KEGG   ENZYME: 4.1.1.103
Entry
EC 4.1.1.103                Enzyme                                 
Name
gamma-resorcylate decarboxylase;
graF (gene name);
tsdA (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2,6-dihydroxybenzoate carboxy-lyase
Reaction(IUBMB)
2,6-dihydroxybenzoate = 1,3-dihydroxybenzene + CO2 [RN:R11353]
Reaction(KEGG)
R11353
Substrate
2,6-dihydroxybenzoate [CPD:C21298]
Product
1,3-dihydroxybenzene [CPD:C01751];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from several bacterial strains, is involved in the degradation of gamma-resorcylate. It contains a zinc ion and a water molecule at the active site. The reaction is reversible, but equilibrium greatly favors the decarboxylation reaction.
History
EC 4.1.1.103 created 2016
Pathway
ec00362  Benzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K20941  gamma-resorcylate decarboxylase
Genes
KPNKPN_04278
KPUKP1_0140
KPMKPHS_01250
KPPA79E_4910
KPZKPNIH27_00690
KPVKPNIH29_00645
KPYKPNIH31_00680
KPGKPNIH32_00680
KPTVK055_3197
KPOKPN2242_24405
KPRKPR_0232
KPJN559_5007
KPID364_21795
KPAKPNJ1_05316
KPXPMK1_01765
KPBFH42_17750
KPNKBN49_4581
KVAKvar_4950
KPEKPK_5401
KPKA593_11495 A593_25530
KVDKR75_08920 KR75_23450
KVQSP68_15515
EAEEAE_07765
EARCCG32448
KQVB8P98_26905
KLWDA718_28460
KARLGL98_24275
KGRJJJ10_26780
EBTEBL_c04090 EBL_c36970
YREHEC60_06115
OOIA6A10_07195
PAETNCTC13378_01191
PFNHZ99_26470
AGUAS4_34920
NZLD0T92_00825
CHROCXB49_05340
CNCCNE_BB1p12860
BTEBTH_II2163
BTQBTQ_5450
BTJBTJ_4106
BTZBTL_4919
BTVBTHA_5304
BTHEBTN_4575
BTHMBTRA_4840
BTHADR62_4685
BTHLBG87_4907
BURBcep18194_B0258 Bcep18194_B3061
BSEMWJ12_23745
BUGBC1001_0585
BGFBC1003_5621
BGDbgla_2g12820 bgla_2g18650
BGOBM43_4095 BM43_4940 BM43_5584
BPXBUPH_04475 BUPH_06045
BUZAYM40_28680
PCAFDSC91_006830
PMEGFNZ07_08830 FNZ07_23620
PEWKZJ38_16725 KZJ38_23645
PPKU875_17320
PPNODA70_09465
PPNMLV28_21345
PRBX636_17095
PUDG9Q38_01855(tsdA)
POLBpro_2061
AAAAcav_4140
VAPVapar_5311
VPEVarpa_5099
MRMA7982_04688
ESJSJ05684_b42850
ATUAtu2529
ARAArad_7160
AGRAGROH133_08584
ATFAch5_23980
AROB0909_00295
REPIE4803_PC00118
REIIE4771_PD00118
RLEpRL120216
RLTRleg2_5726
RLBRLEG3_09695
RLURLEG12_02380
RHKKim5_PC00121
RADCO657_29290
ROYG3A56_13315(tsdA)
RIIFFM53_025675(tsdA)
RHIDFFM81_029540(tsdA)
RBQJ2J99_28410(tsdA)
RRGJ3P73_26395(tsdA)
BJUBJ6T_69740
BICLMTR13_14520
BRKCWS35_17235
BARHWN72_15315
BSEPHAP48_0029910
MSLMsil_3500
RHZRHPLAN_03690
MHEYH2LOC_012560
PSINCAK95_00325 CAK95_04800
BNDKWG56_11005
SULDB5M07_18650
SPPHKFK14_16355
BSSBSUW23_03505
BHTDIC78_06360
BMOJHC660_07340
BTEQG4P54_03755
BITBIS30_14060
ETMCE91St48_26700
MSENK3U95_01950
MMVMYCMA_05870
MABBMASS_3600
MABLMMASJCM_3590
MIZBAB75_20445
NTPCRH09_29575
NAHF5544_30755
RHARHA1_ro01859
ROAPd630_LPD04622
TPRTpau_1503
STRIC7M71_027605
BCAUI6G59_14590
SACEGIY23_22490
EGDGS424_016950
GLJGKIL_0975
OLEK0B96_14710
 » show all
Reference
1  [PMID:15466039]
  Authors
Yoshida M, Fukuhara N, Oikawa T
  Title
Thermophilic, reversible gamma-resorcylate decarboxylase from Rhizobium sp. strain MTP-10005: purification, molecular characterization, and expression.
  Journal
J Bacteriol 186:6855-63 (2004)
DOI:10.1128/JB.186.20.6855-6863.2004
  Sequence
Reference
2  [PMID:15474471]
  Authors
Ishii Y, Narimatsu Y, Iwasaki Y, Arai N, Kino K, Kirimura K
  Title
Reversible and nonoxidative gamma-resorcylic acid decarboxylase: characterization and gene cloning of a novel enzyme catalyzing carboxylation of resorcinol, 1,3-dihydroxybenzene, from Rhizobium radiobacter.
  Journal
Biochem Biophys Res Commun 324:611-20 (2004)
DOI:10.1016/j.bbrc.2004.09.091
Reference
3  [PMID:16683134]
  Authors
Matsui T, Yoshida T, Yoshimura T, Nagasawa T
  Title
Regioselective carboxylation of 1,3-dihydroxybenzene by 2,6-dihydroxybenzoate decarboxylase of Pandoraea sp. 12B-2.
  Journal
Appl Microbiol Biotechnol 73:95-102 (2006)
DOI:10.1007/s00253-006-0437-z
Reference
4  [PMID:16963440]
  Authors
Goto M, Hayashi H, Miyahara I, Hirotsu K, Yoshida M, Oikawa T
  Title
Crystal structures of nonoxidative zinc-dependent 2,6-dihydroxybenzoate (gamma-resorcylate) decarboxylase from Rhizobium sp. strain MTP-10005.
  Journal
J Biol Chem 281:34365-73 (2006)
DOI:10.1074/jbc.M607270200
Reference
5  [PMID:26319878]
  Authors
Kasai D, Araki N, Motoi K, Yoshikawa S, Iino T, Imai S, Masai E, Fukuda M
  Title
gamma-Resorcylate catabolic-pathway genes in the soil actinomycete Rhodococcus jostii RHA1.
  Journal
Appl Environ Microbiol 81:7656-65 (2015)
DOI:10.1128/AEM.02422-15
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.103
IUBMB Enzyme Nomenclature: 4.1.1.103
ExPASy - ENZYME nomenclature database: 4.1.1.103
BRENDA, the Enzyme Database: 4.1.1.103
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