Entry
Name
pantetheine hydrolase;
pantetheinase;
vanin;
vanin-1
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
(R)-pantetheine amidohydrolase
Reaction(IUBMB)
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:
R02973 ]
Reaction(KEGG)
Substrate
Product
(R)-pantothenate [CPD:
C00864 ];
2-aminoethanethiol [CPD:
C01678 ]
Comment
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].
History
EC 3.5.1.92 created 2006
Pathway
ec00770 Pantothenate and CoA biosynthesis
Orthology
Genes
HSA : 8875(VNN2) 8876(VNN1)
PTR : 463006(VNN3) 463007(VNN2) 746544(VNN1)
PPS : 100978332 100978987(VNN3) 100979321(VNN2)
GGO : 101125335 101126064(VNN3) 101126426(VNN2)
PON : 100436777 100441056(VNN1) 100441798(VNN3)
NLE : 100579766(VNN1) 100580443(VNN3) 115830450
MCC : 708637 708748 708830
MCF : 101865481(VNN2) 102139623 102139985
CSAB : 103240351(VNN2) 103240352 103240354
CATY : 105600441(VNN2) 105600443 105600573
PANU : 101022791(VNN2) 101023852 101024198(VNN1)
TGE : 112622739(VNN2) 112622834 112622835
RRO : 104657993(VNN2) 104657995 104657997
RBB : 108534302(VNN1) 108534304 108534340
TFN : 117097514(VNN2) 117097515 117097516(VNN1)
PTEH : 111554892(VNN1) 111554930(VNN2) 111554957(VNN3)
CJC : 100399050(VNN1) 100399411 100895783(VNN2)
SBQ : 101042912 101043241(VNN1)
CSYR : 103260966(VNN1) 103260967(VNN3) 103260969
MMUR : 105855558 105855559(VNN1) 105855561
OGA : 100951307 100959690 100959693 100960002
MMU : 22361(Vnn1) 26464(Vnn3)
MCAL : 110303054(Vnn1) 110303935
MPAH : 110338225(Vnn1) 110338323
RNO : 29142(Vnn1) 498992(Vnn3)
MCOC : 116097698 116097699
MUN : 110565409 110565410 110565420 110565421
CGE : 100750608(Vnn1) 100754161
NGI : 103724951(Vnn2) 103724954(Vnn1)
HGL : 101710059(Vnn1) 101724572(Vnn3)
CPOC : 100728678(Vnn1) 100728953(Vnn3)
CCAN : 109687502(Vnn1) 109687517(Vnn2)
DORD : 105993512(Vnn1) 105993513
NCAR : 124988630 124989575 124989745
OCU : 100344919 100345689(VNN2) 100356303(VNN1)
TUP : 102490124(VNN1) 102490829(VNN3) 102491237(VNN2)
UAH : 113259459(VNN1) 113259677(VNN3)
ORO : 101376044(VNN1) 101385601(VNN3)
EJU : 114225647(VNN3) 114225655
PYU : 121013451(VNN1) 121013452
PTG : 102970509(VNN3) 102971182(VNN1)
PPAD : 109249916(VNN1) 109249917
BTA : 526704(VNN1) 534929(VNN2) 785817(VNN3)
BOM : 102269407(VNN1) 102269960(VNN2)
BIU : 109563954(VNN1) 109563957
BBUB : 102410831(VNN2) 102411389(VNN1)
CHX : 102172899(VNN1) 102173569(VNN2)
OAS : 101105005(VNN1) 101105417(VNN2) 114116100
ODA : 120863042(VNN1) 120863045(VNN2)
CCAD : 122434053 122434054(VNN1)
SSC : 100152784(VNN3) 100153984(VNN2) 397246(VNN1)
CFR : 102514326 102514743(VNN3) 102515010(VNN2)
CBAI : 105077234(VNN1) 105077235 105077236(VNN2)
CDK : 105096352(VNN1) 105096353(VNN3) 105096354(VNN2)
VPC : 102539632 102540045(VNN3) 102540292(VNN2)
BACU : 103010543(VNN1) 103011016 103011299(VNN2)
LVE : 103079030(VNN2) 103079497(VNN1) 103084601
OOR : 101284042(VNN2) 101284462(VNN1) 101286152(VNN3)
DLE : 111165830(VNN2) 111165838(VNN1)
PCAD : 102989061 102995508(VNN2)
PSIU : 116763260(VNN2) 116763733(VNN1)
ECB : 100067649 100067672(VNN2) 100146975
EPZ : 103557081(VNN2) 103557083 103557085(VNN1)
EAI : 106840575 106840577 106840579
MYB : 102246494(VNN1) 102247599 102247887(VNN2)
MYD : 102761007(VNN1) 102761476(VNN2) 102772945
MMYO : 118659851 118660324 118660430
MLF : 102424773 102425091 102440862(VNN2)
MNA : 107530954 107530955 107530957(VNN1)
PKL : 118706142(VNN1) 118706143 118706144
HAI : 109372141(VNN1) 109372142 109372153 109395289
SHON : 118986690(VNN2) 118986693 118986770
PDIC : 114494440(VNN2) 114494515
PHAS : 123821368(VNN2) 123821617
MMF : 118621074(VNN2) 118621116 118621118
RFQ : 117019053 117020605 117020619
PALE : 102881910 102882154 102894153(VNN2)
PGIG : 120615808(VNN2) 120615809 120615810(VNN1)
PVP : 105289491(VNN2) 105289492 105289493
RAY : 107499937(VNN3) 107499949(VNN1) 107499950(VNN2)
TOD : 119253454(VNN1) 119253455
SARA : 101550949(VNN2) 101551220 101553342
LAV : 100670289 100671136(VNN1)
TMU : 101350854 101351285 101351544 101352933
DNM : 101431017(VNN2) 101432321 101433074(VNN1)
MDO : 100031271(VNN1) 100031277(VNN3)
OAA : 100074927(VNN1) 100085853
CJO : 107311722(VNN1) 107311723
APLA : 101798418 101798651
ACYG : 106032501 106032502 106032503
AFUL : 116487964 116488055
SCAN : 103820544 103820609
PMOA : 120501231 120501233
GFR : 102038583(VNN1) 102041126(VNN2)
FAB : 101807492(VNN1) 101808136
PMAJ : 107201269(VNN3) 107202003
CCAE : 111927686 111927687
CCW : 104690571 104690581 120411723
FPG : 101924145(VNN3) 101924317
EGZ : 104131148 104131149 104131209
NNI : 104008832 104008833 104008895
ACUN : 113478767 113478768
TALA : 104357197 104357198 104357199
PADL : 103912691 103912692 103912737
AROW : 112969461 112969462 112969471
NPD : 112954906 112954924 112954925
ASN : 102384310 102384548 102386374
AMJ : 102558568 102560408 102560855(VNN2)
CPOO : 109312025 109312026 109312027
GGN : 109299757 109299761 109299762
PSS : 102445936(VNN1) 102446172
CPIC : 101933999 122172113
CABI : 116824890 116824891(VNN1)
PVT : 110071965 110071970(VNN1)
SUND : 121928449 121928453
PMUR : 107297840 107297842 107297843 107299200
TSR : 106541945 106543075 106551933(VNN3)
PGUT : 117666274 117666276
PMUA : 114594152 114594153
GJA : 107110525(VNN1) 107110527
STOW : 125429402(VNN1) 125438954
XTR : 496642(vnn1) 496713(vnn2)
RTEM : 120937325 120937326
BBUF : 120998503(VNN1) 120998504
BGAR : 122934963 122936134
BBEL : 109461734 109480583 109486691
PCHN : 125024539 125048283
DPTE : 113791482 113793022 113793031
DFR : 124495498 124495976 124499332
CSCU : 111631959 111631967 111632207
PTEP : 107443103 107445458 107445778
LGI : LOTGIDRAFT_128172 LOTGIDRAFT_204287 LOTGIDRAFT_218395
PCAN : 112557879 112570933
GAE : 121383811 121390084 121390479
HRF : 124116384 124116395 124116396 124117722 124117751 124142427 124152859
HRJ : 124257501 124262810 124279646
MYI : 110445423 110452379 110463544
PMAX : 117317063 117320438 117333384 117333873 117344473
MMER : 123552249 123552250 123552251 123553522
OBI : 106868079 106868152 106874210
OSN : 115209793 115213146 115226225
LAK : 106153227 106179638 106179639
ATEN : 116300340 116300841
DGT : 114524553 114524573 114527090
» show all
Taxonomy
Reference
Authors
Dupre S, Cavallini D.
Title
Purification and properties of pantetheinase from horse kidney.
Journal
Reference
Authors
Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D.
Title
Continuous spectrophotometric assay of pantetheinase activity.
Journal
Reference
Authors
Maras B, Barra D, Dupre S, Pitari G.
Title
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
Journal
Sequence
Reference
Authors
Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA, Naquet P.
Title
Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
Journal
Sequence
Reference
Authors
Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F.
Title
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
Journal
Sequence
Reference
Authors
Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F.
Title
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
Journal
Sequence
Reference
Authors
Pace HC, Brenner C.
Title
The nitrilase superfamily: classification, structure and function.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.92
ExPASy - ENZYME nomenclature database: 3.5.1.92
LinkDB
All DBs