KEGG   ENZYME: 4.2.1.149
Entry
EC 4.2.1.149                Enzyme                                 
Name
crotonobetainyl-CoA hydratase;
CaiD;
L-carnityl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]
Reaction(IUBMB)
L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O [RN:R10675]
Reaction(KEGG)
R10675
Substrate
L-carnitinyl-CoA [CPD:C20750]
Product
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:C20748];
H2O [CPD:C00001]
Comment
The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].
History
EC 4.2.1.149 created 2014
Orthology
K08299  crotonobetainyl-CoA hydratase
Genes
ECO: b0036(caiD)
ECJ: JW0035(caiD)
ECD: ECDH10B_0037(caiD)
EBW: BWG_0034(caiD)
ECOK: ECMDS42_0029(caiD)
ECOC: C3026_00190
ECE: Z0042(caiD)
ECS: ECs_0039(caiD)
ECF: ECH74115_0040(caiD)
ETW: ECSP_0039(caiD)
ELX: CDCO157_0038
EOI: ECO111_0037(caiD)
EOJ: ECO26_0037(caiD)
EOH: ECO103_0038(caiD)
ECOO: ECRM13514_0037(caiD)
ECOH: ECRM13516_0039(caiD)
ESL: O3K_21365
ESO: O3O_04020
ESM: O3M_21265
ECK: EC55989_0036(caiD)
ECG: E2348C_0037(caiD)
EOK: G2583_0038(caiD)
ELR: ECO55CA74_00180
ELH: ETEC_0036
ECW: EcE24377A_0038(caiD)
EUN: UMNK88_36
ECP: ECP_0036
ENA: ECNA114_0023(caiD)
ECOS: EC958_0170(caiD)
ECV: APECO1_1945(caiD)
ECOA: APECO78_03640
ECX: EcHS_A0040(caiD)
ECM: EcSMS35_0037(caiD)
ECY: ECSE_0037
ECR: ECIAI1_0038(caiD)
ECQ: ECED1_0035(caiD)
EUM: ECUMN_0038(caiD)
ECT: ECIAI39_0037(caiD)
EOC: CE10_0037(caiD)
EBR: ECB_00040(caiD)
ECOB: C3029_03935
EBL: ECD_00040(caiD)
EBE: B21_00039(caiD)
EBD: ECBD_3579
ECI: UTI89_C0042(caiD)
EIH: ECOK1_0035(caiD)
ECZ: ECS88_0039(caiD)
ECC: c0045(caiD)
ELO: EC042_0038(caiD)
ELN: NRG857_00190
ESE: ECSF_0041
ECL: EcolC_3619
EKO: EKO11_3876
EKF: KO11_00180(caiD)
EAB: ECABU_c00410(caiD)
EDH: EcDH1_3563
EDJ: ECDH1ME8569_0035(caiD)
ELU: UM146_22960
ELW: ECW_m0036(caiD)
ELL: WFL_00180(caiD)
ELC: i14_0038(caiD)
ELD: i02_0038(caiD)
ELP: P12B_c0031(caiD)
ELF: LF82_0260(caiD)
ECOL: LY180_00185
ECOI: ECOPMV1_00037(caiD_1)
ECOJ: P423_00180
EFE: EFER_0044(caiD)
EAL: EAKF1_ch1386(caiD)
EMA: C1192_12795
ESZ: FEM44_14675(caiD)
ERUY: OSH18_09425(caiD)
STY: STY0080(caiD)
STT: t0071(caiD)
SEX: STBHUCCB_810
SENT: TY21A_00365
STM: STM0070(caiD)
SEO: STM14_0083(caiD)
SEV: STMMW_00721
SEY: SL1344_0071(caiD)
SEM: STMDT12_C00710
SEJ: STMUK_0071(caiD)
SEB: STM474_0073(caiD)
SEF: UMN798_0078(caiD)
SETU: STU288_00350
SETC: CFSAN001921_17070
SENR: STMDT2_00711(caiD)
SEND: DT104_00711(caiD)
SENI: CY43_00345
SEEN: SE451236_06360
SPT: SPA0071(caiD)
SEK: SSPA0067
SPQ: SPAB_00086
SEI: SPC_0075(caiD)
SEC: SCH_0064(caiD)
SEH: SeHA_C0074
SHB: SU5_0705
SENH: CFSAN002069_08880
SEEH: SEEH1578_09380
SEE: SNSL254_A0074
SENN: SN31241_10490
SEW: SeSA_A0078
SEA: SeAg_B0077
SENS: Q786_00345
SED: SeD_A0076
SEG: SG0073(caiD)
SEL: SPUL_0075(caiD)
SEGA: SPUCDC_0075(caiD)
SET: SEN0071(caiD)
SENA: AU38_00345
SENO: AU37_00345
SENV: AU39_00345
SENQ: AU40_00380
SENL: IY59_00360
SENJ: CFSAN001992_10675
SEEC: CFSAN002050_06800
SEEB: SEEB0189_019035
SEEP: I137_00325
SENB: BN855_730(caiD)
SENE: IA1_00355
SENC: SEET0819_07240
SES: SARI_02930
SBG: SBG_0055(caiD)
SBZ: A464_58
SBV: N643_00265
SALZ: EOS98_18890
SFL: SF0033(caiD)
SFX: S0035(caiD)
SFV: SFV_0030(caiD)
SFE: SFxv_0034(caiD)
SFN: SFy_0042
SFS: SFyv_0046
SFT: NCTC1_00033(caiD)
SSN: SSON_0042(caiD)
SDY: SDY_0058(caiD)
SDZ: Asd1617_00063
SHQ: A0259_04020
CRO: ROD_00381(caiD)
CKO: CKO_03347
CFD: CFNIH1_09890
CBRA: A6J81_13220
CWE: CO701_18230
CYO: CD187_20370
CPOT: FOB25_07465(caiD)
CFQ: C2U38_03510
CSED: JY391_18155(caiD)
CAMA: F384_00195
CAF: AL524_22270
CIF: AL515_04985
CFAR: CI104_04635
CIR: C2U53_04695
CIE: AN232_00010
CPAR: CUC49_00175
CTEL: GBC03_25660(caiD)
CITZ: E4Z61_13405(caiD)
CARS: E1B03_04725(caiD)
CIX: M4I31_19980(caiD)
CIB: HF677_019735(caiD)
CENS: P2W74_19345(caiD)
EBT: EBL_c33170(caiD)
ESC: Entcl_2478
KLE: AO703_09845
ASUB: NLZ15_03185(caiD)
YRE: HEC60_04850(caiD)
KIN: AB182_21550
PDZ: HHA33_24115(caiD)
METY: MRY16398_47870(caiD)
PSGC: G163CM_28670(caiD)
TOE: QMG90_18015(caiD)
EBF: D782_3833
EBC: C2U52_03245
EBB: F652_2813
PMR: PMI2658(caiD)
PMIB: BB2000_2649(caiD)
PVL: AOB99_14525
PVG: CRN77_06400
PHAU: PH4a_04765
PROT: BTA34_14505
PCOL: F1325_16720(caiD)
PCIB: F9282_17065(caiD)
PPEE: I6G31_11885(caiD)
PRG: RB151_007330(caiD)
PHEI: NCTC12003_00741(caiD)
PRQ: CYG50_11980(caiD)
PHAG: PZ638_03525(caiD)
EIC: NT01EI_2956
ETR: ETAE_2660(caiD)
ETD: ETAF_2398
ETE: ETEE_0761
ETC: ETAC_12780
EDW: QY76_07195
EDL: AAZ33_14070(caiD)
EHO: A9798_03970
HAV: AT03_19285
HPAR: AL518_07310
OPO: DSM2777_06100
LPV: HYN51_05060
PRAG: EKN56_12475(caiD)
LRI: NCTC12151_02501(caiD)
SLO: Shew_2672
SSE: Ssed_3225
SPL: Spea_4034
SHL: Shal_0224
SWP: swp_4934
SALG: BS332_05375
SLJ: EGC82_18060
SCAA: TUM17387_35790(caiD)
SCHK: GII14_20250(caiD)
SAEG: K0H80_13645(caiD)
SSPA: K0I31_13890(caiD)
SHNS: K0J45_13735(caiD)
SRHS: K0I63_13820(caiD)
NAX: HC341_11765(caiD)
GAI: IMCC3135_12755(caiD)
MRZ: KDW95_01220(caiD) KDW95_01240(caiD)
BCH: Bcen2424_0177
BXE: Bxe_C0322
MLO: mlr5044
MLN: A9174_02185
MCI: Mesci_0427
MCIC: A4R28_26230
MOP: Mesop_0439
MAM: Mesau_00647
MAMO: A6B35_06080
MESW: A9K65_002145
MESM: EJ066_09365
MESP: C1M53_02975
MHUA: MCHK_6109(caiD)
MJR: EB229_02220
MERD: EB233_02335
MESR: FGU64_17225(caiD)
MOH: IHQ72_01600(caiD)
MMEI: LRP31_01855(caiD)
MESO: BSQ44_22625
HOE: IMCC20628_02948
AAK: AA2016_1883
AMIH: CO731_02018(caiD)
AMIS: Amn_44470 Amn_pb00780
ANJ: AMD1_1892(caiD)
PHT: BLM14_08020
PHYL: HB779_13100(caiD)
NIY: FQ775_14120(caiD)
KMN: HW532_09375(caiD)
SME: SMc01641(caiD)
SMK: Sinme_2233
SMQ: SinmeB_2077
SMX: SM11_chr1006(caiD)
SMI: BN406_02077(caiD)
SMEG: C770_GR4Chr2312
SMEL: SM2011_c01641(caiD)
SMER: DU99_12620
SMD: Smed_2177
RHI: NGR_c21610
SFH: SFHH103_02057(caiD)
SFD: USDA257_c45520(caiD)
SIX: BSY16_546
SAME: SAMCFNEI73_Ch2523(caiD)
SINO: SS05631_c23110
ESJ: SJ05684_c23160
EAK: EKH55_2240
EMX: FKV68_14635(caiD)
ENU: PYH37_004725 PYH37_006071
EGI: PZN02_002440
SKM: PZL22_002589
STEG: QA637_11275
EAD: OV14_3675
EAH: FA04_11405
ECAA: J3R84_11550(caiD)
ENP: JVX98_08290(caiD)
RET: RHE_PC00129
REL: REMIM1_PB00143(caiD)
REP: IE4803_PD00564(caiD)
REI: IE4771_PE00579(caiD)
RLE: pRL100378
RLT: Rleg2_4496
RLG: Rleg_6427
RLB: RLEG3_02200
RLU: RLEG12_05430
RTR: RTCIAT899_PC04720
RGA: RGR602_PC01930(caiD)
RHN: AMJ98_PB00186(caiD)
RPHA: AMC79_PA00228(caiD)
RHX: AMK02_PB00200(caiD)
RHK: Kim5_PD00537(caiD)
REZ: AMJ99_PA00186(caiD)
RJG: CCGE525_28950
RHR: CKA34_20740
RAD: CO657_34200
RII: FFM53_035785(caiD)
RHID: FFM81_022455(caiD)
RBQ: J2J99_26490(caiD)
RLN: J0663_29190(caiD)
RBAN: J2J98_28810(caiD)
RRG: J3P73_33665(caiD)
RLS: HB780_06655(caiD)
RAW: NE851_06410
RSUL: N2599_20995
RLW: RlegWSM1455_33810(caiD)
ARA: Arad_9264
RBW: RLCC275e_32505(caiD)
NEN: NCHU2750_44880(caiD)
NPM: QEO92_29790
SHZ: shn_12110
SZO: K8M09_10840(caiD)
SOJ: K6301_09590(caiD)
SSUM: Q9314_17055 Q9314_27200
OIN: IAR37_19850(caiD) IAR37_19855(caiD)
BIC: LMTR13_25655
BXN: I3J27_33855(caiD)
JAV: OXU80_25065 OXU80_25070
NOH: G5V57_30520(caiD)
LAP: ACP90_08775
LABR: CHH27_11740
LABP: FJ695_03415(caiD)
LABT: FIU93_14330(caiD1)
LAGG: B0E33_20850
PAQT: E8L99_09250 E8L99_09290
SIL: SPO2706(caiD-1) SPOA0285(caiD-2)
SIT: TM1040_2793
RUA: D1823_20420
RUT: FIU92_19795(caiD3)
RCON: K3740_22445(caiD)
JAN: Jann_3824
RDE: RD1_0613(caiD)
RLI: RLO149_c000760(caiD)
RPON: G3256_17965(caiD)
PGA: PGA1_c34200(caiD)
PGL: PGA2_c32410(caiD)
PGD: Gal_03487
PHP: PhaeoP97_03321(caiD)
PPIC: PhaeoP14_03227(caiD)
PHQ: D1820_12070
OAT: OAN307_c01290(caiD)
OAR: OA238_c47080(caiD)
OTM: OSB_31140(caiD)
OCT: FTO60_02315(caiD)
LMD: METH_20470
LEJ: ETW24_19425(caiD)
LAQU: R2C4_18445(caiD)
LEV: ETW23_19765(caiD)
LCAE: K3721_17955(caiD)
MALG: MALG_01859
YPAC: CEW88_20160
TPRO: Ga0080559_TMP3876
SUAM: BOO69_17795
SULZ: C1J03_22110
SULI: C1J05_06970 C1J05_19880
SULD: B5M07_09545
SPOT: G6548_16195
SMED: JNX03_13670(caiD)
SINL: DSM14862_02686(caiD)
SUAL: KDD17_13815(caiD)
SPSE: SULPSESMR1_03035(caiD)
TOM: BWR18_00715
RID: RIdsm_00642(caiD_1) RIdsm_04076(caiD_5)
ROM: EI983_04465 EI983_14380
ROH: FIU89_03985(caiD)
RPEL: N7U68_13775 N7U68_18635
AHT: ANTHELSMS3_00030(caiD)
THAA: CFI11_00810
MALU: KU6B_41080(caiD)
LALG: LentiSH36_02634(caiD)
TRY: QF118_10390
PLCG: RVY76_15160
RMAI: MACH21_08190
PAMI: JCM7686_pAMI6p079
PKD: F8A10_13515(caiD)
PMEH: JWJ88_12580(caiD)
PSAP: JHX88_07315(caiD)
PTP: RCA23_c04470(caiD)
RMB: K529_013695
TSCO: R1T40_16995
DON: BSK21_10365
RBZ: B9057_03240
LVS: LOKVESSMR4R_02271(caiD)
GFU: KM031_05375(caiD)
SALO: EF888_13845
SEDI: EBB79_11295 EBB79_22480
PPSO: QPJ95_22125
PSEB: EOK75_06680(caiD) EOK75_14575(caiD)
PAED: G5B38_05425(caiD) G5B38_10250(caiD)
PAMO: BAR1_01805
PALW: PSAL_036230(caiD)
CACT: HZ995_05560(caiD)
THAS: C6Y53_14720(caiD)
HDH: G5B40_03925(caiD)
GCE: KYE46_03995(caiD)
NSM: JO391_19410(caiD)
ACRO: K3J57_14715(caiD)
AALK: LGT41_0007670
AMYL: QBD29_17020
NDR: HT578_01825
SAL: Sala_1808
SPHK: SKP52_16250
SPHP: LH20_03580
SMAG: AN936_15205 AN936_15975
SMAZ: LH19_02315 LH19_03080
STER: AOA14_11420
SGI: SGRAN_3644(caiD2)
SPHQ: BWQ93_10915
SPHO: C3E99_13590
SPHX: E5675_04315
SINA: KNJ79_12600
SPHU: SPPYR_2860(caiD)
SRAD: LLW23_06505
HTQ: FRZ44_11750(caiD) FRZ44_19970(caiD) FRZ44_47680
HADH: FRZ61_11970(caiD) FRZ61_27270(caiD) FRZ61_44380(caiD) FRZ61_45410
NACI: NUH88_15650
DMP: FAK_17950(caiD)
PAUU: E8A73_006725
BFD: NCTC4823_03672(caiD)
MPA: MAP_2645c(echA1)
MAO: MAP4_1173
MAVI: RC58_05820
MAVU: RE97_05815
MAV: MAV_1277 MAV_2597
MIT: OCO_11860 OCO_13790
MIA: OCU_11810 OCU_14260
MID: MIP_01900
MYO: OEM_12000
MCHI: AN480_06995
MIR: OCQ_11880 OCQ_28700
MMAL: CKJ54_05755
MMAN: MMAN_28130 MMAN_41980
MSA: Mycsm_04989
MUL: MUL_0972(echA1_1)
MMI: MMAR_4317(echA1_1)
MMAE: MMARE11_41310(echA1_1)
MLI: MULP_04515(echA1_1)
MPSE: MPSD_44540
MSHO: MSHO_17550
MMC: Mmcs_4079
MKM: Mkms_4155
MJL: Mjls_4093 Mjls_4309
MMM: W7S_05790
MKN: MKAN_07490
MYV: G155_22570
MYE: AB431_06615
MDX: BTO20_08550
MSHG: MSG_03869
MFJ: MFLOJ_47970
MSTO: MSTO_52030
MSIM: MSIM_37940
MSAK: MSAS_21500
MKU: I2456_20315
MLW: MJO58_21180
MXE: MYXE_14510
MNV: MNVI_05690
MPAG: C0J29_23630
MNM: MNVM_07160
MGOR: H0P51_21965
MCOO: MCOO_19830
MBAI: MB901379_03773(caiD_4)
MSEO: MSEO_26470 MSEO_30240
MHEK: JMUB5695_01387
MGAU: MGALJ_29570
MLJ: MLAC_07400
MBRD: MBRA_27910
MSHJ: MSHI_03510
MMAM: K3U93_18710
MSPG: F6B93_17255
MOT: LTS72_03700
MPAA: MKK62_05955
MKY: IWGMT90018_49370
MADI: A7U43_09520
MWU: PT015_11425
MSM: MSMEG_5198
MSG: MSMEI_5063
MSB: LJ00_25710
MSN: LI99_25715
MSH: LI98_25720
MVA: Mvan_4588
MGI: Mflv_2117
MSP: Mspyr1_15440
MCB: Mycch_4000
MNE: D174_21215
MYN: MyAD_20805
MFT: XA26_46280
MPHL: MPHLCCUG_04147(caiD_3)
MVQ: MYVA_4366
MLL: B1R94_06555
MRH: MycrhN_3594
MTHN: 4412656_03465(caiD_7)
MHAS: MHAS_02938(caiD_1)
MDU: MDUV_01330 MDUV_19620 MDUV_30990
MCHT: MCHIJ_25860
MDR: MDOR_28750
MAUU: NCTC10437_04319(caiD_4)
MMAG: MMAD_42460
MMOR: MMOR_19880
MFX: MFAL_38130
MAIC: MAIC_43390
MIJ: MINS_38220
MALV: MALV_21610 MALV_48800
MTY: MTOK_04080
MPSC: MPSYJ_22590
MARZ: MARA_54590
MGAD: MGAD_52890
MHEV: MHEL_09540
MSAR: MSAR_27290
MANY: MANY_26590
MAUB: MAUB_43890
MPOF: MPOR_46530
MPHU: MPHO_25530
MMUC: C1S78_005580
MMAT: MMAGJ_05020
MBOK: MBOE_27610 MBOE_59020
MFG: K6L26_09210
MSEI: MSEDJ_54650
MFLV: NCTC10271_01151(caiD_4)
MCEE: MCEL_44570
MBRM: L2Z93_000833
MMON: EWR22_21015 EWR22_22095
MGO: AFA91_14630
MHOL: K3U96_06215
MSEN: K3U95_21655
MPAE: K0O64_06195
MRF: MJO55_20740
MDF: K0O62_22210
MCRO: MI149_06905
MGRO: FZ046_26260
MKR: MKOR_40760
MPAK: MIU77_04375
MJD: JDM601_1118(echA1_1)
MTER: 4434518_01077(echA1_1)
MMIN: MMIN_27540
MHIB: MHIB_06500
MHER: K3U94_06205
MVM: MJO54_06375
NFA: NFA_29420(echA13)
NFR: ERS450000_01146(caiD_2)
NOZ: DMB37_01565
NAD: NCTC11293_03570(caiD_6)
ROP: ROP_71000
RCR: NCTC10994_01638(caiD_5)
RTM: G4H71_12225
RGO: KYT97_15210
ROZ: CBI38_34350
RGOR: NMQ04_04900
RHOP: D8W71_01680
GOR: KTR9_2790
GOM: D7316_02519(dpgD_2)
GJI: H1R19_06265
GHN: MVF96_20695
DKN: NHB83_17000
SCAD: DN051_01780
STUB: MMF93_31390(caiD)
FSB: GCM10025867_10950
LDN: H9L06_00835
GMN: GMOLON4_1235(caiD)
NOY: EXE57_03890(caiD)
NANO: G5V58_03210(caiD)
SGRG: L0C25_08155
ARHD: VSH64_12540
TFLA: O0235_12565
 » show all
Reference
1  [PMID:11409545]
  Authors
Engemann C, Elssner T, Kleber HP
  Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
  Journal
Arch Microbiol 175:353-9 (2001)
DOI:10.1007/s002030100272
  Sequence
[ag:CAD48582]
Reference
2  [PMID:11551212]
  Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
  Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
  Journal
Biochemistry 40:11140-8 (2001)
DOI:10.1021/bi0108812
  Sequence
[eco:b0036]
Reference
3  [PMID:15731894]
  Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
  Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
  Journal
Arch Microbiol 183:176-89 (2005)
DOI:10.1007/s00203-005-0760-2
  Sequence
[ag:CAD48582]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.149
IUBMB Enzyme Nomenclature: 4.2.1.149
ExPASy - ENZYME nomenclature database: 4.2.1.149
BRENDA, the Enzyme Database: 4.2.1.149
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