KEGG   ENZYME: 4.1.1.117
Entry
EC 4.1.1.117                Enzyme                                 
Name
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase;
sbnH (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate carboxy-lyase (2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate-forming)
Reaction(IUBMB)
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate = 2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate + CO2 [RN:R12309]
Reaction(KEGG)
R12309
Substrate
2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22072]
Product
2-[(2-aminoethylcarbamoyl)methyl]-2-hydroxybutanedioate [CPD:C22073];
CO2 [CPD:C00011]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, participates in the biosynthesis of the siderophore staphyloferrin B.
History
EC 4.1.1.117 created 2019
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23373  2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase
Genes
SDNSden_0584
PSALPSLF89_1986
HSVHNO53_08405
RSORSp0424(ssd)
RSLRPSI07_mp0385
RSNRSPO_m01404
RSMCMR15_mp10437
RSEF504_3900
RSYRSUY_34920(btrK)
RPUCDC45_19750
RSGJK151_14150
CNCCNE_2c14900(lysA)
CUHBJN34_08290
RMERmet_1110(lysA)
BPLAbpln_2g05080
NETNeut_1742
NLCEBAPG3_006485
NIZNNRS527_01543
CPELCPEL_0305
MNOMnod_6954
MAQUMaq22A_c25460(lysA)
PPHRAPZ00_12890
SBDATN00_04605
MAESGa0123461_0244
MFNGa0123462_2021
BWHA9C19_09115
BBADK7T73_21430
GCTGC56T3_0418
GJFM493_02155
GSRGS3922_13805
PCALBV455_03917(btrK)
LGYT479_22375
HHDHBHAL_4879
HLIHLI_03735
SJEAAV35_000870
RUEDT065_14635
SALEEPH95_16140
MSEMGMB29_11065
SAUSA0119(sbnH)
SAVSAV0123
SAWSAHV_0122
SAHSaurJH1_0114
SAJSaurJH9_0110
SAMMW0096(sbnH)
SASSAS0097
SARSAR0126
SACSACOL0107
SAXUSA300HOU_0134(lysA1)
SAASAUSA300_0125
SAOSAOUHSC_00082
SAENWMN_0067(sbnH)
SADSAAV_0091
SUUM013TW_0113(sbnH)
SUVSAVC_00355
SUESAOV_0070
SUJSAA6159_00106(sbnH)
SUKSAA6008_00101(sbnH)
SUCECTR2_79
SUTSAT0131_00109
SUQHMPREF0772_10374
SUZMS7_0115
SUDST398NM01_0135
SUXSAEMRSA15_00890
SUWSATW20_01350(sbnH)
SUGSAPIG0135
SUFSARLGA251_00980(sbnH)
SAUASAAG_00607
SAUERSAU_000077
SAUNSAKOR_00097
SAUSSA40_0090(sbnH)
SAUUSA957_0105(sbnH)
SAUGSA268_0102(sbnH)
SAUZSAZ172_0134(sbnH)
SAUTSAI1T1_2000790
SAUJSAI2T2_1000790
SAUKSAI3T3_1000790
SAUQSAI4T8_1000790
SAUVSAI7S6_1000790
SAUWSAI5S5_1000790
SAUXSAI6T6_1000790
SAUYSAI8T7_1000790
SAUFX998_0102
SABSAB0062
SUYSA2981_0124(sbnH)
SAUBC248_0111
SAUMBN843_1250
SAUCCA347_134
SAURSABB_01717(sbnH)
SAUIAZ30_00640
SAUDCH52_05105
SAMSNI36_00535
SUHSAMSHR1132_00990
SSDSPSINT_0341
SDTSPSE_2117
SDPNCTC12225_02334(lysA_2)
SHUSHYC_00390(sbnH)
SSCHLH95_00390
SSCZRN70_00610
SAGQEP23_09735
SEQOSE1039_25040
SPETCEP67_08210
SLZB5P37_07625
SARLSAP2_02100
SSHNCTC13712_00076(lysA_1)
SRAILN051_00265
SSCUCEP64_13490
SFFFOB90_07400
SSTESAMEA4384403_0108(lysA_1)
MVTI6J10_10610
MBRUMGG13_01660
BAGRBA6348_15320
PTAHPL003_19625
PPEOABE82_04655
POWIJ21_46070
PXLBS614_08695
PKBB4V02_14030
PAIHASL14_00105
PPSCEHS13_31645
PBACHUB98_21850
ANXACH33_02525
ATHEK3F53_16425
CCHLFPL14_15130
SACAFFV09_03650
TUMCBW65_11365 CBW65_11415
TABCIG75_16800
PANABBH88_04010
PANCE2636_16075
LFBC1X05_04265
KPULGXN76_14210
PABSJIR001_05150
STUSTH8232_0696
CSEPCP523_06275
CCTCC1_17280
ROBCK5_31170
BYLA4V09_07165
MHWACT01_03350
ERHERH_0207(lysA)
ERSK210_08220
EIOH9L01_08060
EBMSG0102_00780(lysA_1)
NAHF5544_31195
SHYSHJG_0926
SHOSHJGH_0759
SGSAVL59_29350
SNWBBN63_16025
SALJSMD11_0162(lysA)
SRJSRO_0366 SRO_7379
SRKFGW37_30385
SVRCP971_06275
SFYGFH48_07845
SGFHEP81_00355 HEP81_07705
SBYH7H31_05365
SGOBtest1122_12320
KAUB6264_01465
KITCFP65_6208
RSARSal33209_1689
FRAFrancci3_4053
FREFranean1_0663
FALFRAAL6420
FSYFsymDg_0715
SACGFDZ84_26465
PSEQAD006_29035
PECQAD017_29425
PMADBAY61_28595
ASEACPL_4370(lysA)
AMSAMIS_41880
ACTNL083_3996(lysA)
AFSAFR_21240
ACTSACWT_4241
AIHAiant_88100(lysA_3)
ACTRAsp14428_06990(sbnH)
PFLAPflav_024170(sbnH)
PSUUPsuf_079620(sbnH)
PRYPrubr_61760(lysA_4)
CATICS0771_66390(lysA_2)
DVCDvina_27455
DFUDfulv_25325
DROSDrose_20240
DAURDaura_26770
CCAZCOUCH_21220
SNASnas_3735
NAVJQS30_07790
GLYK3N28_09085
LETO77CONTIG1_03927(btrK)
TSUTresu_1002
 » show all
Reference
1  [PMID:19775248]
  Authors
Cheung J, Beasley FC, Liu S, Lajoie GA, Heinrichs DE
  Title
Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
Mol Microbiol 74:594-608 (2009)
DOI:10.1111/j.1365-2958.2009.06880.x
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.117
IUBMB Enzyme Nomenclature: 4.1.1.117
ExPASy - ENZYME nomenclature database: 4.1.1.117
BRENDA, the Enzyme Database: 4.1.1.117
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