KEGG ENZYME: 4.2.1.116

ENZYME: 4.2.1.116

Entry

EC 4.2.1.116                Enzyme

Name

3-hydroxypropionyl-CoA dehydratase;
3-hydroxypropionyl-CoA hydro-lyase;
3-hydroxypropanoyl-CoA dehydratase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

3-hydroxypropanoyl-CoA hydro-lyase

Reaction(IUBMB)

3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O [RN:R03045]

Reaction(KEGG)

R03045

Substrate

3-hydroxypropanoyl-CoA [CPD:C05668]

Product

acryloyl-CoA [CPD:C00894];
H2O [CPD:C00001]

Comment

Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2].

History

EC 4.2.1.116 created 2009

Pathway

ec00720

Other carbon fixation pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K14469

acrylyl-CoA reductase (NADPH) / 3-hydroxypropionyl-CoA dehydratase / 3-hydroxypropionyl-CoA synthetase

K15019

3-hydroxypropionyl-coenzyme A dehydratase

Genes

PZA:	HU749_011940

HARO:

R50071_22400

HJA:	BST95_10575

PAQM:

E0F26_06440 E0F26_07705

CBRV:

R0137_05460 R0137_10100

PSAA:

QEN71_30535

CABK:

NK8_64140

BGV:	CAL12_16285

ACHA:

KYT87_15855

CHEA:

PVE73_27620

ORM:	HTY61_07290

PECT:

BN1012_Phect2343

BQB:	J4P68_0034680 J4P68_0034780

RBK:	E0H22_25265

AQI:	J5J86_18205

CAUL:

KCG34_08935

PHEY:

O4N75_01985

CAZT:

LV780_06945

SRAD:

LLW23_04770

SPJS:

NUH86_19970

BLAS:

BSY18_2664

BFW:	B5J99_04275

PALG:

HFP57_16695

SAND:

H3309_14800

POQ:	KZX46_11635

PMEA:

KTC28_17240

ELQ:	Ga0102493_111749

ERK:	CD351_07815

PNS:	A9D12_09050

ERQ:	PS060_10460 PS060_15545

PORL:

BG023_111318

PHZ:	CHX26_07195

POT:	E2E27_15415

PORC:

CBR61_06725

STEL:

STAQ_38470(crt)

ABS:	AZOBR_160075

ABQ:	ABAZ39_03340

ABF:	AMK58_10665

AZT:	TSH58p_14860

AZZ:	DEW08_10205

AARE:

D3093_05870

DMP:	FAK_14930 FAK_16740(yngF)

TMV:	OH491_06285

SCHL:

QJS52_22405

CTM:	Cabther_B0610

CVL:	J8C06_12460

CHLO:

J8C02_11660

LUB:	TBR22_A09330 TBR22_A49180

GGR:	HKW67_05055

PSPC:

Strain318_000600

CXI:	ABWH99_16230

TPEL:

P0M28_07795

ZGA:	ZOBELLIA_1046(paaF)

TAY:	JJL45_12040

CTS:

Ctha_1050

BASB:

M662_15040

HSHI:

MUO14_22705

FEC:	QNH15_23765

SCIB:

HUG20_01415

SCIA:

HUG15_02435

NCM:	QNK12_18795

CTHU:

HUR95_12550

FHL:	OE105_10870

DOM:	RRU94_07805 RRU94_25040

BBE:	BBR47_38620

BFM:	BP422_14620

BAGR:

BA6348_11805

BCHS:

JNE38_19600

BCOP:

JD108_08410

BPAB:

PSE45_17820

BHUI:

LOK74_05175

BBOR:

RFB14_09810

BRUM:

NDK47_09780

BREH:

HP435_18340

ASED:

IRT44_18580

ASOC:

CB4_03834(acs)

ATHE:

K3F53_12240

AUD:	PO771_16055

ANEU:

PP175_13385

CHEB:

HH215_01750

AACO:

K1I37_02730

PSHE:

QWY16_14900

STRB:

QWT68_03865

SJT:	PGH26_08765

SPOH:

GGGNBK_15470

LFB:	C1X05_11400

PABS:

JIR001_20550

INT:	RX717_03505

CMIC:

caldi_21510

SSID:

SPSIL_024010(crt_2)

MSIM:

MSIM_34110

MSAK:

MSAS_45100

MBRD:

MBRA_36960

MSPG:

F6B93_09875

MPAA:

MKK62_25705

MYJ:	BCA37_31005

MNE:	D174_05105

MYN:	MyAD_04995

MHOL:

K3U96_16025 K3U96_21285

MBUG:

MU0053_003115 MU0053_004880

MPAK:

MIU77_09260

MHER:

K3U94_12260

MVM:	MJO54_12195

MKK:	MU0083_002026

RKO:	JWS14_47335

RGO:	KYT97_21365

RHOH:

CPI83_27150

RHOX:

RBB84_02215

RHJS:

OYT95_22345

PDEF:

P9209_05995

PSOW:

ABI214_16045

TSD:	MTP03_14810

SCAD:

DN051_38405

SLON:

LGI35_42210

STSD:

HEP87_55520

MLIY:

RYJ27_02180

PSAI:

C3B54_111272

PHRZ:

QN084_20780

SPUE:

AB5L97_01075 AB5L97_03070

NOCL:

KM427_04430

AMAZ:

LUW76_21845

ACIR:

OG979_14750

SPIQ:

OHA34_29380

ACTQ:

OG417_26385

AMQ:	AMETH_4550(paaG)

AACD:

LWP59_05945 LWP59_12750

ARHD:

VSH64_22125

PSEA:

WY02_09185

PSEQ:

AD006_31800

PECQ:

AD017_28325

PSDS:

K1T35_10780 K1T35_45240

KUT:	JJ691_46200

ACTY:

OG774_14130

MICF:

QQG74_13390

ACTE:

ACTI_45900

DACT:

KZZ52_16285

BALA:

DSM104299_01578(echA8_2) DSM104299_01953 DSM104299_04760(echA8_5)

PBAJ:

LRS13_12985

PARN:

NBH00_05565 NBH00_06975

PARQ:

DSM112329_01413(echA8_1) DSM112329_01682(menB_2) DSM112329_04285(paaF)

TALU:

JDY09_03435 JDY09_08375

LEPT:

JVX88_12065

RRS:	RoseRS_3202

RCA:

Rcas_2930

CAU:

Caur_0613

CHL:	Chy400_0662

CAG:

Cagg_3394

TFLA:

O0235_08600

PMET:

G4Y79_13175

MJK:	N2V74_00065 N2V74_05785

HALX:

M0R89_21400

HAKZ:

J0X25_09315

NAY:	HYG81_22555

NOU:	Natoc_3706

NARA:

QQ977_05470 QQ977_05545

MELU:

MTLP_03440

TAC:

Ta0121

FAC:	FACI_IFERC01G0358

FAI:

FAD_1277

STO:

STK_15160

SOH:	D1869_08510

SJV:	SJAV_24900

SSO:	SSO0654(paaF-2)

SOL:

Ssol_1713

SSOA:

SULA_1740

SSOL:

SULB_1741

SSOF:

SULC_1739

SSHI:

J5U23_00433 J5U23_02754

SCAS:

SACC_03270

SIS:	LS215_1590

SIA:	M1425_1482

SIM:	M1627_1597

SID:

M164_1479

SIY:	YG5714_1486

SIN:	YN1551_1350

SII:

LD85_1689

SIH:

SiH_1448

SIR:

SiRe_1359

SIC:

SiL_1361

SULA:

BFU36_02775

SULE:

GFS03_08480

SAI:	Saci_1633(paaF)

SACN:

SacN8_07925

SACR:

SacRon12I_07935

SACS:

SUSAZ_07730

SULO:

GFS33_00250 GFS33_04315

SULL:

EWF20_09680

MSE:

Msed_2001

MEMJ:

MJ1HA_2269

MCN:

Mcup_0286

MHK:	DFR87_08490

MPRU:

DFR88_08165

MTEN:

GWK48_03830

MJN:	MjAS7_0302

AHO:

Ahos_1095

AMAN:

B6F84_09545

ABRI:

DFR85_09170

ASUL:

DFR86_08230

AAMB:

D1866_00345

ACIH:

HS5_24900

SACD:

HS1genome_0093

SAZO:

D1868_05545

CSTY:

KN1_27150

STEP:

IC006_1372

SMET:

RQ359_000540

SAHS:

HS7_05880

NMR:

Nmar_1308

NIR:	NSED_07245

NKR:	NKOR_07370

NID:	NPIRD3C_0817(crt)

NIN:	NADRNF5_0652(crt)

NIW:	Nisw_07195

NCL:	C5F47_07030

NOX:	C5F49_07025

NUE:	C5F50_09800

NIP:	NsoK4_01525

NZT:	NZOSNM25_000506

NCT:

NMSP_0386

NIC:	DSQ20_07975

NGA:	Ngar_c21980

NVN:	NVIE_008340

NEV:

NTE_02211

TAA:	NMY3_00896(echA8_1) NMY3_01290(echA8_2)

NFN:	NFRAN_1867(crt)

NCV:

NCAV_1488

NDV:	NDEV_0058(crt) NDEV_1640(hpcD)

CSY:	CENSYa_0166

NBV:

T478_1057

TAH:	SU86_009010

NIU:	DSQ19_03120

LOB:	NEF87_000100 NEF87_002373 NEF87_003343

» show all

Reference

1 [PMID:18079405]

Authors

Berg IA, Kockelkorn D, Buckel W, Fuchs G

Title

A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.

Journal

Science 318:1782-6 (2007)
DOI:10.1126/science.1149976

Sequence

[mse:Msed_2001]

Reference

2 [PMID:19429610]

Authors

Teufel R, Kung JW, Kockelkorn D, Alber BE, Fuchs G

Title

3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales.

Journal

J Bacteriol 191:4572-81 (2009)
DOI:10.1128/JB.00068-09

Sequence

[mse:Msed_2001]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.116

IUBMB Enzyme Nomenclature:

4.2.1.116

ExPASy - ENZYME nomenclature database:

4.2.1.116

BRENDA, the Enzyme Database:

4.2.1.116

LinkDB

DBGET integrated database retrieval system