Entry
Name
cis-aconitate decarboxylase;
cis-aconitic decarboxylase;
cis-aconitate carboxy-lyase;
CAD1 (gene name);
IRG1 (gene name)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
cis-aconitate carboxy-lyase (itaconate-forming)
Reaction(IUBMB)
cis-aconitate = itaconate + CO2 [RN:
R02243 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme has been characterized from the fungus Aspergillus terreus and from human macrophages. cf. EC
4.1.1.113 , trans-aconitate decarboxylase.
History
EC 4.1.1.6 created 1961, modified 2018
Pathway
ec00660 C5-Branched dibasic acid metabolism
Orthology
K17724 aconitate decarboxylase
Genes
OAA : 100084560 100088444(ACOD1)
TACU : 119922263(ACOD1) 119929468
GGA : 418812(ACOD1) 422307(IRG1L)
PCOC : 116229463 116238891(ACOD1)
MGP : 100546964 100548788(ACOD1)
CJO : 107308047(ACOD1) 107312866
TPAI : 128075979 128092243(ACOD1)
LMUT : 125699758 125703322(ACOD1)
NMEL : 110403338 110408455(ACOD1)
APLA : 101794037(ACOD1) 101794721
ACYG : 106043926(ACOD1) 106047514
AFUL : 116494478 116499701(ACOD1)
TGU : 100226594 101232923(ACOD1)
LSR : 110477957 110480221(ACOD1)
SCAN : 103812269(ACOD1) 103816324
PMOA : 120504791(ACOD1) 120512600
OTC : 121344195(ACOD1) 121346469
PRUF : 121355646(ACOD1) 121362793
ATRC : 139591863(ACOD1) 139597111
GFR : 102032832(ACOD1) 102041070
FAB : 101810292 101810708(ACOD1)
OMA : 130253141(ACOD1) 130253305
PHI : 102102295(IRG1) 102107906
PMAJ : 107201919(ACOD1) 107203748
CCAE : 111928603(ACOD1) 111929257
CCW : 104691709 104695876(ACOD1)
CBRC : 103622107 103624423(ACOD1)
ACOE : 138107472(ACOD1) 138110256
ETL : 114062112 114062620(ACOD1)
ZAB : 102060470 102068328(ACOD1)
ZLE : 135447792 135447938(ACOD1)
ACHL : 103803949 103810815
SVG : 106849992(IRG1) 106863412
MMEA : 130573783(ACOD1) 130584076
HRT : 120748849(ACOD1) 120761937
SATI : 136357815(ACOD1) 136370388
CCIC : 134050228 134057790(ACOD1)
FPG : 101916577(ACOD1) 101922011
FCH : 102045907(ACOD1) 102047977
CCRI : 104164930(IRG1) 104168405
NNT : 104409041(IRG1) 104410599
SHAB : 115603830(ACOD1) 115613073
ACUN : 113480159 113480630(ACOD1)
TALA : 104355633(ACOD1) 104360232
ACHC : 115333923 115350548(ACOD1)
HALD : 104322338(IRG1) 104325262
HLE : 104832735 104838492(IRG1)
CSTI : 104551429(IRG1) 104562892
MNB : 103773582(IRG1) 103776717
DPUB : 104297848 104310316(IRG1)
PPUS : 135184145 135191485(ACOD1)
AVIT : 104273696(IRG1) 104274502
BRHI : 104491115(IRG1) 104500918
EGZ : 104127050(ACOD1) 104127973
NNI : 104018830(IRG1) 104021092
PCRI : 104025612(IRG1) 104037643
PCAO : 104039628 104040309(IRG1)
PADL : 103923687(IRG1) 103925885
AFOR : 103894094 103900937(ACOD1)
FGA : 104071077(IRG1) 104076834
GSTE : 104255772(IRG1) 104258749
CBOY : 140648309(ACOD1) 140658638
CLV : 102094294(ACOD1) 102098383
MUI : 104537629 104548241(IRG1)
PGUU : 104464282 104466032(IRG1)
PLET : 104615639 104622545(IRG1)
EHS : 104509264(IRG1) 104516636
CMAC : 104480716(IRG1) 104487083
CUCA : 104054960(ACOD1) 104066237
BREG : 104630786(IRG1) 104631121
OHA : 104333407 104336655(IRG1)
ACAR : 104519240(ACOD1) 104527041
CPEA : 104393921 104393968(IRG1)
CVF : 104282708 104294423(IRG1)
RTD : 128913114(ACOD1) 128915012
CRID : 134516023(ACOD1) 134520850
AAM : 106489846 106491683(ACOD1)
AROW : 112971758(ACOD1) 112975807
NPD : 112947125 112951767(ACOD1)
TGT : 104570868(IRG1) 104577580
DNE : 112983281 112995731(ACOD1)
SCAM : 104137848 104147457(IRG1)
ASN : 102369682(ACOD1) 102377148
AMJ : 102567064(ACOD1) 102576357
CPOO : 109306430(ACOD1) 109313741
GGN : 109300352 109303394(ACOD1)
CMY : 102939148 102943113(ACOD1)
CCAY : 125637694(ACOD1) 125642632
DCC : 119843897(ACOD1) 119860917
CPIC : 101937974 101939682(ACOD1)
TST : 117870883(ACOD1) 117882931
CABI : 116831679 116836329(ACOD1)
MRV : 120371377 120391174(ACOD1)
ACS : 100561493(acod1) 100567429
ASAO : 132763208 132771434(ACOD1) 132772530
PVT : 110073869(ACOD1) 110080151
SUND : 121923666 121926277(ACOD1)
HCG : 128335601 128350525(ACOD1)
GJA : 107108495 107120147(ACOD1)
STOW : 125431603(ACOD1) 125443008
EMC : 129325959(ACOD1) 129340947
XLA : 108698345 108698346 108708498(acod1.L) 108708981(acod1.S) 121393060 398116(acod1lb.L)
XTR : 100125311(acod1lb) 100490060(acod1la) 100490699(acod1)
NPR : 108794354(ACOD1) 108802827
RTEM : 120921925 120929693(ACOD1)
BBUF : 120977264 120995873(ACOD1)
BGAR : 122919376 122919379 122919799 122932267(ACOD1)
PWL : 138250405(ACOD1) 138262206 138262214 138262469
MUO : 115468687(ACOD1) 115474480
GSH : 117361270 117363023(ACOD1)
DRE : 562007(irg1l) 795305(acod1)
SRX : 107705150 107724458 107746176 107746319
SANH : 107658213 107661550 107663091 107668871
SGH : 107568925 107570155 107573949 107573956 107597428
CCAR : 109060025 109060032 109089282 109096956
CAUA : 113053376 113108796 113109355 113113525 113114446
CGIB : 127964351 127970989 128019722 128026878
PTET : 122352100(acod1) 122357765(irg1l)
LROH : 127171233(acod1) 127176473(irg1l)
OMC : 131547173(acod1) 131553596(irg1l)
PPRM : 120477370(acod1) 120494889(irg1l)
RKG : 130076765(irg1l) 130085858(acod1)
MAMB : 125259309(irg1l) 125270508(acod1)
CIDE : 127494714 127518559
CERY : 137017930(irg1l) 137035475(acod1)
MASI : 127412805 127417954 127446957
TROS : 130555500(acod1) 130563814(irg1l)
TDW : 130427087(acod1) 130438066(irg1l)
MANU : 129422677(irg1l) 129452122(acod1)
PDAB : 135731002(acod1) 135731151(irg1l)
IPU : 108266835 108269388(irg1l)
IFU : 128608830(acod1) 128611816(irg1l)
PHYP : 113525153(acod1) 113542690
SMEO : 124383128(acod1) 124385668(irg1l)
TFD : 113637990(irg1l) 113654169(acod1)
TVC : 132850188(acod1) 132855974(irg1l)
CGAR : 128524039(acod1) 128531316 128531373 128531842 128531844 128531849 128532117 128532148 128532163 128532180 128532187
TRN : 134318771(irg1l) 134324558(acod1)
AMEX : 103038985(acod1) 103041863(irg1l)
CMAO : 118804940(acod1) 118807357(irg1l)
EEE : 113577118(acod1) 113591167
TRU : 101063714(acod1) 101076857 115252431
TFS : 130530246(acod1) 130531649 130531650
TNG : GSTEN00017050G001 GSTEN00027937G001
LCO : 104921461(acod1) 104938224
TBEN : 117475011 117475042(irg1l) 117481067(acod1)
CGOB : 115015081 115026778(acod1)
PGEO : 117453558(irg1l) 117466634(acod1)
GACU : 117544530(acod1) 117556932(irg1l)
EMAC : 134860282(irg1l) 134866877(acod1)
ELY : 117248431(acod1) 117261307(irg1l)
EFO : 125894490(irg1l) 125899838(acod1)
PLEP : 121948499(irg1l) 121948870(acod1)
SLUC : 116043133(acod1) 116064279 116064477 116064502
ECRA : 117952294(irg1l) 117952295 117952395(acod1)
ESP : 116697019 116698380(acod1)
GAT : 120817036 120818364 120833795(acod1)
PPUG : 119211007(irg1l) 119228799(acod1)
AFB : 129090537(irg1l) 129104487(acod1)
PSWI : 130205252(acod1) 130210147(irg1l)
CANA : 137782923(acod1) 137797626(irg1l)
CVE : 137866313(acod1) 137875888(irg1l)
MSAM : 119888190(irg1l) 119904342(acod1)
SCHU : 122880614(irg1l) 122885871(acod1)
CUD : 121516772(irg1l) 121522444(acod1)
SPUL : 138592792(acod1) 138598605(irg1l)
LMIX : 132981745(irg1l) 132986675(acod1)
ALAT : 119006893(irg1l) 119025712(acod1)
MZE : 101483061(acod1) 101486456
ONL : 100692168 100711765(acod1)
OAU : 116316166(acod1) 116324629(irg1l)
OLA : 101163093 101169074(acod1)
OML : 112153498(irg1l) 112155293(acod1)
CSAI : 133446578(acod1) 133447534(irg1l)
XMA : 102219194 102219456 102237340(acod1)
XCO : 114139414 114139415 114148736(acod1)
XHE : 116713906 116714496 116723571(acod1)
PFOR : 103134734(acod1) 103135609 103135613
PLAI : 106940818 106955405 106962435(irg1)
PMEI : 106925652 106925655 106927798(irg1)
GAF : 122837589(irg1l) 122839526(acod1)
PPRL : 129361111(acod1) 129362772(irg1l)
CVG : 107089035 107089037 107092943(irg1)
CTUL : 119792514 119792523 119792524 119794734(acod1)
GMU : 124860059 124860060 124860907 124860946 124871233(acod1)
KMR : 108232367(acod1) 108240560 108240568
ALIM : 106514372 106518098 106527121(irg1)
NWH : 119408268 119408522(irg1l) 119419281(acod1)
AOCE : 111576374(acod1) 111587042(irg1l)
EJA : 138201087(acod1) 138211634(irg1l)
BFRE : 138619919(irg1l) 138625810(acod1)
MCEP : 125008626 125008627 125018095(acod1)
CSEM : 103391176 103391931(acod1)
SSEN : 122778343(irg1l) 122785792(acod1)
SSOE : 131454179(acod1) 131472726(irg1l)
HHIP : 117755244(acod1) 117769644(irg1l)
HSP : 118112454(irg1l) 118119803(acod1)
PPLT : 128446218(irg1l) 128455611(acod1)
SMAU : 118319589(irg1l) 118320548(acod1)
SDU : 111218684(acod1) 111226511 111226512
SLAL : 111658568 111658573 111673038(acod1)
XGL : 120785573(irg1l) 120801545(acod1)
SSCV : 125973445(acod1) 125986261(irg1l)
SBIA : 133508942(irg1l) 133511895(acod1)
PEE : 133408083(irg1l) 133411059(acod1)
PTAO : 133484577(irg1l) 133486496(acod1)
BPEC : 110164034 110170567(acod1)
ENY : 140345669(irg1l) 140359718(acod1)
MALB : 109954119 109965329(acod1)
BSPL : 114847387(acod1) 114865084(irg1l)
SJO : 128363172(irg1l) 128363173 128367663(acod1)
SSCO : 133985625(irg1l) 133986134 133993357(acod1)
GMH : 115532896(acod1) 115551960 115551965
SASA : 106581286 106581616(acod1) 106591804
STRU : 115156248(acod1) 115163980 115190476
OTW : 112225047(acod1) 112234848 112241585(irg1l) 121846965
OMY : 110501238(acod1) 110507150 110515535 118946052
OGO : 123992255 124011404 124011570 124014416(acod1)
ONE : 115119987 115130721(acod1)
OKI : 109871418(acod1) 109885898 109904876 116353555
OKE : 118373518 118386463(acod1)
OMM : 135545431 135546907(acod1) 135551543
OCLA : 139380536 139385752 139390998 139391030
SALP : 111959409(acod1) 112074778
SNH : 120018496 120018497 120036101 120036508 120064474(acod1)
CCLU : 121546846(acod1) 121558036 121558037 121567020
ELS : 105031338(acod1) 106023913 114828687
OEP : 134017683(acod1) 134024185(irg1l)
SFM : 108925368 108929979(acod1)
PKI : 111832676(acod1) 111846354
AANG : 118213732(acod1) 118222853(irg1l)
AROT : 135240662(acod1) 135251148(irg1l)
CCOG : 133116689(acod1) 133125198(irg1l)
PSPA : 121295760 121295890 121304038 121308107 121308109 121308112 121310679 121310917 121310919 121311097 121311262 121311917 121312635 121312673 121312681 121317866 121318734 121320931(acod1) 121325338
ARUT : 117405592(acod1) 117406549 117412119 117412177 117412295 117426783 117426784 117427043 117427147 117430943
LCM : 102345136(ACOD1) 102354684
PMRN : 116943643(ACOD1) 116943649
LRJ : 133349957 133350135(ACOD1)
TATV : 25786324(TrAtP1_012160)
TASP : 36612883(TrAFT101_010539)
PFY : PFICI_09702 PFICI_14898
ANG : An01g09950 An09g06220
ALUC : AKAW2_10071S AKAW2_21039S AKAW2_40624A
ยป show all
Taxonomy
Reference
Authors
BENTLEY R, THIESSEN CP.
Title
Biosynthesis of itaconic acid in Aspergillus terreus. III. The properties and reaction mechanism of cis-aconitic acid decarboxylase.
Journal
J Biol Chem 226:703-20 (1957)
Reference
Authors
Dwiarti L, Yamane K, Yamatani H, Kahar P, Okabe M
Title
Purification and characterization of cis-aconitic acid decarboxylase from Aspergillus terreus TN484-M1.
Journal
Reference
Authors
Kanamasa S, Dwiarti L, Okabe M, Park EY
Title
Cloning and functional characterization of the cis-aconitic acid decarboxylase (CAD) gene from Aspergillus terreus.
Journal
Reference
Authors
Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K
Title
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.6
ExPASy - ENZYME nomenclature database: 4.1.1.6
BRENDA, the Enzyme Database: 4.1.1.6
LinkDB
All DBs