KEGG   ENZYME: 3.5.4.34
Entry
EC 3.5.4.34                 Enzyme                                 
Name
tRNAAla(adenine37) deaminase;
ADAT1;
Tad1p
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
tRNAAla(adenine37) aminohydrolase
Reaction(IUBMB)
adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3 [RN:R10231]
Reaction(KEGG)
R10231
Substrate
adenine37 in tRNAAla;
H2O [CPD:C00001]
Product
hypoxanthine37 in tRNAAla;
NH3 [CPD:C00014]
Comment
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].
History
EC 3.5.4.34 created 2013
Orthology
K15440  tRNA-specific adenosine deaminase 1
Genes
HSA23536(ADAT1)
PTR468030(ADAT1)
PPS100981842(ADAT1)
GGO101139542(ADAT1)
PON100439664(ADAT1)
NLE100606616(ADAT1)
MCC712066(ADAT1)
MCF101925428(ADAT1)
CSAB103233319(ADAT1)
CATY105571269(ADAT1)
PANU101018080(ADAT1)
TGE112613694(ADAT1)
RRO104677849(ADAT1)
RBB108527413(ADAT1)
TFN117088068(ADAT1)
PTEH111552512(ADAT1)
CJC100404128(ADAT1)
SBQ101053316(ADAT1)
CSYR103270392(ADAT1)
MMUR105875461(ADAT1)
LCAT123625418(ADAT1)
OGA100954309(ADAT1)
MMU30947(Adat1)
MCAL110300092(Adat1)
MPAH110337640(Adat1)
RNO690810(Adat1)
MCOC116070213(Adat1)
MUN110554746(Adat1)
CGE100767121(Adat1)
MAUA101827499(Adat1)
PLEU114684836 114709112(Adat1)
MORG121446716(Adat1)
AAMP119801733(Adat1)
NGI103725659(Adat1)
HGL101705855(Adat1)
CPOC100725126(Adat1)
CCAN109700198(Adat1)
DORD105983188(Adat1)
DSP122126265(Adat1)
NCAR124966513
OCU100343387(ADAT1)
OPI101523514(ADAT1)
TUP102499762(ADAT1)
CFA489706(ADAT1)
CLUD112646661(ADAT1)
VVP112915675(ADAT1)
VLG121499665(ADAT1)
AML100479698(ADAT1)
UMR103662068(ADAT1)
UAH113252505(ADAT1)
UAR123791320(ADAT1)
ELK111152827
LLV125089845
MPUF101685979(ADAT1)
ORO101368871(ADAT1)
EJU114200928(ADAT1)
ZCA113935323(ADAT1)
MLX118023555(ADAT1)
FCA101092319(ADAT1)
PYU121009808(ADAT1)
PBG122494480(ADAT1)
PTG102955523(ADAT1)
PPAD109245684(ADAT1)
AJU106983436(ADAT1)
HHV120248185(ADAT1)
BTA618521(ADAT1)
BOM102264752(ADAT1)
BIU109572141(ADAT1)
BBUB102396811(ADAT1)
CHX102176155(ADAT1)
OAS101118042(ADAT1)
ODA120872840(ADAT1)
CCAD122421058(ADAT1)
SSC100521793(ADAT1)
CFR102523223(ADAT1)
CBAI105078717(ADAT1)
CDK105084368(ADAT1)
VPC102535506(ADAT1)
BACU102997798(ADAT1)
LVE103075475(ADAT1)
OOR101288323(ADAT1)
DLE111179499(ADAT1)
PCAD102992688(ADAT1)
PSIU116744240(ADAT1)
ECB100069032(ADAT1)
EPZ103553030(ADAT1)
EAI106835140(ADAT1)
MYB102245792(ADAT1)
MYD102773961(ADAT1)
MMYO118674038(ADAT1)
MLF102428569(ADAT1)
MNA107524732(ADAT1)
PKL118720779(ADAT1)
HAI109384786(ADAT1)
DRO112300653(ADAT1)
SHON118999206(ADAT1)
AJM119048916(ADAT1)
PDIC114488432(ADAT1)
PHAS123806201(ADAT1)
MMF118638526(ADAT1)
RFQ117034496(ADAT1)
PALE102895391(ADAT1)
PGIG120617347(ADAT1)
PVP105305362(ADAT1)
RAY107502661(ADAT1)
MJV108385747(ADAT1)
TOD119249091(ADAT1)
SARA101557573(ADAT1)
LAV100673891(ADAT1)
TMU101348133
DNM101412735(ADAT1)
MDO100021062(ADAT1)
GAS123234574(ADAT1)
SHR100931012(ADAT1)
PCW110192403(ADAT1)
OAA100077425(ADAT1)
GGA415886(ADAT1)
PCOC116243968(ADAT1)
MGP100551118
CJO107319473(ADAT1)
NMEL110404458(ADAT1)
APLA101805235(ADAT1)
ACYG106046625(ADAT1)
AFUL116493846(ADAT1)
TGU100218982(ADAT1)
LSR110468744(ADAT1)
SCAN103816784(ADAT1)
PMOA120496188(ADAT1)
OTC121333848(ADAT1)
PRUF121362577(ADAT1)
GFR102032012(ADAT1)
FAB101814233(ADAT1)
PHI102107809(ADAT1)
PMAJ107209777(ADAT1)
CCAE111934369(ADAT1)
CCW104691867(ADAT1)
CBRC103620544(ADAT1)
ETL114067457(ADAT1)
ZAB102067565(ADAT1)
FPG101910523(ADAT1)
FCH102058985(ADAT1)
CLV102084029(ADAT1)
EGZ104126302(ADAT1)
NNI104023547(ADAT1)
PLET104621565(ADAT1)
PCRI104030621(ADAT1)
ACUN113484610(ADAT1)
TALA104357380(ADAT1)
PADL103916510(ADAT1)
ACHC115345881(ADAT1)
HALD104310861(ADAT1)
CCRI104154485(ADAT1)
CSTI104549177(ADAT1)
EHS104503117(ADAT1)
FGA104073224(ADAT1)
GSTE104250233(ADAT1)
LDI104352867(ADAT1)
MNB103782006(ADAT1)
AAM106498820(ADAT1)
AROW112973328(ADAT1)
NPD112947473(ADAT1)
DNE112985558(ADAT1)
ASN102368236(ADAT1)
AMJ102571449(ADAT1)
CPOO109310765(ADAT1)
GGN109289332(ADAT1)
PSS102448082(ADAT1)
CMY102946863(ADAT1)
CPIC101939226(ADAT1)
TST117886415(ADAT1)
CABI116834356(ADAT1)
MRV120384684(ADAT1)
ACS100561591(adat1)
PVT110076236(ADAT1)
SUND121914759(ADAT1)
PBI103061718
PMUR107283504(ADAT1)
TSR106539676(ADAT1)
PGUT117671086(ADAT1)
VKO123022212(ADAT1)
PMUA114602044(ADAT1)
ZVI118086240(ADAT1)
GJA107124717(ADAT1)
STOW125443732(ADAT1)
XLA108715443(adat1.S)
XTR733776(adat1)
NPR108786552(ADAT1)
RTEM120917944(ADAT1)
BBUF120980792(ADAT1)
BGAR122920899(ADAT1)
DRE792614(adat1)
SRX107740251(adat1)
SANH107695929(adat1)
SGH107555735
CCAR109050808(adat1)
CAUA113067171(adat1)
PPRM120468184(adat1)
MAMB125247542(adat1)
IPU108268589(adat1)
PHYP113541905(adat1)
SMEO124386621(adat1)
TFD113651926(adat1)
AMEX103040099(adat1)
EEE113568338(adat1)
TRU101074345(adat1)
TNGGSTEN00016826G001
LCO104933814(adat1)
NCC104942841(adat1)
CGOB115010229(adat1)
ELY117261891(adat1)
EFO125887812(adat1)
PLEP121949749(adat1)
SLUC116040254(adat1)
ECRA117948969(adat1)
PFLV114560498(adat1)
GAT120809148(adat1)
PPUG119196599(adat1)
MSAM119894272(adat1)
CUD121514665(adat1)
ALAT119024927(adat1)
MZE101472193
ONL100705296(adat1)
OAU116322397(adat1)
OLA101174830(adat1)
OML112152535(adat1)
XMA102227749(adat1)
XCO114150263(adat1)
XHE116728959(adat1)
PRET103466300(adat1)
PFOR103142432(adat1)
PLAI106946774(adat1)
PMEI106933750(adat1)
GAF122835642(adat1)
CVG107099695(adat1)
CTUL119784700(adat1)
GMU124879768(adat1)
NFU107389276(adat1)
KMR108246578(adat1)
ALIM106536367(adat1)
NWH119415988(adat1)
AOCE111568878(adat1)
MCEP125015095(adat1)
CSEM103379688(adat1)
POV109646081(adat1)
SSEN122762330
HHIP117763843(adat1)
HSP118109231(adat1)
LCF108901943(adat1)
SDU111238843(adat1)
SLAL111647716(adat1)
XGL120792942(adat1)
HCQ109513086(adat1)
BPEC110169227(adat1)
MALB109952540(adat1)
BSPL114856890(adat1)
SASA106560904(adat1)
OTW112218467(adat1)
OMY110494236(adat1)
OGO124007924(adat1)
ONE115134356(adat1)
SALP111962303(adat1)
SNH120066200(adat1)
CCLU121531804
ELS105018553(adat1)
SFM108926551(adat1)
PKI111851951
AANG118215688(adat1)
LOC102682946(adat1)
PSPA121296163
ARUT117424312(adat1)
LCM102361760
CMK103175977(adat1)
RTP109919412 109921629(adat1)
BFO118418175
BBEL109473452
CIN100182358
SCLV120347765
SPU105437003 105439891
APLC110984767
SKO102806186
DMEDmel_CG16889(Adat1)
DER6540900
DSIDsimw501_GD22044(Dsim_GD22044)
DYADyak_GE11448
DSR110185656
DPO4816505
DPE6598039
DMN108163774
DWI6653056
DGR6562713
DMODmoj_GI19739
DAZ108611532
DNV108658176
DHE111594671
CCAT101451389
BOD106623676
MDE101900436
SCAC106082931
LCQ111682562
LSQ119604190
HIS119648232
AGAAgaP_AGAP009185 AgaP_AGAP009186
ACOZ120956868
AARA120903355
ASTE118512547
AALB109622813
CQUCpipJ_CPIJ008837
CPII120424364
CNS116338371
BCOO119076977
AME551302
ACER107995223
ALAB122720335
BIM100748498
BBIF117208681
BVK117232351
BVAN117162268
BTER100642445
BPYO122566794
CCAL108624178
OBB114878209
MGEN117220562
NMEA116431243
CGIG122400148
SOC105194728
MPHA105837029
AEC105152138
ACEP105625133
PBAR105425530
VEM105569316
HST105185510
DQU106746248
CFO105256150
FEX115245454
LHU105678875
PGC109863573
OBO105281171
PCF106788639
PFUC122517593
VPS122629036
NVI100121124
CSOL105363747
TPRE106657704
MDL103576482
CGLO123274729
FAS105266963
DAM107042934
AGIF122855244
CCIN107265284
TCA655593
DPA109534526
SOY115886469
ATD109596597
CSET123309260
AGB108908296
LDC111511826
NVL108559961
APLN108734293
PPYR116180970
OTU111421472 111423040
BMOR101739192
BMAN114239742
MSEX115456428
DPLKGM_202066
BANY112054841
PMAC106720662
PPOT106103523
PXU106115593
PRAP110996958
ZCE119838328
HAW110384029
TNL113500585 113500700
SLIU111355534
OFU114364034
PXY105383339 105391525
API100568554
DNX107166552
AGS114120922
RMD113552320
BTAB109038158
DCI103511082
CLEC106661828
HHAL106680071
NLU120348705
PHUPhum_PHUM258700
FOC113209955
TPAL117645980
ZNE110836219 110837336 110839095
CSEC111862138
FCD110842127
DPXDAPPUDRAFT_52553
DMK116918253
PVM113828469 113828577
PJA122266237
PCHN125041689
HAME121863225
PCLA123760075
PTRU123519895
HAZT108667506
EAF111700019
LSM121113789
PPOI119105640 119105642
DSV119435950
RSAN119404310
RMP119187909
VDE111253459
VJA111261883
TUT107361104
DPTE113793346
DFR124492522
CSCU111631165
SDM118199261
TSPTsp_11655
HROHELRODRAFT_161513
LGILOTGIDRAFT_231337
PCAN112577152
BGT106079483
GAE121387976
HRF124140896
HRJ124259152
CRG105331927
MYI110464775
PMAX117337917
MMER123549474
OBI106874675
OSN115215829
LAK106171292 106173818
NVE5518005
EPA110233417
ATEN116286732
ADF107335875
AMIL114955446
PDAM113678039
SPIS111332877
DGT114516505
XEN124437030
HMG100215148
TADTRIADDRAFT_55696
AQU100631880
ATHAT1G01760
ALY9328107
CRB17897246
CSAT104738618 104754329 104758648
EUSEUTSA_v10007725mg
BRP103844675
BNA106358383 106370847
BOE106344189
RSZ108807102
THJ104817020
CPAP110819598
CIT102615864
CICCICLE_v10020429mg
PVY116118217
MINC123215510
TCC18614170
GRA105763844
GHI107929294 107945659
GAB108463002
DZI111304710
EGR104443458 104443461
GMX100789591 100799177
GSJ114405772 114418462
PVUPHAVU_010G096200g
VRA106773759
VAR108347039
VUN114166262
CCAJ109813400
APRC113850248
MTRMTR_8g031440
CAM101515616
LJALj0g3v0318859.2(Lj0g3v0318859.2) Lj0g3v0318859.3(Lj0g3v0318859.3)
ADU107460113
AIP107621135
AHF112705522 112726231
LANG109359083 109363340
FVE101298753
RCN112168121
PPER18787066
PMUM103331894 103343023 103343026
PAVI110759275 110759277
PDUL117617894
MDM103456191
PXB103938654
ZJU107423564
MNT21400314
CSV101204115
CMO103497724
BHJ120078727
MCHA111023070
CMAX111499268
CMOS111460170
CPEP111806493
RCU8261853
JCU105643009
HBR110644553
MESC110618772
POP7464922
PEU105133585
PALZ118041677
JRE108986625
QSU111983562 111989677 111997244 112020666
QLO115956004
TWL120003772
VVI100253329
SLY101259338
SPEN107018821
SOT102587689
SSTN125868378
CANN107870939
NTA107787458 107817174
NSY104225729
NTO104098388
NAU109235195
INI109184458
ITR116015410
SIND105174353
OEU111410324 111410326
EGT105963787
SSPL121750537
HAN110937666
ECAD122593748
LSV111912894
CCAV112526658
DCR108219457
CSIN114296693
CQI110685310 110685344 110696353 110714656
NNU104608721
MING122082627
TSS122648943
PSOM113274942 113304490
NCOL116266246
OSA4337445
DOSAOs04t0683500-01(Os04g0683500)
OBR102700891
BDI100833349
ATS109757904
TDC119357211 119357212 119366496 119366500
TAES123047505 123047506 123050716 123191127
TUA125534567
SBI8070264
ZMA100193265
SITA101783323
SVS117850894
PVIR120658362
PHAI112880170
PDA103719412
EGU105054832
MUS103980686
DCT110099821
PEQ110033256
AOF109848180
ATR18423650 18423653
SMOSELMODRAFT_424531 SELMODRAFT_425916
PPP112280993
CSLCOCSUDRAFT_65938
APROF751_6838
OLUOSTLU_25207
OTAOT_ostta11g00610
MISMICPUN_62956
MPPMICPUCDRAFT_50213 MICPUCDRAFT_51056
SCEYGL243W(TAD1)
SEUBDI49_1739
SPAOSPAR_G00190
AGOAGOS_AFR267W
ERCEcym_2596
KLAKLLA0_A00759g
KMXKLMA_30705(TAD1)
LTHKLTH0G00748g
VPOKpol_380p7
ZROZYRO0E09504g
CGRCAGL0H07733g
NCSNCAS_0E00270(NCAS0E00270)
NDINDAI_0I03230(NDAI0I03230)
TPFTPHA_0G03640(TPHA0G03640)
TBLTBLA_0E00230(TBLA0E00230)
TDLTDEL_0D06340(TDEL0D06340)
TGBHG536_0D05960
KAFKAFR_0J02870(KAFR0J02870)
KNGKNAG_0I00240(KNAG0I00240)
ZMKHG535_0G04990
PPAPAS_chr2-1_0170
DHADEHA2F13574g
PICPICST_50851
PGUPGUG_00949
SPAASPAPADRAFT_63824
LELLELG_05434
CALCAALFM_C700130WA(CaO19.7110)
CTPCTRG_04943
COTCORT_0H00210
CDUCD36_70340
CTENCANTEDRAFT_130230
YLIYALI0B18436g
CLUCLUG_01062
CLUSA9F13_09g01111
CAURCJI97_000916
SLBAWJ20_3609(TAD1)
BNNFOA43_003252
BBRXBRETT_004093
SLUDSCDLUD_002265
NCRNCU03149
NTENEUTE1DRAFT126133(NEUTE1DRAFT_126133)
SMPSMAC_02878
PANPODANSg3913
TTTTHITE_2112167
MTMMYCTH_2297544
MGRMGG_02712
PPEIPpBr36_09717
SSCKSPSK_03312
FGRFGSG_13320
FPUFPSE_11699
FVRFVEG_01988
FOXFOXG_03125
NHENECHADRAFT_36604
TRETRIREDRAFT_55213
TRRM419DRAFT_39098
MAWMAC_00878
MAJMAA_07368
CMTCCM_03277
PLJVFPFJ_00364
VALVDBG_02061
VDAVDAG_02517
CFJCFIO01_10868
CHIGCH63R_09892
SAPOSAPIO_CDS7443
ELAUCREL1_9914
PFYPFICI_02793
SSLSS1G_05425
BFUBCIN_09g03980
MBEMBM_05193
PSCOLY89DRAFT_728138
GLZGLAREA_02365
ANIAN4093.2
AFMAFUA_1G05710
ACTACLA_028890
NFINFIA_019030
ANGANI_1_1274164(An18g03470)
AFVAFLA_010993
ALUCAKAW2_31245A
ACHEACHE_10918A
APUUAPUU_40245A
PCSPc18g02020
PDPPDIP_73730
CIMCIMG_03895
CPWCPC735_004490
UREUREG_02078
PBLPAAG_01794
PBNPADG_00479
ABEARB_05647
TVETRV_01215
BGHBDBG_05013
PNOSNOG_11711
PTEPTT_10741
BZECOCCADRAFT_100025
BSCCOCSADRAFT_98683
BORCOCMIDRAFT_109194
AALTCC77DRAFT_1017837
ZTRMYCGRDRAFT_71372
PFJMYCFIDRAFT_29254
FFUCLAFUR5_01089 CLAFUR5_07716
BCOMBAUCODRAFT_51391
TMLGSTUM_00003411001
SPOSPBC16A3.06
CNECNG03760
CNBCNBG0980
CNGCNAG_03192
CGICGB_G1300W
TMSTREMEDRAFT_25467
TASAA1Q1_05947
PPLPOSPLDRAFT_92092
TVSTRAVEDRAFT_57068
DSQDICSQDRAFT_56976
PCOPHACADRAFT_191808
SHSSTEHIDRAFT_167501
HIRHETIRDRAFT_313542
PSQPUNSTDRAFT_132408
ADLAURDEDRAFT_53149
FMEFOMMEDRAFT_141947
GTRGLOTRDRAFT_35238
LBCLACBIDRAFT_312023
MRRMoror_1616
MOREE1B28_006052
SCMSCHCO_02540792(SCHCODRAFT_02540792)
ABPAGABI1DRAFT73247(AGABI1DRAFT_73247)
ABVAGABI2DRAFT202903(AGABI2DRAFT_202903)
CPUTCONPUDRAFT_54574
SLASERLADRAFT_434997
WSEWALSEDRAFT_56780
WICJ056_002456
UMAUMAG_05895
PFPPFL1_02655
MGLMGL_0207
MRTMRET_1108
MLRMELLADRAFT_89234
SREPTSG_01811
DDIDDB_G0278943
DFADFA_02228
EIVEIN_275230
ACANACA1_108840
TETTTHERM_00389830
PTMGSPATT00008511001
FCYFRACYDRAFT_232848
AAFAURANDRAFT_68845
PIFPITG_04666 PITG_20401
PSOJPHYSODRAFT_532829
SPARSPRG_19825
EHXEMIHUDRAFT_114062
GTTGUITHDRAFT_165055 GUITHDRAFT_72300
NGRNAEGRDRAFT_78282
TVATVAG_069930
 » show all
Reference
1  [PMID:10430867]
  Authors
Maas S, Gerber AP, Rich A
  Title
Identification and characterization of a human tRNA-specific adenosine deaminase  related to the ADAR family of pre-mRNA editing enzymes.
  Journal
Proc Natl Acad Sci U S A 96:8895-900 (1999)
DOI:10.1073/pnas.96.16.8895
  Sequence
[hsa:23536]
Reference
2  [PMID:9707437]
  Authors
Gerber A, Grosjean H, Melcher T, Keller W
  Title
Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2.
  Journal
EMBO J 17:4780-9 (1998)
DOI:10.1093/emboj/17.16.4780
  Sequence
[sce:YGL243W]
Reference
3  [PMID:10629039]
  Authors
Keegan LP, Gerber AP, Brindle J, Leemans R, Gallo A, Keller W, O'Connell MA
  Title
The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.
  Journal
Mol Cell Biol 20:825-33 (2000)
DOI:10.1128/MCB.20.3.825-833.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.34
IUBMB Enzyme Nomenclature: 3.5.4.34
ExPASy - ENZYME nomenclature database: 3.5.4.34
BRENDA, the Enzyme Database: 3.5.4.34
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