Entry
Name
cystathionine beta-synthase;
serine sulfhydrase;
beta-thionase;
methylcysteine synthase;
cysteine synthase (incorrect);
serine sulfhydrylase;
L-serine hydro-lyase (adding homocysteine)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
Reaction(IUBMB)
L-serine + L-homocysteine = L-cystathionine + H2O [RN:
R01290 ]
Reaction(KEGG)
Substrate
Product
Comment
A pyridoxal-phosphate protein. A multifunctional enzyme: catalyses beta-replacement reactions between L-serine, L-cysteine, cysteine thioethers, or some other beta-substituted alpha-L-amino acids, and a variety of mercaptans.
History
EC 4.2.1.22 created 1961 (EC 4.2.1.21 created 1961, incorporated 1964, EC 4.2.1.23 created 1961, incorporated 1972)
Pathway
ec00260 Glycine, serine and threonine metabolism
ec00270 Cysteine and methionine metabolism
ec01110 Biosynthesis of secondary metabolites
Orthology
K01697 cystathionine beta-synthase
K10150 cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase
Genes
HSA : 102724560(CBS) 875(CBS)
PCAD : 102987965(CBS) 112063104
PCOC : 116229833 116229886(CBS)
NMEL : 110403445 110403453
APLA : 101797717 101798015
ACYG : 106036081 106036144
AFUL : 116489662 116497513
SCAN : 103815752 115483834
PMOA : 120511826 120511828
PRUF : 121364531 121364565
GFR : 102034131(CBS) 102037167
FAB : 101819123 101819452(CBS)
PHI : 102106314 102108034(CBS)
PMAJ : 107207872 107207897
CCAE : 111927493 111927519
ACUN : 113478884 113482625
TALA : 104364286 104364287
PADL : 103920301 103920345
ACHC : 115344064 115344078
AROW : 112968438 112968451
AMJ : 102560906(CBS) 102563571
CPOO : 109305861 109305862
CPIC : 101931261 101934026
ACS : 100566358(cbs) 100566739
SUND : 121925395 121926053
PMUR : 107295076 107295077 107296833(CBS) 107298773 107298774 107300199
PGUT : 117669391 117669452
PMUA : 114596125 114596126(CBS)
XLA : 380308(cbs.L) 446655(cbs.S)
DRE : 266987(cbsb) 550524(cbsa)
SRX : 107712539 107715910 107721570 107742639
SANH : 107654262 107661289 107667662 107702723
CCAR : 109048102 109055014 109055023 109090457
CAUA : 113044364 113053629 113105462 113108959
IPU : 100304674(cbsa) 108266313
PHYP : 113537764(cbs) 113546747
SMEO : 124378308(cbsa) 124383202
AMEX : 103027202 103030674
EEE : 113578511 113581350 113590729 113590737
TNG : GSTEN00015823G001 GSTEN00025994G001
SLUC : 116044613 116059043(cbsb)
ECRA : 117939669(cbsa) 117953208(cbsb)
PFLV : 114551178 114563635
PPUG : 119216895 119218241
MSAM : 119903488(cbsb) 119903997
CUD : 121506291 121522806(cbsb)
MZE : 101479719 101487143 106674481
OAU : 116316021(cbsb) 116318484
OML : 112155227 112160040(cbsa)
PRET : 103459803 103474492
PFOR : 103132488 103140297 103147202
PLAI : 106940922 106941439 106958598
PMEI : 106927576 106929518 106930167
GAF : 122827278 122839401(cbsb)
CVG : 107098785 107104210 107104501
CTUL : 119786333(cbsb) 119791185
GMU : 124861297 124870851(cbsb)
KMR : 108232423(cbsb) 108244998
ALIM : 106523943 106531788
NWH : 119419671(cbsb) 119428945
AOCE : 111568100 111579459
CSEM : 103389253 103391608
SLAL : 111662096 111665292
XGL : 120798193(cbsa) 120801464(cbsb)
BPEC : 110153311 110173132
SASA : 106562750 106582148 106586691 106593678
OTW : 112225401 112237151 112241846
OMY : 100136726(cbs) 110496973 110502018 110520495
OGO : 124011286(cbsa) 124044151 124045343
ONE : 115112893 115117646 115124619
SALP : 111959713 111979408
SNH : 120051527 120051537 120058470 120064180
ELS : 105027337 105031003(cbs)
SFM : 108920076 108933121(cbs)
AANG : 118214485 118223378
PSPA : 121320429 121327900
APLC : 110986482 110986497
DSI : Dsimw501_GD17507(Dsim_GD17507)
CQU : CpipJ_CPIJ012752 CpipJ_CPIJ012753
CPII : 120424282 120424297
BVAN : 117155128 117159921
DPA : 109534631 109534936 109544276
SOY : 115879880 115880332 115890453
ATD : 109596611 109602605 109603181 109608201
PPYR : 116163715 116177927 116177936 116177963 116177974
MSEX : 115443396 115443397
DPL : KGM_202278A KGM_202279A
PRAP : 110997439 123689668
ZCE : 119828635 119828637 119828721
HAW : 110373381 110373384 110373464
TNL : 113504890 113504891 113504942 113505017
API : 100164878 100165631 100166111
PHU : Phum_PHUM459670 Phum_PHUM607830
FCD : 110842873 110842983 110849067
DPX : DAPPUDRAFT_218706 DAPPUDRAFT_333777
RSAN : 119376740 119393202
PTEP : 107437916 107437919
CEL : CELE_F54A3.4(cbs-2) CELE_ZC373.1(cbs-1)
CBR : CBG_01937(Cbr-cbs-2)
NAI : NECAME_05024 NECAME_15360
HRO : HELRODRAFT_79716 HELRODRAFT_98264
SPIS : 111330858 111330859
HMG : 100207380 100209141(cbs) 100211731
TAD : TRIADDRAFT_27648 TRIADDRAFT_30632 TRIADDRAFT_53449
NCS : NCAS_0C05620(NCAS0C05620)
NDI : NDAI_0H00500(NDAI0H00500)
TPF : TPHA_0K01840(TPHA0K01840)
TBL : TBLA_0E01580(TBLA0E01580)
TDL : TDEL_0F02810(TDEL0F02810)
KAF : KAFR_0I01230(KAFR0I01230)
SPAA : SPAPADRAFT_131723(CYS4)
CAL : CAALFM_C101870CA(CYS4)
NTE : NEUTE1DRAFT64117(NEUTE1DRAFT_64117)
FGR : FGSG_06544 FGSG_07287
NHE : NECHADRAFT_68815 NECHADRAFT_97650
BFU : BCIN_16g03500(Bccys4)
ANG : ANI_1_354044(An05g00160)
CIM : CIMG_00957 CIMG_05649 CIMG_06088
CPW : CPC735_026540 CPC735_053910 CPC735_067650
SHS : STEHIDRAFT_121688 STEHIDRAFT_121689
ABP : AGABI1DRAFT70201(AGABI1DRAFT_70201)
ABV : AGABI2DRAFT205908(AGABI2DRAFT_205908)
SRE : PTSG_07356 PTSG_07374
DPP : DICPUDRAFT_49929 DICPUDRAFT_89388
PTM : GSPATT00012786001 GSPATT00013222001 GSPATT00016616001
SMIN : v1.2.004841.t1(symbB.v1.2.004841.t1)
PTI : PHATRDRAFT_42003(Cbs)
PIF : PITG_13262 PITG_14697
PSOJ : PHYSODRAFT_301600 PHYSODRAFT_301616 PHYSODRAFT_314387
SPAR : SPRG_06409 SPRG_10298
TCR : 506905.50 508175.360 508177.110 508177.120 508241.140 509149.9 510381.10 511691.10 511691.20
CLAP : NCTC11466_02217(cbs)
KOR : AWR26_04440 AWR26_22585
SPLY : Q5A_008100(cbs) Q5A_011975(cysM_1)
SFJ : SAMEA4384070_1671(cbs)
SOF : NCTC11214_05286(cbs)
PCV : BCS7_13885 BCS7_19480
PVZ : OA04_29640 OA04_41650
PAY : PAU_00518(mtcB) PAU_04068
XPH : XppCFBP6546_16305(XppCFBP6546P_16305)
DJI : CH75_00835 CH75_23915
PTV : AA957_00625 AA957_28080
PKE : DLD99_12390 DLD99_16410
PTRT : HU722_0011440 HU722_0016165
PTZ : HU718_012865 HU718_012920
PHV : HU739_005800 HU739_005855
AXX : ERS451415_01161(cbs)
MNR : ACZ75_07820 ACZ75_23675
MASZ : C9I28_13770 C9I28_16995
MTIM : DIR46_05445 DIR46_24895
MASY : DPH57_04980 DPH57_07910
MALI : EYF70_02940 EYF70_14615
MUM : FCL38_04090 FCL38_15665
MFLA : GO485_11135 GO485_29310
ACP : A2cp1_3442 A2cp1_3846
ANK : AnaeK_3378 AnaeK_3763
AGE : AA314_07914 AA314_09277
AVM : JQX13_28610 JQX13_42930
MBD : MEBOL_000648 MEBOL_001204
CFUS : CYFUS_002940 CYFUS_007757
SCL : sce0438 sce8782(cysB)
SCU : SCE1572_03225 SCE1572_50220
LLU : AKJ09_02503 AKJ09_11128
MRM : A7982_06310 A7982_10099 A7982_12848
MESP : C1M53_03470 C1M53_05260
AMIH : CO731_00550(cysK_1)
RHI : NGR_a00730 NGR_b03540
SINO : SS05631_a45520 SS05631_b51330
ESJ : SJ05684_a40750 SJ05684_b45300
RGA : RGR602_PC00900(cysK-2)
AUA : M673_07140 M673_20070
TSV : DSM104635_02815(cbs)
MBAI : MB901379_03847(cbs)
MHEK : JMUB5695_01315(cbs)
MPHL : MPHLCCUG_04264(cbs)
MAUU : NCTC10437_04400(cbs)
MFLV : NCTC10271_01070(cbs)
MSAL : DSM43276_01063(cbs)
CUJ : CUL131002_0675c(cbs)
NFR : ERS450000_05046(cysM_2) ERS450000_05083(cbs)
NCY : NOCYR_4624(cbs) NOCYR_4658
NBR : O3I_012920 O3I_036500 O3I_036905
NNO : NONO_c31500 NONO_c65690(cbs) NONO_c66200
NSL : BOX37_26020 BOX37_26950
NSR : NS506_01687 NS506_01758 NS506_02214
NTP : CRH09_34210 CRH09_34605
NOZ : DMB37_15145 DMB37_15835 DMB37_33145
NOD : FOH10_01915 FOH10_02295
NAH : F5544_38915 F5544_39365
NAD : NCTC11293_06193(cbs) NCTC11293_06242(cysM_3)
NWL : NWFMUON74_10450 NWFMUON74_11010
NIE : KV110_12535 KV110_35545 KV110_36150
NHU : H0264_03240 H0264_10765
NYA : LTV02_21945 LTV02_22430 LTV02_29485
NGP : LTT66_17810 LTT66_18510
RHA : RHA1_ro00594 RHA1_ro05843
ROA : Pd630_LPD02470 Pd630_LPD04811 Pd630_LPD16016
RCR : NCTC10994_01582(cbs)
RKO : JWS14_03585 JWS14_31945
GOM : D7316_01615(cbs) D7316_02853(cysK)
SCB : SCAB_5301 SCAB_54591
SRC : M271_02840 M271_29250
SALU : DC74_3524 DC74_7699
SALL : SAZ_18740 SAZ_39735
STRE : GZL_05378 GZL_09233
SLD : T261_07848 T261_5014
SCZ : ABE83_06530 ABE83_22625
SRW : TUE45_04581(cbs) TUE45_06288(cysK)
SLE : sle_41970(sle_41970)
SCLF : BB341_15015 BB341_17370
SALW : CP975_14145 CP975_28155
SNW : BBN63_06805 BBN63_21240
SALJ : SMD11_0978 SMD11_4147
SLX : SLAV_05465(cysM1) SLAV_22665(cbs)
SGE : DWG14_04990(cbs) DWG14_08225(mccA)
SLK : SLUN_15880 SLUN_22960
SDX : C4B68_23850 C4B68_36865
SNQ : CP978_02010 CP978_14310
STIR : DDW44_11790 DDW44_23840 DDW44_29235
SRK : FGW37_12840 FGW37_28400
SSPO : DDQ41_00755 DDQ41_09045
SVR : CP971_13330 CP971_27520
SAQU : EJC51_21030 EJC51_46685
SBY : H7H31_00835 H7H31_22010
SLIA : HA039_21230 HA039_32280
SDW : K7C20_02780 K7C20_14795
KAU : B6264_08385 B6264_22075
LEIF : HF024_03750 HF024_13135
LSE : F1C12_09130 F1C12_21180
HUW : FPZ11_11440 FPZ11_16835
GRY : D7I44_00645 D7I44_11170
AGX : AGREI_0613 AGREI_2179
ARR : ARUE_c31870(cbs1) ARUE_c37930(cbs2)
ARZ : AUT26_14910 AUT26_17430
ARQ : BWQ92_11835 BWQ92_16105
ARN : CGK93_17275 CGK93_20475
ARX : ARZXY2_640 ARZXY2_96(cysK)
AAGI : NCTC2676_1_02401(cbs)
ARI : UM93_10430 UM93_16065
PUE : FV140_16495 FV140_19050
PNV : JMY29_14655 JMY29_17625
CCEU : CBR64_02900 CBR64_11265
NAQU : ENKNEFLB_03779(cbs)
AGRA : AGRA3207_004219 AGRA3207_005717
FAL : FRAAL0784(cysM) FRAAL3001
AJA : AJAP_04445 AJAP_08435
AMYB : BKN51_24450 BKN51_27865
AACD : LWP59_22290 LWP59_33690
PSEE : FRP1_08675 FRP1_22445
PSEQ : AD006_01635 AD006_16240
PECQ : AD017_09460 AD017_24075
PHH : AFB00_06740 AFB00_28900
PBRO : HOP40_03570 HOP40_08575
KPHY : AOZ06_06205 AOZ06_29815
ASE : ACPL_4764(cysM) ACPL_952
ACTS : ACWT_0835 ACWT_4633
PSUU : Psuf_005310 Psuf_042700
DVC : Dvina_18040 Dvina_49065
GES : VT84_23005(cysK_2) VT84_30235(cbs)
GMS : SOIL9_00760 SOIL9_23980
LRS : PX52LOC_03294 PX52LOC_04086
ULI : ETAA1_33390(cysK) ETAA1_47060(cbs)
AGV : OJF2_11660(cbs) OJF2_31700(cysK_1)
SRM : SRM_01301(cysK) SRM_03001(cysB)
HHY : Halhy_1607 Halhy_6320
SMIZ : 4412673_01065(cbs) 4412673_01966(cysK)
SPHZ : E3D81_04295 E3D81_11165
SPHE : GFH32_09285 GFH32_13355
SDJ : NCTC13534_02748(cysM_1) NCTC13534_03679(cbs)
GRL : LPB144_03055 LPB144_06450
GRS : C7S20_10970 C7S20_13370
FPC : FPSM_01502 FPSM_02106
FPY : FPG101_07465 FPG101_10555
FPO : FPG3_03505 FPG3_06435
FPQ : IB65_03990 IB65_05605
FPV : IA03_04080 IA03_05710
FPW : IA04_03995 IA04_05615
FPK : IA06_04030 IA06_05650
FPSZ : AMR72_03820 AMR72_06495
FJG : BB050_00103(cbs_1) BB050_00678(cbs_2)
FBR : FBFL15_1703 FBFL15_2349
FCO : FCOL_00990 FCOL_10485
FGL : EM308_07955 EM308_13855
FAT : DVK85_00830 DVK85_11540
FKI : FK004_00225 FK004_14410
FPAL : HYN49_06775 HYN49_11045
FMG : HYN48_06445 HYN48_11650
FALB : HYN59_08710 HYN59_15730
FCR : HYN56_10405 HYN56_13960
FSE : DI487_10740 DI487_14295
FSN : GS03_00090(cbs_1) GS03_02195(cbs_2)
FAK : FUA48_00535 FUA48_12270
FFL : HYN86_09205 HYN86_11905
FEN : J0383_02605 J0383_05920
FCV : AWN65_06630 AWN65_09270
RBI : RB2501_10222 RB2501_15549
CAT : CA2559_00130 CA2559_08106
MARM : YQ22_15355 YQ22_17170
MART : BTR34_15140 BTR34_17215
MARE : EJ994_06160 EJ994_08920
CLY : Celly_2204 Celly_2721
CLH : IX49_10955 IX49_13705
KDI : Krodi_0116 Krodi_2944
DOK : MED134_14476 MED134_14792
DDO : I597_1696(cbs_1) I597_1749(cbs_2)
DOD : DCS32_11795 DCS32_12635
LAN : Lacal_1808 Lacal_2360
LVN : BWR22_08680 BWR22_11545
LACI : CW733_01130 CW733_03780
ZGA : ZOBELLIA_2590(cysK2) ZOBELLIA_4054(cysK1)
SPON : HME9304_00739(cysK) HME9304_02985
ASL : Aeqsu_1987 Aeqsu_2814
AEV : EI546_04390 EI546_14975
AIC : JK629_09315 JK629_13645
PTQ : P700755_000665 P700755_003414
NOM : AAT17_00255 AAT17_09495
NSD : BST91_05810 BST91_09340
NOB : CW736_01840 CW736_10230
NOJ : EJ995_05115 EJ995_09765
POM : MED152_00895(cysK) MED152_03850(cbs)
POB : LPB03_01645 LPB03_04410
PRN : BW723_11200 BW723_11670
POLA : BXQ17_01630 BXQ17_02805
POA : CW731_00795 CW731_02315
PHAL : H9I45_01975 H9I45_04440
PLIT : K8354_05665 K8354_10330
WIJ : BWZ20_02315 BWZ20_05005
SYI : SB49_04880 SB49_08320
TDI : AUW17_05900 AUW17_06820
TEN : LPB136_04870 LPB136_05215
TJE : TJEJU_2628 TJEJU_2685(cysK)
TMAR : MARIT_1683 MARIT_1686(cysK)
TMP : F9Y86_01525 F9Y86_01550
LUT : Lupro_00950 Lupro_03720
FOR : FORMB_21180 FORMB_23090
FOH : FORMA_03540 FORMA_16570
SALT : AO058_08070 AO058_11720
SMIS : LDL76_01630 LDL76_15090
AALG : AREALGSMS7_04518(cbs)
OLL : CW732_13885 CW732_18185
OAQ : DZC78_02970 DZC78_14050
FEK : C1H87_00055 C1H87_05935
AUE : C5O00_01525 C5O00_13495
KOS : KORDIASMS9_04201(cbs) KORDIASMS9_04718(cbs)
KAN : IMCC3317_12620(cbs_1) IMCC3317_18030(cbs_2)
AQB : D1818_03970 D1818_08545
AQA : D1815_03630 D1815_22525
AQD : D1816_03005 D1816_10240
EMAR : D1013_13265 D1013_16855
MUR : EQY75_06935 EQY75_09860
PSYN : E9099_10820 E9099_15305
AFLA : FHG64_01900 FHG64_15305
ANP : FK178_03560 FK178_08050
OCI : FEZ18_11555 FEZ18_14435
MGEL : G5B37_03260 G5B37_05645
MESQ : C7H62_0282 C7H62_2555
GAA : HX109_01000 HX109_13515
CAGG : HYG79_12575 HYG79_17785
ALTI : ALE3EI_1696 ALE3EI_2065
MARX : INR76_08310 INR76_11750
LPAL : LDL79_03265 LDL79_13670
SINH : LS482_14155 LS482_18330
ASAG : FGM00_08545 FGM00_13060
FLG : LV716_12135 LV716_17290
SABU : MBM09_10335 MBM09_13840
ZSP : MQE36_13005 MQE36_14990
BIA : GMA17_05165 GMA17_08840
FBE : FF125_05210 FF125_15510
WVI : Weevi_0419 Weevi_1710
EMN : M876_03500 M876_10080
EEN : BBD30_02010 BBD30_13785
ELB : VO54_00107(cbs_1) VO54_01609(cbs_2)
EMG : BBD33_09905 BBD33_15995
EGO : BBD34_02140 BBD34_14265
EGM : AYC65_04970 AYC65_12050
ELZ : FCS00_05625 FCS00_18115
ELT : FGE20_02265 FGE20_07885
CHZ : CHSO_2070(srpG2) CHSO_2714(srpG2) CHSO_3814(srpG)
CGN : OK18_01660 OK18_18255
CIH : ATE47_07660 ATE47_10540
CHH : A0O34_14890 A0O34_18980
CIO : CEQ15_07295 CEQ15_12625
CHRY : CEY12_04595 CEY12_08710
CPIP : CJF12_03470 CJF12_19835
CHRS : EAG08_05350 EAG08_20045
CHRZ : CO230_06040 CO230_07900
CARH : EGY05_09840 EGY05_15470
CSHA : EG350_09775 EG350_14585
CNK : EG343_02190 EG343_07530 EG343_20955
CJT : EG359_03700 EG359_08460
CIL : EG358_06105 EG358_12175
CCAU : EG346_13215 EG346_18640
CBEN : EG339_18710 EG339_23245
CGLE : NCTC11432_00875(cbs_1) NCTC11432_02025(cbs_2)
CTAI : NCTC12078_00524(cbs_1) NCTC12078_03361(cbs_2)
CLAC : EG342_18655 EG342_24215
CTAK : 4412677_00497(cbs_1) 4412677_00900(cbs_2)
CSAL : NBC122_01781(cbs_1) NBC122_02404(cbs_2)
CBP : EB354_06945 EB354_15155
CJG : NCTC13459_00687(cbs_1) NCTC13459_01129(cbs_2)
CCAS : EIB73_02875 EIB73_05195
CANT : NCTC13489_00717(cbs_1) NCTC13489_01144(cbs_2)
KDA : EIB71_08305 EIB71_10450
KHI : EG338_09870 EG338_12420
KBE : J4771_01965 J4771_12700
EVA : EIB75_05245 EIB75_15685
CNR : EB819_05430 EB819_07445
EBV : F0358_00585 F0358_08915
EFAL : FH779_04045 FH779_12460
ESTE : HNV03_01710 HNV03_07745
CIV : IMZ16_09195 IMZ16_10140
FBO : J9309_08435 J9309_09160
OHO : Oweho_0910 Oweho_2012
IAL : IALB_2142 IALB_2149(cysM)
PYA : PYCH_08690 PYCH_09090
APE : APE_1223.1 APE_1586(cysK)
ACJ : ACAM_0775 ACAM_0997(cysK)
» show all
Taxonomy
Reference
Authors
Braunstein AE, Goryachenkova EV, Tolosa EA, Willhardt IH, Yefremova LL.
Title
Specificity and some other properties of liver serine sulphhydrase: evidence for its identity with cystathionine -synthase.
Journal
Reference
Authors
Nakagawa H, Kimura H.
Title
Purification and properties of cystathionine synthetase synthetase from rat liver: separation of cystathionine synthetase from serine dehydratase.
Journal
Reference
Authors
SCHLOSSMANN K, BRUEGGEMANN J, LYNEN F.
Title
[Biosynthesis of cysteine. I. Detection and isolation of serine sulfhydrase from baker's yeast.]
Journal
Biochem Z 336:258-73 (1962)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.22
ExPASy - ENZYME nomenclature database: 4.2.1.22
LinkDB
All DBs