KEGG   ENZYME: 4.2.1.153
Entry
EC 4.2.1.153                Enzyme                                 
Name
3-methylfumaryl-CoA hydratase;
Meh;
mesaconyl-C4-CoA hydratase;
mesaconyl-coenzyme A hydratase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)
Reaction(IUBMB)
(S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O [RN:R09282]
Reaction(KEGG)
R09282
Substrate
(S)-citramalyl-CoA [CPD:C01011]
Product
3-methylfumaryl-CoA [CPD:C18323];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
History
EC 4.2.1.153 created 2014
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K09709  3-methylfumaryl-CoA hydratase
Genes
SEMSTMDT12_C09120
SEJSTMUK_0862
SETUSTU288_10120
SETCCFSAN001921_12720
SENICY43_04590
SEENSE451236_10320
SPQSPAB_02637
SEISPC_0855
SECSCH_0850
SENHCFSAN002069_04565
SEEHSEEH1578_13675
SENNSN31241_19100
SEWSeSA_A1008
SELSPUL_2112
SEGASPUCDC_2098
SENAAU38_04165
SENOAU37_04150
SENVAU39_04155
SENQAU40_04625
SENLIY59_04225
SENJCFSAN001992_07155
SEEBSEEB0189_015070
SEEPI137_09615
SENBBN855_8360
SENEIA1_04360
SESSARI_02574
PGELG71_13515
PSETTHL1_4235
PLALFXN65_13735
AEIAOY20_13435
AUGURS_0098
ALKMNKI27_11375
ASEMNNL22_07730
STAWNCG89_13770
THIPN838_00845
SHAILMH63_18350
GAIIMCC3135_16895(meh)
HAKKO116_00799
ADIB5T_00173
AXEP40_00850
APACS7S_00615
OMEOLMES_2171
SDFACG33_03905
RPJN234_09420 N234_24295 N234_29230
REHH16_A2424(h16_A2424) H16_B0679(h16_B0679)
CNCCNE_2c06310 CNE_2c17680 CNE_BB1p09760
CUHBJN34_24690
REUReut_B3538
RMERmet_3897
CTIRALTA_B0530
CBWRR42_s3314
CGDCR3_4507(meh)
CCUPBKK81_18890 BKK81_30850 BKK81_32480
CUPBKK80_23050 BKK80_23835 BKK80_25505
CUUBKK79_28325 BKK79_29120 BKK79_31380
CPAUEHF44_20345
COXE0W60_08355 E0W60_17875 E0W60_33285
CCAMM5D45_27155
CCAXKZ686_19445
CUKKB879_14100 KB879_20875
CNANA2G96_23445
BTDBTI_2432
BOKDM82_902
BOCBG90_33
BUUWS70_10445
BHGI6G56_08985
BUDAQ610_11350
BVIBcep1808_5396
BVEAK36_3488
BURBcep18194_C7300 Bcep18194_C7720
BCMBcenmc03_6655 Bcenmc03_6893
BCHBcen2424_6175
BCJBCAS0019
BCENDM39_6413 DM39_6676
BCEWDM40_5520
BCEOI35_7018
BAMBamb_6271
BACBamMC406_5975
BCEDDM42_6390
BCEPAPZ15_33395
BPYRABD05_34465
BCONNL30_33755 NL30_35120
BUBBW23_6273
BSEMWJ12_18985
BPSLWS57_16945 WS57_18520
BMECWJ16_18905 WJ16_19805
BSTGWT74_17805
BSTLBBJ41_34375 BBJ41_37990
BARINLX30_34670 NLX30_37340
BAENL3V59_38285 L3V59_39010
BGDbgla_1g16820
BGOBM43_2917
BYIBYI23_C007610 BYI23_D006010
BUEBRPE67_CCDS03790 BRPE67_DCDS07810
BULBW21_2399
BUQAC233_24745
BGPBGL_1c14840
BPLAbpln_1g14540
BURKDM992_35065
BXEBxe_B2585 Bxe_C0575 Bxe_C0656
BXBDR64_4918 DR64_7789 DR64_7871
BGEBC1002_5321 BC1002_5361
BPYBphyt_6604
BUZAYM40_06755 AYM40_33270
BFNOI25_3905 OI25_5158 OI25_7324 OI25_7336 OI25_7419
BCAIK788_0001674
PSPWBJG93_20460 BJG93_29320
PARABTO02_26490
PARBCJU94_30260
PHSC2L64_38455 C2L64_40685
PTERC2L65_34450
PGPCUJ91_18845
PCJCUJ87_29645
PCAFDSC91_002606
PMEGFNZ07_05305
PTROG5S35_09240 G5S35_27045
PGISI6I06_17970
PACPFAZ97_08815
PACSFAZ98_08650 FAZ98_25495 FAZ98_25520
PEWKZJ38_29045
PDIOPDMSB3_0487.1(meh)
PBRYNDK50_34495
PSAAQEN71_39300
PKFRW095_12670
PPAIE1956_08690 E1956_32280
PNUPnuc_1241
PDQCL55_00006440
PTRPDCO17_04260
PANIDCO16_02300
PCOSC2747_03250
PYTPKF023_11790
PIUAOC20_05995
PWUA8O14_06745
PARDDN92_02085
PTXABW99_01565 ABW99_18550
CABASBC2_19170(meh)
TVLFAZ95_32275 FAZ95_35715
BPARBN117_0582
BPABPP0616
BBHBN112_2817
BBRBB0622
BBMBN115_0595
BBXBBS798_0596
BBROBAU06_00055
BFZBAU07_00030
BOHAKI39_00025
BOJCBF45_05140
BGVCAL12_00050
ADYHLG70_00400
PIGEGT29_19990
PACRFXN63_11585
KGYEHF36_05545
PARKLSG25_15045
RFRRfer_3484
RHYRD110_23575
RHFEUB48_08780
RHOBHTY51_17650
POLBpro_0584 Bpro_4554
PNAPnap_2143 Pnap_3808
PVACHC248_01526(meh)
AJSAjs_0119
ACIDCBP33_00605
ACIPCBP36_00655
ACINCBP34_00615
ACISCBP35_18300
ARADKI609_00900
ATEMPQV96_09105
AMONH9L24_14975
VEIVeis_4807
DACDaci_0197
DELDelCs14_0200
DTSBI380_22740
DHKBO996_02000
DLAI6G47_22705
VAPVapar_2026
VPEVarpa_3862
VPDVAPA_1c06610 VAPA_1c21470 VAPA_2c05870
VBOCKY39_21090
VAMC4F17_02325
CTTCtCNB1_0220
CTESO987_01120
CKEB5M06_05515
CSERCCO03_14440
CAQTKAQ61_17040
CODOLAD35_00905
CTEZCT3_00830
ADNAlide_0163 Alide_2927
ADKAlide2_0152 Alide2_1520
RTARta_14200 Rta_16620
OTKC6570_10715
OTDJ1M35_12325
LIHL63ED372_02961
LIMILINBF2_08360
HYBQ5W_20095
HYLLPB072_14645
HYNF9K07_24625 F9K07_27755
HTNKI616_13915
DPYBA022_14250
DIHG7047_08595 G7047_22695 G7047_24165 G7047_26170
DAERH9K75_13280
DRGH9K76_23180
DIADtpsy_0137
MELAC6568_08405
MJELVC68_00530
STHMIS481_02890
ATERMW290_10325 MW290_30855
LCHLcho_0819 Lcho_2415
HSEHsero_2799
HSZACP92_14045
HHTF506_16010
HRBHrubri_2850
HEEhmeg3_12915
HHFE2K99_14680
HFRG5S34_14670
MASWAM586_25995
MENYLSQ66_05930
MLIRLPB04_17565
MFLAGO485_26100
NOKFAY22_02470
GLCJQN73_04420
ACTBRHM62_09755
XYKGT347_01945
XYGR9X41_09330
ETBN7L95_27915
RBUPG1C_11190
URUDSM104443_00819(meh)
ARESIWH25_16380
OTROTERR_27840(meh)
APETToN1_04120 ToN1_05500
AZAAZKH_1921
AZRCJ010_16450 CJ010_17080
AZQG3580_09945
ACOMCEW83_02955
APPCAP2UW1_2504
BPRCD521_0597
BEBABWI17_00520
MCIMesci_6211
MOPMesop_2795
MESWA9K65_031200
MESPC1M53_21180
NIYFQ775_07240
NTUNTH_04506(meh)
MESOBSQ44_23715
CHEAPVE73_18575
SFHSFHH103_02514
SIXBSY16_6076
EMXFKV68_30915
ALFCFBP5473_24785
RIRBN877_p0638
ALEGCFBP4996_29195
REPIE4803_PC00151
REIIE4771_PD00151
RHTNT26_0720
RFVRFYW14_04040
SHZshn_33390
ABAWD5400_02105
BMEBMEII1075
BMELDK63_2183
BMIBMEA_B0168
BMZBM28_B0161
BMGBM590_B0161
BMWBMNI_II0159
BMEEDK62_2093
BMFBAB2_0163
BMBBruAb2_0162
BMCBAbS19_II01550
BAABAA13334_II00475
BABODK55_2161
BABRDO74_2286
BABTDK49_2269
BABBDK48_2531
BABUDK53_2974
BABSDK51_2462
BABCDO78_3183
BMSBRA0167
BSIBS1330_II0164
BSFBSS2_II0158
BSUIBSSP1_II0127
BSUPBSPT1_II0128
BSUVBSPT2_II0128
BSUCBSSP2_II0129
BMTBSUIS_B0170
BSZDK67_2188
BSVBSVBI22_B0163
BSWIY71_09925 IY71_11905
BSGIY72_09665 IY72_11445
BOVBOV_A0148
BCSBCAN_B0167
BSKBCA52141_II0977
BOLBCOUA_II0167
BCARDK60_3043
BMRBMI_II164
BPPBPI_II164
BPVDK65_2305
BCETV910_201037
BCEEV568_201209
BVLBF3285c2_0641
BRUBFS01_11180
BRJBKD03_01610
BIOBR141012304_20027
OPSA8A54_19015
BJAblr7247(blr7247)
BJUBJ6T_21450
BJPRN69_10505
BRABRADO1440
BBTBBta_6665
BRSS23_58710
AOLS58_15660
BRCBCCGELA001_07440
BRADBF49_2777
BICLMTR13_05605
BROBRAD285_0942
BRKCWS35_35360
BOTCIT37_18880
BRQCIT40_05115
BGQX265_30470 X265_39745
BGZXH91_28930 XH91_34300
BBETF8237_09020
BARHWN72_40055 WN72_41405
BVZBRAD3257_1394
BELBE61_32670
BDGLPJ38_11605
BSEPHAP48_0025610
BQBJ4P68_0010440
BSEIKMZ68_05895
BBANJ4G43_011225
BCANBcanWSM471_31805
BAUTQA635_11575
BBRAQA636_10705
BGKIC762_28240
BCOUIC761_29025
BPAHQA639_08775
BXNI3J27_06590
BROSQUH67_07050
BRAZLRP30_08045
RPATX73_008270
RPBRPB_3937
RPCRPC_4267
RPDRPD_3697
RPERPE_4306
RPTRpal_1800
RPXRpdx1_3913
RBKE0H22_07405 E0H22_24955
TRBHB776_15075
TALZRPMA_08005
BVVBHK69_16395
BVESQO058_20600 QO058_24130
BOSBSY19_3911
BOIBLM15_13655
BOFFQV39_06310 FQV39_10050 FQV39_32460
XAUXaut_1345
XDIEZH22_00440 EZH22_12120 EZH22_23005 EZH22_28780
AZCAZC_2508
SNOSnov_0364
ANCGBB76_18375
APOLK9D25_21915
MRDMrad2831_2851
METM446_5229
MNOMnod_6786
MORMOC_3216
MAQUMaq22A_c24950
MPHYMCBMB27_02291
MEEDA075_23495
METXA3862_17540
METIDK427_09375
MTEADK419_27665
MINDmvi_24510
MTADM6G65_16775
MOCBB934_09990
MLGCWB41_06950
CHELAL346_22455
RHZRHPLAN_59150
MMEDMame_00532
AALAIGS74_02985 IGS74_16275
AALMLUX29_18370
JIEOH818_14605
LAPACP90_10505
LABRCHH27_09900
LABTFIU93_16065
LAGGB0E33_22425
SIWGH266_08400
PSTGE8M01_03170
ACUTMRB58_12355 MRB58_13700
CCRCC_1109
CCSCCNA_01166
CHQAQ619_04930
CAUFCSW63_08165
CAULKCG34_02820
PZUPHZ_c2566
TSVDSM104635_00476
SILSPO1598
SITTM1040_3340
RUAD1823_17060
RUTFIU92_14400
RLIRLO149_c031950
DSHDshi_1047 Dshi_2493
OATOAN307_c05440
OAROA238_c01680
OTMOSB_01640
OCTFTO60_00820
LEJETW24_16585
LEVETW23_02345
LCAEK3721_01965
REDroselon_02263
MALGMALG_03764
CONTQ29_18895
YANAYJ57_15860
TPROGa0080559_TMP1645
PABYGa0080574_TMP5123
SUAMBOO69_01195 BOO69_21610
SULZC1J03_21135
SULIC1J05_19140
SMEDJNX03_11990
SUALKDD17_01275 KDD17_12270
SPSESULPSESMR1_03470(meh) SULPSESMR1_04144(meh)
TOMBWR18_13440 BWR18_14695
RMMROSMUCSMR3_02201(meh)
ROKRAK1035_0985
RIDRIdsm_00211 RIdsm_01155 RIdsm_04625
ROMEI983_15855
ROHFIU89_16610 FIU89_18565
RPELN7U68_10220
AHTANTHELSMS3_00805 ANTHELSMS3_05144
SAGUCDO87_11210 CDO87_15520 CDO87_24220
THAACFI11_02310 CFI11_18065
ROTFIV09_02230 FIV09_12810
MALUKU6B_14490 KU6B_52380(meh)
TGLHFZ77_10300 HFZ77_15560
LSALKBK07_02520
LALGLentiSH36_02637
TRYQF118_02305
PLCGRVY76_14510
MARUFIU81_05555
RMAIMACH21_17120(meh)
FYTQF092_04130
PDEPden_0194 Pden_0221 Pden_4111
PYEA6J80_20575
PCONB0A89_09820
PZHCX676_16845
PARUCYR75_12710
PARSDRW48_03075
PSANHGN31_06345
PMEHJWJ88_18455
PSEWJHW44_13855
PSAPJHX88_01625
PFISJHX87_16660
PSTLJHW45_17435
PVERE3U25_08695 E3U25_12535
PAEZPAE61_14115
PDIMPAF18_12440
RSUNHU_02252 NHU_03858
RHMB5V46_01310 B5V46_07925
RHCRGUI_2865
DAAAKL17_1608 AKL17_4341
RBGBG454_05630
SEDIEBB79_09205
PPSOQPJ95_22185
HMLHmaOT1_14850
PSEBEOK75_18775
LITFPZ52_16960
PPRUFDP22_07400
PAEDG5B38_13720
MONG8E03_07240
PAMOBAR1_15750
POZI0K15_19130
PSHQF3W81_18710
PGVSL003B_0531
CACTHZ995_04835
THASC6Y53_15095
HDHG5B40_17340
ACROK3J57_00710
AMYLQBD29_02685
AMAQGO499_02500
LVRT8T21_02560 T8T21_18005
HBCAEM38_02605
ZMOZMO0486
ZMNZa10_0768
ZMMZmob_1013
ZMBZZ6_0779
ZMIZCP4_0797
ZMCA265_00787
ZMRA254_00787
ZMPZymop_0731
NARSaro_3796
NPPPP1Y_AT31363 PP1Y_AT32009
NPNJI59_17590
NORFA702_12975
NGFFRF71_05155
NOGGKE62_08300
NOLNSDW_17000
SALSala_1693
SPHKSKP52_16110
SPHPLH20_14910 LH20_19540
SMAGAN936_15845
SMAZLH19_02445
STERAOA14_14400
SGISGRAN_3004
SPHQBWQ93_19320
SPHOC3E99_10390
SPHXE5675_04465
SINAKNJ79_06720
SPHUSPPYR_0404
SPHDHY78_18250 HY78_30010
RDICMV14_04070
SPHAD3Y57_02040 D3Y57_02185 D3Y57_03950
SLANGV829_02850
SPAPH3Z74_06290
SCHYGVO57_11750
SRADLLW23_04525
SNAPPQ455_08165
SABIPBT88_17720
SCHSphch_0993
SYBTZ53_19650
SPHBEP837_03071
SPHTK426_13805 K426_15975 K426_18725 K426_23319
SYAA6768_05910
SCLOSCLO_1006490
SUFLFIL70_08825 FIL70_14445
SBARH5V43_03380 H5V43_06495
SPPHKFK14_04860
CIJWG74_00625
SPHGAZE99_04460
SFLASPHFLASMR4Y_01388(meh)
SPHYCHN51_00940
SLAAEUU25_00770 EUU25_06485
BLASBSY18_3599 BSY18_3945
BMAAT8S45_12490
SPHJBSL82_08405
ACOBP0Y56_09700
AEPAMC99_02361
ALHG6N82_07875
ARUEQQX03_01005
AMXAM2010_2445
PMASNCF86_13705
ADOA6F68_00853
TFVIDJ81_01935
ERYCP97_12710
EFVCHH26_00245
QCINCF85_15350
QSPL1F33_01240
QSOIRL76_13680
QARK3148_02390
QGEK3136_03045
QPSK3166_11275
ELIELI_12040
ELQGa0102493_11762
ERKCD351_03080
ERRDVR09_01645
ERFFIU90_03310
EMVHQR01_04845
PNSA9D12_05430
PORLBG023_11588
PHZCHX26_03240
POTE2E27_01895
NTDEGO55_04515
AFLVQQW98_03950
ACRAcry_2579
AMVACMV_29040
RGIRGI145_21785
RMTIAI58_03500 IAI58_04060
RFLRmf_26040(meh) Rmf_26160
RCVPFY06_14740
SRFLHU95_13055 LHU95_17440
RAPRHOA_0689(meh)
ABSAZOBR_p150096 AZOBR_p330131
ABQABAZ39_15020 ABAZ39_20985
ABFAMK58_14525
ATIAL072_22055
AZTTSH58p_23070 TSH58p_25135
AZMDM194_21440
AARED3093_19945 D3093_21530
SKTIGS68_05135
SMUCJL100_022620
SROEJL101_021270
MAGXXM1_1789
MAGNWV31_16735
FERFNB15_13590
DEXHWD60_12840
MAGamb0879
HTQFRZ44_08670
HADHFRZ61_08610
VSUP3M64_13860
ELIOKO353_15230
TMOTMO_0524(htd2)
APBSAR116_0876
SNEANBZ79_16605
MIDMIP_00232
MMMW7S_08350
MDXBTO20_25345
MSAKMSAS_56260
MSMMSMEG_1993
MSGMSMEI_1949
MSBLJ00_09945
MSNLI99_09945
MSHLI98_09945
MVAMvan_0531
MGIMflv_0552 Mflv_0634
MSPMspyr1_01900
MVQMYVA_0215
MDUMDUV_29920
MMAGMMAD_55310
MDFK0O62_00545
NNONONO_c28430 NONO_c33480
RHSA3Q41_04797(meh)
RKOJWS14_41695
GOCCXX93_03630
GITC6V83_01035
GAMGII34_22330
GOILK459_05350
GSIP5P27_18580
SPINKV203_05300
TSDMTP03_06810(meh)
TOYFO059_14035
SGRFSGFS_027590
SCINCP977_30965
STUIGCM10017668_62540
SGJIAG43_24595
SINEKI385_04075
SLFJEQ17_46545
SAKBK1J60_08825
SSPNLXH13_35325
SLONLGI35_35010
SANTQR300_38365
YIALO772_34930
MIOAOA12_04740
MIHBJP65_11495
SALCC2138_12295
SALDFVA74_01335
LYDD7I47_06160
PLAPEAO79_06730
LINSG7067_12365
LARIKI794_06455
LRPMUN76_11420
SUBALQ955_15075
PEIH9L10_11005
OCPNF557_15920
BLYA2T55_01925
BLINBLSMQ_0280
BRIFDF13_01700
BLUTEW640_12870
BSPOL1F31_01545
DCOSAMEA4475696_1392
GYUFE374_03290
PACPPA2185
PAKHMPREF0675_5250
PAVTIA2EST22_10670
PAXTIA2EST36_10650
PAZTIA2EST2_10600
PAWPAZ_c22680
PADTIIST44_03745
PCNTIB1ST10_11120
PACCPAC1_11120
PACHPAGK_2083
PACNTIA1EST1_10735
CACNRN83_11230
PRAPALO_11370
PRLBCB70_07470
CEQUO6R08_10305
AACIASQ49_06830
AEFGEV26_00900
NCGKGD84_12850
ACTWF7P10_39315
AMAZLUW76_47025
ACIROG979_00530
SPIQOHA34_37780
NOWGBF35_13600
NFSOIE67_31995
SENSACE_4582
SACGFDZ84_33570
AOIAORI_4918(meh)
AJAAJAP_14945
AMQAMETH_3801
AMYCCU254_14600 CU254_18705
AACDLWP59_10295
AROONQK81_42325
ATHML1857_20980
AMOGQRX60_32590 QRX60_44740
ACYNORV05_23425
PSEAWY02_06585
PSEHXF36_08215
PSEQAD006_28125
PECQAD017_07720
PAUTPdca_37050
PPELH6H00_19830 H6H00_21370
KUTJJ691_16430
KBUQ4V64_06115 Q4V64_51200
KPHYAOZ06_25460
LEDBBK82_38645
SACEGIY23_13725
ACTYOG774_20260
PLABC6361_21485
PLATC6W10_16410
PFLAPflav_031930
PSUUPsuf_090480
RRSRoseRS_4177
RCARcas_0908
CAUCaur_0180
CHLChy400_0192
CAGCagg_1332
AMUCPan181_06510
GGRHKW67_06670
DINSelin_1611
 » show all
Reference
1  [PMID:19955419]
  Authors
Zarzycki J, Brecht V, Muller M, Fuchs G
  Title
Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus.
  Journal
Proc Natl Acad Sci U S A 106:21317-22 (2009)
DOI:10.1073/pnas.0908356106
  Sequence
[cau:Caur_0180]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.153
IUBMB Enzyme Nomenclature: 4.2.1.153
ExPASy - ENZYME nomenclature database: 4.2.1.153
BRENDA, the Enzyme Database: 4.2.1.153
LinkDB

DBGET integrated database retrieval system