KEGG ENZYME: 3.8.1.6

ENZYME: 3.8.1.6

Entry

EC 3.8.1.6                  Enzyme

Name

4-chlorobenzoate dehalogenase;
halobenzoate dehalogenase

Class

Hydrolases;
Acting on halide bonds;
In carbon-halide compounds

Sysname

4-chlorobenzoate chlorohydrolase

Reaction(IUBMB)

4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride [RN:R01307]

Reaction(KEGG)

R01307

Substrate

4-chlorobenzoate [CPD:C02370];
H2O [CPD:C00001]

Product

4-hydroxybenzoate [CPD:C00156];
chloride [CPD:C00698]

Comment

Catalyses the first step in the degradation of chlorobenzoate in Pseudomonas. In many microorganisms, this activity comprises three separate enzymes, EC 6.2.1.33 (4-chlorobenzoate---CoA ligase), EC 3.8.1.7 (4-chlorobenzoyl-CoA dehalogenase) and EC 3.1.2.23 (4-hydroxybenzoyl-CoA thioesterase).

History

EC 3.8.1.6 created 1989, modified 1999

Reference

1 [PMID:6497878]

Authors

Muller R, Thiele J, Klages U, Lingens F.

Title

Incorporation of [18O]water into 4-hydroxybenzoic acid in the reaction of 4-chlorobenzoate dehalogenase from pseudomonas spec. CBS 3.

Journal

Biochem Biophys Res Commun 124:178-82 (1984)
DOI:10.1016/0006-291X(84)90933-1

Reference

2 [PMID:18889931]

Authors

HEPPEL LA, PORTERFIELD VT

Title

Enzymatic dehalogenation of certain brominated and chlorinated compounds.

Journal

J Biol Chem 176:763-9 (1948)

Other DBs

ExplorEnz - The Enzyme Database:

3.8.1.6

IUBMB Enzyme Nomenclature:

3.8.1.6

ExPASy - ENZYME nomenclature database:

3.8.1.6

BRENDA, the Enzyme Database:

3.8.1.6

CAS:	94047-11-7

LinkDB

DBGET integrated database retrieval system