Entry
Name
acyl-homoserine-lactone acylase;
acyl-homoserine lactone acylase;
AHL-acylase;
AiiD;
N-acyl-homoserine lactone acylase;
PA2385 protein;
quorum-quenching AHL acylase;
quorum-quenching enzyme;
QuiP
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-acyl-L-homoserine-lactone amidohydrolase
Reaction(IUBMB)
an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate [RN:
R09646 ]
Reaction(KEGG)
Substrate
Product
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria. This quorum-quenching enzyme removes the fatty-acid side chain from the homoserine lactone ring of AHL-dependent quorum-sensing signal molecules. It has broad specificity for AHLs with side changes ranging in length from 11 to 14 carbons. Substituents at the 3'-position, as found in N-(3-oxododecanoyl)-L-homoserine lactone, do not affect this activity.
History
EC 3.5.1.97 created 2007
Orthology
K07116 acyl-homoserine-lactone acylase
Genes
RGL : CS053_01895 CS053_11925
DJI : CH75_08665 CH75_21520
PAE : PA1032(quiP) PA2385(pvdQ)
PAEV : N297_1068(quiP) N297_2458(pvdQ)
PAEI : N296_1068(quiP) N296_2458(pvdQ)
PAU : PA14_33820(pvdQ) PA14_50980(pac)
PAP : PSPA7_2876 PSPA7_4349
PAG : PLES_29171(pvdQ) PLES_42911(quiP)
PAF : PAM18_2656(pvdQ) PAM18_4013(quiP)
PNC : NCGM2_1893(pac) NCGM2_3396(pvdQ)
PAEB : NCGM1900_1577(pac) NCGM1900_4144(pvdQ)
PDK : PADK2_13340 PADK2_20525
PSG : G655_13120 G655_20125
PRP : M062_05630 M062_12440
PAEP : PA1S_13695 PA1S_20795
PAER : PA1R_gp0186 PA1R_gp4632
PAEM : U769_13305 U769_20635
PAEL : T223_14915 T223_21915
PAES : SCV20265_2933 SCV20265_4406
PAEU : BN889_01092(quiP_3) BN889_02613(pvdQ)
PAEG : AI22_13150 AI22_20170
PAEC : M802_1065(quiP) M802_2455(pvdQ)
PCQ : PcP3B5_14340(quiP_1) PcP3B5_31380(pvdQ)
PMUI : G4G71_23900 G4G71_25465
PPU : PP_1108(quiP) PP_2901(pvdQ)
PPG : PputGB1_2882 PputGB1_4305
PPW : PputW619_1137 PputW619_2403
PPB : PPUBIRD1_1157 PPUBIRD1_2835
PPUH : B479_14970 B479_20785
PPUT : L483_12680 L483_25925
PPUN : PP4_10510(quiP) PP4_29180(pvdQ)
PPUD : DW66_3279 DW66_4539
PMON : X969_14425 X969_20405
PMOT : X970_14070 X970_20040
PMOS : O165_008025 O165_016840
PPJ : RK21_00379 RK21_01639
PMOL : CLJ08_06765 CLJ08_24035
PST : PSPTO_2161 PSPTO_4133
PSYR : N018_06160 N018_09175
PSP : PSPPH_1391 PSPPH_1937
PAMG : BKM19_012400 BKM19_022950
PAVL : BKM03_18500 BKM03_22435
PVD : CFBP1590__1424(quiP) CFBP1590__2019(pvdQ)
PCAB : JGS08_17030 JGS08_20025
PFL : PFL_1268(quiP) PFL_2902(pvdQ)
PPRC : PFLCHA0_c13030(quiP1) PFLCHA0_c29480(pvdQ)
PPRO : PPC_1321 PPC_2934(pvdQ)
PFE : PSF113_1228 PSF113_2796
PFN : HZ99_02660 HZ99_24320
PFO : Pfl01_1213 Pfl01_2563(pvdQ)
PFC : PflA506_1277(quiP) PflA506_2831(pvdQ)
PPZ : H045_03385 H045_09260
PMAN : OU5_0210(pvdQ) OU5_2200(quiP)
PTV : AA957_07535 AA957_28315
PVR : PverR02_06780 PverR02_16825
PAZO : AYR47_13795 AYR47_23235
POI : BOP93_06310 BOP93_11695
PRX : HRH33_07380 HRH33_14520
PFW : PF1751_v1c12610(quiP) PF1751_v1c28040(pvdQ)
PFF : PFLUOLIPICF701805 PFLUOLIPICF722185
PFX : A7318_05790 A7318_12555
PBA : PSEBR_a1158 PSEBR_a2993
PBC : CD58_06540 CD58_13435
PPUU : PputUW4_01158 PputUW4_02454(pvdQ)
PSV : PVLB_05515 PVLB_10405
PSK : U771_07730 U771_17730
PCH : EY04_05790 EY04_13720
PCZ : PCL1606_32000 PCL1606_48140
PCP : JM49_16220 JM49_23860
PLQ : AA042_04745 AA042_17445
PALK : PSAKL28_11690 PSAKL28_34620
PSW : LK03_00620 LK03_17510
PPV : NJ69_02440 NJ69_06295
PSES : PSCI_2682(pvdQ) PSCI_3059
PSEM : TO66_06460 TO66_14485
PSEC : CCOS191_1218(quiP) CCOS191_2888(pvdQ)
PSOS : POS17_1288 POS17_3177
PKR : AYO71_08805 AYO71_16050
PANR : A7J50_1451 A7J50_3095
PSIL : PMA3_05190 PMA3_13095
PYM : AK972_3162 AK972_4674
PKE : DLD99_06820 DLD99_13500
PUM : HGP31_06320 HGP31_16495
POJ : PtoMrB4_14410(quiP) PtoMrB4_31380(pvdQ)
PGY : AWU82_14370 AWU82_22430
PVK : EPZ47_06330 EPZ47_13380
PEZ : HWQ56_11675 HWQ56_22280
PBZ : GN234_02455 GN234_12115
PATA : JWU58_13980 JWU58_21465
PZE : HU754_007585 HU754_015800
PMOE : HV782_007125 HV782_015930
PSEP : C4K39_1327 C4K39_2787 C4K39_5179
PVW : HU752_023150 HU752_026755
PTRT : HU722_0007655 HU722_0015890
PXA : KSS93_09215 KSS93_17710
PSAM : HU731_002400 HU731_022540
PTZ : HU718_007240 HU718_016035
PQI : KH389_16590 KH389_20830
PSHH : HU773_006895 HU773_013150
PXN : HU772_005770 HU772_011345
PHV : HU739_004815 HU739_011430
PPRG : HU725_005270 HU725_010040
PANH : HU763_011535 HU763_018965
PASG : KSS96_07385 KSS96_15670
PFAK : KSS94_05985 KSS94_15610
PMUY : KSS95_08830 KSS95_13750
PMAM : KSS90_14140 KSS90_20030
PAZE : KSS91_06670 KSS91_13475
PALV : KSS97_13315 KSS97_22730
PORY : EJA05_06005 EJA05_14915
PTK : EXN22_10900 EXN22_21440
PTW : TUM18999_33890(pvdQ) TUM18999_47740(quiP)
PZA : HU749_007345 HU749_016125
PIE : HU724_006865 HU724_014530
PWY : HU734_011565 HU734_019665
PTAE : NCTC10697_01001(quiP_2) NCTC10697_03122(pvdQ)
AVN : Avin_19340 Avin_25350
AVL : AvCA_19340 AvCA_25350
AVD : AvCA6_19340 AvCA6_25350
ACX : Achr_15410 Achr_38830
PSYC : DABAL43B_2798(pvdQ)
SCAA : TUM17387_30790(aaiD)
HJA : BST95_05335 BST95_13275
HALC : EY643_01200 EY643_09210
AFUS : EYZ66_00905 EYZ66_09290
WOC : BA177_08070 BA177_16175
APAC : S7S_03045 S7S_07555
PSPI : PS2015_598 PS2015_945
BGL : bglu_2g10130 bglu_2g12920
BGP : BGL_2c00990 BGL_2c16680
BPLA : bpln_2g01000 bpln_2g17350
PLG : NCTC10937_02093(pvdQ) NCTC10937_04196(quiP_2)
VPE : Varpa_2408 Varpa_4314 Varpa_4490
VBO : CKY39_09205 CKY39_14380 CKY39_24420
VAM : C4F17_08365 C4F17_14730 C4F17_27735
DPY : BA022_01500 BA022_08855
PBH : AAW51_0007 AAW51_4251(pvdQ)
KIA : G8A07_00500 G8A07_11315
MNR : ACZ75_00930 ACZ75_00935 ACZ75_05685 ACZ75_07845 ACZ75_20900
MASS : CR152_10910 CR152_10925 CR152_25830
MASZ : C9I28_03060 C9I28_03065 C9I28_04325
MASY : DPH57_07925 DPH57_17590 DPH57_18985 DPH57_18990
MALI : EYF70_00950 EYF70_14630 EYF70_24985 EYF70_24990
MUM : FCL38_04075 FCL38_24345 FCL38_24350
MFLA : GO485_19770 GO485_19775 GO485_29290
MPLI : E1742_01210 E1742_14900 E1742_14910
MFB : MFUL124B02_18280 MFUL124B02_23225
CCX : COCOR_04399(pvdQ) COCOR_05166(pvdQ1) COCOR_06657(aac)
SUR : STAUR_0150 STAUR_4198
AVM : JQX13_07385 JQX13_15535
CFUS : CYFUS_000359 CYFUS_005966
CCS : CCNA_01077 CCNA_01180
CAUF : CSW63_08305 CSW63_17460
CAUL : KCG34_08575 KCG34_16565
PHB : HYN04_02115 HYN04_09910
HBC : AEM38_03510 AEM38_08735
SMAG : AN936_03260 AN936_18950
SMAZ : LH19_17965 LH19_22830
SECH : B18_16805 B18_24005
SPAP : H3Z74_06455 H3Z74_22595 H3Z74_22715
SPAI : FPZ24_13050 FPZ24_13925
SYA : A6768_11260 A6768_17885
CIJ : WG74_03520 WG74_07270
POQ : KZX46_07460 KZX46_10230
PNS : A9D12_07535 A9D12_08540
PORL : BG023_111214 BG023_11906
PHZ : CHX26_05495 CHX26_06695
POT : E2E27_15930 E2E27_17190
PARH : I5S86_06730 I5S86_12990
MSAL : DSM43276_01102(aac_1)
SCZ : ABE83_07110 ABE83_33970
SSIA : A7J05_02860 A7J05_03715
SFK : KY5_0496c KY5_0653c KY5_7669c
SKA : CP970_01175 CP970_40295
SVN : CP980_01600 CP980_29885
SCAV : CVT27_00535 CVT27_26705
SRIM : CP984_17575 CP984_35255
SCYG : S1361_03590(aac1) S1361_37335(aac3)
AMYB : BKN51_02095 BKN51_09995
KPHY : AOZ06_09370 AOZ06_38065
SYY : SYNGTS_2134(slr0378)
SYT : SYNGTI_2133(slr0378)
SYS : SYNPCCN_2132(slr0378)
SYQ : SYNPCCP_2132(slr0378)
GLP : Glo7428_0396 Glo7428_1780
CYC : PCC7424_0589 PCC7424_5764
TPX : Turpa_1792 Turpa_2195
TRS : Terro_2136 Terro_2500 Terro_4029
TALB : FTW19_10545 FTW19_11280
GPH : GEMMAAP_08155 GEMMAAP_16110
GGR : HKW67_06550 HKW67_18880
GBA : J421_0674 J421_6287 J421_6288
PSEG : D3H65_22425 D3H65_22445
LACS : H4075_15205 H4075_21300
FLV : KJS94_09580 KJS94_10665
ALM : AO498_05860 AO498_13120
MDA : IPZ59_07060 IPZ59_11770
SPIK : EXU85_15825 EXU85_27100 EXU85_29160
SPIB : G8759_13010 G8759_27790
STAE : HNV11_04335 HNV11_09590
PSEZ : HME7025_01556 HME7025_01566
RSI : Runsl_0129 Runsl_0169 Runsl_0284 Runsl_3533
RUN : DR864_08110 DR864_24845
RUP : DTQ70_00075 DTQ70_11695
EOL : Emtol_2106 Emtol_2167
ADD : HUW48_05505 HUW48_08370
RBI : RB2501_05425 RB2501_08450
SPON : HME9304_01082(pvdQ)
FOP : FNB79_00780 FNB79_14280
AQB : D1818_02505 D1818_06955
ASAG : FGM00_00170 FGM00_09800
» show all
Taxonomy
Reference
Authors
Lin YH, Xu JL, Hu J, Wang LH, Ong SL, Leadbetter JR, Zhang LH
Title
Acyl-homoserine lactone acylase from Ralstonia strain XJ12B represents a novel and potent class of quorum-quenching enzymes.
Journal
Sequence
Reference
Authors
Sio CF, Otten LG, Cool RH, Diggle SP, Braun PG, Bos R, Daykin M, Camara M, Williams P, Quax WJ
Title
Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.97
ExPASy - ENZYME nomenclature database: 3.5.1.97
LinkDB
All DBs