KEGG ENZYME: 4.1.1.126

ENZYME: 4.1.1.126

Entry

EC 4.1.1.126                Enzyme

Name

anhydromevalonate phosphate decarboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

(2E)-3-methyl-5-phosphooxypent-2-enoate carboxy-lyase

Reaction(IUBMB)

(2E)-3-methyl-5-phosphooxypent-2-enoate = 3-methylbut-3-en-1-yl phosphate + CO2 [RN:R12895]

Reaction(KEGG)

R12895

Substrate

(2E)-3-methyl-5-phosphooxypent-2-enoate [CPD:C22453]

Product

3-methylbut-3-en-1-yl phosphate [CPD:C20345];
CO2 [CPD:C00011]

Comment

The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.

History

EC 4.1.1.126 created 2023

Pathway

ec00900

Terpenoid backbone biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K25518

anhydromevalonate phosphate decarboxylase

Genes

BGK:	IC762_29465

MJA:

MJ_1133

MFE:	Mefer_0287

MVU:	Metvu_1374

MFS:	MFS40622_0069

MIF:	Metin_1023

MJH:	JH146_0714

MESG:

MLAUSG7_0678

MESA:

MLASG1_0345

MIG:	Metig_0474

MMP:

MMP1288

MMQ:	MmarC5_0305

MMX:	MmarC6_1386

MMZ:	MmarC7_0533

MMD:

GYY_07275

MMAK:

MMKA1_15130

MMAO:

MMOS7_13950

MMAD:

MMJJ_15550(ubiD)

MAE:

Maeo_0014

MVN:	Mevan_0598

MVO:	Mvol_0032 Mvol_0092

MOK:	Metok_1181

METF:

CFE53_03010

MTH:

MTH_1394

MMG:	MTBMA_c17800

MWO:	MWSIV6_1774

MTEE:

MTTB_15830

METC:

MTCT_1267

METE:

tca_01347(bsdC)

METZ:

METMT2_0059

METK:

FVF72_04615

MTHM:

FZP57_08685

METJ:

FZP68_02040

MST:

Msp_1479

METB:

AW729_07910

MEIS:

PXD04_03325

MRU:

mru_2187

MSI:

Msm_1286

MEB:

Abm4_1723

MMIL:

sm9_2302

MEYE:

TL18_00230

MOL:

YLM1_1642

MARO:

MarbSA_12240

METV:

K4897_04895

MEL:	Metbo_0178

MEW:	MSWAN_2305

METH:

MBMB1_1946

MFC:

BRM9_2286

MFI:	DSM1535_1220

MCUB:

MCBB_2229

MSUB:

BK009_08990

METN:

BK008_04610

METT:

CIT01_05340

METO:

CIT02_07800

MEME:

HYG87_06200

MFEG:

GCM10025860_06000

MEER:

NKF70_06170

MRID:

FGU46_05440

MFV:

Mfer_0955

MKA:	MK0234(ubiD)

AFU:

AF_1643

AFG:	AFULGI_00018930

APO:	Arcpr_1653

AVE:	Arcve_0618

AST:	Asulf_01062

FPL:

Ferp_1543

GAC:

GACE_1859

GAH:

GAH_00517

PFU:

PF1138

PFI:

PFC_04915

PHO:	PH0963(PH0963)

PAB:

PAB1798

PYN:

PNA2_1640

PYA:	PYCH_04010

PYS:

Py04_0819

PYC:	TQ32_05685

TKO:

TK0929

TON:

TON_0392

TGA:	TGAM_1657(ubiD-2)

TSI:

TSIB_0620

TBA:	TERMP_00411

THE:

GQS_03265

THA:

TAM4_1818

THM:

CL1_0336

TLT:

OCC_04640

THS:

TES1_0474

TNU:

BD01_0317

TEU:

TEU_07305

TGY:	X802_01205

THV:	ADU37_CDS13680

TCH:	CHITON_0854

TPEP:

A0127_00490

TPIE:

A7C91_07975

TGG:	A3K92_04035

TCE:	A3L02_09380

TBS:	A3L01_02655

THH:	CDI07_02610

TSL:	A3L11_06600

TTD:	A3L14_04205

TPRF:

A3L09_05430

TRL:	A3L10_03925

TPAF:

A3L08_05655

THY:	A3L12_06085

TIC:	FH039_05000

TCQ:	TIRI35C_0756

THEM:

FPV09_04195

THEI:

K1720_06170

TAGG:

NF865_09810

PPAC:

PAP_03940

MBA:	Mbar_A0716

MBY:	MSBRM_0329

MBW:	MSBRW_0285

MBAR:

MSBR2_2052

MBAK:

MSBR3_2121

MAC:

MA_0246

MMA:

MM_1526

MMAZ:

MmTuc01_1585

MMJ:	MSMAS_3141

MMAC:

MSMAC_3161

MVC:	MSVAZ_0315

MEK:	MSKOL_0299

MLS:	MSLAZ_0091

METM:

MSMTP_3039

MEF:	MSWH1_0173

MEQ:	MSWHS_0172

MSJ:	MSSAC_0232

MSZ:	MSSIH_0201

MSW:	MSSIT_0205

MTHR:

MSTHT_2039

MTHE:

MSTHC_1247

MHOR:

MSHOH_3878

MFZ:	AOB57_009510

MHAB:

RSJ42_17120

METW:

AAY43_04250

MBU:	Mbur_1473(ubiD)

MMET:

MCMEM_1973

MELO:

J7W08_08755

MMH:

Mmah_1773

MHAZ:

BHR79_04815

MPOT:

BKM01_00940

MEV:	Metev_2056

MZH:	Mzhil_1541

MPY:

Mpsy_2253

MZI:	HWN40_10870

MMAV:

RE476_12230

MSEB:

RE474_09120

MHZ:	Metho_2162

MEHF:

MmiHf6_15580(ubiD)

MEES:

MmiEs2_00940(ubiD)

MTP:

Mthe_0940

MCJ:

MCON_1237

MHI:

Mhar_2380

MHU:

Mhun_2438

MRTJ:

KHC33_16805

MLA:

Mlab_0057

MEM:	Memar_2139

MBG:	BN140_1347(ubiD)

MEMA:

MMAB1_1716

MCHK:

MchiMG62_24480

MSUM:

OH143_04980

MRC:	R6Y96_01580

MPI:

Mpet_1884

MEND:

L6E24_01020

MEFW:

F1737_03005

MAQE:

RJ40_06740

MFK:	E2N92_06905

MOU:	OU421_09615

MESB:

L1S32_00810

MANQ:

L1994_03860

MBN:

Mboo_0122

MFO:	Metfor_0250

MPL:

Mpal_0510

MPD:

MCP_1907

MEZ:

Mtc_1487

RCI:

RRC445

MJK:	N2V74_02525 N2V74_03335

HALH:

HTSR_1039(ubiD)

HHSR:

HSR6_1072(ubiD)

HSU:	HLASF_0829(ubiD)

HSF:	HLASA_0826(ubiD)

HAHS:

HSRCO_1215(ubiD2)

HUT:

Huta_0617

HTI:	HTIA_0365(ubiD)

HALA:

Hrd1104_02520

HASV:

SVXHr_1977(ubiD)

HABN:

HBNXHr_1964(ubiD)

HDS:	HSR122_0652(ubiD)

HARC:

HARCEL1_02630

HDF:	AArcSl_1770(ubiD)

HAAA:

AArcCO_0144(ubiD)

MEAM:

MU439_04170

MEAE:

QEN48_05820

TAR:	TALC_00691

MAX:	MMALV_10070

MER:	MMINT_12400

MEAR:

Mpt1_c06960(ubiD)

MEUZ:

KRP56_03340

MARC:

AR505_1172

ABI:

Aboo_0767

ACF:	AciM339_0300

APE:

APE_2078

ACJ:

ACAM_1300

SMR:

Smar_0621

SHC:	Shell_0174

IHO:

Igni_0551

IIS:

EYM_06455

IPC:

IPA_02045

DKA:

DKAM_0144

DFD:	Desfe_0219

DMU:	Desmu_0695

TAG:

Tagg_1156

TCS:	IMZ38_03595

IAG:

Igag_1939

THG:	TCELL_0126

HBU:

Hbut_1635

PFM:	Pyrfu_0192

PDL:	Pyrde_0504

PABI:

PABY_02560

PARE:

PYJP_14530

PAI:

PAE2232

PIS:

Pisl_0856

PCL:

Pcal_0948

PAS:

Pars_1921

PYR:

P186_0457

POG:

Pogu_0206

TNE:

Tneu_1397

PYW:	PYWP30_01477

CMA:

Cmaq_0422

TTN:	TTX_1591(ubiD)

TUZ:

TUZN_1947

VDI:

Vdis_2362

VMO:

VMUT_0714

VSO:	Vsou_21070

TPE:

Tpen_0404

THB:	N186_03050

TCB:	TCARB_1674

THF:	MA03_07925

THEL:

IG193_05515

ASC:

ASAC_1369

ACIA:

SE86_04525

CLG:	Calag_0755

FFO:	FFONT_1069

KCR:

Kcr_1286

NMR:

Nmar_1597

NIR:	NSED_08645

NKR:	NKOR_08690

NID:	NPIRD3C_0457

NIN:	NADRNF5_0289(ubiD)

NIW:	Nisw_05905

NCL:	C5F47_08375

NOX:	C5F49_08260

NUE:	C5F50_11630

NIP:	NsoK4_00285

NZT:	NZOSNM25_000187

NCT:

NMSP_1539

NIC:	DSQ20_09285

NGA:	Ngar_c07630

NVN:	NVIE_013060

NEV:

NTE_02706

TAA:	NMY3_03586(bsdC)

NFN:	NFRAN_0939

NCV:

NCAV_0139

NDV:

NDEV_1956

CSY:	CENSYa_1735

NBV:

T478_1315

TAH:	SU86_005060

NIU:	DSQ19_00980

CCAI:

NAS2_1615

BARC:

AOA65_2281

BARB:

AOA66_1340

FLT:	Sv326_0058

LOKI:

Lokiarch_22670(ubiD)

» show all

Reference

1 [PMID:30224495]

Authors

Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H.

Title

Modified mevalonate pathway of the archaeon Aeropyrum pernix proceeds via trans-anhydromevalonate 5-phosphate.

Journal

Proc Natl Acad Sci U S A 115:10034-10039 (2018)
DOI:10.1073/pnas.1809154115

Reference

2 [PMID:31924615]

Authors

Yoshida R, Yoshimura T, Hemmi H.

Title

Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells.

Journal

Appl Environ Microbiol 86:AEM.02889-19 (2020)
DOI:10.1128/AEM.02889-19

Sequence

[mma:MM_1526]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.1.126

IUBMB Enzyme Nomenclature:

4.1.1.126

ExPASy - ENZYME nomenclature database:

4.1.1.126

BRENDA, the Enzyme Database:

4.1.1.126

LinkDB

DBGET integrated database retrieval system