| Entry |
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| Name |
2-methylfumaryl-CoA hydratase;
Mcd;
erythro-beta-methylmalonyl-CoA hydrolyase;
mesaconyl-coenzyme A hydratase (ambiguous);
mesaconyl-C1-CoA hydratase
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| Class |
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
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| Sysname |
(2R,3S)-2-methylmalyl-CoA hydro-lyase (2-methylfumaryl-CoA-forming)
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| Reaction(IUBMB) |
(2R,3S)-2-methylmalyl-CoA = 2-methylfumaryl-CoA + H2O [RN: R05076]
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| Reaction(KEGG) |
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| Substrate |
(2R,3S)-2-methylmalyl-CoA [CPD: C06027]
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| Product |
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| Comment |
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
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| History |
EC 4.2.1.148 created 2014
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| Pathway |
| ec00630 | Glyoxylate and dicarboxylate metabolism |
| ec00660 | C5-Branched dibasic acid metabolism |
| ec00720 | Carbon fixation pathways in prokaryotes |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K14449 | 2-methylfumaryl-CoA hydratase |
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| Genes |
| REH: | H16_B0354(h16_B0354) |
| CUH: | BJN34_06615 BJN34_32795 |
| URU: | DSM104443_01837(mch) |
| UPL: | DSM104440_01704(mch) |
| APP: | CAP2UW1_2498 CAP2UW1_2509 |
| RBS: | RHODOSMS8_02865(mch) |
| MAQU: | Maq22A_c24130(meaC) |
| SINL: | DSM14862_02489(mch) |
| SPSE: | SULPSESMR1_00397(mch) |
| RMM: | ROSMUCSMR3_02502(mch) |
| AHT: | ANTHELSMS3_02130(mch) |
| LVS: | LOKVESSMR4R_02800(mch) |
| NAG: | AArcMg_1646 AArcMg_4139 |
| NAN: | AArc1_1993 AArc1_5074 |
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| Reference |
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| Authors |
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G |
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| Title |
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 4.2.1.148 |
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| LinkDB |
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