KEGG ENZYME: 3.4.22.36

ENZYME: 3.4.22.36

Entry

EC 3.4.22.36                Enzyme

Name

caspase-1;
interleukin 1beta-converting enzyme;
protease VII;
protease A;
interleukin 1beta precursor proteinase;
interleukin 1 converting enzyme;
interleukin 1beta-converting endopeptidase;
interleukin-1beta convertase;
interleukin-1beta converting enzyme;
interleukin-1beta precursor proteinase;
prointerleukin 1beta protease;
precursor interleukin-1beta converting enzyme;
pro-interleukin 1beta proteinase;
ICE

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp!

Comment

From mammalian monocytes. This enzyme is part of the family of inflammatory caspases, which also includes caspase-4 (EC 3.4.22.57) and caspase-5 (EC 3.4.22.58) in humans and caspase-11 (EC 3.4.22.64), caspase-12, caspase-13 and caspase-14 in mice. Contains a caspase-recruitment domain (CARD) in its N-terminal prodomain, which plays a role in procaspase activation [6,7]. Cleaves pro-interleukin-1beta (pro-IL-1beta) to form mature IL-1beta, a potent mediator of inflammation. Also activates the proinflammatory cytokine, IL-18, which is also known as interferon-gamma-inducing factor [6]. Inhibited by Ac-Tyr-Val-Ala-Asp-CHO. Caspase-11 plays a critical role in the activation of caspase-1 in mice, whereas caspase-4 enhances its activation in humans [7]. Belongs in peptidase family C14.

History

EC 3.4.22.36 created 1993, modified 1997, modified 2007

Orthology

K01370

caspase 1

Genes

HSA:	834(CASP1)

PTR:	101058924(CASP1) 735456

PPS:	100986637(CASP1)

GGO:

101136563

PON:	100437679 100442809

PPYG:

129007266 129007786

NLE:	100588974(CASP1)

HMH:

116476876

SSYN:

129479581(CASP1)

MCC:	100426388 706568

MCF:	102118885(CASP1)

MTHB:

126936244 126936247 126936524

MNI:	105493685 105493689

CSAB:

103248363 103248365(CASP1) 103248933

CATY:

105588753 105588757

PANU:

101006831(CASP1) 101008696 101009375

TGE:	112605777(CASP1) 112605780 112605953 112605954

MLEU:

105534146 105534147(CASP1) 105534152

RRO:	104665271(CASP1) 104665273 104665280

RBB:	108513176 108513177 108513179(CASP1)

TFN:	117080358(CASP1) 117080362

PTEH:

111540082(CASP1) 113222446(CARD16)

CANG:

105500956(CASP5) 105500957 105501187

CJC:

100385618

SBQ:	101048062(CASP1)

CIMI:

108315450(CASP1)

ANAN:

105719329

CSYR:

103267233

MMUR:

105862475

LCAT:

123641767(CASP1)

PCOQ:

105822170(CASP1)

OGA:	100954360(CASP1)

MMU:	12362(Casp1)

MCAL:

110302061(Casp1)

MPAH:

110328145(Casp1)

RNO:	25166(Casp1)

MCOC:

116072579

ANU:

117699845

ASYL:

127689464

MUN:	110552936(Casp1)

CGE:

100759171

MAUA:

101833858

PROB:

127216912

PLEU:

114686853(Casp1)

MORG:

121451709(Casp1)

MFOT:

126491723

AAMP:

119809530

NGI:	103743236(Casp1)

HGL:	101725179(Casp1)

CPOC:

100725217 100730749

CCAN:

109694935(Casp1)

DORD:

105980798

DSP:

122104170

DMER:

138821308 138838827

PLOP:

125349533

NCAR:

124958768

MMMA:

107145897(Casp1)

ITI:

101954543

OCU:

100101588

TUP:	102490614(CASP1)

GVR:	103595946(CASP1)

BTA:	514214(CASP1)

BIU:	109570010(CASP1)

BBUB:

102395839(CASP1)

BBIS:

104982832

OAS:	101117013(CASP1)

BTAX:

128060592(CASP1)

CSUM:

138092751(CASP1)

ODA:

120876143

CCAD:

122449949(CASP1)

MREE:

136175979

OVR:

110141490

MBEZ:

129554236

SSC:	397319(CASP1)

CFR:	102514999(CASP1)

CBAI:

105067586(CASP1)

CDK:	105100418(CASP1)

VPC:	102539634(CASP1)

BACU:

103013120

BMUS:

118899438(CASP1)

LVE:

103078860

OOR:	101289850(CASP1)

LALB:

132525375(CASP1)

GMF:	115841672(CASP1)

DLE:	111167579(CASP1)

PCAD:

102982110(CASP1)

PSIU:

116758539(CASP1)

PPHC:

136126316(CASP1)

NASI:

112415749(CASP1)

ECB:	100033888(CASP1)

EPZ:

103559838

EAI:	106837656(CASP1)

MYB:	102247565 102258149(CASP1)

MYD:

102769699

MLF:

102430049

MDT:

132241716

MYUM:

139018515

EFUS:

103299256(CASP1)

MNA:

107532340

DRO:	112314315(CASP1)

SHON:

119000398(CASP4)

AJM:	119060758(CASP1)

PDIC:

114500801(CASP1)

PHAS:

123819732(CASP1)

MMF:

118627674

HAI:	109377701(CASP1)

RFQ:	117029604(CASP1)

PGIG:

120599661

PVP:	105297444(CASP1)

TOD:	119239974 119240905

SARA:

101552446

SFUM:

130024179

SETR:

126016066

TMU:

101359297

ETF:

101653570

DNM:	101418396(CASP1)

MDO:	100032592 100032596 100032610

GAS:	123239007 123241350

SHR:

100935043

AFZ:

127554938

OAA:

100078458

TACU:

119941451

GGA:	395764(CASP1)

PCOC:

116228215

MGP:

100549639

CJO:

107322632

TPAI:

128083529

LMUT:

125703079

NMEL:

110407545 110407549(CARD16)

APLA:

101789899

ACYG:

106041090

CATA:

118254061

AFUL:

116497120

FPG:

101914004

FCH:

102051371

CCRI:

104165383

NNT:

104399235

SHAB:

115603126

ACUN:

113487354

TALA:

104365266

ACHC:

115346730

HALD:

104319279

HLE:

104843152

AGEN:

126039307

HHAR:

128149310

GCL:

127024575

CSTI:

104553005

LDI:

104340060

MNB:

103772009

EGZ:

104131761

NNI:

104012458

PCRI:

104024129

PCAO:

104051788

PADL:

103916608

AFOR:

103896572

FGA:

104075256

GSTE:

104264268

CBOY:

140660984

CLV:

102097973

CNIC:

135995707

MUI:

104546136

PGUU:

104471583

PLET:

104618301

CMAC:

104484947

CUCA:

104060329

BREG:

104640475

OHA:

104334769

ACAR:

104523057

CPEA:

104391009

CVF:

104289860

RTD:

128912921

CRID:

134518779

AAM:

106484675

AROW:

112965025

NPD:

112956725

TGT:

104575689

DNE:

112987315

SCAM:

104146224

ASN:

102373345

AMJ:	102575910(CASP1)

CPOO:

109317659

PSS:

102454294

CMY:

102948326

CCAY:

125623888

DCC:

119844751

CPIC:

101951713

TST:

117867574

CABI:

116818724

MRV:

120387352

ACS:

100554079

ASAO:

132763419

PVT:

110084544

SUND:

121916819

PBI:

103067193

PMUR:

107288559

CTIG:

120309235

PGUT:

117667558 117667559

PCAE:

139308535 139318756

APRI:

131188892

PTEX:

113441504

NSS:

113414673

VKO:

123036743

PMUA:

114585476

PRAF:

128402662

ZVI:	118097339(CASP4)

HCG:

128336113

GJA:

107112418

STOW:

125446049

EMC:

129345099

XLA:	378669(casp1.S) 397719(casp1.L)

XTR:	100491605(casp1)

NPR:

108790873

RTEM:

120927540

ACAT:

141128907

BBUF:

120994809

BGAR:

122930493

DTC:

141080528

MUO:

115482582

GSH:

117348733

DRE:	566185(caspbl) 57933(caspa)

SRX:	107713782 107719146 107723996 107737821 107738044 107748007

SANH:

107659780 107666787 107679276 107683527 107685936

SGH:	107558420 107570904 107571421 107571890 107573577 107574341 107592160 107600521

CCAR:

109059688(caspa) 109062408 109062412 109079016 109093960 109094019(casp23)

CAUA:

113052249 113059546 113074243 113082415 113105593 113115174 113115897

CGIB:

127975488 128029032 128030415

PTET:

122360331(caspa) 122360767

LROH:

127178989(caspa)

GRF:	141335985 141335987

OMC:	131522386(caspa) 131537445 131537504 131537508 131547693 131547742

PPRM:

120462205(caspa)

RKG:	130100674(caspa)

MAMB:

125242858(caspa) 125271030 125271512

CIDE:

127496856 127508390 127511353

CERY:

137031784 137032780 137036066(caspa)

MASI:

127453477 127454625

TROS:

130557700(caspa)

TDW:	130433600(caspa) 130433602

MANU:

129448540(caspa)

PDAB:

135789071 135789072(caspa)

IPU:	108267794(casp23)

PHYP:

113540111

AMEX:

103039157(caspa) 111188785 125802140

CMAO:

118798716 118799123

EEE:	113573520 113574405

CHAR:

105908639 122133338(caspa)

SPIL:

134078289

TRU:	101062626 101064415

TFS:	130534928 130535589 130535590

LCO:

104924732

NCC:

104959782

TBEN:

117470464(caspa) 117482809

CGOB:

115017511

PGEO:

117455465 117457271

GACU:

117554819

EMAC:

134879956

ELY:	117250483 117259553

PLEP:

121943038

SLUC:

116047679

ECRA:

117942397

ESP:

116672700

PFLV:

114552537 114552861

GAT:	120814011 120814012 120824590(caspa)

PPUG:

119217527 119217533

AFB:

129089059

CLUM:

117741247

PSWI:

130210600 130210609

CANA:

137790408

CVE:	137873442 137873466

MSAM:

119883616 119883617 119891577

SCHU:

122879677

CUD:

121516260

SPUL:

138596708

LMIX:

132980599

ALAT:

119031242 119031258

ASTR:

137596327

MZE:	101463887 101464464 101468196 101481357 112429920 112431722 112432409

ONL:	100702756 100708116 100708386 102079862 102081456(card16) 102082075 106097268 112846027

OAU:	116310644 116323593 116323605 116323606 116328039 120434310 120439261

OLA:

101174762

OML:	112140709 112149501

CSAI:

133441804 133441807 133442377

XMA:	102220363 102220624 102229031 111605766

XCO:	114133584 114133591 114133592 114142065

XHE:	116708295 116717316 116737431

PRET:

103474681 103477732

PFOR:

103136355 103148109 103154678 107833734

PLAI:

106939894 106950220 106952931 106952932 106952936

PMEI:

106908161 106917731 106917742 106920431

GAF:	122832182 122832183 122833093

PPRL:

129369807 129369976 129370003

CVG:	107081895 107081897 107081901

CTUL:

119797303 119797316

GMU:	124884212 124884250 124884286

NFU:

107380030

ALIM:

106519401 106533471

NWH:

119410885

AOCE:

111582467

EJA:

138197400

BFRE:

138625418

MCEP:

125013084 125013085

CSEM:

103378482

POV:

109630250

SSEN:

122773572

SSOE:

131462425(caspa)

HHIP:

117772844(caspa)

HSP:	118106031(caspa)

PPLT:

128439598(caspa) 128439599

SMAU:

118295301

SDU:	111237425 111238154

SLAL:

111654143

XGL:

120791739

HCQ:	109518426 109518427

SSCV:

125972695 125972696

SBIA:

133505182

PEE:

133405528

PTAO:

133482418

BPEC:

110163616

ENY:

140369581

BSPL:

114868518

SJO:	128353177 128353178 128354004 128359924 128360330 128360332 128360388 128366902

SSCO:

133976669 133980835 133980837 134001466 134004359

GMH:	115539033 115560686 115560691 115561048

SASA:

106612902

STRU:

115206220

OTW:

112266955

OMY:	110503799 110507087

OGO:

124005214

ONE:	115136855 115141735

OKI:

109909078

OKE:	118378924 118397359

OMM:	135546337 135546340 135552815

OCLA:

139382413

SALP:

111959666 111982518

SNH:	120018779 120029080 120036891 120037031 120042531 120051700

CCLU:

121567657 121567662

ELS:

105011822

OEP:

134028796

SFM:

108922456

PKI:

111841516

AANG:

118210370

AROT:

135236649

CCOG:

133107843 133107844 133108103 133108195 133108196 133108197 133108563 133108735

LOC:	102688855 102696999(casp1)

PSPA:

121308504

ARUT:

117414382 117429871 117430514

PSEX:

120530645

LCM:

102363742

RTP:

109916765

CPLA:

122564102

HOC:

132830292

LERI:

129710763

HAKA:

140731799

PMRN:

116944762

LRJ:

133345359

FOC:

113209168

TPAL:

117639242

» show all

Reference

1 [PMID:1919001]

Authors

Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DD, Mumford RA, et al.

Title

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

Journal

J Immunol 147:2964-9 (1991)

Reference

2 [PMID:1574116]

Authors

Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, et al.

Title

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.

Journal

Nature 356:768-74 (1992)
DOI:10.1038/356768a0

Sequence

[hsa:834]

Reference

3 [PMID:7845238]

Authors

Thornberry NA.

Title

Interleukin-1 beta converting enzyme.

Journal

Methods Enzymol 244:615-31 (1994)
DOI:10.1016/0076-6879(94)44045-x

Reference

4 [PMID:8861900]

Authors

Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J.

Title

Human ICE/CED-3 protease nomenclature.

Journal

Cell 87:171 (1996)
DOI:10.1016/S0092-8674(00)81334-3

Reference

5 [PMID:9054418]

Authors

Margolin N, Raybuck SA, Wilson KP, Chen W, Fox T, Gu Y, Livingston DJ.

Title

Substrate and inhibitor specificity of interleukin-1 beta-converting enzyme and related caspases.

Journal

J Biol Chem 272:7223-8 (1997)
DOI:10.1074/jbc.272.11.7223

Reference

6 [PMID:15163405]

Authors

Martinon F, Tschopp J

Title

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.

Journal

Cell 117:561-74 (2004)
DOI:10.1016/j.cell.2004.05.004

Reference

7 [PMID:11104820]

Authors

Chang HY, Yang X.

Title

Proteases for cell suicide: functions and regulation of caspases.

Journal

Microbiol Mol Biol Rev 64:821-46 (2000)
DOI:10.1128/mmbr.64.4.821-846.2000

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.36

IUBMB Enzyme Nomenclature:

3.4.22.36

ExPASy - ENZYME nomenclature database:

3.4.22.36

BRENDA, the Enzyme Database:

3.4.22.36

CAS:	122191-40-6

LinkDB

DBGET integrated database retrieval system