| Entry |
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| Name |
1-pyrroline-4-hydroxy-2-carboxylate deaminase;
HPC deaminase;
1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
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| Sysname |
1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (ring-opening)
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| Reaction(IUBMB) |
1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3 [RN: R02280]
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| Reaction(KEGG) |
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| Substrate |
1-pyrroline-4-hydroxy-2-carboxylate [CPD: C04282];
H2O [CPD: C00001]
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| Product |
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| History |
EC 3.5.4.22 created 1976
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| Pathway |
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| Orthology |
| K21062 | 1-pyrroline-4-hydroxy-2-carboxylate deaminase |
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| Genes |
| RTG: | NCTC13098_06402(dapA_7) |
| SFJ: | SAMEA4384070_1862(dapA_1) |
| SGRI: | SGBXF1_01843(dapA_1) |
| XCA: | xcc-b100_1754(dapA2) |
| XFU: | XFF4834R_chr25690(dapA2) |
| XPH: | XppCFBP6546_19680(XppCFBP6546P_19680) |
| XHD: | LMG31886_17420(dapA_1) |
| RGL: | CS053_00930 CS053_07845 |
| POJ: | PtoMrB4_26300(dapA_1) |
| PCQ: | PcP3B5_24840(dapA_1) |
| PPG: | PputGB1_3970 PputGB1_4134 |
| PPUT: | L483_24385 L483_25130 |
| PPRC: | PFLCHA0_c14500(dapA2) |
| PMUD: | NCTC8068_02999(dapA_4) |
| PBC: | CD58_14010 CD58_17505 |
| PPUU: | PputUW4_03028(dapA2) |
| PPSH: | G5J76_10815 G5J76_14150 |
| PVK: | EPZ47_13955 EPZ47_23820 |
| PTW: | TUM18999_27460(dapA_1) |
| PTAE: | NCTC10697_01419(dapA_2) |
| PKM: | PZ739_20585 PZ739_21420 |
| PFOU: | OZ911_21075 OZ911_21805 |
| PSKP: | KU43P_13320(dapA_2) |
| PBUB: | V6B39_11390 V6B39_15040 |
| PSML: | V6P94_10815 V6P94_14400 |
| PSMZ: | V6L79_10960 V6L79_14590 |
| SEUR: | FM038_25720 FM038_25740 |
| PSEN: | PNC201_08050(dapA2) |
| COBE: | CLAM6_21110(dapA_1) |
| MPON: | MACH16_00690(dapA_1) |
| BYI: | BYI23_B007720 BYI23_D012920 |
| BURT: | BTHE68_31370 BTHE68_63620 |
| PARB: | CJU94_22140 CJU94_24680 |
| PCJ: | CUJ87_17795 CUJ87_32190 |
| PCAF: | DSC91_002489 DSC91_002493 |
| PDIO: | PDMSB3_1685.1 PDMSB3_2312.1 |
| PTX: | ABW99_01810 ABW99_02280 |
| PLG: | NCTC10937_03095(dapA_3) |
| BUO: | BRPE64_BCDS05520 BRPE64_DCDS01050 |
| CABK: | NK8_34210 NK8_52030 |
| BUE: | BRPE67_BCDS11670 BRPE67_DCDS01600 |
| TVL: | FAZ95_14685 FAZ95_32805 |
| BBRO: | BAU06_06555 BAU06_21900 |
| BFZ: | BAU07_19740 BAU07_22035 |
| BOH: | AKI39_03760 AKI39_06355 |
| BGV: | CAL12_06890 CAL12_20750 CAL12_24010 |
| AXY: | AXYL_00724 AXYL_02984 |
| AXO: | NH44784_014041 NH44784_048971 |
| AXN: | AX27061_0754 AX27061_3050 |
| AXX: | ERS451415_00740(dapA_1) ERS451415_03031(dapA_3) |
| ADT: | APT56_04005 APT56_13055 |
| AIS: | BUW96_05025 BUW96_21995 |
| ACHB: | DVB37_03075 DVB37_06550 |
| APES: | FOC84_08770 FOC84_30770 |
| AAEG: | RA224_17865 RA224_28785 |
| ASEL: | RAS12_14820 RAS12_18415 |
| ACHA: | KYT87_03100 KYT87_07080 |
| ACHH: | ABFG95_18615 ABFG95_27495 |
| VPD: | VAPA_1c40980 VAPA_1c54310(dapA4) |
| VAZ: | H7F35_04165 H7F35_11290 |
| CTT: | CtCNB1_4597 CtCNB1_4598 |
| UPL: | DSM104440_02165(dapAL) |
| MLO: | mll3981 mll6811 mlr6292 |
| MLN: | A9174_06110 A9174_14105 |
| MESP: | C1M53_19250 C1M53_22645 |
| MHUA: | MCHK_0428 MCHK_5289 |
| MJR: | EB229_06305 EB229_14220 |
| MERD: | EB233_06255 EB233_28100 |
| MMEI: | LRP31_05800 LRP31_30590 |
| MESJ: | MJ8_17770 MJ8_60410 |
| MEWS: | QAZ47_07610 QAZ47_10945 |
| MEWM: | QAZ22_07640 QAZ22_10935 |
| AMIH: | CO731_01293(dapA_2) |
| AMAX: | ABWH92_03195 ABWH92_17890 |
| SMEG: | C770_GR4pB177 C770_GR4pD1338 |
| SMEL: | SM2011_b20259 SM2011_c03259 |
| SFD: | USDA257_c35130(dapA4) |
| SAME: | SAMCFNEI73_Ch1603(dapA) |
| EAW: | ACEP9W_25860 ACEP9W_28935 |
| AVV: | RvVAT039_39290(dapA) |
| AVF: | RvVAR031_42220(dapA) |
| SOJ: | K6301_15690 K6301_17115 |
| HOE: | IMCC20628_02927 IMCC20628_03322 |
| OCC: | KMS41_17065 KMS41_20570 |
| BVES: | QO058_12545 QO058_24800 |
| BOI: | BLM15_13005 BLM15_24175 |
| STAR: | G3545_19675 G3545_23230 |
| APRA: | G3A50_09715 G3A50_10390 G3A50_11705 |
| MAQU: | Maq22A_1p30570(dapA) |
| DNP: | N8A98_00905 N8A98_12320 |
| DAG: | PSQ19_00025 PSQ19_19160 |
| MHAR: | L1P08_09515 L1P08_13545 |
| MEY: | TM49_07675 TM49_22130 |
| MAAD: | AZF01_15400 AZF01_19445 |
| MLUT: | JET14_17010 JET14_20320 |
| NOH: | G5V57_12520 G5V57_20375 G5V57_25515 |
| LABT: | FIU93_09460(dapA2) FIU93_14075(dapA3) |
| PSTG: | E8M01_06260 E8M01_16605 |
| BVY: | NCTC9239_01935(dapA) |
| AEX: | Astex_2591 Astex_3397 |
| ASTM: | MMA231_03806(dapA_3) |
| TSV: | DSM104635_00273(dapA_1) |
| SINL: | DSM14862_03886(dapA_4) |
| RMM: | ROSMUCSMR3_03767(dapA) |
| PAMI: | JCM7686_pAMI4p143 JCM7686_pAMI5p165 |
| PALW: | PSAL_037670(dapA_5) |
| RHP: | LPB142_00845 LPB142_07550 |
| NOV: | TQ38_021130 TQ38_024020 |
| SSAN: | NX02_07360 NX02_19040 |
| BLAS: | BSY18_2026 BSY18_674 |
| BFW: | B5J99_01690 B5J99_12555 |
| PBRU: | LZC95_21555 LZC95_24860 LZC95_35975 |
| PRUE: | LVJ94_20575 LVJ94_24035 LVJ94_35805 |
| PALJ: | LZC94_09595 LZC94_16445 LZC94_23095 LZC94_45645 |
| MTAR: | DF168_00311(dapA_2) |
| RML: | FF011L_16020(dapA_2) FF011L_31680(dapA_4) |
| MFF: | MFFC18_24000(dapA_1) |
| ROL: | CA51_21340(dapA_1) CA51_31060(dapA_2) |
| RUV: | EC9_24400(dapA_2) EC9_26200(dapA_3) |
| RCF: | Poly24_33630(dapA_2) |
| AHEL: | Q31a_34450(dapA_1) Q31a_47930(dapA_2) |
| LCRE: | Pla8534_37840(dapA_1) |
| AAGG: | ETAA8_57530(dapA_2) |
| RLC: | K227x_06430(dapA_1) K227x_30720(dapA_4) |
| SMAM: | Mal15_60710(dapA_3) |
| SNEP: | Enr13x_22880(dapA_1) Enr13x_37330(dapA_2) |
| SMAE: | TBK1r_22940(dapA_2) |
| PND: | Pla175_21550(dapA_1) |
| GPN: | Pan110_30140(dapA_4) |
| GFM: | Enr17x_17350(dapA_3) |
| GAZ: | Pan241w_16720(dapA_3) |
| TPOL: | Mal48_25240(dapA_2) |
| CCOP: | Mal65_06930(dapA_1) |
| GES: | VT84_21630(dapA_3) VT84_29725(dapA_5) |
| GOG: | C1280_06015 C1280_19350 |
| GMS: | SOIL9_05890 SOIL9_37410 |
| LRS: | PX52LOC_04252 PX52LOC_06844 |
| SMIZ: | 4412673_01387(dapA_2) |
| STHA: | NCTC11429_00327(dapA_1) |
| MGOT: | MgSA37_00735(dapAL) |
| ZGA: | ZOBELLIA_4010(dapA1) |
| PHG: | KCTC32516_01302(dapAL) |
| AANR: | KCTC52924_03776(yjhH) |
| KOS: | KORDIASMS9_03298(dapA) |
| KAN: | IMCC3317_06520(dapA_2) |
| SPON: | HME9304_02945(dapA) |
| CGLE: | NCTC11432_00787(dapA_2) |
| NCM: | QNK12_02640(dapA) QNK12_12495 |
| PPQ: | PPSQR21_010220(dapA) |
| SCO: | SCO6292(SCBAC8D1.05) |
| SVT: | SVTN_02125 SVTN_28830 |
| SNR: | SNOUR_06180 SNOUR_36780 |
| SLK: | SLUN_30380 SLUN_34375 |
| SGX: | H4W23_02805 H4W23_29975 |
| SDW: | K7C20_03170 K7C20_36875 |
| SAUH: | SU9_002390 SU9_033570 |
| STAA: | LDH80_04465 LDH80_10455 |
| SXT: | KPP03845_105651(dapAL) |
| SHAU: | K9S39_09790 K9S39_38175 |
| SLUO: | PS467_40865 PS467_40925 |
| AMAU: | DSM26151_17870(dapAL) |
| ARR: | ARUE_232p01530(dapA) |
| AAQ: | AOC05_01960 AOC05_16080 |
| NGV: | CDO52_01670 CDO52_12675 |
| NOA: | BKM31_05570 BKM31_06620 |
| NGN: | LCN96_34980 LCN96_36035 |
| NFS: | OIE67_12490 OIE67_13445 |
| ACTU: | Actkin_02380(dapAL) |
| MHAW: | RMN56_25265 RMN56_28570 |
| PRY: | Prubr_07370(dapA_1) Prubr_70630 |
| BALA: | DSM104299_01702(dapA_1) |
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| Reference |
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| Authors |
Singh RM, Adams E. |
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| Title |
Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde). |
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| Journal |
J Biol Chem 240:4344-51 (1965) |
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| Reference |
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| Authors |
Singh RM, Adams E. |
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| Title |
Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline. |
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| Journal |
J Biol Chem 240:4352-6 (1965) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.4.22 |
| ExPASy - ENZYME nomenclature database: | 3.5.4.22 |
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| LinkDB |
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