KEGG   ENZYME: 4.2.1.48
Entry
EC 4.2.1.48                 Enzyme                                 
Name
D-glutamate cyclase;
D-glutamate hydro-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Reaction(IUBMB)
D-glutamate = 5-oxo-D-proline + H2O [RN:R01583]
Reaction(KEGG)
R01583
Substrate
D-glutamate [CPD:C00217]
Product
5-oxo-D-proline [CPD:C02237];
H2O [CPD:C00001]
Comment
Also acts on various derivatives of D-glutamate.
History
EC 4.2.1.48 created 1972
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K22210  D-glutamate cyclase
Genes
HSA: 80017(DGLUCY)
PTR: 453104(DGLUCY)
PPS: 100971567(DGLUCY)
GGO: 101153207(DGLUCY)
PON: 100172319(DGLUCY)
PPYG: 129012156(DGLUCY)
NLE: 100586901(DGLUCY)
HMH: 116456096(DGLUCY)
SSYN: 129487535(DGLUCY)
MCC: 700168(DGLUCY)
MCF: 102135732(DGLUCY)
MTHB: 126959650
MNI: 105467555(DGLUCY)
CSAB: 103229551(C24H14orf159)
CATY: 105596569
PANU: 101012503(DGLUCY)
TGE: 112628451(DGLUCY)
MLEU: 105548007
RRO: 104656701(DGLUCY)
RBB: 108523309(CUNH14orf159)
TFN: 117071547(DGLUCY)
PTEH: 111538216(DGLUCY)
CANG: 105517296
CJC: 100412631(DGLUCY)
SBQ: 101047007
CIMI: 108316818(DGLUCY)
ANAN: 105717760(DGLUCY)
CSYR: 103275586(CUNH14orf159)
MMUR: 105876286(C3H14orf159)
PCOQ: 105822929
OGA: 100949551(DGLUCY)
MMU: 217830(Dglucy)
MCAL: 110306840(Dglucy)
MPAH: 110324645(C7H14orf159)
RNO: 362769(Dglucy)
MCOC: 116080006(Dglucy)
ANU: 117696943(Dglucy)
ASYL: 127687030(Dglucy)
MUN: 110558364(Dglucy)
CGE: 100753550(Dglucy)
MAUA: 101828173(Dglucy)
PROB: 127231067(Dglucy)
PLEU: 114705025(Dglucy)
MORG: 121434364(Dglucy)
MFOT: 126507214
AAMP: 119818709(Dglucy)
NGI: 103724611(CUNH14orf159)
HGL: 101711224
CPOC: 100735106(Dglucy)
CCAN: 109699498(CUNH14orf159)
NCAR: 124976082
MMMA: 107144620(Dglucy)
ITI: 101967644(Dglucy)
TUP: 102469364
GVR: 103603089
CFA: 100688910(DGLUCY)
VVP: 112907347(DGLUCY)
VLG: 121492493(DGLUCY)
NPO: 129496335(DGLUCY)
AML: 100482436(DGLUCY)
UMR: 103670181(DGLUCY)
UAH: 113267360(DGLUCY)
UAR: 123798891(DGLUCY)
ELK: 111148542
LLV: 125104759
MPUF: 101689641
MNP: 132000092(DGLUCY)
MLK: 131836763(DGLUCY)
NVS: 122893791(DGLUCY)
ORO: 101371157
EJU: 114204443(DGLUCY)
ZCA: 113909354(DGLUCY)
MLX: 118002490(DGLUCY)
NSU: 110571747(DGLUCY)
LWW: 102744332(DGLUCY)
FCA: 101085897(DGLUCY)
PYU: 121032192(DGLUCY)
PCOO: 112855858(DGLUCY)
PBG: 122468118(DGLUCY)
PVIV: 125168765(DGLUCY)
LRUF: 124512240
LGF: 123583749(DGLUCY)
AJU: 106987920(DGLUCY)
PTG: 102949759
PPAD: 109274456(CUNH14orf159)
PUC: 125909251
PLEZ: 122223055(DGLUCY)
HHV: 120232099(DGLUCY)
BBIS: 104985863
CSUM: 138095018(DGLUCY)
MREE: 136146986(DGLUCY)
MBEZ: 129550093(DGLUCY)
SSC: 100626547(C7H14orf159)
CFR: 102521322(DGLUCY)
CBAI: 105079860
CDK: 105095965(DGLUCY)
VPC: 102529318(DGLUCY)
BACU: 102999377
BMUS: 118889531(DGLUCY)
LVE: 103084864
OOR: 101287758(DGLUCY)
LALB: 132527226(DGLUCY)
DLE: 111175940(DGLUCY)
PSIU: 116746127(DGLUCY)
NASI: 112393856(DGLUCY)
ECB: 100063012(DGLUCY)
EPZ: 103558013(DGLUCY)
EAI: 106825335(DGLUCY)
MYB: 102252495
MYD: 102753826
MMYO: 118659289(DGLUCY)
MLF: 102432492(DGLUCY)
MDT: 132230517(DGLUCY)
MYUM: 139009520 139010418
PKL: 118712976(DGLUCY)
EFUS: 103292237(DGLUCY)
MNA: 107531588
DRO: 112311934(DGLUCY)
SHON: 118976806(DGLUCY)
AJM: 119037910(DGLUCY)
PDIC: 114492950(DGLUCY)
PHAS: 123808597(DGLUCY)
MMF: 118636098(DGLUCY)
PPAM: 129065828(DGLUCY)
HAI: 109382680(CUNH14orf159)
RFQ: 117023309(DGLUCY)
PALE: 102898067(DGLUCY)
PGIG: 120619609(DGLUCY)
PVP: 105300806(DGLUCY)
RAY: 107515436
MJV: 108399442(DGLUCY)
TOD: 119239281(DGLUCY)
SARA: 101546022
SFUM: 130041375(DGLUCY)
SETR: 126003636(DGLUCY)
LAV: 100659904(DGLUCY)
ETF: 101646009(DGLUCY)
DNM: 101419340(DGLUCY)
MDO: 100017774(C1H14orf159)
GAS: 123234039(DGLUCY)
SHR: 100931620(DGLUCY)
AFZ: 127549411
PCW: 110217799(CUNH14orf159)
TVP: 118829960(DGLUCY)
OAA: 100083826(DGLUCY)
TACU: 119931952(DGLUCY)
GGA: 423409(C5H14orf159)
PCOC: 116228912(DGLUCY)
MGP: 100539918(DGLUCY)
CJO: 107315200(DGLUCY)
TPAI: 128085985(DGLUCY)
LMUT: 125695522(DGLUCY)
NMEL: 110402184(C6H14orf159)
APLA: 101791243(DGLUCY)
ACYG: 106036649(DGLUCY)
CATA: 118244812(DGLUCY)
AFUL: 116489751(DGLUCY)
TGU: 100229540(DGLUCY)
LSR: 110471379(DGLUCY)
SCAN: 103826477(DGLUCY)
PMOA: 120503771(DGLUCY)
OTC: 121332518(DGLUCY)
PRUF: 121355992(DGLUCY)
ATRC: 139589836(DGLUCY)
GFR: 102037421
FAB: 101806679(C5H14orf159)
OMA: 130254191(DGLUCY)
PHI: 102108442
PMAJ: 107205561(DGLUCY)
CCAE: 111929884(DGLUCY)
CCW: 104685987(DGLUCY)
CBRC: 103612114(CUNH14orf159)
ACOE: 138111768(DGLUCY)
ETL: 114058212(DGLUCY)
ZAB: 102073109(DGLUCY)
ZLE: 135448097(DGLUCY)
ACHL: 103800958
SVG: 106849333
MMEA: 130576164(DGLUCY)
HRT: 120754034(DGLUCY)
SATI: 136362937(DGLUCY)
CCIC: 134044954(DGLUCY)
FPG: 101913280
FCH: 102058374(DGLUCY)
CCRI: 104161490
NNT: 104402204
SHAB: 115606770(DGLUCY)
ACUN: 113480812(DGLUCY)
TALA: 104364674(DGLUCY)
ACHC: 115333825(DGLUCY)
HALD: 104323816
HLE: 104841859
AGEN: 126050526
HHAR: 128140186(DGLUCY)
GCL: 127017420
CSTI: 104559936
LDI: 104350567
MNB: 103769010
DPUB: 104304113
PPUS: 135179619(DGLUCY)
AVIT: 104266984
EGZ: 104135348(DGLUCY)
NNI: 104022218
PCRI: 104028681
PCAO: 104053883
PADL: 103912999
AFOR: 103900294(CUNH14orf159)
FGA: 104078679
GSTE: 104263081
CLV: 102096431(CUNH14orf159)
MUI: 104545233
PGUU: 104468771
PLET: 104625060
EHS: 104503047
CMAC: 104483647
CUCA: 104059622(DGLUCY)
TEO: 104372077
BREG: 104639823
OHA: 104331484
ACAR: 104526349(DGLUCY)
CPEA: 104394155
CVF: 104286944
RTD: 128908986(DGLUCY)
CRID: 134515417(DGLUCY)
AAM: 106482923
AROW: 112972654(DGLUCY)
NPD: 112953467(DGLUCY)
TGT: 104568817
DNE: 112990234(DGLUCY)
SCAM: 104153782
ASN: 102380281(DGLUCY)
AMJ: 102576478(CUNH14orf159)
CPOO: 109321685(CUNH14orf159)
GGN: 109298523(CUNH14orf159)
PSS: 102453950(DGLUCY)
CMY: 102931212(DGLUCY)
CCAY: 125637746(DGLUCY)
DCC: 119857607(DGLUCY)
CPIC: 101937326(DGLUCY)
TST: 117876192(DGLUCY)
CABI: 116816894(DGLUCY)
MRV: 120403369(DGLUCY)
ACS: 100562196(c1h14orf159)
ASAO: 132763314(DGLUCY)
PVT: 110086580(CUNH14orf159)
SUND: 121914907(DGLUCY)
PBI: 103063698(DGLUCY)
PMUR: 107297288(DGLUCY)
CTIG: 120309571(DGLUCY)
TSR: 106546543
PGUT: 117665912(DGLUCY)
APRI: 131187848(DGLUCY)
PTEX: 113444344(DGLUCY)
NSS: 113419664(DGLUCY)
VKO: 123026939(DGLUCY)
PMUA: 114591021(DGLUCY)
PRAF: 128407957(DGLUCY)
ZVI: 118078179(DGLUCY)
HCG: 128334222(DGLUCY)
GJA: 107113340
STOW: 125426641(DGLUCY)
EMC: 129324474(DGLUCY)
XLA: 108698713(dglucy.L)
XTR: 549215(dglucy)
NPR: 108788696(CUNH14orf159)
RTEM: 120921213(DGLUCY)
BBUF: 120982146(DGLUCY)
BGAR: 122922084(DGLUCY)
PWL: 138260057(DGLUCY)
MUO: 115477382(DGLUCY)
GSH: 117363399(DGLUCY)
DRE: 560387(dglucy)
SRX: 107730207
SANH: 107679776
SGH: 107582942
CCAR: 109107902(dglucy)
CAUA: 113117328(dglucy)
CGIB: 127976240
PTET: 122361840 122361911
LROH: 127180093(dglucy)
OMC: 131523004(dglucy)
PPRM: 120476230(dglucy)
RKG: 130080235(dglucy)
MAMB: 125269384(dglucy)
CIDE: 127498091
CERY: 137006344(dglucy)
MASI: 127455145
TROS: 130560724(dglucy)
TDW: 130436517(dglucy)
MANU: 129417005(dglucy)
PDAB: 135778115(dglucy)
AMEX: 103041880(dglucy)
CMAO: 118823329(dglucy)
EEE: 113574126(dglucy)
CHAR: 105892847(dglucy)
SPIL: 134068117(dglucy)
TRU: 101064729(dglucy)
TFS: 130540108(dglucy)
PLEP: 121953640(dglucy)
SLUC: 116065766(dglucy)
ECRA: 117935476(dglucy)
ESP: 116669961(dglucy)
PFLV: 114546972(dglucy)
GAT: 120833002(dglucy)
PPUG: 119227288(dglucy)
AFB: 129103340(dglucy)
CLUM: 117751300(dglucy)
PSWI: 130201227(dglucy)
CANA: 137803305(dglucy)
CVE: 137877698(dglucy)
MSAM: 119910853(dglucy)
CUD: 121526235 121526683
SPUL: 138591051 138591328
LMIX: 132993072(dglucy)
ALAT: 119019729(dglucy)
ASTR: 137610775 137611078 137611174(dglucy)
MZE: 101472904(dglucy)
ONL: 100699337(dglucy)
OAU: 116327984(dglucy)
OLA: 101156702(dglucy)
OML: 112145000(dglucy)
CSAI: 133462528(dglucy)
XMA: 102226444(dglucy)
XCO: 114134371(dglucy)
XHE: 116709043(dglucy)
PRET: 103460669
PFOR: 103154203
PLAI: 106940573
PMEI: 106909503
GAF: 122845725(dglucy)
PPRL: 129374892(dglucy)
CVG: 107101552
CTUL: 119785374(dglucy)
GMU: 124855425(dglucy)
NFU: 107391670(csgr16h14orf159)
KMR: 108247027(dglucy)
ALIM: 106521235
NWH: 119427802(dglucy)
AOCE: 111576395(dglucy)
MCEP: 125023124(dglucy)
CSEM: 103383443 103383463
POV: 109628237(cunh14orf159)
SSEN: 122782986(dglucy)
SSOE: 131444673(dglucy)
HHIP: 117756188(dglucy)
HSP: 118116005(dglucy)
PPLT: 128451405(dglucy)
SMAU: 118285923(dglucy)
LCF: 108886860 108896079 108897871
XGL: 120795425(dglucy)
HCQ: 109519777 109519787
SBIA: 133512835(dglucy)
PEE: 133412837(dglucy)
PTAO: 133487503(dglucy)
BPEC: 110163870 110166339(cunh14orf159)
ENY: 140370885(dglucy) 140370887
MALB: 109965009(cunh14orf159)
BSPL: 114848488(dglucy)
SJO: 128375284(dglucy)
SSCO: 134000761(dglucy)
GMH: 115544179(dglucy)
SASA: 106611165(cssa09h14orf159)
STRU: 115162142(dglucy)
OTW: 112256792(dglucy)
OMY: 110505723(dglucy)
OGO: 124046597(dglucy)
ONE: 115138649(dglucy)
OKI: 109904195(dglucy)
OKE: 118368150(dglucy)
OMM: 135525708(dglucy)
OCLA: 139383287
SALP: 111963420(dglucy)
SNH: 120023204(dglucy)
CCLU: 121544321(dglucy)
ELS: 105015466(dglucy)
OEP: 134026721(dglucy)
SFM: 108933257(dglucy)
PKI: 111852007(dglucy)
AANG: 118225631(dglucy)
AROT: 135253235(dglucy)
CCOG: 133128035(dglucy)
LOC: 102682775(clg7h14orf159) 102692206
PSPA: 121323817 121329475(dglucy)
ARUT: 117402760 117424686 117974027
PSEX: 120518516 120518648(dglucy)
LCM: 102346195
CMK: 103189663(dglucy)
RTP: 109913902(dglucy)
CPLA: 122553350(dglucy)
HOC: 132818004(dglucy)
LERI: 129700050(dglucy)
PMRN: 116948420(DGLUCY)
LRJ: 133352751(DGLUCY)
BFO: 118417907 118420680 118421745
BBEL: 109473801 109482494
CIN: 100180171 100182513
SCLV: 120326613
SPU: 577417
LPIC: 129264336
AJJ: 139961487 139970617 139979093
APLC: 110976733 110976775
ARUN: 117290761 117299680
AAMU: 139942182 139943313
AFIL: 140151959 140152984 140153652
AJC: 117111427
SKO: 100368287
PFLL: 139149981 139149983 139149985
NVE: 5517941 5520806
EPA: 110237437 110242750
ATEN: 116306890 116306892
ADF: 107345094
AMIL: 114950348 114963825
MCAZ: 138025969 138033625 138047290
MFOO: 137968974 137979731 138003157 138004071 138004082
PDAM: 113669485 113670518 113670519 113671845 113671883
SPIS: 111323950 111333603 111339366
DGT: 114520257
XEN: 124441941
HMG: 100204445
HSY: 130656911
RES: 135685622 135685664
AQU: 100637788
SRE: PTSG_03849
FCY: FRACYDRAFT_234119
TVA: TVAG_2v0267260
GTT: GUITHDRAFT_115230
PCAF: DSC91_003834 DSC91_007304
PACS: FAZ98_16120 FAZ98_16130 FAZ98_30245
PAND: DRB87_00220 DRB87_00230
BBH: BN112_2783
BBM: BN115_0626
BBX: BBS798_0630
PIG: EGT29_25985
DIH: G7047_04775
SIMP: C6571_14745 C6571_14755
MESO: BSQ44_13830
SMQ: SinmeB_6592
SMI: BN406_06782
SMER: DU99_19640
SFH: SFHH103_04191 SFHH103_04193
SAME: SAMCFNEI73_pC1585
SINO: SS05631_a42580 SS05631_a42600
ESJ: SJ05684_a37780
BOF: FQV39_07995
PSTG: E8M01_06755
CID: P73_2835
PABY: Ga0080574_TMP528
SAGU: CDO87_23055
RSU: NHU_04230
RHM: B5V46_17770
PAED: G5B38_21360
KNA: B0W47_14230
HADH: FRZ61_46790
DMS: E8L03_06740
GMR: GmarT_08600
GIM: F1728_09980
GPN: Pan110_09310
MRI: Mal4_49100
SDYN: Mal52_21760
PLON: Pla110_04020
GOG: C1280_24635
TIM: GMBLW1_22520
LRS: PX52LOC_06605
FTJ: FTUN_6987
TSPH: KIH39_25660
FWA: DCMF_00955
LPIL: LIP_2227
MGO: AFA91_03835
BLB: BBMN68_890
BLZ: BLGT_03245
BLA: BLA_0133
BLC: Balac_0142
BLT: Balat_0142
BBB: BIF_01419
BBC: BLC1_0133
BNM: BALAC2494_00981
BLV: BalV_0138
BLW: W7Y_0140
BLS: W91_0141
BANI: BL12_00715
BANL: BLAC_00730
BANM: EN10_00730
BDE: BDP_0108
BDN: BBDE_0098
BTP: D805_1222
RIV: Riv7116_1919
FIS: FIS3754_24270
FFO: FFONT_0039
CSU: CSUB_C1123
BARC: AOA65_1114
 » show all
Reference
1  [PMID:14087295]
  Authors
MEISTER A, BUKENBERGER MW, STRASSBURGER M.
  Title
THE OPTICALLY-SPECIFIC  ENZYMATIC CYCLIZATION OF D-GLUTAMATE.
  Journal
Biochem Z 338:217-29 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.48
IUBMB Enzyme Nomenclature: 4.2.1.48
ExPASy - ENZYME nomenclature database: 4.2.1.48
BRENDA, the Enzyme Database: 4.2.1.48
CAS: 37290-80-5
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