KEGG   ENZYME: 3.4.22.36
Entry
EC 3.4.22.36                Enzyme                                 
Name
caspase-1;
interleukin 1beta-converting enzyme;
protease VII;
protease A;
interleukin 1beta precursor proteinase;
interleukin 1 converting enzyme;
interleukin 1beta-converting endopeptidase;
interleukin-1beta convertase;
interleukin-1beta converting enzyme;
interleukin-1beta precursor proteinase;
prointerleukin 1beta protease;
precursor interleukin-1beta converting enzyme;
pro-interleukin 1beta proteinase;
ICE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp!
Comment
From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.
History
EC 3.4.22.36 created 1993, modified 1997, modified 2007
Orthology
K01370  caspase 1
Genes
HSA834(CASP1)
PTR101058924(CASP1)
PPS100985633 100986637(CASP1)
GGO101136563
PON100437679(CASP1) 100442809
NLE100588974(CASP1)
MCC100426388 706568
MCF102118885(CASP1)
MTHB126936244 126936247 126936524
CSAB103248363 103248365(CASP1) 103248933
CATY105588753 105588757
PANU101006831(CASP1) 101008696 101009375
TGE112605777(CASP1) 112605780 112605953 112605954
RRO104665271(CASP1) 104665273 104665280
RBB108513176 108513177 108513179(CASP1)
TFN117080358(CASP1) 117080362
PTEH111540082(CASP1) 113222446(CARD16)
CANG105500956(CASP5) 105500957 105501187
CJC100385618(CASP1)
SBQ101048062(CASP1)
CSYR103267233
MMUR105862475
LCAT123641767(CASP1)
PCOQ105822170(CASP1)
OGA100954360(CASP1)
MMU12362(Casp1)
MCAL110302061(Casp1)
MPAH110328145(Casp1)
RNO25166(Casp1)
MCOC116072579
MUN110552936
CGE100759171
MAUA101833858
PLEU114686853(Casp1)
MORG121451709(Casp1)
MFOT126491723
AAMP119809530
NGI103743236(Casp1)
HGL101725179(Casp1)
CPOC100725217 100730749
CCAN109694935(Casp1)
DORD105980798
DSP122104170
NCAR124958768
OCU100101588
TUP102490614(CASP1)
GVR103595946(CASP1)
BTA514214(CASP1)
BIU109570010(CASP1)
BBUB102395839(CASP1)
BBIS104982832
OAS101117013
ODA120876143
CCAD122449949(CASP1)
SSC397319(CASP1)
CFR102514999(CASP1)
CBAI105067586(CASP1)
CDK105100418(CASP1)
VPC102539634(CASP1)
BACU103013120
LVE103078860
OOR101289850(CASP1)
DLE111167579(CASP1)
PCAD102982110(CASP1)
PSIU116758539(CASP1)
ECB100033888(CASP1)
EPZ103559838(CASP1)
EAI106837656(CASP1)
MYB102247565 102258149(CASP1)
MYD102769699
MLF102430049
MNA107532340
HAI109377701(CASP1)
DRO112314315(CASP1)
SHON119000398(CASP4)
AJM119060758(CASP1)
PDIC114500801(CASP1)
PHAS123819732(CASP1)
MMF118627674
RFQ117029604(CASP1)
PGIG120599661
PVP105297444(CASP1)
RAY107504293(CASP1)
TOD119239974 119240905
SARA101552446
TMU101359297
ETF101653570
DNM101418396(CASP1)
MDO100032592 100032596 100032610
GAS123239007 123241350
SHR100935043
OAA100078458
GGA395764(CASP1)
PCOC116228215
MGP100549639
CJO107322632
NMEL110407545 110407549(CARD16)
APLA101789899
ACYG106041090
AFUL116497120
FPG101914004
FCH102051371
CLV102097973
EGZ104131761
NNI104012458
PLET104618301
PCRI104024129
PCAO104051788
ACUN113487354
TALA104365266
PADL103916608
AFOR103896572
ACHC115346730
HALD104319279
HLE104843152
AGEN126039307
GCL127024575
CCRI104165383
CSTI104553005
CMAC104484947
MUI104546136
FGA104075256
GSTE104264268
LDI104340060
MNB103772009
OHA104334769
NNT104399235
PGUU104471583
ACAR104523057
CPEA104391009
CVF104289860
CUCA104060329
AAM106484675
AROW112965025
NPD112956725
TGT104575689
DNE112987315
SCAM104146224
ASN102373345
AMJ102575910(CASP1)
CPOO109317659
PSS102454294
CMY102948326
CPIC101951713
TST117867574
CABI116818724
MRV120387352
ACS100554079
PVT110084544
SUND121916819
PBI103067193
PMUR107288559
CTIG120309235
PGUT117667558 117667559
VKO123036743
PMUA114585476
ZVI118097339(CASP4)
GJA107112418
STOW125446049
XLA378669(casp1.S) 397719(casp1.L)
XTR100491605(casp1)
NPR108790873
RTEM120927540
BBUF120994809
BGAR122930493
DRE566185(caspbl) 57933(caspa)
SRX107713782 107719146 107723996 107737821 107738044 107748007
SANH107659780 107666787 107679276 107683527 107685936
SGH107558420 107570904 107571421 107571890 107573577 107574341 107592160 107600521
CCAR109055187 109059688 109062412 109079016 109089143 109093960 109094019
CAUA113052249 113059546 113074243 113082415 113105593 113115174 113115897
PPRM120462205(caspa)
MAMB125242858(caspa) 125271030 125271512
IPU108267794(casp23)
PHYP113540111
AMEX103021832 103039157 103043169 111188785
EEE113573520 113574405
TRU101062626 101064415
LCO104924732
NCC104959782
CGOB115017511
ELY117250483 117259553
PLEP121943038
SLUC116047679 118492972
ECRA117942397
ESP116672700
PFLV114552537 114552861 114566870
GAT120814011 120814012 120824590(caspa)
PPUG119217527 119217533
MSAM119883616 119883617 119891577
CUD121516260
ALAT119031242 119031258
MZE101463887 101464464 101468196 101481357 112429920 112431722 112432409
ONL100702756 100708116 100708386 102079862 102081456(card16) 102082075 106097268 109196975 112846027
OAU116310644 116323593 116323605 116323606 116328039 120434310 120439261
OLA101174762
OML112140709 112149501
XMA102220363 102220624 102229031 111605766
XCO114133584 114133591 114133592 114142065
XHE116708295 116717316 116737431
PRET103474681 103477732
PFOR103136355 103148109 103154678 107833734
PLAI106939894 106950220 106952931 106952932 106952936
PMEI106908161 106917731 106917742 106920431
GAF122832182 122832183 122833093
CVG107081895 107081897 107081901
CTUL119797303 119797316
GMU124884212 124884250 124884286
NFU107380030
ALIM106519401 106533471
NWH119410885
AOCE111582467
MCEP125013084 125013085
CSEM103378482
POV109630250
SSEN122773572
HHIP117772844(caspa)
HSP118106031(caspa)
LCF108891827
SDU111237425 111238154
SLAL111654143
XGL120791739
HCQ109518426 109518427
BPEC110163616
BSPL114868518
SASA106612902
STRU115206220
OTW112266955
OMY110503799 110507087
OGO124005214
ONE115136855 115141735
SALP111959666 111982518
SNH120018779 120029080 120036891 120037031 120042531 120051700 120059763
CCLU121567657 121567662
ELS105011822
SFM108922456
PKI111841516
AANG118210370
LOC102688855 102696999(casp1)
PSPA121308504
ARUT117414382 117429871 117430514
PSEX120530645
LCM102363742
RTP109916765
FEX115233805
FOC113209168
TPAL117639242
 » show all
Reference
1  [PMID:1919001]
  Authors
Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DD, Mumford RA, et al.
  Title
IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.
  Journal
J Immunol 147:2964-9 (1991)
Reference
2  [PMID:1574116]
  Authors
Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, et al.
  Title
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
  Journal
Nature 356:768-74 (1992)
DOI:10.1038/356768a0
  Sequence
[hsa:834]
Reference
3  [PMID:7845238]
  Authors
Thornberry NA.
  Title
Interleukin-1 beta converting enzyme.
  Journal
Methods Enzymol 244:615-31 (1994)
DOI:10.1016/0076-6879(94)44045-x
Reference
4  [PMID:8861900]
  Authors
Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.
  Title
Human ICE/CED-3 protease nomenclature.
  Journal
Cell 87:171 (1996)
DOI:10.1016/S0092-8674(00)81334-3
Reference
5  [PMID:9054418]
  Authors
Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ.
  Title
Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.
  Journal
J Biol Chem 272:7223-8 (1997)
DOI:10.1074/jbc.272.11.7223
Reference
6  [PMID:15163405]
  Authors
Martinon F, Tschopp J
  Title
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
  Journal
Cell 117:561-74 (2004)
DOI:10.1016/j.cell.2004.05.004
Reference
7  [PMID:11104820]
  Authors
Chang HY, Yang X.
  Title
Proteases for cell suicide: functions and regulation of caspases.
  Journal
Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.36
IUBMB Enzyme Nomenclature: 3.4.22.36
ExPASy - ENZYME nomenclature database: 3.4.22.36
BRENDA, the Enzyme Database: 3.4.22.36
CAS: 122191-40-6
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