Entry
Name
4-oxalomesaconate hydratase;
4-oxalmesaconate hydratase;
4-carboxy-2-oxohexenedioate hydratase;
4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase;
oxalmesaconate hydratase;
gamma-oxalmesaconate hydratase;
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase;
LigJ;
GalB
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate 1,2-hydro-lyase (2-hydroxy-4-oxobutane-1,2,4-tricarboxylate-forming)
Reaction(IUBMB)
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + H2O [RN:
R04478 ]
Reaction(KEGG)
Substrate
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate [CPD:
C04115 ]
Product
(1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate [CPD:
C04324 ];
H2O [CPD:
C00001 ]
Comment
This enzyme participates in the degradation of 3,4-dihydroxybenzoate (via the meta-cleavage pathway), syringate and 3,4,5-trihydroxybenzoate, catalysing the reaction in the opposite direction [1-3]. It accepts the enol-form of 4-oxalomesaconate, 2-hydroxy-4-carboxy-hexa-2,4-dienedioate [4].
History
EC 4.2.1.83 created 1986, modified 2011
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K10220 4-oxalmesaconate hydratase
K16515 4-oxalomesaconate hydratase
Genes
XOO : XOO4559(fldW) XOO4562(fldW)
XPH : XppCFBP6546_13615(XppCFBP6546P_13615)
XHD : LMG31886_42490(ligJ)
LRZ : BJI69_03975 BJI69_16435
PEZ : HWQ56_18635 HWQ56_20100(galB)
MME : Marme_0831 Marme_3420
MPC : Mar181_0340 Mar181_0379
RME : Rmet_3705(ligJ) Rmet_4204
CBW : RR42_s1328 RR42_s1579
CCAM : M5D45_21680 M5D45_26500
BCEN : DM39_6317(ligJ) DM39_6516(ligJ) DM39_6583(ligJ)
BMK : DM80_3763(ligJ) DM80_6490(ligJ)
BMUL : NP80_4019(ligJ) NP80_5251(ligJ)
BGF : BC1003_3989 BC1003_4352
BGD : bgla_1g29820 bgla_2g01760
BGO : BM43_447(ligJ) BM43_6954(ligJ)
BYI : BYI23_B002540 BYI23_D009690
BUE : BRPE67_BCDS04970 BRPE67_DCDS11740
BUQ : AC233_22910 AC233_32525 AC233_32600
BGP : BGL_2c07570 BGL_2c20990
BPLA : bpln_2g08430 bpln_2g21100
BCAI : K788_0001313 K788_0001937 K788_0005434 K788_0006050
PSPW : BJG93_19085 BJG93_19290
PHS : C2L64_29350 C2L64_39350
PTER : C2L65_19025 C2L65_36630 C2L65_41325 C2L65_44685
PGP : CUJ91_20620 CUJ91_24900 CUJ91_24975
PCJ : CUJ87_18755 CUJ87_29870
PTRO : G5S35_26875 G5S35_28070 G5S35_33210
PGIS : I6I06_18630 I6I06_18785 I6I06_25470
PACP : FAZ97_26225 FAZ97_33675 FAZ97_34645 FAZ97_35020
PACS : FAZ98_23660 FAZ98_25945 FAZ98_30410 FAZ98_34240
PEW : KZJ38_26770 KZJ38_27485 KZJ38_32535
PDIO : PDMSB3_0778.1(ligJ)
PSAA : QEN71_19630 QEN71_31330 QEN71_33635
PKF : RW095_05335 RW095_10070
PPAI : E1956_29955 E1956_34565 E1956_36290
PTX : ABW99_00695 ABW99_15640
PAND : DRB87_01275 DRB87_18405
CABK : NK8_43380 NK8_57990 NK8_62540
TCAR : U0034_11240 U0034_28500
BOJ : CBF45_10650 CBF45_13170
ACHO : H4P35_18385 H4P35_24135
AMUI : PE062_15405 PE062_20845
PIG : EGT29_05115 EGT29_07665
PARK : LSG25_04770 LSG25_07715
ACIP : CBP36_05675 CBP36_20265
ACIS : CBP35_13265 CBP35_20340
ACIQ : ACDW_40130 ACDW_44280
DEL : DelCs14_1668 DelCs14_2355
DLA : I6G47_02115 I6G47_26125
CKE : B5M06_09325 B5M06_14265
CRJ : QMY55_10880 QMY55_19195
CENP : M9799_00870 M9799_13110
HYN : F9K07_12185 F9K07_22855 F9K07_27965
DIH : G7047_01830 G7047_04620 G7047_26550
SMIO : CATMQ487_07990(fldW_1) CATMQ487_34490(fldW_2)
DUG : HH213_15605 HH213_29555
TMJ : P0M04_30040 P0M04_30105
URU : DSM104443_01939(ligJ_1) DSM104443_02501(ligJ_2)
RHI : NGR_b14820 NGR_b16280
AVV : RvVAT039_pl06140 RvVAT039_pl06800(fldW)
RLE : RL2853 pRL120276(ligJ)
RAW : NE851_22955 NE851_32450
NEN : NCHU2750_55110(galB)
BGQ : X265_24085 X265_37900
BGZ : XH91_21290 XH91_37100
MTAD : M6G65_24080 M6G65_27560
BGOE : IFJ75_11185 IFJ75_11325
AHT : ANTHELSMS3_03532(galB)
PPAN : ESD82_01070 ESD82_14295
CMAG : CBW24_02300 CBW24_15900
NPP : PP1Y_AT15873 PP1Y_AT31226 PP1Y_Mpl10427
NPN : JI59_20885 JI59_24705
NOV : TQ38_025030 TQ38_028405
NDR : HT578_08950 HT578_09600
RDI : CMV14_06880 CMV14_06945
SHYD : CJD35_16815 CJD35_19565
SPAG : sphantq_03932(ligJ)
RGI : RGI145_02075 RGI145_16730
NCB : C0V82_20155 C0V82_22490
PARH : I5S86_11350 I5S86_11480(galB)
PAUN : MJA45_02735 MJA45_09410
ADAU : NZD86_15560 NZD86_15630 NZD86_19190
MGO : AFA91_01510 AFA91_26590
ROA : Pd630_LPD00181 Pd630_LPD00208
RKO : JWS14_17110 JWS14_17155 JWS14_21130 JWS14_40260 JWS14_47015
SGRF : SGFS_022080 SGFS_097110 SGFS_099520
SMAL : SMALA_3248 SMALA_7815
SSOI : I1A49_02825 I1A49_20035 I1A49_42915
SLE : sle_08640(sle_08640)
SGM : GCM10017557_09450 GCM10017557_43740(fldW) GCM10017557_73350(fldW)
SGD : ELQ87_04770 ELQ87_11400
SFUG : CNQ36_03740 CNQ36_19915
SLF : JEQ17_07835 JEQ17_24550
SSPN : LXH13_02825 LXH13_34020 LXH13_37100 LXH13_38800
SLUO : PS467_02250 PS467_17940 PS467_40265
AARC : G127AT_10865 G127AT_14140 G127AT_14180
ARZ : AUT26_02360 AUT26_19535
ACTQ : OG417_13660 OG417_26270 OG417_26820
AMQ : AMETH_2826 AMETH_3607
AACD : LWP59_16020 LWP59_23285
ARHD : VSH64_08810 VSH64_08860 VSH64_11545 VSH64_16405
PAUT : Pdca_42190(fldW) Pdca_48080
PMAD : BAY61_13635 BAY61_21985
ACTR : Asp14428_20390(fldW)
DACT : KZZ52_32665 KZZ52_33315 KZZ52_36775
BALA : DSM104299_05099(galB)
SBAE : DSM104329_00730(galB)
» show all
Taxonomy
Reference
Authors
Maruyama K
Title
Enzymes responsible for degradation of 4-oxalmesaconic acid in Pseudomonas ochraceae.
Journal
Reference
Authors
Maruyama K
Title
Purification and properties of gamma-oxalomesaconate hydratase from Pseudomonas ochraceae grown with phthalate.
Journal
Reference
Authors
Hara H, Masai E, Katayama Y, Fukuda M
Title
The 4-oxalomesaconate hydratase gene, involved in the protocatechuate 4,5-cleavage pathway, is essential to vanillate and syringate degradation in Sphingomonas paucimobilis SYK-6.
Journal
Reference
Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.83
ExPASy - ENZYME nomenclature database: 4.2.1.83
LinkDB
All DBs