Entry
Name
tRNAAla(adenine37) deaminase;
ADAT1;
Tad1p
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
tRNAAla(adenine37) aminohydrolase
Reaction(IUBMB)
adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3 [RN:
R10231 ]
Reaction(KEGG)
Substrate
adenine37 in tRNAAla;
H2O [CPD:
C00001 ]
Product
hypoxanthine37 in tRNAAla;
NH3 [CPD:
C00014 ]
Comment
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].
History
EC 3.5.4.34 created 2013
Orthology
K15440 tRNA-specific adenosine deaminase 1
Genes
PLEU : 114684836 114709112(Adat1)
DMER : 138825101 138826698
GVR : 103583736 103594034(ADAT1)
ASAO : 132782912(ADAT1) 132783189
DSI : Dsimw501_GD22044(Dsim_GD22044)
VCAN : 122408314 122412585
ZNE : 110836219 110837336 110839095
AFRA : 136027053 136027064
PPOI : 119105640 119105642
CSAT : 104738618 104754329 104758648
EGR : 104443458 104443461 120293459
TPRA : 123894393 123900072
LANG : 109359083 109363340
PMUM : 103331894 103343023 103343026
PAVI : 110759275 110759277
CILL : 122298583 122298633 122298656
SMIL : 130999128 130999173
CQI : 110685310 110685344 110696353 110714656
PSOM : 113274942 113304490
TDC : 119357211 119357212 119366496 119366500
TAES : 123047505 123047506 123050716 123191127
MFLO : 136493958 136493963 136497355
SMO : SELMODRAFT_424531 SELMODRAFT_425916
MPP : MICPUCDRAFT_50213 MICPUCDRAFT_51056
CGR : 2888459(GVI51_H07645)
NCS : NCAS_0E00270(NCAS0E00270)
NDI : NDAI_0I03230(NDAI0I03230)
TPF : TPHA_0G03640(TPHA0G03640)
TBL : TBLA_0E00230(TBLA0E00230)
TDL : TDEL_0D06340(TDEL0D06340)
KAF : KAFR_0J02870(KAFR0J02870)
KNG : KNAG_0I00240(KNAG0I00240)
LBG : 92210990(LODBEIA_P57940)
CAL : CAALFM_C700130WA(CaO19.7110)
CTEN : 18249433(PSN45_004083)
ASAU : 88174558(PUMCH_003494)
YLI : 2907375(YALI2_C00506g)
NTE : NEUTE1DRAFT126133(NEUTE1DRAFT_126133)
SMP : 10805839(SMAC4_02878)
RTHE : 98124958(VTJ83DRAFT_3887)
TATV : 90958850(TrAtP1_001818)
TASP : 36610015(TrAFT101_000760)
MAW : 19245189(J3458_009362)
MBRN : 26245323(G6M90_00g092110)
PLJ : 28882498(PLICBS_001478)
CDET : 87951001(CDEST_14501)
CPW : 9693906(D8B26_003364)
PTRR : 6339598(PtrM4_002890)
ADAC : 96084501(ACET3X_004179)
FFU : CLAFUR5_01089 CLAFUR5_07716
CDEC : 89989723(IAS62_002950)
CTEG : 91990968(I308_104112)
CBAS : 91985121(I312_105076)
CDEP : 91089423(L203_105214)
KMG : 30167327(I203_103113)
KNE : 92181363(IAR55_004105)
KDJ : 28970514(I303_107411)
KBI : 30211607(I302_108417)
KPIN : 30173362(I206_106168)
KSH : 87959150(IL334_007020)
KER : 91100821(V865_002017)
CCAC : CcaHIS019_0411080(CcaverHIS019_0411080)
ABP : AGABI1DRAFT73247(AGABI1DRAFT_73247)
ABV : AGABI2DRAFT202903(AGABI2DRAFT_202903)
SCM : SCHCO_02540792(SCHCODRAFT_02540792)
PIF : PITG_04666 PITG_20401
TVA : 4762198(TVAGG3_0220760)
» show all
Taxonomy
Reference
Authors
Maas S, Gerber AP, Rich A
Title
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes.
Journal
Sequence
Reference
Authors
Gerber A, Grosjean H, Melcher T, Keller W
Title
Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2.
Journal
Sequence
Reference
Authors
Keegan LP, Gerber AP, Brindle J, Leemans R, Gallo A, Keller W, O'Connell MA
Title
The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.34
ExPASy - ENZYME nomenclature database: 3.5.4.34
LinkDB
All DBs