KEGG   ENZYME: 4.2.1.171
Entry
EC 4.2.1.171                Enzyme                                 
Name
cis-L-3-hydroxyproline dehydratase;
cis-L-3-hydroxyproline hydro-lyase;
c3LHypD
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O [RN:R11625]
Reaction(KEGG)
R11625
Substrate
cis-3-hydroxy-L-proline [CPD:C19706]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
History
EC 4.2.1.171 created 2017
Pathway
ec00330  Arginine and proline metabolism
Orthology
K09123  cis-L-3-hydroxyproline dehydratase
K21624  cis-L-3-hydroxyproline dehydratase
Genes
FGRFGSG_12672
FPUFPSE_04942
FVNFVRRES_08487
FVRFVEG_06026
FOXFOXG_08647
NHENECHADRAFT_47437 NECHADRAFT_75968
FFCNCS54_00212200 NCS54_00358700
FKRNCS57_00207300 NCS57_00364200
FMUJ7337_004742
TRETRIREDRAFT_59073
TRRM419DRAFT_74960
PLJVFPFJ_04120
PTKZJDV02_004404
CFJCFIO01_08286
CHIGCH63R_05392
PFYPFICI_14003
ANIANIA_08629
AFMAFUA_6G00490
NFINFIA_047620
AORAO090005000232 AO090011000420
ANGAn05g02230
AFVAFLA_003015 AFLA_007807
ALUCAKAW2_81366A
ACHEACHE_30838S
APUUAPUU_10326S APUU_12323S
PCSN7525_011371
AALTCC77DRAFT_973712
FFUCLAFUR5_10550
CBETCB0940_08741
CCACCcaHIS019_0400830(CcaverHIS019_0400830)
SMINv1.2.027818.t1(symbB.v1.2.027818.t1)
PTIPHATRDRAFT_47407
FCYFRACYDRAFT_147078
TPSTHAPSDRAFT_263799
AAFAURANDRAFT_25937
EHXEMIHUDRAFT_464728
SLIGGTU79_12535
PAOPat9b_4270
TCIA7K98_03655
PAEPA1259
PAEVN297_1298
PAEIN296_1298
PAUPA14_47930
PAPPSPA7_4133
PAGPLES_40531
PAFPAM18_3772
PNCNCGM2_2141
PAEBNCGM1900_1317
PDKPADK2_19355
PSGG655_18875
PRPM062_06850
PAEPPA1S_19620
PAERPA1R_gp4865
PAEMU769_19460
PAELT223_20710
PAESSCV20265_4155
PAEUBN889_01338(acnD)
PAEGAI22_14345
PAECM802_1295
PAEOM801_1298
SECHB18_18030
PALCA0T30_01495
PMUIG4G71_28390
PNTG5B91_04390
PPAAB7D75_18885
PORAPT59_02410
PFEPSF113_3724(acnD)
PCGAXG94_01235
PMEDE3Z27_15360
PBAPSEBR_a3202
PBCCD58_14035
PDRH681_03730
PFZAV641_10920
PALKPSAKL28_28670
PRHLT40_08305
PFKPFAS1_24885
PPSLBJP27_16675
PSETTHL1_3344 THL1_3354
PUMHGP31_13910
PGGFX982_00231
PPSHG5J76_14175
PVKEPZ47_13980
PBZGN234_05105
PKHJLK41_24650
PDWBV82_1493
PVWHU752_014605 HU752_019980
PQIKH389_15865
PAZEKSS91_13940
PALVKSS97_15470
PTKEXN22_15850
PZAHU749_017235
PCASLOY40_14815
PKJQ1W70_21720
PCUCPSH97_10615
PTRLOU419_04155
PRHZCRX69_05425
PHEFPSH57_16170
PSTTCH92_01045
PDENF1C79_29240
MBSMRBBS_3090(tfdDII) MRBBS_3771
MPQABA45_14590 ABA45_17665
MSQBKP64_15685
MARAD0851_07090
MANPEHN06_15625
MSANLPB19_16680
ABCACICU_02599
ABXABK1_2717
ABZABZJ_02793
ABRABTJ_01114
ABDABTW07_2847
ABHM3Q_2866
ABJBJAB07104_02757
ABAJBJAB0868_02639
ABWBL01_04805
AVIVLF296_05015
TLOJ9253_15835 J9253_15855
THIPN838_12815 N838_12860 N838_12870 N838_25860
SPIUSPICUR_01015
SROSBBH56_00085
HAMHALO1339
HSIBOX17_15820
HOLHORIV_50720
HNPSR894_14715
MRZKDW95_05240
THINCRN91_06570
BYIBYI23_C003400
BUEBRPE67_CCDS08810
PSAAQEN71_36505
PLGNCTC10937_03090(acnD_2)
CDNBN940_10836
CENPM9799_16870
XYKGT347_12675
XYGR9X41_13655
MLOmll7353
MLNA9174_28980
MCIMesci_5127 Mesci_5761
MCICA4R28_01460
MOPMesop_5709 Mesop_6338
MAMMesau_05204 Mesau_05810
MAMOA6B35_11260 A6B35_31395 A6B35_31430
MESWA9K65_028120
MESMEJ066_15875
MESPC1M53_22690 C1M53_25745
MHUAMCHK_0861
MJREB229_29560
MERDEB233_25595
MOHIHQ72_30340
MMEILRP31_29715
NKIKW403_09930
NRHT8J41_04005
NTUNTH_02373
AAKAA2016_4178
AMIHCO731_04096(ykfB)
AMISAmn_22550
ANJAMD1_4117
PHTBLM14_28020
SMESM_b20269
SMKSinme_3904
SMQSinmeB_4401
SMXSM11_pD1342
SMIBN406_06397
SMEGC770_GR4pD1328
SMELSM2011_b20269
SMERDU99_32025
SMDSmed_3862
RHINGR_c20510
SFHSFHH103_04919
SIXBSY16_2983
ESJSJ05684_b60010
EAKEKH55_4112
EMXFKV68_08830 FKV68_18765 FKV68_29340
EGIPZN02_002064
SKMPZL22_001039
STEGQA637_13150
EADOV14_a1338
EAHFA04_26875
ECAAJ3R84_21105
ENPJVX98_03955 JVX98_05445
ATUAtu4683
ATAAWN88_02300
AGRAGROH133_09591
ATFAch5_44050
AGCBSY240_1189
AGTEYD00_22635
ASALCFBP5507_15640
RIRBN877_II1777
RPUSCFBP5875_22530
ACUCKZ699_23385
ALEGCFBP4996_24750
RLEpRL120183
RLTRleg2_2920 Rleg2_6270
RLGRleg_2143
RHLLPU83_0079
RHVBA939_17435
RHRCKA34_24580
RADCO657_07130 CO657_14970
ROYG3A56_25895 G3A56_27920
RIIFFM53_000485
RRGJ3P73_13310
RROSD4A92_14680
RAWNE851_02080
AROB0909_14110
RBWRLCC275e_10980
RHIZQMO80_003708
RHTNT26_0740
RFVRFYW14_00933
SHZshn_20870
SZOK8M09_18915
PDESFE840_011060
BVESQO058_19440
BOIBLM15_16215
BOFFQV39_07085
BOWNWE53_04125
BAPABBC0178_003880
STARG3545_19660
LNEFZC33_04685
SNOSnov_0156
ANCGBB76_15705
APRAG3A50_11695 G3A50_17100
APOLK9D25_02010
MOCBB934_22210
MTEZHPT29_010405
PEMOF122_09000
DEQXM25_06480
DAGPSQ19_00040
DRPPSQ90_03085
MMYRMXMO3_02558
YTIFNA67_10595
MHARL1P08_15150
PLEOOHA_1_00386
AUAM673_01845
AUBLXB15_02640
JAVOXU80_05805
LAPACP90_03845
LABRCHH27_14510 CHH27_14515 CHH27_14520 CHH27_16900
LABPFJ695_09465 FJ695_25345 FJ695_25350 FJ695_25355
LABTFIU93_09480(hpbD2)
LAGGB0E33_15405
RPOPK1718_06480 K1718_06485 K1718_27215
PAQTE8L99_00855
ACUTMRB58_03890
APAHKB221_08735
SILSPO0606 SPO1594 SPO1595
RUAD1823_12765 D1823_12770 D1823_12775 D1823_21560
RUTFIU92_00705(hpbD1) FIU92_00710(hpbD2) FIU92_00715(hpbD3) FIU92_20915(hpbD5)
RCONK3740_13660
LMDMETH_03715 METH_03720 METH_21600
LEJETW24_04555 ETW24_04565 ETW24_21125
LAQUR2C4_00195
LEVETW23_15635 ETW23_15645 ETW23_22605
LCAEK3721_03860 K3721_19995
YPACCEW88_21655
SULZC1J03_24310 C1J03_24880
SULIC1J05_17360
SULDB5M07_16970
SINLDSM14862_03938
SFAVPL335_15950
SDUBR1T39_17435
RMMROSMUCSMR3_03766
ROKRAK1035_2606
ROMEI983_11265 EI983_11280 EI983_11285
ROHFIU89_04720(hpbD)
RPELN7U68_02680
AHTANTHELSMS3_01689
HATRC74_17905
LSALKBK07_17620
RMAIMACH21_04910
RHPLPB142_00840
RBLB6K69_11125
PDEPden_4854
PAMIJCM7686_pAMI5p194
PCONB0A89_11820
PARUCYR75_12385
PARSDRW48_02020
PAAKFIU66_17575
PKDF8A10_10085
PPANESD82_09110 ESD82_09265
PSANHGN31_03530
PMEHJWJ88_18830
PAEZPAE61_15555
PALSPAF20_17090
PFEOE3U26_15715
GEHHYN69_18950
GFUKM031_16585
TAWEI545_04775
PSEBEOK75_17430
LITFPZ52_12375
PAEDG5B38_02540 G5B38_08205 G5B38_08210
PALWPSAL_037680
CACTHZ995_06700 HZ995_06705 HZ995_06920
CMAGCBW24_05650
FAPGR316_11095
SINRO5O51_10065
AALKLGT41_0005615
AMYLQBD29_01610 QBD29_15440 QBD29_15445
PBAEP8S53_16060
KSCCD178_02790
NTND5366_04125
HTQFRZ44_05750
HADHFRZ61_05880
APMHIMB5_00009000
APBSAR116_0305
ALKALEK_0483
SCIAHUG15_20565
NCMQNK12_12465
BHVBLHYD_07880
MDXBTO20_21610
MMAGMMAD_17950
CCYCSCMU_39940
ROPROP_33630
ROAPd630_LPD07639
RKOJWS14_15390
SVLStrvi_4532
SPHVF9278_41770
MANTBHD05_12270
ARQBWQ92_12360
MPHMLP_31270
PROPQQ658_07770
ROOG5S37_15600
PSLPsta_4279
PIRVN12_04975(hpbD)
RULUC8_12350(hpbD)
RMLFF011L_25140(hpbD)
ROLCA51_17900(hpbD)
RUVEC9_16410(hpbD)
RCFPoly24_22630(hpbD)
AHELQ31a_31920(hpbD)
LCREPla8534_37390(hpbD)
BVOPan97_28130(hpbD)
BREMPSR63_25240
RLCK227x_20600(hpbD)
SMAMMal15_54400(hpbD)
SNEPEnr13x_18630(hpbD)
PLMPlim_2539
PEHSpb1_33100(hpbD)
FMRFuma_04875(ykfB_3)
GFMEnr17x_02110(hpbD)
GAWV144x_54800(hpbD)
MRIMal4_18100(hpbD)
TPOLMal48_25250(hpbD)
PVARSH412_000371
CCOPMal65_51760(hpbD)
GESVT84_28150(hpbD)
GOGC1280_02595
GMSSOIL9_51450
TIMGMBLW1_09120
LRSPX52LOC_08191
FTJFTUN_7844
ULIETAA1_44860(hpbD)
TSPHKIH39_25405
AGVOJF2_01180(hpbD)
HBSIPV69_07755
PFERIRI77_22655
GBAJ421_4704
HDFAArcSl_2466
 » show all
Reference
1  [PMID:25608448]
  Authors
Zhang X, Kumar R, Vetting MW, Zhao S, Jacobson MP, Almo SC, Gerlt JA
  Title
A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily.
  Journal
J Am Chem Soc 137:1388-91 (2015)
DOI:10.1021/ja5103986
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.171
IUBMB Enzyme Nomenclature: 4.2.1.171
ExPASy - ENZYME nomenclature database: 4.2.1.171
BRENDA, the Enzyme Database: 4.2.1.171
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