KEGG   ENZYME: 4.1.1.103
Entry
EC 4.1.1.103                Enzyme                                 
Name
gamma-resorcylate decarboxylase;
graF (gene name);
tsdA (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2,6-dihydroxybenzoate carboxy-lyase
Reaction(IUBMB)
2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 [RN:R11353]
Reaction(KEGG)
R11353
Substrate
2,6-dihydroxybenzoate [CPD:C21298]
Product
1,3-dihydroxybenzene [CPD:C01751];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.
History
EC 4.1.1.103 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20941  gamma-resorcylate decarboxylase
Genes
KPN: KPN_04278
KPU: KP1_0140
KPM: KPHS_01250
KPP: A79E_4910
KPZ: KPNIH27_00690
KPV: KPNIH29_00645
KPY: KPNIH31_00680
KPG: KPNIH32_00680
KPT: VK055_3197
KPO: KPN2242_24405
KPR: KPR_0232
KPJ: N559_5007
KPI: D364_21795
KPA: KPNJ1_05316
KPX: PMK1_01765
KPB: FH42_17750
KPNK: BN49_4581
KVA: Kvar_4950
KPE: KPK_5401
KPK: A593_11495 A593_25530
KVD: KR75_08920 KR75_23450
KVQ: SP68_15515
KQV: B8P98_26905
EAE: EAE_07765
EAR: CCG32448
KLW: DA718_28460
KAR: LGL98_24275
KGR: JJJ10_26780
KLM: BWI76_01050
KLP: GUC22_26170
EBT: EBL_c04090 EBL_c36970
YRE: HEC60_06115
SNEV: OI978_03945
OOI: A6A10_07195
PAET: NCTC13378_01191
PFN: HZ99_26470
PBRE: QDY63_09725
AGU: AS4_34920
MSPN: M8T91_07590 M8T91_17875
NZL: D0T92_00825
CHRO: CXB49_05340
CNC: CNE_BB1p12860
BTE: BTH_II2163
BTQ: BTQ_5450
BTJ: BTJ_4106
BTZ: BTL_4919
BTV: BTHA_5304
BTHE: BTN_4575
BTHM: BTRA_4840
BTHA: DR62_4685
BTHL: BG87_4907
BUR: Bcep18194_B0258 Bcep18194_B3061
BSEM: WJ12_23745
BSER: R0290_29555
BUG: BC1001_0585
BGF: BC1003_5621
BGD: bgla_2g12820 bgla_2g18650
BGO: BM43_4095 BM43_4940 BM43_5584
BPX: BUPH_04475 BUPH_06045
BUZ: AYM40_28680
PCAF: DSC91_006830
PMEG: FNZ07_08830 FNZ07_23620
PEW: KZJ38_16725 KZJ38_23645
PBRY: NDK50_34235
PPAI: E1956_34520 E1956_44095 E1956_45025
PLAD: PPGU16_72420
PAZZ: PBP221_74870
PPK: U875_17320
PPNO: DA70_09465
PPNM: LV28_21345
PRB: X636_17095
TVL: FAZ95_22880 FAZ95_26345
PUD: G9Q38_01855(tsdA)
POL: Bpro_2061
ASAH: AVXHC19_42870(tsdA)
AAA: Acav_4140
VAP: Vapar_5311
VPE: Varpa_5099
VAZ: H7F35_06810
ESJ: SJ05684_b42850
ATU: Atu2529
AGR: AGROH133_08584
ATF: Ach5_23980
ASAL: CFBP5507_11360(tsdA)
ACUC: KZ699_11065(tsdA)
ALEG: CFBP4996_11010(tsdA) CFBP4996_29015
AGRC: GSF67_12230(tsdA)
REP: IE4803_PC00118
REI: IE4771_PD00118
RLE: pRL120216
RLT: Rleg2_5726
RLB: RLEG3_09695
RLU: RLEG12_02380
RHK: Kim5_PC00121
RAD: CO657_29290
ROY: G3A56_13315(tsdA)
RII: FFM53_025675(tsdA)
RHID: FFM81_029540(tsdA)
RBQ: J2J99_28410(tsdA)
RRG: J3P73_26395(tsdA)
RAW: NE851_32200(tsdA)
RLW: RlegWSM1455_24575(tsdA)
RCT: PYR68_15385(tsdA)
ARA: Arad_7160
ARO: B0909_00295
RBW: RLCC275e_24325(tsdA)
RHIZ: QMO80_005033(tsdA)
BJU: BJ6T_69740
BIC: LMTR13_14520
BRK: CWS35_17235
BARH: WN72_15315
BSEP: HAP48_0029910
BRAZ: LRP30_11865
PTAW: DW352_10795 DW352_13360 DW352_13375 DW352_18565 DW352_22045
MSL: Msil_3500
RHZ: RHPLAN_03690
MHEY: H2LOC_012560
MIWA: SS37A_30860
PSIN: CAK95_00325 CAK95_04800
BND: KWG56_11005
SULD: B5M07_18650
SPPH: KFK14_16355
MRM: A7982_04688
BSS: BSUW23_03505
BIT: BIS30_14060
BHT: DIC78_06360
BMOJ: HC660_07340
BTEQ: G4P54_03755
BCAB: EFK13_03990
CRW: CROST_012800
CFB: CLFE_027800 CLFE_035600
CAUN: CLAUR_002400 CLAUR_016060
ETM: CE91St48_26700
EGD: GS424_016950
MSEN: K3U95_01950
MMV: MYCMA_05870
MABB: MASS_3600
MABL: MMASJCM_3590
MIZ: BAB75_20445
NTP: CRH09_29575
NAH: F5544_30755
RHA: RHA1_ro01859
ROA: Pd630_LPD04622
RHOJ: JVH1_27995(tsdA)
RHJS: OYT95_01790 OYT95_29415(tsdA)
PDEF: P9209_13405
TPR: Tpau_1503
SOV: QZH56_00915 QZH56_35755
STRI: C7M71_027605
BEI: GCM100_26200
BCAU: I6G59_14590
SGRG: L0C25_05405
ARHD: VSH64_00880 VSH64_20525
ACAB: QRX50_25145 QRX50_45305
AMYD: K1T34_00285 K1T34_29760
KUT: JJ691_13280
SACE: GIY23_22490
GLJ: GKIL_0975
 » show all
Reference
1  [PMID:15466039]
  Authors
Yoshida M, Fukuhara N, Oikawa T
  Title
Thermophilic, reversible gamma-resorcylate decarboxylase from Rhizobium sp. strain MTP-10005: purification, molecular characterization, and expression.
  Journal
J Bacteriol 186:6855-63 (2004)
DOI:10.1128/JB.186.20.6855-6863.2004
  Sequence
[ag:BAD54753]
Reference
2  [PMID:15474471]
  Authors
Ishii Y, Narimatsu Y, Iwasaki Y, Arai N, Kino K, Kirimura K
  Title
Reversible and nonoxidative gamma-resorcylic acid decarboxylase: characterization and gene cloning of a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene, from Rhizobium radiobacter.
  Journal
Biochem Biophys Res Commun 324:611-20 (2004)
DOI:10.1016/j.bbrc.2004.09.091
Reference
3  [PMID:16683134]
  Authors
Matsui T, Yoshida T, Yoshimura T, Nagasawa T
  Title
Regioselective carboxylation of 1,3-dihydroxybenzene by 2,6-dihydroxybenzoate decarboxylase of Pandoraea sp. 12B-2.
  Journal
Appl Microbiol Biotechnol 73:95-102 (2006)
DOI:10.1007/s00253-006-0437-z
Reference
4  [PMID:16963440]
  Authors
Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T
  Title
Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.
  Journal
J Biol Chem 281:34365-73 (2006)
DOI:10.1074/jbc.M607270200
Reference
5  [PMID:26319878]
  Authors
Kasai D, Araki N, Motoi K, Yoshikawa S, Iino T, Imai S, Masai E, Fukuda M
  Title
gamma-Resorcylate catabolic-pathway genes in the soil actinomycete Rhodococcus jostii RHA1.
  Journal
Appl Environ Microbiol 81:7656-65 (2015)
DOI:10.1128/AEM.02422-15
  Sequence
[rha:RHA1_ro01859]
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.103
IUBMB Enzyme Nomenclature: 4.1.1.103
ExPASy - ENZYME nomenclature database: 4.1.1.103
BRENDA, the Enzyme Database: 4.1.1.103
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