Entry
Name
N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase;
MshB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase
Reaction(IUBMB)
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + H2O = 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + acetate [RN:
R09651 ]
Reaction(KEGG)
Substrate
1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol [CPD:
C19784 ];
H2O [CPD:
C00001 ]
Product
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol [CPD:
C19702 ];
acetate [CPD:
C00033 ]
Comment
This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway [1]. In addition to acetylase activity, the enzyme possesses weak activity of EC
3.5.1.115 , mycothiol S-conjugate amidase, and shares sequence similarity with that enzyme [2]. The enzyme requires a divalent transition metal ion for activity, believed to be Zn2+ [3].
History
EC 3.5.1.103 created 2010
Orthology
K15525 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase
Genes
MAVM : MAA44156_02957(mshB_2)
MMAE : MMARE11_40980(mshB)
MBAI : MB901379_03736(mshB_1)
MHEK : JMUB5695_01418(mshB_1)
MKY : IWGMT90018_49010(mshB)
MPHL : MPHLCCUG_04078(mshB)
MTHN : 4412656_03418(mshB)
MAUU : NCTC10437_04268(mshB_1)
MFLV : NCTC10271_01192(mshB)
MBUG : MU0053_001110(mshB)
MSAL : DSM43276_01182(mshB_1)
MTER : 4434518_01109(mshB)
CDIP : ERS451417_00874(mshB)
COI : CPCIP5297_04025(mshB)
CUN : Cul210932_0856(mshB)
CUQ : Cul210931_0819(mshB)
CUJ : CUL131002_0834(mshB)
CMIN : NCTC10288_01565(mshB)
CRL : NCTC7448_01639(mshB_2)
CCYS : SAMEA4530656_1445(mshB_1)
NFR : ERS450000_05171(mshB_2)
NNO : NONO_c35200(mshB1) NONO_c64660(mshB2)
NAD : NCTC11293_06084(mshB_1)
NWL : NWFMUON74_12020(mshB)
NSPU : IFM12276_07890(mshB)
RRT : 4535765_01322(mshB_2)
RCR : NCTC10994_01480(mshB_1)
RANT : RHODO2019_12420(mshB)
RHOP : D8W71_17665 D8W71_24090(mshB)
WHR : OG579_03040 OG579_06030(mshB)
GPO : GPOL_174p01020 GPOL_c31260
GOQ : ACH46_05875 ACH46_11165
GTA : BCM27_13920 BCM27_17095
GOC : CXX93_08405(mshB) CXX93_11985
GIT : C6V83_11630 C6V83_14750(mshB)
GRU : GCWB2_10840(mca3) GCWB2_17315(mshB2)
GOM : D7316_01227(mshB_1) D7316_05359(mshB_2)
GAV : C5O27_10885(mshB) C5O27_16700
GOD : GKZ92_10540 GKZ92_16245(mshB)
GOS : QAD21_13710 QAD21_16680(mshB)
GOJ : GR168_13160 GR168_16050(mshB)
GAM : GII34_12875 GII34_16135(mshB)
GPD : GII33_12135 GII33_15595(mshB)
GJI : H1R19_13170 H1R19_16180(mshB)
GOI : LK459_17750(mshB) LK459_20610
GHN : MVF96_13660 MVF96_16560(mshB)
GAMI : IHQ52_13770 IHQ52_20100(mshB)
GSI : P5P27_10145 P5P27_13850(mshB)
GOO : HUN08_09625 HUN08_12250(mshB)
GOP : ACE11G_05040(mshB) ACE11G_08165
TPUL : TPB0596_34720(mshB)
SHO : SHJGH_2104 SHJGH_5987
SAMB : SAM23877_4908(mshB)
SCZ : ABE83_02665 ABE83_11875
SRW : TUE45_01129(mca_1) TUE45_05617(mshB_2)
SLE : sle_26120(sle_26120)
STSI : A4E84_19600 A4E84_26295
SALW : CP975_23225(mshB) CP975_33030
SGM : GCM10017557_27750(mshB)
SNR : SNOUR_15865(mshB) SNOUR_36675
SALL : SAZ_03075 SAZ_27940
SVU : B1H20_00655 B1H20_23970
SLX : SLAV_03235(mca2) SLAV_14000(mshB2)
STRO : STRMOE7_01480 STRMOE7_25165
SLK : SLUN_25995(mshB) SLUN_30735
SNK : CP967_11375(mshB) CP967_29295
SAQU : EJC51_28215 EJC51_31600(mshB)
SGF : HEP81_02901(mshB_1) HEP81_07330(mshB_2)
SCAV : CVT27_22690(mshB) CVT27_30860
SCOE : CP976_21560 CP976_28125(mshB)
STUI : GCM10017668_46500(mshB)
SHUN : DWB77_02791(mshB_2)
SLIA : HA039_01950 HA039_11405(mshB)
SGOB : test1122_18225(mshB)
SXT : KPP03845_104889(mshB)
KAB : B7C62_24395 B7C62_33325
KVR : CIB50_0002336(mshB_2)
DCO : SAMEA4475696_2002(mshB_2)
PAUS : NCTC13651_00189(mshB_1)
PPC : HMPREF9154_0117(mshB) HMPREF9154_2775
ARUB : J5A65_01270(mshB) J5A65_13050
TLA : TLA_TLA_01778(mshB_2)
NAQU : ENKNEFLB_03672(mshB)
KSL : OG809_02390(mshB) OG809_28830
AGRA : AGRA3207_005823(mshB)
NGN : LCN96_25040 LCN96_49565(mshB)
FRA : Francci3_3459 Francci3_3864
SACG : FDZ84_16760(mshB) FDZ84_20150(mshB)
AMYZ : HUW46_05649(mshB_2)
ABAR : AMYBAR_006371(mshB)
KUT : JJ691_60650 JJ691_68500
ACTU : Actkin_00787(mshB_3)
ACTY : OG774_21990 OG774_27035(mshB)
MSAG : GCM10017556_15750(mshB)
ACTR : Asp14428_56270(mshB)
CATI : CS0771_19480(mshB) CS0771_62310
CAI : Caci_0756 Caci_5063 Caci_6362
ABAM : B1s21122_01305(mshB)
EKE : EK0264_04710(mshB) EK0264_19150
» show all
Taxonomy
Reference
Authors
Rawat M, Kovacevic S, Billman-Jacobe H, Av-Gay Y
Title
Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.
Journal
Reference
Authors
Newton GL, Av-Gay Y, Fahey RC
Title
N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis.
Journal
Sequence
Reference
Authors
Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN
Title
The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.5.1.103
LinkDB
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