KEGG   ENZYME: 3.5.4.27
Entry
EC 3.5.4.27                 Enzyme                                 
Name
methenyltetrahydromethanopterin cyclohydrolase;
5,10-methenyltetrahydromethanopterin cyclohydrolase;
N5,N10-methenyltetrahydromethanopterin cyclohydrolase;
methenyl-H4MPT cyclohydrolase;
5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
5,10-methenyltetrahydromethanopterin 10-hydrolase (ring-opening)
Reaction(IUBMB)
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = 5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03464]
Reaction(KEGG)
R03464
Substrate
5,10-methenyl-5,6,7,8-tetrahydromethanopterin [CPD:C04330];
H2O [CPD:C00001]
Product
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274]
Comment
Methanopterin is a pterin analogue. The enzyme is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.
History
EC 3.5.4.27 created 1989
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01499  methenyltetrahydromethanopterin cyclohydrolase
Genes
MCAMCA2863
METUGNH96_03530(mch)
MMEOOOT43_14015(mch)
MMTMetme_2265
MDNJT25_019335
MDHAYM39_08540
MKOMKLM6_1778
METLU737_14820
MPADKEF85_11475
MELLIVG45_03930
MRPNM686_014190(mch)
MMOTQZJ86_13655(mch)
MAHMEALZ_2425(mch)
MBUREQU24_09125
MPSYCEK71_15610
MMAIsS8_3394
MSZEMSZNOR_2917(mch)
MMOBF6R98_19020
MEINmethR_P2328
MOZMoryE10_28870(mch)
MISZMishRS11D_40060(mch)
MESLKKZ03_09080(mch)
MEIYMIN45_P1841
MCAUMIT9_P1441
MEJQ7A_44
MECQ7C_1772
MPINLGT42_002855(mch)
MMAFGCM100_17930(mch)
MTHAVSX76_15975(mch)
BLEPAL038_01000
NHLNhal_3876
NWRE3U44_04675
TSYTHSYN_31780
SEDSAAY24_01650
COXE0W60_31930
BUGBC1001_3948
BGFBC1003_5455
BYIBYI23_B014460
BUEBRPE67_BCDS01450
BUQAC233_22025
BXEBxe_B2433(mch)
BXBDR64_4761(mch)
BPHBphy_5946 Bphy_6484
BGEBC1002_3223
BPXBUPH_00532
BCAIK788_0001556
PSPWBJG93_19395(mch)
PARABTO02_24125
PARBCJU94_31195
PHSC2L64_21815 C2L64_38295
PTERC2L65_26155 C2L65_34290
PGPCUJ91_21500
PCJCUJ87_23420
PTSCUJ90_28070
PGISI6I06_22465
PEWKZJ38_25875(mch)
PDIOPDMSB3_0629.1(mch)
PSAAQEN71_32820(mch) QEN71_34085(mch)
PKFRW095_18805(mch)
PPAIE1956_20450
BUOBRPE64_BCDS01590
CABKNK8_41330
TCARU0034_17530(mch)
VAPVapar_3082
VPDVAPA_1c31460(mch)
MPTMpe_A2609
METPC1M51_15095
RGERGE_40250(mch)
ATERMW290_07945(mch)
LCHLcho_3150
AONDEH84_18995
METRBSY238_3292(mch)
MFAMfla_1658
MMBMmol_1344
MEHM301_1554
MEIMsip34_1502
MEPMPQ_1565
MBACBN1209_0747(mch)
MEUACJ67_08170
MPAUZMTM_11840(mch)
SPLBSFPGR_25980(mch)
AZAAZKH_p0273
AZDCDA09_11315
THUAC731_004845
THAUC4PIVTH_3698(mch)
THKCCZ27_13250
THAGCKCBHOJB_02581(mch)
DDZDSYM_25690
MCIMesci_4260
MCICA4R28_05755
MESWA9K65_023620
MOHIHQ72_13875
MMEILRP31_14005(mch)
PHTBLM14_23790
RGARGR602_PC01568(mch)
NPMQEO92_19220(mch)
XAUXaut_1788
XDIEZH22_07500
STARG3545_09780
LNEFZC33_09335
SNOSnov_0750
ANCGBB76_00750
APRAG3A50_16495
APOLK9D25_20190(mch)
MEAMex_1p1763(mch)
MDIMETDI2515(mch)
MEXMext_1831
MCHMchl_2166
MPOMpop_1782
MZAB2G69_16815
MRDMrad2831_0530
METM446_5780
MNOMnod_6004
MORMOC_0685(mch)
METAY590_08770
MAQUMaq22A_c16475(mch)
MPHYMCBMB27_00107
MEEDA075_05730
METDC0214_10525
METXA3862_28300
METSDK389_20655
METIDK427_18445
MMESMMSR116_16690
MTEADK419_10795
MINDmvi_45910(mch)
MOGMMB17_20025(mch)
MTADM6G65_13665(mch)
MSLMsil_2387
MTUNMTUNDRAET4_2723(mch)
MLGCWB41_06045
MEDKQEV83_11770(mch)
HDNHden_1477
HDTHYPDE_31258
HMCHYPMC_1627(mch)
HNIW911_13175
FILBN1229_v1_0586(mch)
FIYBN1229_v1_0588(mch)
MCGGL4_1786
METGHT051_10180
MSCBN69_1353
MBRYB1812_02320
MROSEHO51_13055
MHEYH2LOC_003815
MPARF7D14_05050
MIWASS37A_00070(mch_1)
MTWCQW49_13495
MECQMSC49_12090(mch)
CMETK6K41_25475(mch)
PLEOOHA_1_01035(mch)
HDIHDIA_2312(mch)
AALAIGS74_05780
AALMLUX29_06535(mch)
AUZSa4125_38530(mch)
AUBLXB15_00980(mch)
JAVOXU80_18200(mch)
GBEGbCGDNIH1_0773
GBHGbCGDNIH2_0773
GBCGbCGDNIH3_0773
GBSGbCGDNIH4_0773
ALIAZOLI_p10687(mch1) AZOLI_p10889(mch2)
ABSAZOBR_p270082(mch)
ABQABAZ39_25470
ABFAMK58_22330
ATIAL072_27075
AZTTSH58p_01205
AZMDM194_17080
AOZHUE56_08920
AARED3093_24960
AZSE6C72_18245 E6C72_22455
CBTCLH_1638(mch)
PALMRBG61_02415(mch)
CMICcaldi_15520(mch)
DMTDESME_10945
DORDesor_4012
DAIDesaci_3581
DMIDesmer_3120
FWADCMF_01135 DCMF_03915
CBOLCGC65_05105
HORHore_19220
HASHalsa_0947
MPHEHGG69_02450
CAPCLDAP_00590(mch)
RBARB6759(mch)
PSLPsta_3184
PIRVN12_11975(mch)
RULUC8_55600(mch)
RMLFF011L_43370(mch)
MFFMFFC18_17580(mch)
ROLCA51_33360(mch)
RUVEC9_35480(mch)
RCFPoly24_34900(mch)
AHELQ31a_62590(mch)
LCREPla8534_46610(mch)
AAGGETAA8_05120(mch)
BVOPan97_33090(mch)
BREMPSR63_21930(mch)
RLCK227x_27840(mch)
SMAMMal15_33980(mch)
SNEPEnr13x_45510(mch)
LPAVPLANPX_1003
LLHI41_11730(mch)
AMUCPan181_44380(mch)
PNDPla175_40180(mch)
AMOBHG15A2_09750(mch)
BGOKPr1d_22320(mch)
PLMPlim_2586
PEHSpb1_33570(mch)
PBSPlabr_2150
PLSVT03_28970(mch)
PLHVT85_05465(mch)
FMRFuma_00366(mch)
GMRGmarT_12110(mch)
GIMF1728_08720
GPNPan110_11880(mch)
GFMEnr17x_12910(mch)
GAZPan241w_13090(mch)
GAWV144x_45740(mch)
MRIMal4_29800(mch)
SDYNMal52_18780(mch)
PLONPla110_19000(mch)
ACAFCA12_34930(mch)
SVPPan189_27040(mch)
TPOLMal48_18260(mch)
CHYAV22_26960(mch)
CCOSPan44_15750(mch)
PVARSH412_003487(mch)
CCOPMal65_23800(mch)
GESVT84_09780(mch)
GOGC1280_06325(mch)
GMSSOIL9_11460
TIMGMBLW1_05840
LRSPX52LOC_02773(mch)
FTJFTUN_8522
ULIETAA1_18410(mch)
TSPHKIH39_22355(mch)
IPAIsop_0325
SACISinac_1236
PBORBSF38_00163(mch)
AGVOJF2_59280(mch)
TPLAElP_59070(mch)
SSMSpirs_2846
AMOAnamo_1135
ARAMKAR29_10130
MOXDAMO_0461(mch)
MJAMJ_1636
MFEMefer_1327
MVUMetvu_1361
MFSMFS40622_0639
MIFMetin_0908
MJHJH146_0538
MESGMLAUSG7_0104(mch)
MESAMLASG1_1287(mch)
MIGMetig_0087
MMPMMP1191(mch)
MMQMmarC5_0399
MMXMmarC6_1482
MMZMmarC7_0438
MMDGYY_06780
MMAKMMKA1_13660(mch)
MMAOMMOS7_12990(mch)
MMADMMJJ_16540(mch)
MAEMaeo_0441
MVNMevan_0507
MVOMvol_0378
MOKMetok_1590
METFCFE53_06735(mch)
MTHMTH_773
MMGMTBMA_c11690(mch)
MWOMWSIV6_1147(mch)
MTEEMTTB_06150
METCMTCT_0692
METEtca_00740(mch)
METZMETMT2_0406
METKFVF72_07680(mch)
MTHMFZP57_05450(mch)
METJFZP68_00760(mch)
MSTMsp_1238(mch)
METBAW729_09545
MEISPXD04_01400(mch)
MRUmru_1619(mch)
MSIMsm_1723
MEBAbm4_1203(mch)
MMILsm9_1330(mch)
MEYETL18_04360
MOLYLM1_1103
MAROMarbSA_04250
METVK4897_00150(mch)
MELMetbo_2195
MEWMSWAN_0451
METHMBMB1_0537(mch)
MFCBRM9_1751(mch)
MFIDSM1535_2390(mch)
MCUBMCBB_0462(mch)
MSUBBK009_00605
METNBK008_08410
METTCIT01_01545(mch)
METOCIT02_04240(mch)
MEMEHYG87_03185(mch)
MFEGGCM10025860_14460
MFVMfer_0254
MKAMK0625(mch)
AFUAF_1935
AFGAFULGI_00021950
APOArcpr_0990
AVEArcve_2011
ASTAsulf_01966
FPLFerp_0606
GACGACE_0343
GAHGAH_01155
MBAMbar_A2233
MBYMSBRM_1678
MBWMSBRW_2514
MBARMSBR2_0727
MBAKMSBR3_0457
MACMA_1710(mch)
MMAMM_2653
MMAZMmTuc01_2718
MMJMSMAS_2053
MMACMSMAC_1059
MVCMSVAZ_1281
MEKMSKOL_1225
MLSMSLAZ_1037
METMMSMTP_2066
MEFMSWH1_1963
MEQMSWHS_3107
MSJMSSAC_3299
MSZMSSIH_1132
MSWMSSIT_1182
MTHRMSTHT_0435
MTHEMSTHC_0286
MHORMSHOH_2598
MFZAOB57_000035(mch)
MBUMbur_0653(mch)
MMETMCMEM_0808
MELOJ7W08_02205(mch)
MMHMmah_1138
MHAZBHR79_07850
MPOTBKM01_08510
MEVMetev_1611
MZHMzhil_1348
MPYMpsy_3012
MZIHWN40_06075(mch)
MMAVRE476_04520(mch)
MSEBRE474_00635(mch)
MHZMetho_1529
MTPMthe_0252
MCJMCON_1290(mch)
MHIMhar_2174
MHUMhun_0444 Mhun_2384
MRTJKHC33_12350(mch) KHC33_16595(mch)
MLAMlab_0399
MEMMemar_0263 Memar_0668
MBGBN140_0141(mch1) BN140_1778(mch3)
MEMAMMAB1_2292(mch)
MCHKMchiMG62_07930
MSUMOH143_08070(mch) OH143_10070(mch)
MRCR6Y96_02265(mch) R6Y96_09325(mch)
MPIMpet_0065
MENDL6E24_01800(mch) L6E24_07730(mch)
MEFWF1737_10680(mch)
MAQERJ40_10830(mch)
MFKE2N92_11075(mch)
MOUOU421_09265(mch)
MESBL1S32_00440(mch)
MANQL1994_10950(mch)
MBNMboo_0680
MFOMetfor_2532
MPLMpal_2022
MPDMCP_1132(mch-1) MCP_1888(mch-2)
MEZMtc_1063(mch-1) Mtc_1978(mch-2)
RCILRC191(mch-1) RCIX2742(mch-2)
MJKN2V74_07500(mch)
HALVNG_1686G(mch)
HSLOE_3383R(mch)
HANRLJ422_06805(mch)
HDLHALDL1_13235
HHBHhub_3179(mch)
HAGSJT689_08135
HABOJRZ79_06550(mch)
HNOLT974_11800(mch)
HLULT972_03110(mch)
HALHHTSR_0323
HHSRHSR6_0309(mch)
HSUHLASF_1805
HSFHLASA_1791
HAHSHSRCO_2408(mch3)
SALRFQU85_07455
HALREFA46_001470
HJEHacjB3_04520
HDOMUK72_08695(mch)
HALXM0R89_02735(mch)
HAXZM0R88_02720(mch)
HAYCNGM10_12675(mch)
HAXYNGM07_07235(mch)
SALIL593_12155
SAIMK0C01_07840(mch)
HARAAArcS_1105(mch2)
HMArrnAC1616(mch)
HHIHAH_2159(mch)
HHNHISP_11005
HABSG26_03375
HTABVU17_10515
HALJG9465_15375
HSINKDQ40_02600
NPHNP_2634A(mch)
NMONmlp_2018(mch)
NHOHWV23_16790
NSALHWV07_18180
HUTHuta_1145
HTIHTIA_1038
HALAHrd1104_00960
HASVSVXHr_0469(mch)
HABNHBNXHr_0448(mch)
HMUHmuk_1816
HALZE5139_12200
HALLLC1Hm_1117(mch)
HAZPGBQ70_12210
HALIBV210_13610
HSNDV733_14155
HDSHSR122_2710(mch)
HRRHZS55_12710
HPELHZS54_16640
HLTI7X12_01230
HARCHARCEL1_01570
SSAIN0B31_10465(mch)
HAADMW046_11205(mch)
HWAHQ_2798A(mch)
HWCHqrw_3170(mch)
HVOHVO_2573
HMEHFX_2599
HGIABY42_12905
HALEG3A49_16560
HLSKU306_00075(mch)
HLNSVXHx_2025(mch2)
HBOHbor_10140
HAQDU484_04960
HAJDU500_05400
HAERDU502_03105
HRAEI982_10145
HLMDV707_04070
HALMFCF25_02980
HLAHlac_1693
HALPDOS48_08545
HALBEKH57_03305
HEZZEO776_08115
HALQHrr1229_003010
HSSJ7656_08315
HSAIHPS36_13725
HAZZKI388_05770(mch)
SRUBC2R22_15900
HAEhalTADL_3392
HALNB4589_001465
HALGHUG10_00565
HALUHUG12_17145
HMPK6T50_14670(mch)
HREK6T36_14630(mch)
HRMK6T25_02130(mch)
HACBHbl1158_06735(mch)
HDFAArcSl_1968(mch)
HAHHalar_1179
HTUHtur_2210
HSALJMJ58_17890
HAKZJ0X25_17525(mch)
NMGNmag_0205(mch)
HXAHalxa_1038
NATNJ7G_2078
NPENatpe_0864
NVRFEJ81_04450
NPLFGF80_06355
NAYHYG81_05585(mch)
HALYHYG82_07980
HJTDVR14_13650
HLOJ0X27_04755
NGENatgr_2851
HRUHalru_2071
SAWLNGM29_13965(mch)
HALVNGM15_05240(mch)
NOUNatoc_3488
HLRHALLA_14455
HLCCHINAEXTREME13965
NAJB1756_01145
NAGAArcMg_2172
NANAArc1_1514
NARAQQ977_01390(mch)
NBGDV706_00340 DV706_16930
NASGCU68_16020
HDABB347_06500
MELUMTLP_03080
MEAMMU439_06355(mch)
MEAEQEN48_03790(mch)
BARCAOA65_2050(mch)
LOKILokiarch_00580(mch_1) Lokiarch_17800(mch_2)
 » show all
Reference
1  [PMID:4062290]
  Authors
Donnelly MI, Escalante-Semerena JC, Rinehart KL Jr, Wolfe RS.
  Title
Methenyl-tetrahydromethanopterin cyclohydrolase in cell extracts of Methanobacterium.
  Journal
Arch Biochem Biophys 242:430-9 (1985)
DOI:10.1016/0003-9861(85)90227-9
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.27
IUBMB Enzyme Nomenclature: 3.5.4.27
ExPASy - ENZYME nomenclature database: 3.5.4.27
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.4.27
BRENDA, the Enzyme Database: 3.5.4.27
CAS: 99533-50-3
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