Entry
Name
3-dehydroshikimate dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
3-dehydroshikimate hydro-lyase
Reaction(IUBMB)
3-dehydro-shikimate = 3,4-dihydroxybenzoate + H2O [RN:
R01627 ]
Reaction(KEGG)
Substrate
3-dehydro-shikimate
Product
Comment
Catalyses an early step in the biosynthesis of petrobactin, a siderophore produced by many bacteria, including the human pathogen Bacillus anthracis. Requires divalent ions, with a preference for Mn2+.
History
EC 4.2.1.118 created 2009
Pathway
ec00400 Phenylalanine, tyrosine and tryptophan biosynthesis
ec01053 Biosynthesis of siderophore group nonribosomal peptides
ec01110 Biosynthesis of secondary metabolites
Orthology
K09483 3-dehydroshikimate dehydratase
K15652 3-dehydroshikimate dehydratase
K26400 3-dehydroshikimate dehydratase
Genes
NTE : NEUTE1DRAFT139743(NEUTE1DRAFT_139743)
SMP : 10802439(SMAC4_07402)
RTHE : 98124019(VTJ83DRAFT_3038)
SSCK : SPSK_00738 SPSK_03395 SPSK_06383
FGR : FGSG_03879 FGSG_05703
FPU : FPSE_06306 FPSE_06597
FPOA : FPOAC1_006301 FPOAC1_008651
FVN : FVRRES_06905 FVRRES_09248
FVR : FVEG_05966 FVEG_09878
NHE : NECHADRAFT_32792 NECHADRAFT_51252 NECHADRAFT_55795 NECHADRAFT_98157
FFC : NCS54_00213100 NCS54_00879700 NCS54_01290900
FKR : NCS57_00208200 NCS57_01454500
FMU : J7337_000084 J7337_004801
TATV : 25785719(TrAtP1_012342)
TASP : 36609566(TrAFT101_010368)
MAW : 19249720(J3458_020252) 90963073(J3458_012629) 90964082(J3458_020709)
MBRN : 26242620(qa-4_1) 26245199(qa-4_0)
PCHM : VFPPC_03049 VFPPC_13531 VFPPC_16764
AMUS : LMH87_005398 LMH87_010127
PLJ : 28892417(PLICBS_000124)
CFJ : CFIO01_01550 CFIO01_09602
CDET : 87949386(CDEST_12886)
ELA : UCREL1_7070 UCREL1_7617
PFY : PFICI_14925 PFICI_15084
BFU : BCIN_06g00850 BCIN_09g06540
PSCO : LY89DRAFT_590036 LY89DRAFT_680001
GLZ : GLAREA_09761 GLAREA_11529
AFM : AFUA_1G11560 AFUA_3G03510 AFUA_3G14820
ACT : ACLA_024080 ACLA_093830
AOR : AO090038000266 AO090103000429 AO090701000638
ANG : An04g08090 An08g03840 An09g03290
AFV : AFLA_005157 AFLA_008753 AFLA_013103
ALUC : AKAW2_30244S AKAW2_30652S AKAW2_40379A
ACHE : ACHE_10204A ACHE_30244A ACHE_80024A
APUU : APUU_30067A APUU_31275A APUU_50614A
PCS : N7525_001281 N7525_003337 N7525_003939 N7525_007849
PDP : PDIP_30910 PDIP_78140
POU : POX_d05551 POX_d06136
BGH : BDBG_00207 BDBG_07998
PNO : SNOG_10412 SNOG_11437
PTRR : 6347417(PtrM4_036220)
ADAC : 96082888(ACET3X_002566)
ZTR : MYCGRDRAFT_67847(QA4)
CBET : CB0940_06133 CB0940_09467
CCAC : CcaHIS019_0500510(CcaverHIS019_0500510)
UMA : UMAG_00025 UMAG_10219
PFP : PFL1_00203 PFL1_00212
SGRA : EX895_000009 EX895_002616 EX895_003153
REE : electrica_02127(lly)
RTG : NCTC13098_03101(hpd)
KIE : NCTC12125_01190(hpd)
GKD : K6Q96_02935 K6Q96_09435
PPG : PputGB1_3362 PputGB1_4069
PPW : PputW619_2225 PputW619_3862
PPUT : L483_10045 L483_24900
PPUN : PP4_12570(quiC) PP4_33440
PPRC : PFLCHA0_c53570(vllY)
PMUD : NCTC8068_04583(lly)
PSV : PVLB_10935 PVLB_18200
PPV : NJ69_03045 NJ69_05765
PEZ : HWQ56_22850 HWQ56_25130
PXA : KSS93_17270 KSS93_22595
PQI : KH389_03370 KH389_07630
PPRG : HU725_012975 HU725_016755
PFAK : KSS94_14360 KSS94_20020
PWY : HU734_011295 HU734_018785
PTAE : NCTC10697_00707(hpd_1)
PSIH : LOY51_11835 LOY51_20220
PKM : PZ739_09875 PZ739_21125
PKK : QQ992_16390 QQ992_21010
PFOU : OZ911_10440 OZ911_21580
PSKP : KU43P_14040(quiC) KU43P_20510
PSIV : LZ023_08420 LZ023_10955
HAAH : HALA3H3_360163 HALA3H3_370003
HABD : OM794_22385 OM794_22465 OM794_22580
HAFN : KF947_10900 KF947_10965
HOL : HORIV_71360 HORIV_71500
HNP : SR894_21845 SR894_21910
HTT : HZS52_05085 HZS52_05175
BPL : BURPS1106A_A0481(hppD)
PLG : NCTC10937_03702(hpd)
MESS : ABSY17_10565 ABSY17_23365
MEAA : ACG873_17055 ACG873_28425
PHT : BLM14_17555 BLM14_19960
RHI : NGR_b00190 NGR_b22740
SFH : SFHH103_01320 SFHH103_06820
SFD : USDA257_c21400(melA1) USDA257_c22230(vllY)
SIX : BSY16_4235 BSY16_5040
SAME : SAMCFNEI73_pA0197(hpd) SAMCFNEI73_pC0017(hpd)
SINO : SS05631_b49810 SS05631_b64220
EAH : FA04_19990 FA04_32170
ECAA : J3R84_21190 J3R84_21420
ENP : JVX98_04505 JVX98_28585
REP : IE4803_CH00102 IE4803_PA00161 IE4803_PD00661
REI : IE4771_CH00102 IE4771_PC00162 IE4771_PE00685
RLU : RLEG12_03540 RLEG12_05885
RPHA : AMC79_PA00327 AMC79_PB00162
RHK : Kim5_CH00101 Kim5_PB00198 Kim5_PD00634
RLN : J0663_21455 J0663_29635
RROS : D4A92_07710 D4A92_21715
RAW : NE851_03425 NE851_34295
NGG : RG540_CH14410 RG540_PA12140
ABAW : D5400_03565 D5400_06995
RBK : E0H22_04410 E0H22_07545
LAP : ACP90_08165 ACP90_08355
PSTG : E8M01_18755 E8M01_24930
PARR : EOJ32_02840 EOJ32_13040
PMAU : CP157_00998(asbF) CP157_03021(hpd_2)
SBIN : SBA_ch2_1470 SBA_ch2_3390
SPYG : YGS_C2P0954 YGS_C2P1150
SPAG : sphantq_03771 sphantq_04117
AHU : A6A40_15765 A6A40_19085
SROE : JL101_010055 JL101_034840
PARH : I5S86_12590 I5S86_22055
PALR : HGI30_15360 HGI30_17840
CCHL : FPL14_04840 FPL14_24360
RPY : Y013_09925 Y013_14045
SLE : sle_11660(sle_11660)
DCO : SAMEA4475696_0797(lly)
NAQU : ENKNEFLB_00210(hpd_1)
MQR : AB3M34_03310 AB3M34_16730
PSDS : K1T35_34470 K1T35_37325
ASIC : Q0Z83_040610 Q0Z83_102970
ACTE : ACTI_07240 ACTI_69250
» show all
Taxonomy
Reference
Authors
Fox DT, Hotta K, Kim CY, Koppisch AT
Title
The missing link in petrobactin biosynthesis: asbF encodes a (-)-3-dehydroshikimate dehydratase.
Journal
Reference
Authors
Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH
Title
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 4.2.1.118
LinkDB
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