Entry
Name
inosine/xanthosine triphosphatase;
yjjX (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
inosine/xanthosine 5'-triphosphate phosphohydrolase
Reaction(IUBMB)
(1) inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate [RN:
R00719 ];
(2) xanthosine 5'-triphosphate + H2O = xanthosine 5'-diphosphate + phosphate [RN:
R12589 ]
Reaction(KEGG)
Substrate
inosine 5'-triphosphate [CPD:
C00081 ];
H2O [CPD:
C00001 ];
xanthosine 5'-triphosphate [CPD:
C00700 ]
Product
inosine 5'-diphosphate [CPD:
C00104 ];
phosphate [CPD:
C00009 ];
xanthosine 5'-diphosphate [CPD:
C01337 ]
Comment
The enzyme, characterized from the bacterium Escherichia coli, preferentially hydrolyses inosine triphosphate and xanthosine triphosphate, which are formed by oxidative deamination damage. By hydrolysing these damaged nucleotides, the enzyme prevents their incorporation into RNA.
History
EC 3.6.1.73 created 2020
Pathway
Orthology
K01529 inosine/xanthosine triphosphatase
Genes
ECOO : ECRM13514_5694(yjjX)
ECOH : ECRM13516_5434(yjjX)
EDJ : ECDH1ME8569_4251(yjjX)
ECOI : ECOPMV1_04856(yjjX)
SETC : CFSAN001921_17505(yjjX)
SEEN : SE451236_05940(yjjX)
SENH : CFSAN002069_09280(yjjX)
SEEC : CFSAN002050_06405(yjjX)
SEEB : SEEB0189_019460(yjjX)
SENC : SEET0819_06830(yjjX)
RTG : NCTC13098_06337(yjjX)
REE : electrica_04329(yjjX)
CLAP : NCTC11466_03919(yjjX)
KIE : NCTC12125_03062(yjjX)
AHN : NCTC12129_04287(yjjX)
PDZ : HHA33_21630 HHA33_24375(yjjX)
SMW : SMWW4_v1c06690(yjjX)
SERA : Ser39006_005770(yjjX)
SFJ : SAMEA4384070_0705(yjjX)
SOF : NCTC11214_00857(yjjX)
PAQU : DMB82_0017555(yjjX)
PPAV : LOZ86_02520 LOZ86_18555(yjjX)
DIC : Dpoa569_000524(yjjX) Dpoa569_001192
LPOP : I6N93_02045(yjjX) I6N93_13645
EPE : CI789_05350 CI789_15245
TPTY : NCTC11468_03163(yjjX)
PHEI : NCTC12003_00657(yjjX)
PRJ : NCTC6933_00715(yjjX)
EDL : AAZ33_02560(yjjX) AAZ33_18725
LRI : NCTC12151_02692(yjjX)
VOS : KNV97_06295(yjjX) KNV97_21710(yjjX)
CTHU : HUR95_08950 HUR95_10385
PFAE : AJGP001_06470(yjjX)
TVO : TVG0394586(TVG0394586)
ABRI : DFR85_01350 DFR85_11050
AAMB : D1866_05240 D1866_06640
ACIH : HS5_12100 HS5_27270
CSTY : KN1_05430 KN1_25490
» show all
Taxonomy
Reference
Authors
Zheng J, Singh VK, Jia Z
Title
Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.73
ExPASy - ENZYME nomenclature database: 3.6.1.73
LinkDB
All DBs