| Entry |
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| Name |
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aspartic endopeptidases
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| Reaction(IUBMB) |
Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His bond in B chain of insulin
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| Comment |
Occurs intracellularly, in lysosomes. A zymogen form is known [4]. In peptidase family A1 (pepsin A family).
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| History |
EC 3.4.23.5 created 1965 as EC 3.4.4.23, transferred 1972 to EC 3.4.23.5, modified 1986
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| Orthology |
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| Genes |
| PCAD: | 102977235(CTSD) 114485787 114485885 |
| AJM: | 119057540(CTSD) 119059015 |
| PVP: | 105299530(CTSD) 105311653 105311654 |
| PMOA: | 120505232 120511363(CTSD) |
| PHI: | 102106589 102113116(CTSD) |
| ETL: | 114059842(CTSD) 114072405 |
| AMJ: | 102558679(CTSD) 102576563 |
| CMY: | 102948221(CTSD) 119564902 |
| CPIC: | 101953135 101953957(CTSD) |
| MRV: | 120388483 120403710(CTSD) |
| ACS: | 100563621 100567238(ctsd) |
| PVT: | 110076569(CTSD) 110078570 |
| SUND: | 121934257 121936820(CTSD) |
| PBI: | 103055064(CTSD) 103055181 |
| PMUR: | 107282504 107290778(CTSD) |
| TSR: | 106546581 106549898(CTSD) |
| PGUT: | 117665216(CTSD) 117669135 |
| VKO: | 123021373(CTSD) 123032095 |
| PMUA: | 114581579 114599332(CTSD) |
| ZVI: | 118079267 118088246(CTSD) 118089110 118095051 |
| GJA: | 107116580 107118828(CTSD) |
| STOW: | 125426183(CTSD) 125444275 |
| XLA: | 398994(napsa.L) 443721(ctsd.S) 443829 |
| XTR: | 101733630 101735147 116410386 394561(ctsd) 448214(napsa) 613063 |
| NPR: | 108790987 108790992 108792630 |
| RTEM: | 120916518 120917294 120917295 |
| BBUF: | 120981127 120981181 |
| BGAR: | 122920181 122921117 |
| DRE: | 336746(napsa) 65225(ctsd) |
| SRX: | 107723590 107730483 107740314 107748792 |
| SANH: | 107672139 107672285 107686244 107695135 |
| SGH: | 107576314 107578338 107583260 107583812(ctsd) |
| CCAR: | 109049111 109058510 109105685(ctsd) 109105691 |
| CAUA: | 113046815 113047624 113061519 113118288 |
| PPRM: | 120461985(ctsd) 120462280(napsa) |
| MAMB: | 125254203(ctsd) 125273711(napsa) |
| IPU: | 100528208(napsa) 100862736(ctsd) 124626810 |
| PHYP: | 113524057 113534474(ctsd) |
| SMEO: | 124382239(napsa) 124395754(ctsd) |
| TFD: | 113640126(napsa) 113652590(ctsd) |
| AMEX: | 103026424 103032210 |
| TRU: | 777955(ctsd) 777956(ctsd2) |
| TNG: | GSTEN00002939G001 GSTEN00002940G001 GSTEN00006405G001 GSTEN00021670G001 |
| LCO: | 104924100 109142810(ctsd) |
| NCC: | 104966021(ctsd) 104967883 |
| CGOB: | 115012740 115024835 |
| ELY: | 117256421(ctsd) 117267941(napsa) |
| PLEP: | 121938483(ctsd) 121956748(napsa) |
| SLUC: | 116065272(napsa) 116067287(ctsd) |
| ECRA: | 117954117(ctsd) 117957766(napsa) |
| PFLV: | 114554310(ctsd) 114569243 |
| GAT: | 120828220(napsa) 120834419(ctsd) |
| PPUG: | 119220210(napsa) 119224953(ctsd) |
| MSAM: | 119885426(napsa) 119890271 119890600 |
| CUD: | 121503363(napsa) 121506838(ctsd) |
| ALAT: | 119013684(napsa) 119018030(ctsd) |
| MZE: | 101473375(ctsd) 101475375 |
| ONL: | 100690050(ctsd) 100700357 |
| OAU: | 116327850(napsa) 116334288(ctsd) |
| OLA: | 101161712 101168958 111946846 |
| OML: | 112141981(ctsd) 112146263(napsa) |
| XMA: | 102221671(ctsd) 102225207 |
| XCO: | 114142967(ctsd) 114159781 |
| XHE: | 116719271(ctsd) 116735110 |
| PRET: | 103462981 103468494 |
| PFOR: | 103147381 103155220 |
| PLAI: | 106949364 106964602 |
| PMEI: | 106908427 106924557 |
| GAF: | 122822231(napsa) 122824639(ctsd) |
| CTUL: | 119771563(napsa) 119780580(ctsd) |
| GMU: | 124863828 124866937(ctsd) |
| ALIM: | 106520647 106532654 106537140 |
| CSEM: | 103378862(ctsd) 103393287 |
| POV: | 109643581 109647905 109648166 |
| SSEN: | 122772539(ctsd) 122785475(napsa) |
| HHIP: | 117759155(ctsd) 117766568(napsa) |
| SDU: | 111223324(ctsd) 111230367 |
| SLAL: | 111646321 111648175 111656646(ctsd) |
| XGL: | 120791202(ctsd) 120806118(napsa) |
| HCQ: | 109514434(ctsd) 109520249 |
| BPEC: | 110162358 110173248 |
| MALB: | 109971559(ctsd) 109972414 |
| BSPL: | 114851852(ctsd) 114860247(napsa) |
| SASA: | 106562496 106584518 106587969(CATD) 106592547 106600890 106607447(CATD) |
| OTW: | 112222204 112224690(ctsd) 112225886 112258482 |
| OMY: | 100136761 110486128 110521353 110538020 118936249 |
| OGO: | 123998568 124015511(napsa) 124019850 124019880 124024511 |
| ONE: | 115104015 115110117 115144806 |
| SALP: | 111971994 111980404 111981447 112079540 |
| SNH: | 120034184 120034537 120037872 120037903 120051757 |
| ELS: | 105009674(ctsd) 105028876 105029662 |
| SFM: | 108928864 108930663 108934581 108942262 |
| PKI: | 111835976 111840384 111845240 111859461 |
| AANG: | 118215248(ctsd) 118216291(napsa) 118228397 |
| PSPA: | 121294928 121305978(napsa) 121322596 121330244 |
| ARUT: | 117421652 117431943 117434446 117966750 |
| LCM: | 102351433(CTSD) 102355307 |
| BFO: | 118407207 118410421 118411258 118414060 |
| BBEL: | 109475415 109475550 109478977 |
| SCLV: | 120345659 120345732 |
| APLC: | 110975442 110980673 110987235 |
| DME: | Dmel_CG10104(CG10104) Dmel_CG13095(Bace) Dmel_CG1548(cathD) Dmel_CG17134(CG17134) Dmel_CG17283(CG17283) Dmel_CG31661(CG31661) Dmel_CG31926(CG31926) Dmel_CG31928(CG31928) Dmel_CG33128(CG33128) Dmel_CG5860(CG5860) Dmel_CG5863(CG5863) Dmel_CG6508(CG6508) |
| DER: | 6541215 6541490 6541956 6542760 6542852 6543136 6543397 6543412 6549334 6552324 6552345 6552346 |
| DSE: | 6608064 6609140 6611709 6612067 6612068 6616756 6616757 6616758 6617379 6617380 6617381 6617382 |
| DSI: | Dsimw501_GD10217(Dsim_GD10217) Dsimw501_GD11051(Dsim_GD11051) Dsimw501_GD19153(Dsim_GD19153) Dsimw501_GD19154(Dsim_GD19154) Dsimw501_GD19155(Dsim_GD19155) Dsimw501_GD23098(Dsim_GD23098) Dsimw501_GD23099(Dsim_GD23099) Dsimw501_GD23100(Dsim_GD23100) Dsimw501_GD23101(Dsim_GD23101) Dsimw501_GD23735(Dsim_GD23735) Dsimw501_GD23736(Dsim_GD23736) Dsimw501_GD27017(Dsim_GD27017) |
| DYA: | Dyak_GE10127 Dyak_GE10128 Dyak_GE10129 Dyak_GE10927 Dyak_GE13586 Dyak_GE17582 Dyak_GE17593 Dyak_GE17604 Dyak_GE17615 Dyak_GE18490 Dyak_GE18491 Dyak_GE23596 |
| DAN: | 6494100 6497195 6499198 |
| DSR: | 110178061 110183091 110183092 110183093 110183099 110183463 110183464 110183869 110187874 110187984 110188061 110189203 110191585 |
| DPO: | Dpse_GA10074 Dpse_GA13759 Dpse_GA14340 Dpse_GA14439 Dpse_GA16375 Dpse_GA16570 Dpse_GA16571 Dpse_GA17303 Dpse_GA19184 Dpse_GA19187 Dpse_GA22213 Dpse_GA25369 Dpse_GA26724 |
| DPE: | 113565758 6587516 6587568 6587570 6590222 6590926 6593976 6595692 6595693 6595694 6596586 6598350 |
| DMN: | 108157688 108157689 108157847 108158243 108158972 108161530 108161531 108161532 108161533 108162717 108163700 108165158 117188903 117188906 117189111 117189112 117189113 117189114 117189441 117191493 117191867 |
| DWI: | 26529619 26530191 6640039 6640271 6642405 6642406 6642551 6642552 6643831 6647431 6647432 6647433 6648248 |
| DGR: | 6559459 6561284 6562191 6562192 6566126 6566127 6566188 6566189 6568105 |
| DMO: | Dmoj_GI11124 Dmoj_GI11125 Dmoj_GI14564 Dmoj_GI14567 Dmoj_GI19550 Dmoj_GI20282 Dmoj_GI24781 |
| DAZ: | 108611792 108611793 108615105 108616595 108619031 108619997 108619998 |
| DNV: | 108653946 108655199 108657879 108657880 108659959 115562128 115562144 |
| DHE: | 111591968 111591969 111591977 111593899 111595826 111595835 111600679 111601483 |
| DVI: | 6624800 6626982 6627658 6634476 6634477 |
| CCAT: | 101455167 101455337 101455507 101455674 101455851 101455855 101461571 101461751 101461927 110118532 |
| BOD: | 106620884 106624636 106625220 106627567 106627570 106627571 106627576 106627859 |
| MDE: | 101890957 101891130 101891302 101891479 101891661 101891831 101894200 101894831 101895159 101895331 |
| SCAC: | 106088349 106088351 106088352 106088353 106088354 106091515 |
| LCQ: | 111677605 111685051 111686728 111686731 111686732 111686734 |
| CNS: | 116337021 116337471 116349678 |
| MPHA: | 105835079 105836265 |
| AEC: | 105146927 105146957 105146958 105146959 105146960 105146961 105146962 105146984 105147358 |
| ACEP: | 105618739 105624796 105626963 105626973 105626983 105626994 105627253 |
| CFO: | 105247753 105247754 105247755 105247767 105248148 105248149 105248337 105248997 105250119 105251298 105252159 105252160 105252875 105254123 105254125 105254126 105255112 105255113 105255172 105255173 105255320 105255526 105255527 105256040 105256303 105256508 105257479 105257594 105257595 105257692 105257694 105257830 105257919 105258344 105258491 105258678 105259409 112637054 112637320 112637482 112637490 112637953 112637954 112637955 112637956 112637957 112637958 112637959 112638135 112638136 112638138 112638139 112638151 112638152 112638154 112638155 112638156 112638157 112638633 112638662 112638666 112639245 112639466 112639467 112639473 112639474 112639479 |
| FEX: | 115237715 115237716 115237729 115246051 115246058 115246061 115246062 |
| TPRE: | 106648925 106648926 |
| CGLO: | 123269961 123269962 |
| AGIF: | 122853368 122853369 |
| CCIN: | 107274681 107274682 |
| DPA: | 109533217 109536099 109540497 |
| ATD: | 109601676 109604296 109608484 |
| CSET: | 123308087 123315172 123318371 |
| LDC: | 111502796 111502808 111502809 111503340 |
| APLN: | 108739049 108739400 |
| PPYR: | 116166516 116166517 116167297 116177138 |
| MSEX: | 115450033 119189808 |
| API: | 100168373(Cathd) 100169529 |
| AGS: | 114127628 114128319 114128321 |
| BTAB: | 109040703 109040858 |
| CLEC: | 106662769 106663446 106668004 106668038 106668057 106668063 106668169 106668627 106672519 106672741 106672743 106672746 106672747 106672748 106672749 106672754 106673712 112126476 |
| HHAL: | 106677347 106677349 106677813 106679806 106679810 106681111 106682325 106682496 106684832 106689815 106690232 106690635 112210518 |
| NLU: | 111053072 111061281 111064039 120352553 120352554 |
| PHU: | Phum_PHUM318490 Phum_PHUM318500 |
| ZNE: | 110837825 110838153 110838168 |
| CSEC: | 111873754 111873775 |
| DPX: | DAPPUDRAFT_189045 DAPPUDRAFT_227643 DAPPUDRAFT_92408 |
| DMK: | 116915408 116915419 116932988 |
| PJA: | 122255822 122255823 122256897 122259113 |
| PCHN: | 125031327 125036249 125037789 125037834 |
| HAME: | 121870457 121874273 |
| PCLA: | 123760880 123760881 123766550 |
| PTRU: | 123503454 123510786 |
| HAZT: | 108674695 108678423 |
| LSM: | 121130298 121132333 121132595 |
| ISC: | IscW_ISCW003823 IscW_ISCW013185 IscW_ISCW023880 |
| DSV: | 119436005 119436278 119443879 119444494 119444495 119445520 119449880 119450275 119450286 119450337 119456885 119457085 119458237 119458978 119459579 |
| RSAN: | 119373623 119373640 119373654 119373661 119373668 119373807 119375245 119381015 119382724 119386481 119391070 119403239 119404776 119404797 |
| RMP: | 119162347 119167381 119167387 119169345 119176763 119176766 119177014 119177016 119177017 119177366 119182865 119183054 119183247 119185053 |
| PTEP: | 107442437 107455892 |
| CEL: | CELE_H22K11.1(asp-3) CELE_R12H7.2(asp-4) |
| CBR: | CBG_05258(Cbr-asp-4) CBG_10895(Cbr-asp-3) |
| BMY: | BM_BM8660(Bma-asp-4) |
| NAI: | NECAME_01817 NECAME_02620 NECAME_02622 NECAME_02623 NECAME_06496 NECAME_08060 NECAME_16669 |
| LGI: | LOTGIDRAFT_173095 LOTGIDRAFT_176001 |
| SMM: | Smp_013040.1 Smp_018800 Smp_132470 Smp_132480 Smp_136720 Smp_136730 Smp_136830.1 |
| OVI: | T265_00659 T265_01444 T265_01821 T265_03432 T265_05066 T265_07601 T265_07602 T265_09448 T265_09450 T265_09451 T265_09452 T265_09960 T265_10533 T265_11050 T265_11591 T265_11965 T265_13639 T265_15011 T265_15347 |
| XEN: | 124455518 124455538 124455874 |
| TAD: | TRIADDRAFT_19041 TRIADDRAFT_19349 TRIADDRAFT_36909 TRIADDRAFT_36922 TRIADDRAFT_51077 TRIADDRAFT_51616 TRIADDRAFT_61606 |
| CSAT: | 104718323 104718324 104720201 104723046 104727896 104729100 104731313 104731550 109126818 |
| BRP: | 103828080 103855967 103855971 |
| BNA: | 106351717 106379037 106420092 111209153 |
| BOE: | 106309133 106310830 106329651 106329655 106333596 |
| RSZ: | 108834176 108846953 108853128 |
| ZMA: | 103630050 103637842 103650796 118476727 |
| ANG: | ANI_1_314184(An04g01440) |
| TRG: | TRUGW13939_03406 TRUGW13939_04908 |
| TASA: | A1Q1_01736 A1Q1_03568 A1Q1_05904 A1Q1_06626 A1Q1_06819 |
| PPL: | POSPLDRAFT_100521 POSPLDRAFT_100773 POSPLDRAFT_33536 |
| TVS: | TRAVEDRAFT_114719 TRAVEDRAFT_125666 TRAVEDRAFT_147373 TRAVEDRAFT_154002 TRAVEDRAFT_16295 TRAVEDRAFT_166755 TRAVEDRAFT_173323 TRAVEDRAFT_27566 TRAVEDRAFT_35573 TRAVEDRAFT_56073 TRAVEDRAFT_69055 |
| DSQ: | DICSQDRAFT_127694 DICSQDRAFT_144708 DICSQDRAFT_145728 DICSQDRAFT_145919 DICSQDRAFT_166513 DICSQDRAFT_181335 DICSQDRAFT_70096 DICSQDRAFT_72830 DICSQDRAFT_83284 DICSQDRAFT_93072 DICSQDRAFT_98502 |
| PCO: | PHACADRAFT_132810 PHACADRAFT_132901 PHACADRAFT_132970 PHACADRAFT_160625 PHACADRAFT_201008 PHACADRAFT_203568 PHACADRAFT_203594 PHACADRAFT_203598 PHACADRAFT_246256 PHACADRAFT_246257 PHACADRAFT_246265 PHACADRAFT_264907 |
| SHS: | STEHIDRAFT_56915 STEHIDRAFT_56983 STEHIDRAFT_77950 |
| HIR: | HETIRDRAFT_146489 HETIRDRAFT_173308 HETIRDRAFT_64456 |
| PSQ: | PUNSTDRAFT_101191 PUNSTDRAFT_112865 PUNSTDRAFT_118414 PUNSTDRAFT_118871 PUNSTDRAFT_121063 PUNSTDRAFT_135462 PUNSTDRAFT_139159 PUNSTDRAFT_141854 PUNSTDRAFT_55941 PUNSTDRAFT_65257 |
| ADL: | AURDEDRAFT_112888 AURDEDRAFT_117425 |
| FME: | FOMMEDRAFT_107506 FOMMEDRAFT_111520 FOMMEDRAFT_111617 FOMMEDRAFT_21992 FOMMEDRAFT_72805 |
| GTR: | GLOTRDRAFT_101798 GLOTRDRAFT_115817 GLOTRDRAFT_116661 GLOTRDRAFT_37409 |
| LBC: | LACBIDRAFT_144077(LbPR_A11) LACBIDRAFT_302848(LbPR_A1) LACBIDRAFT_314168 LACBIDRAFT_324403(PR_A2) |
| MRR: | Moror_14148 Moror_384 |
| CCI: | CC1G_03281 CC1G_07585 |
| SCM: | SCHCODRAFT_256911 SCHCODRAFT_54219 SCHCODRAFT_65201 SCHCODRAFT_82048 SCHCODRAFT_82906 |
| ABP: | AGABI1DRAFT112343(AGABI1DRAFT_112343) AGABI1DRAFT70451(AGABI1DRAFT_70451) AGABI1DRAFT91098(AGABI1DRAFT_91098) |
| ABV: | AGABI2DRAFT142735(AGABI2DRAFT_142735) AGABI2DRAFT149875(AGABI2DRAFT_149875) AGABI2DRAFT186102(AGABI2DRAFT_186102) AGABI2DRAFT192307(AGABI2DRAFT_192307) |
| CPUT: | CONPUDRAFT_110698 CONPUDRAFT_113546 CONPUDRAFT_119288 CONPUDRAFT_126245 CONPUDRAFT_148126 CONPUDRAFT_156962 CONPUDRAFT_160863 CONPUDRAFT_166898 CONPUDRAFT_81421 CONPUDRAFT_83398 CONPUDRAFT_84768 CONPUDRAFT_94192 CONPUDRAFT_99352 |
| SLA: | SERLADRAFT_412860 SERLADRAFT_441879 SERLADRAFT_466841 |
| PFP: | PFL1_00437 PFL1_00598 PFL1_04662 |
| MGL: | MGL_0599 MGL_1932 MGL_3329 MGL_3565 MGL_4243 |
| MRT: | MRET_0835 MRET_1618 MRET_2661 MRET_4286 MRET_4287 MRET_4390 |
| MSYM: | MSY001_2778(PGA3) MSY001_3347 |
| PGR: | PGTG_03988 PGTG_08035 PGTG_10977 PGTG_16098 |
| MLR: | MELLADRAFT_112392 MELLADRAFT_115846 MELLADRAFT_33371 MELLADRAFT_89072 |
| PCB: | PCHAS_133370(PC100152.00.0) |
| TET: | TTHERM_00052190 TTHERM_00128320 TTHERM_00321680 TTHERM_00437370 TTHERM_00647470 TTHERM_01027660 TTHERM_01053040 |
| PTM: | GSPATT00000591001 GSPATT00001325001 GSPATT00002719001 GSPATT00002820001 GSPATT00003024001 GSPATT00004715001 GSPATT00018927001 GSPATT00020686001 GSPATT00021507001 GSPATT00021997001 GSPATT00022764001 GSPATT00023179001 GSPATT00024460001 GSPATT00025780001 GSPATT00038986001 |
| SMIN: | v1.2.002327.t1(symbB.v1.2.002327.t1) v1.2.005246.t1(symbB.v1.2.005246.t1) v1.2.010189.t1(symbB.v1.2.010189.t1) v1.2.033392.t2(symbB.v1.2.033392.t2) |
| AAF: | AURANDRAFT_23053 AURANDRAFT_71302 |
| EHX: | EMIHUDRAFT_356350 EMIHUDRAFT_358471 EMIHUDRAFT_362303 |
| NGR: | NAEGRDRAFT_32195 NAEGRDRAFT_81926 NAEGRDRAFT_82503 |
|
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| Reference |
1 |
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| Authors |
Barrett, A.J. |
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| Title |
Cathepsin D and other carboxyl proteinases. |
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| Journal |
In: Barrett, A.J. (Ed.), Proteinases in Mammalian Cells and Tissues, North-Holland Publishing Co., Amsterdam, 1977, p. 209-248. |
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| Reference |
|
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| Authors |
Takahashi T, Tang J |
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| Title |
Cathepsin D from porcine and bovine spleen. |
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| Journal |
|
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| Reference |
|
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| Authors |
Faust PL, Kornfeld S, Chirgwin JM. |
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| Title |
Cloning and sequence analysis of cDNA for human cathepsin D. |
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| Journal |
|
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| Sequence |
|
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| Reference |
|
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| Authors |
Conner GE. |
|---|
| Title |
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme. |
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| Journal |
|
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.23.5 |
| ExPASy - ENZYME nomenclature database: | 3.4.23.5 |
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| LinkDB |
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