KEGG   ENZYME: 3.6.1.39
Entry
EC 3.6.1.39                 Enzyme                                 
Name
thymidine-triphosphatase;
thymidine triphosphate nucleotidohydrolase;
dTTPase;
deoxythymidine-5'-triphosphatase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
dTTP nucleotidohydrolase
Reaction(IUBMB)
dTTP + H2O = dTDP + phosphate [RN:R02095]
Reaction(KEGG)
R02095;
(other) R00159 R02330
Substrate
dTTP [CPD:C00459];
H2O [CPD:C00001]
Product
dTDP [CPD:C00363];
phosphate [CPD:C00009]
Comment
Also acts, more slowly, on dUTP and UTP.
History
EC 3.6.1.39 created 1984
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:6297538]
  Authors
Dahlmann N.
  Title
Human serum thymidine triphosphate nucleotidohydrolase: purification and properties of a new enzyme.
  Journal
Biochemistry 21:6634-9 (1982)
DOI:10.1021/bi00269a004
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.39
IUBMB Enzyme Nomenclature: 3.6.1.39
ExPASy - ENZYME nomenclature database: 3.6.1.39
BRENDA, the Enzyme Database: 3.6.1.39
CAS: 37367-74-1
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