KEGG   ENZYME: 3.5.1.118
Entry
EC 3.5.1.118                Enzyme                                 
Name
gamma-glutamyl hercynylcysteine S-oxide hydrolase;
EgtC
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
gamma-glutamyl-S-(hercyn-2-yl)cysteine S-oxide amidohydrolase
Reaction(IUBMB)
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate [RN:R11021]
Reaction(KEGG)
R11021
Substrate
gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20995];
H2O [CPD:C00001]
Product
S-(hercyn-2-yl)-L-cysteine S-oxide [CPD:C20994];
L-glutamate [CPD:C00025]
Comment
The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria.
History
EC 3.5.1.118 created 2015
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K07008  gamma-glutamyl hercynylcysteine S-oxide hydrolase
Genes
APRSBI364_03775
ACIIC4901_08390
SALNSALB1_3449
ABSAZOBR_p310212
MTURv3702c(egtC)
MTVRVBD_3702c
MTCMT3805
MRAMRA_3738
MTFTBFG_13733
MTBTBMG_03745
MTKTBSG_03769
MTZTBXG_003716
MTGMRGA327_22800
MTIMRGA423_23345
MTECCDC5079_3433
MTURCFBS_3923
MTLCCDC5180_3384
MTOMTCTRI2_3772
MTDUDA_3702c
MTNERDMAN_4055
MTJJ112_19895
MTUBMT7199_3767
MTUCJ113_25835
MTUEJ114_19775
MTXM943_19020
MTUHI917_25960
MTULTBHG_03637
MTUTHKBT1_3907
MTUUHKBT2_3917
MTQHKBS1_3920
MBOBQ2027_MB3728C
MBBBCG_3761c
MBTJTY_3763
MBMBCGMEX_3762c
MBKK60_038410
MBXBCGT_3564
MAFMAF_37100
MMICRN08_4082
MCEMCAN_37231
MCQBN44_120100
MCVBN43_90209
MCXBN42_90218
MCZBN45_110058
MPAMAP_0304c
MAOMAP4_3567
MAVIRC58_17725
MAVURE97_17755
MAVMAV_0401
MITOCO_03540
MIAOCU_03610
MIDMIP_00738
MYOOEM_03660
MCHIAN480_01805
MIROCQ_03560
MMALCKJ54_01710(egtC)
MMANMMAN_46300(egtC)
MSAMycsm_06028
MULMUL_4286
MMCMmcs_4880
MKMMkms_4969
MJLMjls_5248
MMIMMAR_5213
MMAEMMARE11_50360
MMMW7S_01740
MLIMULP_05490(egtC)
MKNMKAN_13325
MYVG155_27725
MYEAB431_27330
MGOAFA91_03450
MHADB586_03750
MDXBTO20_03105
MSHGMSG_04706(egtC)
MFJMFLOJ_39070(egtC)
MSTOMSTO_42930(egtC)
MSIMMSIM_27480(egtC)
MSAKMSAS_31080(egtC)
MKUI2456_26525(egtC)
MGROFZ046_03790(egtC)
MXEMYXE_03640(egtC)
MNVMNVI_14040(egtC)
MPAGC0J29_28785(egtC)
MNMMNVM_22170(egtC)
MGORH0P51_26680(egtC)
MCOOMCOO_28650(egtC)
MBAIMB901379_04623(egtC)
MSEOMSEO_36220(egtC)
MPSEMPSD_02560(egtC)
MSHOMSHO_10440(egtC)
MHEKJMUB5695_00321(egtC)
MGAUMGALJ_40190(egtC)
MLJMLAC_45730(egtC)
MBRDMBRA_18300(egtC)
MSHJMSHI_37080(egtC)
MKRMKOR_31810(egtC)
MDFK0O62_26745(egtC)
MMAMK3U93_23415(egtC)
MHOLK3U96_02220(egtC)
MHERK3U94_21790(egtC)
MSENK3U95_26775(egtC)
MPAEK0O64_26855(egtC)
MSPGF6B93_21310(egtC)
MOTLTS72_26795(egtC)
MVMMJO54_21645(egtC)
MRFMJO55_25025(egtC)
MPAAMKK62_01135(egtC)
MSMMSMEG_6248
MSGMSMEI_6087
MSBLJ00_30895
MSNLI99_30900
MSHLI98_30905
MVAMvan_5484
MGIMflv_1317
MSPMspyr1_48620
MCBMycch_4829
MNED174_25560
MYNMyAD_25100
MFTXA26_56030
MPHLMPHLCCUG_00353(egtC)
MVQMYVA_5374
MRHMycrhN_2100
MTHN4412656_04307(egtC)
MHASMHAS_03907(egtC)
MDUMDUV_47510(egtC)
MCHTMCHIJ_17970(egtC)
MDRMDOR_34090(egtC)
MAUUNCTC10437_05229(egtC_2)
MMAGMMAD_50020(egtC)
MMORMMOR_09300(egtC)
MFXMFAL_07410(egtC)
MAICMAIC_03590(egtC)
MIJMINS_21340(egtC)
MALVMALV_39940(egtC)
MTYMTOK_19910(egtC)
MPSCMPSYJ_14320(egtC)
MARZMARA_45910(egtC)
MGADMGAD_39080(egtC)
MHEVMHEL_26100(egtC)
MSARMSAR_12300(egtC)
MANYMANY_34900(egtC)
MAUBMAUB_28600(egtC)
MPOFMPOR_01130(egtC)
MPHUMPHO_41580(egtC)
MMUCC1S78_026765(egtC)
MMATMMAGJ_31200(egtC)
MBOKMBOE_07340(egtC)
MFGK6L26_04010(egtC)
MSEIMSEDJ_04760(egtC)
MFLVNCTC10271_00326(egtC)
MCEEMCEL_35680(egtC)
MABMAB_0371
MMVMYCMA_0195
MABBMASS_0367
MABLMMASJCM_0363
MCHEBB28_01810
MIZBAB75_02375
MSTEMSTE_00330(egtC)
MSAOMYCSP_01625
MSALDSM43276_00321(egtC)
MJDJDM601_3982
MTER4434518_03929(egtC_2)
MMINMMIN_14020(egtC)
MHIBMHIB_32420(egtC)
ASDAS9A_2108
MPAKMIU77_00530(egtC)
NFANFA_48850
NFRERS450000_05024(egtC)
NCYNOCYR_4671
NBRO3I_036995
NNONONO_c66350(egtC)
NSRNS506_01660
NTPCRH09_34700(egtC)
NOZDMB37_15935
NODFOH10_01815
NAHF5544_39495
NADNCTC11293_06259(egtC_2)
NWLNWFMUON74_10240
NIEKV110_36245
NTCKHQ06_11075
NYALTV02_22540
NGPLTT66_17705(egtC)
RHARHA1_ro05702
RERRER_43180
REYO5Y_20235
REBXU06_20405
RQIC1M55_21750(egtC)
ROPROP_57710
ROAPd630_LPD02317
REQREQ_12480
RPYY013_21560
RBYCEJ39_08080(egtC)
RHBNY08_2331
RAVAAT18_07300
RFAA3L23_00520(egtC)
RHSA3Q41_02833(egtC)
RHWBFN03_01860
RRZCS378_22370(egtC)
RHUA3Q40_02532(egtC)
RHQIM25_11350
RHODAOT96_01795
RRT4535765_01116(egtC_2)
RCRNCTC10994_01624(egtC_1)
RTMG4H71_04780(egtC)
RKOJWS14_31230(egtC)
RGOKYT97_28825(egtC)
SPINKV203_14465(egtC)
TOYFO059_06630
SCOSCO0912(SCM1.45)
SALBXNR_5670
SMASAVERM_7339(egtC)
SGRSGR_697
SGBWQO_31705
SCBSCAB_11231
SSXSACTE_6223
SVLStrvi_4090
SHYSHJG_7893
SHOSHJGH_7655
SRCM271_04970
SMALSMALA_7431
SSOII1A49_40915(egtC)
SCTSCAT_4661
SCYSCATT_46530
SFASfla_0406
SBHSBI_01720
SVESVEN_6868
SDVBN159_1331
SALSSLNWT_7176
STRPF750_6593
SFISFUL_6744
SCIB446_32010
SALUDC74_6877
SALLSAZ_35725
SLVSLIV_33370
SGUSGLAU_29360
SVTSVTN_34050
STREGZL_01889
SCWTU94_30470
SLDT261_1096
SLCSL103_23140
SXISXIM_40590
STRMM444_29580
SAMBSAM23877_6628(egtC)
SPRISPRI_0730
SCZABE83_02235
SCXAS200_07590
SRWTUE45_00192(egtC)
STRFASR50_31990
SLEsle_06850(sle_06850)
SRNA4G23_05243(egtC)
SPAVSpa2297_29070
STRTA8713_28670
SCLFBB341_01710
SGSAVL59_16355
STSIA4E84_35865
SKYD0C37_30430(egtC)
SALWCP975_32105(egtC)
SGMGCM10017557_08720(egtC)
SCADDN051_06570(egtC)
SLSSLINC_7406
SNRSNOUR_08410
SPLULK06_001545
STRDNI25_03150
SNWBBN63_03440
SAUOBV401_40775
SSIAA7J05_03975
SVUB1H20_32550
SPUNBFF78_04720
SGVB1H19_34875
SLAUSLA_6649
SALFSMD44_07735
SALJSMD11_0806
SLXSLAV_06115(egtC2)
STROSTRMOE7_32365
SFKKY5_7466c
SNZDC008_30820(egtC)
SGEDWG14_01146(egtC_1)
SRJSRO_0887
SLKSLUN_35080(egtC)
SDXC4B68_03755(egtC)
SGDELQ87_04135(egtC)
SQZFQU76_31350(egtC)
SCYAEJ357_04510(egtC)
SASTCD934_31545(egtC)
SNQCP978_05160(egtC)
STIRDDW44_28480(egtC)
SKACP970_02860(egtC)
SGZC0216_12615(egtC)
SVNCP980_05105(egtC)
SNKCP967_00610(egtC)
SHAWCEB94_36720(egtC)
SRKFGW37_27935(egtC)
SFICEIZ62_03280(egtC)
SGALCP966_32085(egtC)
SSPODDQ41_29460(egtC)
SVRCP971_05380(egtC)
SPADDVK44_31775(egtC)
SFYGFH48_07300(egtC)
SAQUEJC51_40710(egtC)
SGFHEP81_00866(egtC)
SCAVCVT27_31295(egtC)
SSEOD0Z67_26300(egtC)
SBYH7H31_32635(egtC)
SRIMCP984_04950(egtC)
SSUBCP968_05395(egtC)
SPHVF9278_42710(egtC)
SCINCP977_30675(egtC)
SFUGCNQ36_03155(egtC)
SPACB1H29_03975
STSUB7R87_31260
SCHACP983_04575(egtC)
SGXH4W23_35700(egtC)
SCOECP976_38160(egtC)
SBATG4Z16_03280(egtC)
SSPBCP982_35765(egtC)
SNFJYK04_07183(egtC_3)
SPLACP981_32925(egtC)
SBROGQF42_38860(egtC)
STUIGCM10017668_06270(egtC)
SATAC5746_37020(egtC)
SCHFIPT68_32695(egtC)
SHUNDWB77_01278(egtC)
SHARHUT13_20295(egtC)
SCYGS1361_34725(egtC)
SFEUIM697_19425(egtC)
SLIAHA039_02860(egtC)
SDWK7C20_31595(egtC)
SCALI6J39_32350(egtC)
SAUHSU9_029820(egtC)
SFBCP974_27940(egtC)
SMOBJ7W19_29435(egtC)
SPRACP972_32045(egtC)
SPEUCGZ69_32685(egtC)
SROIIAG44_35310(egtC)
SXNIAG42_04105(egtC)
SGJIAG43_01380(egtC)
SHKJ2N69_33975(egtC)
SANUK7396_05825(egtC)
STRYEQG64_32495(egtC)
SDDD9753_03470(egtC)
SACTDMT42_33785(egtC)
SMAOCAG99_16350
SGOBtest1122_11455(egtC)
SINEKI385_37415(egtC)
SLFJEQ17_07330(egtC)
KSKKSE_64550
KABB7C62_33775
KAUB6264_00785
KITCFP65_6447
STRIC7M71_003905(egtC)
YIALO772_26260(egtC)
AGGC1N71_14230
ARTPE5206_18080(egtC)
LMOIVV02_12410
BLYA2T55_04170
BLINBLSMQ_0779
AUSIPK37_04990 IPK37_11745
NAQUENKNEFLB_01972(egtC)
KFLKfla_5161
KQIF1D05_08730(egtC)
NDANdas_0639
NALB005_3534
NGVCDO52_21010(egtC)
STRREKD16_07230(egtC)
TCUTcur_3639
ACTWF7P10_32760(egtC)
AGRAAGRA3207_006137(egtC)
SROSros_0330
NOABKM31_30900
NOWGBF35_07830(egtC)
NCXNocox_11930(egtC)
NGNLCN96_14310(egtC)
TBITbis_2649
FRAFrancci3_4513
FREFranean1_7302
FRIFraEuI1c_7154
FALFRAAL6624 FRAAL6842
FSYFsymDg_4503
NMLNamu_1080
GOBGobs_0203
SENSACE_3824(cbiN)
SACGFDZ84_35810(egtC)
SVISvir_22450
SACCEYD13_12495(egtC)
AMDAMED_4962
AMNRAM_25260
AMMAMES_4903
AMZB737_4903
AOIAORI_3754
AJAAJAP_20385
AMQAMETH_3013(cbiN)
AMYCCU254_17955(egtC)
AMYBBKN51_11245
AABA4R43_11140
AMYYYIM_27650(egtC)
AORISD37_19255
AACDLWP59_14995(egtC)
PDXPsed_3381
PSEAWY02_03170
PSEEFRP1_09625
PSEHXF36_11000
PSEQAD006_17185
PECQAD017_25020
PHHAFB00_25185
PAUTPdca_32240(egtC)
PBROHOP40_24485(egtC)
APRECNX65_10830(egtC)
AMIAmir_2124
SESPBN6_30870
SSYIEKG83_34690(egtC)
KALKALB_2952
KPHYAOZ06_20025
LEDBBK82_27280
AHMTL08_10810
ACTIUA75_11535
ACADUA74_11450
AHGAHOG_10785(egtC)
ACTAC1701_22035(egtC)
PMADBAY61_17180
SACEGIY23_10330(egtC)
STPStrop_2115
SAQSare_2258
MAUMicau_3409
MILML5_4985
MICBMicB006_2466
MTUACSH63_08015(egtC)
MICHFJK98_16745(egtC)
MTEMGCE86_13000(egtC)
MCABHXZ27_18520(egtC)
MSAGGCM10017556_54350(egtC)
VMAVAB18032_23560
MCRAID554_01380(egtC)
ASEACPL_6425(cbiN)
AMSAMIS_61660
ACTNL083_7397
AFSAFR_38620
ACTSACWT_6292
AIHAiant_21060(egtC)
PLKCIK06_14640(egtC)
PLABC6361_04530(egtC)
PLATC6W10_01055(egtC)
PFLAPflav_033910(egtC)
PSUUPsuf_076990(egtC)
VERHUT12_20335(egtC)
CATICS0771_27260(egtC)
DVCDvina_39825(egtC)
NHYJQS43_04870(egtC)
CCAZCOUCH_05010(egtC)
CAICaci_8030
SNASnas_5170
BLABLA_0878
BLCBalac_1534
BLTBalat_1534
BBBBIF_01627
BBCBLC1_1480
BNMBALAC2494_01216
BLVBalV_1483
BLWW7Y_1529
BLSW91_1562
BANIBl12_1434
BANLBLAC_07645
BNIBANAN_07375
BANMEN10_07755
BCHOBcFMB_01815
AEYCDG81_09255(egtC)
EUZDVS28_a3892
 » show all
Reference
1  [PMID:20420449]
  Authors
Seebeck FP
  Title
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
  Journal
J Am Chem Soc 132:6632-3 (2010)
DOI:10.1021/ja101721e
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.118
IUBMB Enzyme Nomenclature: 3.5.1.118
ExPASy - ENZYME nomenclature database: 3.5.1.118
BRENDA, the Enzyme Database: 3.5.1.118
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