KEGG   ENZYME: 3.5.1.92
Entry
EC 3.5.1.92                 Enzyme                                 
Name
pantetheine hydrolase;
pantetheinase;
vanin;
vanin-1
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
(R)-pantetheine amidohydrolase
Reaction(IUBMB)
(R)-pantetheine + H2O = (R)-pantothenate + 2-aminoethanethiol [RN:R02973]
Reaction(KEGG)
R02973
Substrate
(R)-pantetheine [CPD:C00831];
H2O [CPD:C00001]
Product
(R)-pantothenate [CPD:C00864];
2-aminoethanethiol [CPD:C01678]
Comment
The enzyme hydrolyses only one of the amide bonds of pantetheine. The substrate analogues phosphopantetheine and CoA are not substrates. The enzyme recycles pantothenate (vitamin B5) and produces 2-aminoethanethiol (cysteamine), a potent anti-oxidant [5].
History
EC 3.5.1.92 created 2006
Pathway
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K08069  pantetheine hydrolase
Genes
HSA8875(VNN2) 8876(VNN1)
PTR463006(VNN3) 463007(VNN2) 746544(VNN1)
PPS100978332 100978987(VNN3) 100979321(VNN2)
GGO101125335 101126064(VNN3) 101126426(VNN2)
PON100436777 100441056(VNN1) 100441798(VNN3)
NLE100579766(VNN1) 100580443(VNN3) 115830450
MCC708637 708748 708830
MCF101865481(VNN2) 102139623 102139985
CSAB103240351(VNN2) 103240352 103240354
CATY105600441(VNN2) 105600443 105600573
PANU101022791(VNN2) 101023852 101024198(VNN1)
TGE112622739(VNN2) 112622834 112622835
RRO104657993(VNN2) 104657995 104657997
RBB108534302(VNN1) 108534304 108534340
TFN117097514(VNN2) 117097515 117097516(VNN1)
PTEH111554892(VNN1) 111554930(VNN2) 111554957(VNN3)
CJC100399050(VNN1) 100399411 100895783(VNN2)
SBQ101042912 101043241(VNN1)
CSYR103260966(VNN1) 103260967(VNN3) 103260969
MMUR105855558 105855559(VNN1) 105855561
OGA100951307 100959690 100959693 100960002
MMU22361(Vnn1) 26464(Vnn3)
MCAL110303054(Vnn1) 110303935
MPAH110338225(Vnn1) 110338323
RNO29142(Vnn1) 498992(Vnn3)
MCOC116097698 116097699
MUN110565409 110565410 110565420 110565421
CGE100750608(Vnn1) 100754161
NGI103724951(Vnn2) 103724954(Vnn1)
HGL101710059(Vnn1) 101724572(Vnn3)
CPOC100728678(Vnn1) 100728953(Vnn3)
CCAN109687502(Vnn1) 109687517(Vnn2)
DORD105993512(Vnn1) 105993513
DSP122116881 122117054
NCAR124988630 124989575 124989745
OCU100344919 100345689(VNN2) 100356303(VNN1)
OPI101524958 101527393
TUP102490124(VNN1) 102490829(VNN3) 102491237(VNN2)
CFA442973(VNN1)
VVP112919447(VNN1)
VLG121484510(VNN1)
AML100465598(VNN1)
UMR103663395(VNN1)
UAH113259459(VNN1) 113259677(VNN3)
UAR123797578(VNN1)
ELK111147800
LLV125102712
MPUF101672747(VNN1)
ORO101376044(VNN1) 101385601(VNN3)
EJU114225647(VNN3) 114225655
ZCA113927558 113927853
MLX118000789 118001370
FCA101096984 101097240
PYU121013451(VNN1) 121013452
PBG122489999 122490000
PTG102970509(VNN3) 102971182(VNN1)
PPAD109249916(VNN1) 109249917
AJU106976871 106976873
HHV120238345(VNN1)
BTA526704(VNN1) 534929(VNN2) 785817(VNN3)
BOM102269407(VNN1) 102269960(VNN2)
BIU109563954(VNN1) 109563957
BBUB102410831(VNN2) 102411389(VNN1)
CHX102172899(VNN1) 102173569(VNN2)
OAS101105005(VNN1) 101105417(VNN2) 114116100
ODA120863042(VNN1) 120863045(VNN2)
CCAD122434053 122434054(VNN1)
SSC100152784(VNN3) 100153984(VNN2) 397246(VNN1)
CFR102514326 102514743(VNN3) 102515010(VNN2)
CBAI105077234(VNN1) 105077235 105077236(VNN2)
CDK105096352(VNN1) 105096353(VNN3) 105096354(VNN2)
VPC102539632 102540045(VNN3) 102540292(VNN2)
BACU103010543(VNN1) 103011016 103011299(VNN2)
LVE103079030(VNN2) 103079497(VNN1) 103084601
OOR101284042(VNN2) 101284462(VNN1) 101286152(VNN3)
DLE111165830(VNN2) 111165838(VNN1)
PCAD102989061 102995508(VNN2)
PSIU116763260(VNN2) 116763733(VNN1)
ECB100067649 100067672(VNN2) 100146975
EPZ103557081(VNN2) 103557083 103557085(VNN1)
EAI106840575 106840577 106840579
MYB102246494(VNN1) 102247599 102247887(VNN2)
MYD102761007(VNN1) 102761476(VNN2) 102772945
MMYO118659851 118660324 118660430
MLF102424773 102425091 102440862(VNN2)
MNA107530954 107530955 107530957(VNN1)
PKL118706142(VNN1) 118706143 118706144
HAI109372141(VNN1) 109372142 109372153 109395289
DRO112297069 112297375
SHON118986690(VNN2) 118986693 118986770
AJM119039937(VNN2)
PDIC114494440(VNN2) 114494515
PHAS123821368(VNN2) 123821617
MMF118621074(VNN2) 118621116 118621118
RFQ117019053 117020605 117020619
PALE102881910 102882154 102894153(VNN2)
PGIG120615808(VNN2) 120615809 120615810(VNN1)
PVP105289491(VNN2) 105289492 105289493
RAY107499937(VNN3) 107499949(VNN1) 107499950(VNN2)
MJV108397063 108398567
TOD119253454(VNN1) 119253455
SARA101550949(VNN2) 101551220 101553342
LAV100670289 100671136(VNN1)
TMU101350854 101351285 101351544 101352933
DNM101431017(VNN2) 101432321 101433074(VNN1)
MDO100031271(VNN1) 100031277(VNN3)
GAS123245590 123245591
SHR100933586 100934104
PCW110208893 110208894
OAA100074927(VNN1) 100085853
GGA421702(VNN1)
PCOC116240286
MGP100541961 100542733
CJO107311722(VNN1) 107311723
NMEL110396026
APLA101798418 101798651
ACYG106032501 106032502 106032503
AFUL116487964 116488055
TGU100217969 100220807
LSR110476003 110476058
SCAN103820544 103820609
PMOA120501231 120501233
OTC121346174
PRUF121354853
GFR102038583(VNN1) 102041126(VNN2)
FAB101807492(VNN1) 101808136
PHI102100467 102102180
PMAJ107201269(VNN3) 107202003
CCAE111927686 111927687
CCW104690571 104690581 120411723
ETL114064430
ZAB102065972 102066154
FPG101924145(VNN3) 101924317
FCH102058065(VNN1)
CLV102083923 102093091
EGZ104131148 104131149 104131209
NNI104008832 104008833 104008895
ACUN113478767 113478768
TALA104357197 104357198 104357199
PADL103912691 103912692 103912737
ACHC115344455(VNN1)
AAM106497918 106497928
AROW112969461 112969462 112969471
NPD112954906 112954924 112954925
DNE112995728 112995765
ASN102384310 102384548 102386374
AMJ102558568 102560408 102560855(VNN2)
CPOO109312025 109312026 109312027
GGN109299757 109299761 109299762
PSS102445936(VNN1) 102446172
CMY102942174
CPIC101933999 122172113
TST117874922 117874923
CABI116824890 116824891(VNN1)
MRV120400847 120401411
ACS100553191 100566816
PVT110071965 110071970(VNN1)
SUND121928449 121928453
PBI103059808 103060046
PMUR107297840 107297842 107297843 107299200
TSR106541945 106543075 106551933(VNN3)
PGUT117666274 117666276
VKO123020545 123032829
PMUA114594152 114594153
ZVI118082089 118082092
GJA107110525(VNN1) 107110527
STOW125429402(VNN1) 125438954
XLA108705431 108705439
XTR496642(vnn1) 496713(vnn2)
NPR108799348
RTEM120937325 120937326
BBUF120998503(VNN1) 120998504
BGAR122934963 122936134
PSPA121316927
ARUT117410868
BFO118406135
BBEL109461734 109480583 109486691
SKO100371918
DMK116926132
PJA122260577 122261978
PCHN125024539 125048283
PCLA123761105
PTRU123504183
HAZT108667421
LSM121117678
TUT107372229
DPTE113791482 113793022 113793031
DFR124495498 124495976 124499332
CSCU111631959 111631967 111632207
PTEP107443103 107445458 107445778
SDM118180521 118200208
LGILOTGIDRAFT_128172 LOTGIDRAFT_204287 LOTGIDRAFT_218395
PCAN112557879 112570933
BGT106058822
GAE121383811 121390084 121390479
HRF124116384 124116395 124116396 124117722 124117751 124142427 124152859
HRJ124257501 124262810 124279646
CRG105345878
MYI110445423 110452379 110463544
PMAX117317063 117320438 117333384 117333873 117344473
MMER123552249 123552250 123552251 123553522
OBI106868079 106868152 106874210
OSN115209793 115213146 115226225
LAK106153227 106179638 106179639
NVE5506952 5509997
EPA110253943
ATEN116300340 116300841
ADF107357429
AMIL114976578
PDAM113665188
SPIS111337869
DGT114524553 114524573 114527090
XEN124434554
TADTRIADDRAFT_21249
 » show all
Reference
1  [PMID:440106]
  Authors
Dupre S, Cavallini D.
  Title
Purification and properties of pantetheinase from horse kidney.
  Journal
Methods Enzymol 62:262-7 (1979)
DOI:10.1016/0076-6879(79)62227-9
Reference
2  [PMID:6549111]
  Authors
Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D.
  Title
Continuous spectrophotometric assay of pantetheinase activity.
  Journal
Anal Biochem 142:175-81 (1984)
DOI:10.1016/0003-2697(84)90534-7
Reference
3  [PMID:10567687]
  Authors
Maras B, Barra D, Dupre S, Pitari G.
  Title
Is pantetheinase the actual identity of mouse and human vanin-1 proteins?
  Journal
FEBS Lett 461:149-52 (1999)
DOI:10.1016/S0014-5793(99)01439-8
  Sequence
[hsa:8876] [mmu:22361]
Reference
4  [PMID:8934567]
  Authors
Aurrand-Lions M, Galland F, Bazin H, Zakharyev VM, Imhof BA, Naquet P.
  Title
Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing.
  Journal
Immunity 5:391-405 (1996)
DOI:10.1016/S1074-7613(00)80496-3
  Sequence
[mmu:22361]
Reference
5  [PMID:11042271]
  Authors
Pitari G, Malergue F, Martin F, Philippe JM, Massucci MT, Chabret C, Maras B, Dupre S, Naquet P, Galland F.
  Title
Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice.
  Journal
FEBS Lett 483:149-54 (2000)
DOI:10.1016/S0014-5793(00)02110-4
  Sequence
[mmu:22361]
Reference
6  [PMID:11491533]
  Authors
Martin F, Malergue F, Pitari G, Philippe JM, Philips S, Chabret C, Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F.
  Title
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
  Journal
Immunogenetics 53:296-306 (2001)
DOI:10.1007/s002510100327
  Sequence
[hsa:8876 8875] [mmu:26464]
Reference
7  [PMID:11380987]
  Authors
Pace HC, Brenner C.
  Title
The nitrilase superfamily: classification, structure and function.
  Journal
Genome Biol 2:REVIEWS0001 (2001)
DOI:10.1186/gb-2001-2-1-reviews0001
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.92
IUBMB Enzyme Nomenclature: 3.5.1.92
ExPASy - ENZYME nomenclature database: 3.5.1.92
BRENDA, the Enzyme Database: 3.5.1.92
CAS: 56093-18-6
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