10288_00303(tpdA)
CPEG: CPELA_01560(dapE2)
CXE: FOB82_04250
CEE: CENDO_10075(dapE3) CENDO_10080(dapE4)
CSAN: E3227_05410
CGK: CGERO_01555(dapE1)
CRF: FRC0190_02075
CRL: NCTC7448_00466(tpdA)
CCHO: CCHOA_01490(dapE1)
CPRE: Csp1_22730(argE)
CPSO: CPPEL_01460(dapE2)
CSUR: N24_2820
CCYS: SAMEA4530656_0144(tpdA)
CMAT: HBA49_05075
CYZ: C3B44_10195
CKF: I6I12_02405
CANS: GP473_01315
CLIA: C3E79_09535
CPRP: I6I69_07260 I6I69_07265
CAMC: I6I65_06330
CGLU: I6J20_11745
CUO: CUROG_01650(dapE1)
CLIZ: G7Y31_10450
CSIL: CBE74_10360
CTUB: I6I74_03775
CLUJ: IAU68_10075
CQN: G7Y29_09340
CKW: CKALI_01685(dapE)
CCOE: CETAM_11755(dapE2)
COK: COCCU_12260(dapE3)
CZO: IAU67_01400
CORY: FQV43_00955
CMF: GWO64_010625
CUW: LH390_10175
CPOY: GP475_10885
CACC: CACC_10390(dapE3)
CFY: I6L56_07360
CPSL: KBP54_09570
CHIN: J5O04_12300
CJH: CJEDD_10525(dapE3)
CPSP: L9H27_01650 L9H27_01655
CMAS: CMASS_09210(dapE3)
CHEI: CHEID_01410(argE)
CIHU: CIHUM_09565(dapE3)
CCOY: CCOY_10450(dapE3)
CHAD: CHAD_10675(dapE3)
CFG: CFREI_12290(dapE2)
CAQM: CAQUA_01765(dapE2)
CCAW: CCANI_12425(dapE2)
CAUI: CAURIS_09835(dapE3)
CFAC: CFAEC_11855(dapE2)
CFOU: CFOUR_09710(dapE3)
CFEU: CFELI_11670(dapE3) CFELI_12340(dapE4)
CAUS: CAURIC_01835(dapE1)
CATR: CATRI_11645(dapE2)
CDUR: CDUR_11960(dapE2)
CCOU: CCONF_10145(dapE3)
CHAN: CHAN_12505(dapE2)
CAFE: CAFEL_09575(dapE3)
CGF: CGUA_11735(dapE2)
CGOI: CGOTT_10210(dapE3)
CAPP: CAPP_09980(argE2)
CBOV: CBOVI_08985(dapE2)
CSUE: QP029_02400
CBRE: QP027_09810
CPYR: CYJ47_00980
CRIE: AK829_11585
CIK: H0194_04165 H0194_04170
CORN: BJP05_01490
CGP: KBP53_09960
CPSK: Q0N40_08505
CHES: R3O64_11335
CBEL: ABMV07_11660
BFV: C628_13515
NFA: NFA_5650
NFR: ERS450000_03658
NCY: NOCYR_0580
NBR: O3I_003130
NNO: NONO_c05890
NSL: BOX37_02635
NSR: NS506_01356
NTP: CRH09_03710
NOZ: DMB37_24050
NOD: FOH10_28250
NAH: F5544_03085
NAD: NCTC11293_01336
NWL: NWFMUON74_05740
NIE: KV110_03440
NTC: KHQ06_03215
NHU: H0264_04325
NYA: LTV02_28410
NGP: LTT66_15970
NSPU: IFM12276_02750
NYU: D7D52_04915
NVU: V7968_10555
RHA: RHA1_ro03735
RER: RER_38700
REY: O5Y_17920
REB: XU06_18115
RQI: C1M55_19180
ROP: ROP_35530
ROA: Pd630_LPD00072 Pd630_LPD09155
RPY: Y013_00255
RBY: CEJ39_10845
RHB: NY08_304
RAV: AAT18_10455
RHW: BFN03_17630
RRZ: CS378_00195
RHU: A3Q40_00860(dapE_1)
RHQ: IM25_14205
RHOD: AOT96_29810
RRT: 4535765_01749(dapE_2)
RCR: NCTC10994_01121(dapE_2)
RKO: JWS14_20320
RGO: KYT97_26530
ROZ: CBI38_00365
RPSK: JWS13_24740
RGOR: NMQ04_07685
RHOP: D8W71_21320
RHOO: RA302_18690
RHOU: KZJ41_11640
RHOW: A4U64_01030 A4U64_14190
RHOJ: JVH1_17950
RHOS: QWW67_00215
RHOQ: QWW98_00215
RHOY: QNA09_07975
RHOH: CPI83_10865
RHOX: RBB84_04470
RHJS: OYT95_18740 OYT95_42525
RFA: A3L23_03595(dapE_3)
RHS: A3Q41_04631(dapE_5)
REQ: REQ_30750
PDEF: P9209_13615
PSOW: ABI214_23040
WHR: OG579_16400
GBR: Gbro_0480
GPO: GPOL_c07130
GOR: KTR9_0398
GOQ: ACH46_04980
GTA: BCM27_02805
GOC: CXX93_17010
GIT: C6V83_05910
GRU: GCWB2_02410(dapE1)
GOM: D7316_04011(ylmB_2)
GAV: C5O27_02735
GOD: GKZ92_02210
GOJ: GR168_02455
GAM: GII34_21115
GPD: GII33_20820
GJI: H1R19_02110
GOI: LK459_06820
GHN: MVF96_02500
GAMI: IHQ52_02335
GMG: NWF22_08345
GSI: P5P27_03920
GOP: ACE11G_13170
SPIN: KV203_08565
TPR: Tpau_3706
TSM: ASU32_21150
TPUL: TPB0596_40470
TSD: MTP03_41790
DTM: BJL86_2773
DIT: C3V38_03370
DIZ: CT688_13945
DPC: A6048_14590
DLU: A6035_13590
DKN: NHB83_14155
DCD: VYL96_13605
CBQ: AL705_03440
TOY: FO059_07765
SCO: SCO1074(SCG22.20)
SALB: XNR_0080
SMA: SAVERM_1471
SGR: SGR_6533
SGB: WQO_02410
SFI: SFUL_600
SANL: KZO11_02145
SGRF: SGFS_015010
SCYE: R2B67_33660
SCB: SCAB_82771
SSX: SACTE_0494
SVL: Strvi_5817
SHY: SHJG_2522
SHO: SHJGH_2286
SRC: M271_43075
SMAL: SMALA_0783
SSOI: I1A49_07495
SFA: Sfla_5763
SBH: SBI_02014
SVE: SVEN_0709 SVEN_6675
SDV: BN159_7845
SALS: SLNWT_0361
STRP: F750_0823
SCI: B446_05520
SLV: SLIV_32425
SGU: SGLAU_03895
SVT: SVTN_04915 SVTN_32950
STRE: GZL_07329
SCW: TU94_04040
SLD: T261_6924
SLC: SL103_12770
SXI: SXIM_51810
STRM: M444_06405
STRC: AA958_01935
SAMB: SAM23877_1160
SPRI: SPRI_6429
SCZ: ABE83_32520
SRW: TUE45_01421(dapE_1)
STRF: ASR50_05350
SLE: sle_60360(sle_60360)
SRN: A4G23_00382(dapE_1)
SPAV: Spa2297_03560
STRT: A8713_03500
SCLF: BB341_26365
SGS: AVL59_29925
STSI: A4E84_04965
SKY: D0C37_01575
SALW: CP975_04095
SGM: GCM10017557_74940
SCAD: DN051_33610
SPHW: NFX46_25275
SGRS: V9K83_29115
SLS: SLINC_1141
SNR: SNOUR_33425
SALU: DC74_1820
SALL: SAZ_09685
SPLU: LK06_029845
STRD: NI25_33815
SNW: BBN63_31360
SAUO: BV401_07760
SSIA: A7J05_30920
SVU: B1H20_01955
SPUN: BFF78_36965
SGV: B1H19_08620
SLAU: SLA_0571
SALF: SMD44_00870
SALJ: SMD11_0653
SLX: SLAV_32395(dapE5)
STRO: STRMOE7_07330
SFK: KY5_0868
SNZ: DC008_03535
SGE: DWG14_07568(ylmB_1)
SRJ: SRO_6480
SLK: SLUN_05075
SDX: C4B68_36135
SGD: ELQ87_35575 ELQ87_36095
SQZ: FQU76_02020
SCYA: EJ357_05165
SAST: CD934_30180
SNQ: CP978_31450
STIR: DDW44_29925
SKA: CP970_38630
SGZ: C0216_18910
SVN: CP980_29355
SNK: CP967_31660
SHAW: CEB94_05480
SRK: FGW37_28615
SFIC: EIZ62_29420
SGAL: CP966_03185
SSPO: DDQ41_10075
SVR: CP971_04795
SPAD: DVK44_01305
SFY: GFH48_36015
SAQU: EJC51_07625
SGF: HEP81_06825
SCAV: CVT27_02085
SSEO: D0Z67_02250
SBY: H7H31_02710
SRIM: CP984_34735
SSUB: CP968_29430
SPHV: F9278_03540
SCIN: CP977_04610 CP977_29915
SFUG: CNQ36_04210
SPAC: B1H29_32555
STSU: B7R87_02210
SCHA: CP983_38475
SGX: H4W23_05485 H4W23_34040
SCOE: CP976_04990
SBAT: G4Z16_30245
SSPB: CP982_37935
SNF: JYK04_00996(dapE_1) JYK04_01484(argE)
SPLA: CP981_05930
SBRO: GQF42_07005
STUI: GCM10017668_06430
SATA: C5746_05450
SCHF: IPT68_04520
SHUN: DWB77_06572(dapE_6)
SHAR: HUT13_00125
SCYG: S1361_05540(dapE1)
SFEU: IM697_18690
SLIA: HA039_31470
SDW: K7C20_05560
SVD: CP969_06690
SCAL: I6J39_02075
SAUH: SU9_004545
SFB: CP974_01990
SMOB: J7W19_03645
SPRA: CP972_04865
SPEU: CGZ69_04170
SROI: IAG44_05225
SXN: IAG42_18580 IAG42_31805
SGJ: IAG43_03220
SHK: J2N69_04045
SANU: K7396_30100
STRY: EQG64_02050
SDD: D9753_31610
SACT: DMT42_04395 DMT42_22390
SMAO: CAG99_27335
SGOB: test1122_25180
SINE: KI385_08715
SLF: JEQ17_42230
SDEC: L3078_05035
SAOV: G3H79_34020
SDUR: M4V62_36860
SYAN: NRK68_04080
SRUG: F0345_26750
SAKB: K1J60_40995
STAA: LDH80_06640 LDH80_33900
SNIG: HEK616_21800
SVIO: HWN34_01410
SCAE: IHE65_41275
STUB: MMF93_03250
SSPN: LXH13_04165
SCIR: STRCI_000838 STRCI_007745
SXT: KPP03845_100148(dapE_1) KPP03845_101203(argE)
SLON: LGI35_08560
SDRZ: NEH16_01390 NEH16_28585
STUD: STRTU_006117
STEE: F3L20_22500
SENG: OJ254_21610
SGK: PET44_04975
SANT: QR300_36705
SYUN: MOV08_33930
SARG: HKX69_30875
SJN: RI060_38275
SCYN: N8I84_35890
SOV: QZH56_02750
SFIY: F0344_32675
SHAU: K9S39_36805
SKG: KJK29_35380
SCOA: QU709_39955
SLAI: P8A22_35330
SFP: QUY26_36125
SCHG: NRO40_02845
STTN: BSL84_03835
SINN: ABB07_33465
STRZ: OYE22_02660
SCAY: PYS65_31570
KBU: Q4V64_48800
SARM: DVA86_04430
SPRF: K4G22_00160
SLUO: PS467_07130
STPB: QR97_32545
SRPA: HEP86_07420
SMIB: SMIR_35365
SCAJ: O1G22_36835
STRW: QHG49_30905
STRL: HEP84_09415
STSD: HEP87_09210
SRPZ: HEP85_05760
SCHE: QRN89_04040
SGLY: P8A20_33565
SCAT: P8A18_02095
STII: DRB96_13415
STIC: DRB89_12585
SABD: N8I86_05955
STRV: EZV63_03640
SPAZ: ABXI76_34270
SPIH: ABXR15_00550
SMOD: POD33_30880
SPOF: P8A21_03045 P8A21_04060
SCT: SCAT_0798
SCY: SCATT_07990
KSK: KSE_36480
KAB: B7C62_01785
KAU: B6264_00205
KIT: CFP65_6672
KIS: HUT16_15955
KCH: O1G21_07615
STRH: GXP74_24735
ABRY: NYE86_14125
AGLA: OIE69_12640 OIE69_32550
AREV: RVR_9239
LXL: KDY119_02345
CUB: BJK06_06070
AMAU: DSM26151_29510(dapE_4)
LALL: MUN78_15050
ASUF: MNQ99_06385
AKO: N9A08_01495
CET: B8281_10340
SANW: G7063_09820
CELH: GXP71_09330
OEK: FFI11_010245
PSEI: GCE65_05480
TEH: GKE56_10930
HALT: IM660_12280
RHAL: LQF10_07075
RSUA: LQF12_10615
AEB: C6I20_07555
MQR: AB3M34_10675
NGN: LCN96_13735
FRI: FraEuI1c_6368
NML: Namu_3301
MMAR: MODMU_2775
AMD: AMED_3897
AMN: RAM_19840
AMM: AMES_3851
AMZ: B737_3851
APRT: MUY14_09570
PDX: Psed_4253
PBRO: HOP40_08660
SESP: BN6_59070
KPHY: AOZ06_23080
ASE: ACPL_4018
AMS: AMIS_18090
ACTS: ACWT_3889
AIH: Aiant_64400
ACTL: L3i22_064350
ASIC: Q0Z83_030650
AOU: ACTOB_002033
ACTE: ACTI_40120
CAI: Caci_6602
 » show all
Reference
1  [PMID:13436444]
  Authors
SEMENZA G
  Title
Chromatographic purification of cysteinyl-glycinase.
  Journal
Biochim Biophys Acta 24:401-13 (1957)
DOI:10.1016/0006-3002(57)90212-3
Reference
2  [PMID:6108111]
  Authors
Rankin BB, McIntyre TM, Curthoys NP
  Title
Brush border membrane hydrolysis of S-benzyl-cysteine-p-nitroanilide, and activity of aminopeptidase M.
  Journal
Biochem Biophys Res Commun 96:991-6 (1980)
DOI:10.1016/0006-291x(80)90050-9
Reference
3  [PMID:2865778]
  Authors
Hirota T, Nishikawa Y, Takahagi H, Igarashi T, Kitagawa H
  Title
Simultaneous purification and properties of dehydropeptidase-I and aminopeptidase-M from rat kidney.
  Journal
Res Commun Chem Pathol Pharmacol 49:435-45 (1985)
Reference
4  [PMID:12675513]
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
5  [PMID:18515361]
  Authors
Emter R, Natsch A
  Title
The sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria.
  Journal
J Biol Chem 283:20645-52 (2008)
DOI:10.1074/jbc.M800730200
  Sequence
[ag:ACA03770]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.13.23
IUBMB Enzyme Nomenclature: 3.4.13.23
ExPASy - ENZYME nomenclature database: 3.4.13.23
BRENDA, the Enzyme Database: 3.4.13.23
LinkDB

DBGET integrated database retrieval system