KEGG   ENZYME: 4.1.1.75
Entry
EC 4.1.1.75                 Enzyme                                 
Name
5-guanidino-2-oxopentanoate decarboxylase;
alpha-ketoarginine decarboxylase;
2-oxo-5-guanidinopentanoate carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)
Reaction(IUBMB)
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 [RN:R03178]
Reaction(KEGG)
R03178
Substrate
5-guanidino-2-oxopentanoate [CPD:C03771]
Product
4-guanidinobutanal [CPD:C02647];
CO2 [CPD:C00011]
Comment
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
History
EC 4.1.1.75 created 1999
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12253  5-guanidino-2-oxopentanoate decarboxylase
Genes
PREPCA10_40350
PFUWKF707C_17620
POJPtoMrB4_51010(aruI)
PLALFXN65_08190
PAEPA4977(aruI)
PAEVN297_5149
PAEIN296_5149
PAUPA14_65795
PAPPSPA7_5710
PAGPLES_53651(aruI)
PNCNCGM2_0541
PAEBNCGM1900_5725
PDKPADK2_26375
PSGG655_26230
PRPM062_26240
PAEPPA1S_26995
PAERPA1R_gp2900
PAEMU769_27260
PAELT223_27455
PAESSCV20265_5640
PAEGAI22_07000
PAECM802_5147
PAEOM801_5014
SECHB18_10960
PCQPcP3B5_02220(aruI_1)
PMUIG4G71_03195
PNTG5B91_32205
PPUPP_3723(aruI)
PPFPput_2040
PPGPputGB1_2183
PPTPPS_3191
PPBPPUBIRD1_2039
PPIYSA_09434
PPXT1E_1730
PPUHB479_15835
PPUTL483_19375
PPUNPP4_20990
PPUDDW66_3462
PMONX969_15345
PMOTX970_14990
PPJRK21_01447
PALDLU682_011575
PIXRIN61_01165
PFLPFL_2714
PPRCPFLCHA0_c27750(ilvB1)
PPROPPC_2761(aruI)
PMANOU5_1976
PTVAA957_03675
PAZOAYR47_18015
PTOLI7845_10660
PFWPF1751_v1c20110
PFFPFLUOLIPICF726665
PFXA7318_09785
PPUUPputUW4_02749
PDRH681_24935
PSKU771_11345
PKCPKB_0123
PCZPCL1606_34610
PCHPC4K32_2706
PALKPSAKL28_23950
PSEMTO66_13285
PSOSPOS17_2710(aruI)
PANRA7J50_2200
PSETTHL1_3998
PYMAK972_2095
PUMHGP31_15875
PMAOPMYSY11_3759(aruI)
PDWBV82_5126
PSEPC4K39_2739
PPIIQL104_17235
PVWHU752_013320
PAZEKSS91_15430
PORYEJA05_15315
PTKEXN22_14855
PWYHU734_015265
PTAENCTC10697_02326(ilvB_2)
PCAVD3880_08970
PIZLAB08_R27900
PPEGKUA23_18865
PSIHLOY51_15675
PASILG197_21545
PKMPZ739_16625
PNBNK667_09515
PTAIICN73_22465
PKKQQ992_10575
PKJQ1W70_23970
PHOMKJF94_09170
PTRLOU419_28455
PSJYAA098_17130
PSNCC0058_12330
PFOUOZ911_17045
PSKPKU43P_29790(aruI)
PBAMNUH87_05425
PDENF1C79_24145
COLWA3Q33_05685
CBERB5D82_00660
MICCAUP74_02851(aruI_1)
MAGAMag101_09645
MHYDGTQ55_10570
SIXBSY16_6046
SHZshn_17240
SSUMQ9314_27100
NOHG5V57_06975
RUAD1823_07575
RUTFIU92_05590(ilvG)
RCONK3740_06455
RUYNOR97_05565
RDERD1_1943(ilvB)
RLIRLO149_c010380
RPONG3256_13050
RFUROLI_008540(aruI)
OATOAN307_c15390
OAROA238_c27100
OTMOSB_09640(aruI)
OCTFTO60_10835
SUAMBOO69_05960
SULZC1J03_15970
SULIC1J05_05650
SPOTG6548_11780
SMEDJNX03_06855
SUALKDD17_03895
SULBIV89_001371
SPSESULPSESMR1_00851(aruI)
TOMBWR18_04905
RMMROSMUCSMR3_00989(aruI)
ROKRAK1035_3857
RIDRIdsm_03467(aruI)
ROMEI983_05210
ROHFIU89_06845(aruI)
RPELN7U68_12610
AHTANTHELSMS3_04191(aruI)
SAGUCDO87_17335
SSTLABFK29_08490
THAACFI11_16070
MALUKU6B_35330(aruI)
TRYQF118_10155
PTPRCA23_c27460
YPHYAABB29_11165
YAGAABB28_02325
YRHAABB31_11595
PAEDG5B38_11405
PAMOBAR1_13645
CACTHZ995_02610
ACROK3J57_10185
AALKLGT41_0009545
AMYLQBD29_12200
LVRT8T21_07515
BOSGGKR98_16850
SPHTK426_15955
SKTIGS68_03240
HTQFRZ44_22350(aruI)
HADHFRZ61_24760(aruI)
NACINUH88_06265
BTSBtus_2445
KYRCVV65_12220
ALKAJ0B03_10680
TMRTmar_0213
THEFE1B22_04660
THEPDYI95_000885
NTHNther_1932
AARAcear_1212
SLCSL103_18460
SCADDN051_41845
SALUDC74_6010 DC74_661
SALLSAZ_03825 SAZ_31125
MIPAXH82_05260
MOYCVS54_03500(aruI)
AGYATC03_03680
LEULeucomu_03870 Leucomu_11420
LTREVS81_04360
LEBG7066_00485 G7066_04190
LVIG7068_13330
LINSG7067_05385 G7067_05435
LLUTK1X41_11780 K1X41_12460
AGGC1N71_00685
AREAL755_01895
ACRYAC20117_15030
KRHKRH_21370
KFVAS188_05060
KIIKocCE7_11605
KRSEQG70_15495
KODHBK84_11540
KVRCIB50_0000905(aruI)
MPHMLP_52890
PSIMKR76_17655
TCUTcur_0450
NMLNamu_2951
GOBGobs_3087
AMQAMETH_5699(ilvB)
AABA4R43_27960
AMYYYIM_01385(aruI1)
VERHUT12_14960
ACTEACTI_50670(ilvB1)
PLIMPHILAsVB114_04455
ABAMB1s21122_02855
TROtrd_0363
TLITlie_1792
MOXDAMO_0156
HALNB4589_001925
 » show all
Reference
1  [PMID:237915]
  Authors
Vanderbilt AS, Gaby NS, Rodwell VW.
  Title
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida.
  Journal
J Biol Chem 250:5322-9 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.75
IUBMB Enzyme Nomenclature: 4.1.1.75
ExPASy - ENZYME nomenclature database: 4.1.1.75
BRENDA, the Enzyme Database: 4.1.1.75
CAS: 56831-67-5
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