| Entry |
|
|---|
| Name |
4-hydroxyphenylpyruvate decarboxylase;
4-hydroxyphenylpyruvate carboxy-lyase
|
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
|
|---|
| Sysname |
4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)
|
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| Reaction(IUBMB) |
4-hydroxyphenylpyruvate = 4-hydroxyphenylacetaldehyde + CO2 [RN: R03341]
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| Reaction(KEGG) |
|
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| Substrate |
4-hydroxyphenylpyruvate [CPD: C01179]
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| Product |
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| Comment |
Reacts with dopamine to give the benzylisoquinoline alkaloid skeleton.
|
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| History |
EC 4.1.1.80 created 2002
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| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Reference |
1 |
|---|
| Authors |
Rueffer M, Zenk MH. |
|---|
| Title |
Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation. |
|---|
| Journal |
Z Naturforsch C: Biosci 42:319-332 (1987) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.80 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.80 |
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| LinkDB |
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