KEGG ENZYME: 4.1.2.56

ENZYME: 4.1.2.56

Entry

EC 4.1.2.56                 Enzyme

Name

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase;
griI (gene name)

Class

Lyases;
Carbon-carbon lyases;
Aldehyde-lyases

Sysname

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate L-aspartate 4-semialdehyde-lyase (glycerone phosphate-forming)

Reaction(IUBMB)

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate = glycerone phosphate + L-aspartate 4-semialdehyde [RN:R10673]

Reaction(KEGG)

R10673

Substrate

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate [CPD:C20644]

Product

glycerone phosphate [CPD:C00111];
L-aspartate 4-semialdehyde [CPD:C00441]

Comment

Part of the pathway for the biosynthesis of grixazone, a mixture of yellow pigments produced by the bacterium Streptomyces griseus.

History

EC 4.1.2.56 created 2014

Pathway

ec00997

Biosynthesis of various other secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K18287

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase

Genes

BUR:	Bcep18194_C6861

BCEP:

APZ15_32405 APZ15_37520

BSTL:

BBJ41_35540

MCHT:

MCHIJ_41750

NIE:	KV110_28200

RTM:	G4H71_04120

RGO:	KYT97_13020

GPO:	GPOL_c23170

GOC:	CXX93_17250

GOM:	D7316_02313(griI)

GAM:	GII34_12230

GPD:	GII33_11540

SGR:	SGR_4249(griI)

SANL:

KZO11_09795 KZO11_14630(griI) KZO11_24545

SGRF:

SGFS_035530 SGFS_074020 SGFS_087250

SCYE:

R2B67_21120(griI)

SCB:	SCAB_69871

SRC:	M271_02970

SBH:

SBI_01604

SVE:

SVEN_5126

SVT:	SVTN_26400

SLD:

T261_2095

SPRI:

SPRI_1929

STSI:

A4E84_17120

SLS:	SLINC_4428 SLINC_5463

SNR:	SNOUR_07205

SPLU:

LK06_031745

SGV:	B1H19_08405

SFK:

KY5_6732

SLK:	SLUN_21415

SKA:	CP970_06995

SGAL:

CP966_31000

SPAD:

DVK44_19840

STUI:

GCM10017668_29380

SFEU:

IM697_30800

SDW:	K7C20_14905

SROI:

IAG44_38350

SMAO:

CAG99_20775

SLF:	JEQ17_24465

SDEC:

L3078_11305

SAKB:

K1J60_34235

SCAE:

IHE65_08585 IHE65_34340

SLON:

LGI35_32540

SANT:

QR300_02505

SJN:	RI060_03965

SHAU:

K9S39_40195

SKG:	KJK29_03015

SCOA:

QU709_14195 QU709_20145

SLAI:

P8A22_17055

SLUO:

PS467_03250

STRI:

C7M71_007300

STRH:

GXP74_28270

ABRY:

NYE86_23070

MIO:	AOA12_03105

MPH:

MLP_27040

FRA:	Francci3_2070 Francci3_4205

SACG:

FDZ84_06740 FDZ84_27225

AROO:

NQK81_43515

ACOR:

LCL61_30700

APRE:

CNX65_15995

AMI:

Amir_3141

SESP:

BN6_21360(griI1) BN6_63900(griI2)

SSYI:

EKG83_17795 EKG83_36325

SACX:

IOD16_25785

KAL:

KALB_2249

KUT:	JJ691_51010

KPHY:

AOZ06_26455

LED:	BBK82_37155

ACTU:

Actkin_05213(griI)

UME:	RM788_01330 RM788_07310

MICB:

MicB006_2904

MSAG:

GCM10017556_11900

MCHL:

PVK74_09475

ACTN:

L083_5377

ACTE:

ACTI_84880

PFLA:

Pflav_059810

PSUU:

Psuf_020560 Psuf_091150

DVC:	Dvina_29180 Dvina_40330

DFU:	Dfulv_30530

DROS:

Drose_22875

DMAT:

Dmats_24420 Dmats_35190

DACT:

KZZ52_19490

GLY:	K3N28_00690

AEY:	CDG81_10245

» show all

Reference

1 [PMID:17003031]

Authors

Suzuki H, Ohnishi Y, Furusho Y, Sakuda S, Horinouchi S

Title

Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes.

Journal

J Biol Chem 281:36944-51 (2006)
DOI:10.1074/jbc.M608103200

Sequence

[sgr:SGR_4249]

Other DBs

ExplorEnz - The Enzyme Database:

4.1.2.56

IUBMB Enzyme Nomenclature:

4.1.2.56

ExPASy - ENZYME nomenclature database:

4.1.2.56

BRENDA, the Enzyme Database:

4.1.2.56

LinkDB

DBGET integrated database retrieval system