KEGG   ENZYME: 4.2.1.152
Entry
EC 4.2.1.152                Enzyme                                 
Name
hydroperoxy icosatetraenoate dehydratase;
epidermal lipoxygenase-3 (ambiguous);
eLOX3 (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
hydroperoxyicosatetraenoate hydro-lyase (oxoicosatetraenoate-forming)
Reaction(IUBMB)
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O [RN:R10761]
Reaction(KEGG)
R10761 > R13044 R13045
Substrate
hydroperoxyicosatetraenoate [CPD:C20832]
Product
oxoicosatetraenoate [CPD:C20833];
H2O [CPD:C00001]
Comment
Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) [2]. The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.
History
EC 4.2.1.152 created 2014
Pathway
ec00590  Arachidonic acid metabolism
Orthology
K18684  hydroperoxy icosatetraenoate dehydratase/isomerase
Genes
HSA59344(ALOXE3)
PTR455102(ALOXE3)
PPS100972484(ALOXE3)
GGO101143347(ALOXE3)
PON100451294(ALOXE3)
NLE100586195
HMH116458633(ALOXE3)
MCC716840(ALOXE3)
MCF102115677(ALOXE3)
MTHB126939828
MNI105473880(ALOXE3)
CSAB103242340(ALOXE3)
CATY105581968(ALOXE3)
PANU101015325(ALOXE3)
TGE112609608(ALOXE3)
MLEU105549852(ALOXE3)
RRO104661680(ALOXE3)
RBB108514454(ALOXE3)
TFN117067738(ALOXE3)
PTEH111527078(ALOXE3)
CANG105523640(ALOXE3)
CJC100410917(ALOXE3)
SBQ101049071(ALOXE3)
CIMI108306542(ALOXE3)
CSYR103263442(ALOXE3)
MMUR105877288(ALOXE3)
LCAT123650919(ALOXE3)
PCOQ105819408(ALOXE3)
OGA100958391(ALOXE3)
MMU23801(Aloxe3)
MCAL110305086(Aloxe3)
MPAH110332034(Aloxe3)
RNO287424(Aloxe3)
MCOC116078132(Aloxe3)
ANU117710950(Aloxe3)
MUN110551722(Aloxe3)
CGE100754187(Aloxe3)
MAUA101838996(Aloxe3)
PROB127219082(Aloxe3)
PLEU114693158(Aloxe3)
MORG121457114(Aloxe3)
MFOT126514115
AAMP119812707(Aloxe3)
NGI103752100(Aloxe3)
HGL101709560(Aloxe3)
CPOC100731721(Aloxe3)
CCAN109693886(Aloxe3)
DORD105983368(Aloxe3)
DSP122100410(Aloxe3)
PLOP125365465(Aloxe3)
NCAR124980809
MMMA107158021(Aloxe3)
OCU100342323
OPI101524657(ALOXE3)
TUP102493953(ALOXE3)
GVR103597843(ALOXE3)
CFA489487(ALOXE3)
CLUD112647409(ALOXE3)
VVP112924867(ALOXE3)
VLG121500136(ALOXE3)
NPO129497164(ALOXE3)
AML100479842(ALOXE3)
UMR103660488(ALOXE3)
UAH113271146(ALOXE3)
UAR123792055(ALOXE3)
ELK111161151
LLV125088017
MPUF101671256(ALOXE3)
MNP132003528(ALOXE3)
MLK131816500(ALOXE3)
NVS122906730(ALOXE3)
ORO101371570(ALOXE3)
EJU114225375(ALOXE3)
ZCA113939629(ALOXE3)
MLX118000045(ALOXE3)
NSU110584484(ALOXE3)
LWW102728543(ALOXE3)
FCA101101515(ALOXE3)
PYU121015957(ALOXE3)
PCOO112857009
PBG122484921(ALOXE3)
PVIV125152155(ALOXE3)
LRUF124519582
PPAD109245905(ALOXE3)
PUC125917697 125917698
AJU106972447
HHV120231419(ALOXE3)
BTA517001(ALOXE3)
BOM102276466(ALOXE3)
BIU109573427(ALOXE3)
BBUB102408112(ALOXE3)
BBIS104990749(ALOXE3)
CHX102173227(ALOXE3)
OAS101121693(ALOXE3)
BTAX128064853(ALOXE3)
ODA120866020(ALOXE3)
CCAD122445980(ALOXE3)
MBEZ129543367(ALOXE3)
SSC100511043(ALOXE3)
CFR102517831(ALOXE3)
CBAI105077530(ALOXE3)
CDK105103062
VPC102528339(ALOXE3)
BACU102998369(ALOXE3)
BMUS118886084
OOR101281475(ALOXE3)
DLE111185793(ALOXE3)
PCAD102992018(ALOXE3)
NASI112401885(ALOXE3)
ECB100062351(ALOXE3)
EPZ103564279(ALOXE3)
EAI106844234(ALOXE3)
MYB102250064(ALOXE3)
MYD102763007(ALOXE3)
MMYO118672110(ALOXE3)
MLF102435376(ALOXE3)
PKL118726788
EFUS103296881(ALOXE3)
MNA107544535(ALOXE3)
DRO112308514(ALOXE3)
SHON118974644
AJM119049055(ALOXE3)
PDIC114515164
PHAS123809290(ALOXE3)
MMF118634238(ALOXE3)
PPAM129072170
HAI109395102(ALOXE3)
RFQ117013451(ALOXE3)
PALE102893198(ALOXE3)
PGIG120589697(ALOXE3)
PVP105291240(ALOXE3)
RAY107515646(ALOXE3)
MJV108409698 118973972
TOD119232234(ALOXE3)
SARA101554994(ALOXE3)
SETR125997994
LAV100671875(ALOXE3)
TMU101348431
ETF101660496
DNM101433166(ALOXE3)
MDO100014706(ALOXE3)
GAS123243987(ALOXE3)
SHR100934620(ALOXE3)
AFZ127560852
PCW110194412
OAA100078389(ALOXE3)
GGA425997(ALOX15B)
CJO107314128
NMEL110401191
ACYG106049819
CATA118261419
TGU115493074
LSR110480955 110482566
SCAN103824640
PMOA120503612
OTC121337727
PRUF121357289
GFR102043765(ALOXE3)
FAB101818404(ALOXE3) 101820391
OMA130260841
PHI102104136 102111055
PMAJ107198965
CCAE111942155
CCW120412173
CBRC103625181
ETL114071482
ZAB102064963
SVG106863902
MMEA130586382
HRT120764546
NNI104022923
PCRI104030873
PLET104621328
TALA116963178
ACHC115337612 115337613
HLE104834235 104836076
AGEN126037044
GCL127028893
CCRI104154924
LDI104350827
ACAR114818373
AVIT104280152
AAM106484843 106500300(ALOXE3)
AROW112962918 112972483
SCAM104142868
ASN102375634 102379888
AMJ102558959(ALOXE3) 102564354
PSS102450844
CMY102946032 102946254 114018354 119564589 119564653
CCAY125628546 125628548
DCC119849240 119849392
CPIC101934678 101943453 101947851 101948565 101952038(ALOX12B)
TST117869933 117869934 117869955 117870000 117870107
CABI116839650 116839651
MRV120381499 120381501 120381799 120381807 120381808 120381913
ACS100557249 100557446 100557643 100557840 100558037 100558230 100558427 100558626
ASAO132777569 132777570 132777571 132777572 132777573 132777574 132777575 132777576 132779184 132779297
PVT110071007 110071137 110071138 110087753 110088257 110088279 110088292
SUND121933934 121934888 121934889 121935423 121935497
PBI103062621 103064438 107326021 112540458(ALOXE3)
PMUR107297127 107297128 107297129 107297130 107297132
CTIG120305736 120305737 120305739 120305742
PGUT117657096 117660229 117671250 117671251 117671255
APRI131196695 131196696 131196697 131196698
PTEX113451314 113451315
NSS113426537 113426539 113426540
VKO123016598 123016642 123016652
PMUA114581886 114581887 114582384 114582617 114583620
PRAF128399234 128400134 128400135 128400136 128400137
ZVI118094283 118094804 118094805 118094999
HCG128329520 128331538 128331593 128331594
GJA107115224 107120726 107120728
STOW125444427 125444768 125444782 125445316
EMC129338609 129338691 129338760 129338828 129338873 129339997
XLA108707611 108707612(alox15b.L) 108707613 108708795 108708797 108708798 734312(alox12b.S)
XTR100494252(alox15b) 100494678 100496875 116408939 548458(alox12b)
NPR108796083 108796085 108796093 108799096
RTEM120928225 120929270 120929271 120929272
BGAR122924120
MUO115457882
GSH117349536(ALOXE3)
DRE794132(si:dkey-17e16.9)
SRX107756080
SANH107673846 107699996
SGH107548144
CCAR109063989
CAUA113038569
CGIB127985407(si:dkey-17e16.9)
PTET122326467(si:dkey-17e16.9)
LROH127152701(si:dkey-17e16.9)
OMC131528522(si:dkey-17e16.9)
RKG130072112(si:dkey-17e16.9)
MAMB125253227(si:dkey-17e16.9)
CIDE127504177(si:dkey-17e16.9)
MASI127428480(si:dkey-17e16.9)
MANU129423478(si:dkey-17e16.9)
EEE113590746
TRU101063080 101064929 101065403
TFS130516479 130516481
TNGGSTEN00023059G001 GSTEN00033460G001
LCO104926147 104928887 104939860 109137379
NCC104945566 104965473(b3gntl1)
TBEN117470014 117470056 117470086 117470100 117492281 117492340 117492376 117492377 117492378 117493656
CGOB115003520 115003907 115003908
PGEO117439535 117439538 117439644 117440207
GACU117537535 117537537 117551647 117551648 117551750
EMAC134876478 134876692
ELY117250386 117270324 117270482 117270947 117270948 117270949 117271028 117271031 117271148
EFO125896652 125896654 125896655 125896673 125897371 125897569 125897570 125897571
PLEP121955229 121955231 121955232
SLUC116066135 116066173
ECRA117961557(si:dkey-17e16.9)
ESP116705832
AFB129107577 129107578 129107580
CLUM117727281 117727283 117727394 117727632
PSWI130202224 130202225 130202640 130203015
SCHU122863174 122863176
CUD121521149 121521554
ALAT119012490 119012492 119012534 119012535
MZE101465465 101468181 101476255 101480284 112429854 112434905
ONL100689972 100691581 100694795 100701198 100702747 100706043 100706304 109194246 109194292
OAU116309996(zgc:152891) 116310798(si:dkey-17e16.9) 116327369 116327377 116327379 116329960 116330064 116330065 116330066 116330067
OLA101165367 101168429
OML112158170
CSAI133464619
XMA102225361 102225623
XCO114144052 114158302
XHE116733716 116733717
PRET103457519 103457522 103457523
PFOR103134921 103134944
PLAI106958151 106959115
PMEI106928763 106928764
GAF122825686
PPRL129352438 129352439
CVG107086029
CTUL119795946
NFU107374447
KMR108228955(zgc:152891) 108240061
ALIM106517057 106519785
NWH119418224
AOCE111570537 111570984 111575944
MCEP124999076 124999077 124999078 124999079 124999091
CSEM103381087 103393539 103393540
POV109636209
SSEN122783964 122783965 122783967
HHIP117758044 117758046 117758047 117758048 117758050
HSP118099179 118099180 124851192 124851193 124851194
SMAU118289740 118289741
LCF108880880(si:dkey-17e16.9) 108891324(zgc:152891)
SDU111236613 111236740 111236750 111236756
SLAL111653009 111655584 111655591 111655606
XGL120788899(si:dkey-17e16.9) 120802480(zgc:152891)
HCQ109527797
SSCV125990038 125990039
SBIA133496366 133496367 133496972
PEE133416907
PTAO133468118 133468273
BPEC110155993 110156036
MALB109955487
SJO128377259
SASA100194745(loxe3) 106593018 106602265 106602285 106607993 106607999 106610314 106610332
STRU115179646 115179723 115206553
OTW112217364 112217711 112226389
OMY110491145 110497317 110514910 110517354 110521065 110522385 110534564 118941428 118941429
OGO123995239 123995544
ONE115139270
OKI109866271
OKE118372343 118383601
SALP111972916 111973191
SNH120019324 120019325
CCLU121549254
ELS105010254 105014517 105020997 105029908 114830628
SFM108925302
AANG118224951 118225212
LOC102692216 102697403
PSPA121319168 121319184
ARUT117396925
PSEX120525109 120526473
LCM102352103
HOC132835331
LERI129693449 129694912 129715533 129716169
LPIC129283057
PJA122248285
PCHN125029265
CQD128686355
HAZT108675024
VDE111245717
VJA111262905
UDV129231011
LPOL106458610 106464143
BGT106071023 106071096
CRG105319482
CANU128184095
MYI110442376
PMAX117321221
MMER123541244 123551042 123551206 123551207
RPHI132742009 132759083 132759087
DPOL127849020 127849037 127850057 127857276 127859244
ATEN116292301
XEN124451873
HSY130621681
CICCICLE_v10027295mg
SLY101244897
 » show all
Reference
1  [PMID:12881489]
  Authors
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR
  Title
The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase.
  Journal
Proc Natl Acad Sci U S A 100:9162-7 (2003)
DOI:10.1073/pnas.1633612100
  Sequence
[hsa:59344]
Reference
2  [PMID:17045234]
  Authors
Yu Z, Schneider C, Boeglin WE, Brash AR
  Title
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.
  Journal
Arch Biochem Biophys 455:188-96 (2006)
DOI:10.1016/j.abb.2006.09.002
  Sequence
[hsa:59344] [mmu:23801]
Reference
3  [PMID:20921226]
  Authors
Zheng Y, Brash AR
  Title
Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids.
  Journal
J Biol Chem 285:39866-75 (2010)
DOI:10.1074/jbc.M110.155374
  Sequence
[hsa:59344]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.152
IUBMB Enzyme Nomenclature: 4.2.1.152
ExPASy - ENZYME nomenclature database: 4.2.1.152
BRENDA, the Enzyme Database: 4.2.1.152
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